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searching for Bcl-xL 75 found (137 total)

alternate case: bcl-xL

APAF1 (1,677 words) [view diff] case mismatch in snippet view article find links to article

PMID 15262985. Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation"

CLPTM1L (1,570 words) [view diff] exact match in snippet view article find links to article

agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL. Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation

Protectin D1 (2,846 words) [view diff] exact match in snippet view article find links to article

role in regulating the expression of the Bcl-2 family proteins (Bcl-2, Bcl-xL, Bax and Bad) that precedes the release of the cytochrome c complex from

Bcl-x interacting domain (87 words) [view diff] exact match in snippet view article find links to article

Dai S, Zhu Y, Marrack P, Kappler JW (September 2003). "The structure of a Bcl-xL/Bim fragment complex: implications for Bim function". Immunity. 19 (3):

IKZF3 (1,211 words) [view diff] exact match in snippet view article find links to article

A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology. 167 (11):

Peter Colman (1,299 words) [view diff] case mismatch in snippet view article find links to article

G. (2014). "De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization". Journal of Medicinal

BNIP3L (880 words) [view diff] exact match in snippet view article find links to article

19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability".

Craig B. Thompson (2,348 words) [view diff] case mismatch in snippet view article find links to article

homeostasis. His group discovered the first Bcl-2 homolog to be identified, Bcl-Xl, and described the first BH3-only containing regulatory family member, Bcl-xS

Denis Alexander (1,801 words) [view diff] exact match in snippet view article find links to article

'An oncogenic tyrosine kinase inhibits DNA repair and DNA damage-induced Bcl-xL deamidation in T cell transformation'. Alexander, D.R. (2004) Cell Cycle

RTN1 (1,052 words) [view diff] case mismatch in snippet view article find links to article

Tsujimoto Y (November 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity"

Phorbol-12-myristate-13-acetate-induced protein 1 (1,311 words) [view diff] exact match in snippet view article find links to article

JM, Huang DC (June 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. 19 (11):

RAD9A (3,997 words) [view diff] exact match in snippet view article find links to article

BH3 motif, located in the N-terminal of the protein, inhibits Bcl-2 and Bcl-xL proteins that produce the anti-apoptotic activity in the mitochondria, thereby

BCAP31 (1,228 words) [view diff] case mismatch in snippet view article find links to article

Nicholson DW, Cromlish JA, Shore GC (October 1997). "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum". The

Richard Youle (614 words) [view diff] exact match in snippet view article find links to article

that an important step in the initiation of cell death is the migration of Bcl-xL and Bax, two members of the Bcl-2 protein family, from the cytosol onto

Suresh Kumar Rayala (499 words) [view diff] exact match in snippet view article find links to article

groups in predicting the activity of small molecule inhibitors for Bcl-2 and Bcl-xL". Chemical Biology & Drug Design. 90 (2): 308–316. doi:10.1111/cbdd.12952

YWHAQ (1,999 words) [view diff] exact match in snippet view article find links to article

Hsu SY, Kaipia A, Zhu L, Hsueh AJ (November 1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by

Germinal center B-cell like diffuse large B-cell lymphoma (2,442 words) [view diff] case mismatch in snippet view article find links to article

Pro-apoptotic proteins include Bax and Bak. Anti-apoptotic proteins include Bcl-2, Bcl-XL, Bcl-w, Mcl-1. When anti-apoptotic family members are overexpressed, apoptotic

PAR1 (gene) (436 words) [view diff] exact match in snippet view article

NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism" (PDF). J. Cell. Biochem. 96 (3): 641–52. doi:10.1002/jcb

Tyrosine-protein kinase BLK (847 words) [view diff] exact match in snippet view article find links to article

(1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783–6. doi:10.1074/jbc

RPS6KA2 (1,058 words) [view diff] case mismatch in snippet view article find links to article

MR, Ruan H, Comb MJ (2000). "BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival". J. Biol. Chem. 275 (33): 25865–9. doi:10

GFI1B (471 words) [view diff] exact match in snippet view article find links to article

PMID 17272506. Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06

DU145 (795 words) [view diff] case mismatch in snippet view article find links to article

including cyclin A, cyclin D1, and antiapoptotic proteins, such as BCL-2, and BCL-xL. After treatment of DU-145 with EXT, the aforementioned genes are strongly

Serum albumin (793 words) [view diff] exact match in snippet view article find links to article

human serum albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2 2bx8: HUMAN SERUM ALBUMIN COMPLEXED WITH AZAPROPAZONE 2bxa: HUMAN

Reticulon 4 (1,924 words) [view diff] case mismatch in snippet view article find links to article

Tsujimoto Y (Nov 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity"

Reticulon 4 (1,924 words) [view diff] case mismatch in snippet view article find links to article

Tsujimoto Y (Nov 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity"

PAX7 (1,377 words) [view diff] case mismatch in snippet view article find links to article

(June 2000). "Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR". Oncogene. 19

NF-kappa-B-activating protein (492 words) [view diff] exact match in snippet view article find links to article

endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL". Am. J. Physiol. Heart Circ. Physiol. 292 (5): H2467–74. doi:10.1152/ajpheart

