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searching for Aggrecanase 14 found (17 total)

ADAMTS4 (1,619 words) [view diff] exact match in snippet view article find links to article

proteoglycans in articular cartilage in osteoarthritis. Which of these aggrecanases is more important in cartilage degradation appears to be species-specific

ADAMTS-4 endopeptidase (128 words) [view diff] exact match in snippet view article find links to article

ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction Glutamyl endopeptidase; bonds

ADAMTS8 (585 words) [view diff] exact match in snippet view article find links to article

Collins-Racie LA, Flannery CR, Zeng W, et al. (2005). "ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage". Matrix Biol

ADAMTS9 (623 words) [view diff] exact match in snippet view article find links to article

Collins-Racie LA, et al. (2006). "Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5,

Amanda Fosang (605 words) [view diff] exact match in snippet view article find links to article

damage in arthritic disease. Her work showing that ADAMTS-5 is the major aggrecanase in mouse cartilage was published in the high-profile international journal

MMP19 (954 words) [view diff] exact match in snippet view article find links to article

Neame PJ, et al. (1995). "Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan". Biochem

MMP17 (946 words) [view diff] exact match in snippet view article find links to article

PMID 14645246. Gao G, Plaas A, Thompson VP, et al. (2004). "ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl

Mannosamine (101 words) [view diff] exact match in snippet view article find links to article

Kurz B, Sandy JD, Grodzinsky AJ (February 2000). "Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition

Brevican (1,040 words) [view diff] exact match in snippet view article find links to article

Y (Dec 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry

MMP8 (1,249 words) [view diff] exact match in snippet view article find links to article

Neame PJ, et al. (1995). "Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan". Biochem

Matrix metallopeptidase 13 (1,782 words) [view diff] exact match in snippet view article find links to article

(December 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry

CYR61 (4,894 words) [view diff] exact match in snippet view article find links to article

cartilage from patients with osteoarthritis and appears to suppress ADAMTS4 (aggrecanase) activity, possibly leading to cartilage cell (chondrocyte) cloning.

Disease-modifying osteoarthritis drug (2,374 words) [view diff] exact match in snippet view article find links to article

ISSN 1063-4584. Malfait AM, Tortorella MD (2019-09-17). "The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic". Clinical and Experimental Rheumatology

Proteases in angiogenesis (5,423 words) [view diff] exact match in snippet view article find links to article

ADAMTS can be divided into three groups: procollagen aminopeptidase, aggrecanase, and ADAMTS13 which cleaves von Willebrand factor. Unlike with MMPs,