SIVA1 (1,004 words) [view diff] case mismatch in snippet view article find links to article

Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis". Apoptosis. 9 (1):

Dibenzoylmethane (458 words) [view diff] case mismatch in snippet view article find links to article

by Hydroxydibenzoylmethane through Coordinative Modulation of Cyclin D3, BCL-XL, and Bax, Release of Cytochrome c, and Sequential Activation of Caspases

PIM2 (gene) (1,990 words) [view diff] case mismatch in snippet view article

multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL". BMC Cell Biol. 7: 1. doi:10.1186/1471-2121-7-1. PMC 1368972. PMID 16403219

CD80 (2,429 words) [view diff] case mismatch in snippet view article find links to article

costimulation can promote T cell survival by enhancing the expression of Bcl-XL". Immunity. 3 (1): 87–98. doi:10.1016/1074-7613(95)90161-2. PMID 7621080

YWHAE (1,633 words) [view diff] exact match in snippet view article find links to article

PMID 9312143. Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by

PPP1CA (1,801 words) [view diff] exact match in snippet view article find links to article

García A, Fleischer A, Rebollo A (July 2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad". Eur. J. Immunol. 32

BCL2L10 (706 words) [view diff] case mismatch in snippet view article find links to article

1016/S0168-1656(99)00121-2. PMID 10486928. Pan G, O'Rourke K, Dixit VM (1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". J. Biol. Chem. 273 (10): 5841–5. doi:10

Farnesoid X receptor (1,979 words) [view diff] exact match in snippet view article find links to article

JC, Peter ME (Feb 2002). "Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator

Fibrolamellar hepatocellular carcinoma (2,189 words) [view diff] case mismatch in snippet view article find links to article

Michael V.; Zhou, Daohong; Simon, Sanford M. (8 September 2022). "Targeting BCL-XL in fibrolamellar hepatocellular carcinoma". JCI Insight. 7 (17): e161820

John Angus Hickman (924 words) [view diff] case mismatch in snippet view article find links to article

Research. 50: 2203 and 2211. Jonas, E.A. (2004). "Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals"

S100A10 (4,728 words) [view diff] exact match in snippet view article find links to article

PMID 10777578. Hsu SY, Kaipia A, Zhu L, Hsueh AJ (Nov 1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by

STAT6 (2,077 words) [view diff] exact match in snippet view article find links to article

"Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression". The Journal of Biological Chemistry. 276 (28): 26107–13. doi:10

TNFRSF12A (2,216 words) [view diff] case mismatch in snippet view article find links to article

system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression". The Journal of Biological Chemistry. 280 (5): 3483–3492

COX5A (988 words) [view diff] exact match in snippet view article find links to article

specifically with Bcl-2, but not with other members of the Bcl-2 family, such as Bcl-xL, Bax or Bak. The Trans-activator of transcription protein (Tat) of human

Marcela Maus (751 words) [view diff] exact match in snippet view article find links to article

Conference Abstracts: Chimeric antigen receptor (CAR) T cells overexpressing Bcl-xL increase proliferation and antitumor activity alone and in combination with

Bcl-2-interacting killer (1,379 words) [view diff] exact match in snippet view article find links to article

(1998). "Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist". J. Biol. Chem. 273 (14): 7783–6. doi:10.1074/jbc

CD28 family receptor (1,292 words) [view diff] exact match in snippet view article find links to article

transcription within T cells and produce signals that lead to IL-2 production and Bcl-xL regulation, an antiapoptotic protein, which are essential for T cell survival

PTPRT (2,618 words) [view diff] case mismatch in snippet view article find links to article

reduction in the total level of transcription of the STAT3 target genes, Bcl-XL and SOCS3. Likewise, expression of wild-type PTPrho decreases the ability

BECN1 (1,482 words) [view diff] case mismatch in snippet view article find links to article

v t e PDB gallery 2p1l: Structure of the Bcl-XL:Beclin 1 complex

ANTXR1 (997 words) [view diff] case mismatch in snippet view article find links to article

"Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein". J. Biol. Chem. 276 (49): 46326–32. doi:10.1074/jbc.M108930200

BCL2L11 (1,403 words) [view diff] case mismatch in snippet view article find links to article

membrane-bounded organelle BIM-BCL-2 complex mitochondrial outer membrane BIM-BCL-xl complex cytoplasmic dynein complex mitochondrion microtubule endomembrane

T-2 mycotoxin (3,180 words) [view diff] case mismatch in snippet view article find links to article

factor Bas (Bcl-2-associated X protein) was increased and the level of Bcl-xl, an anti-apoptotic factor, was decreased in human chrondocytes (cartilage

Steven J. Burakoff (915 words) [view diff] exact match in snippet view article find links to article

proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase

Said Sebti (927 words) [view diff] exact match in snippet view article find links to article

selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors". Eur J Med Chem. 90: 315–31. doi:10.1016/j.ejmech.2014.11.035

Galectin-4 (1,609 words) [view diff] case mismatch in snippet view article find links to article

expression of B-cell lymphoma-2(Bcl-2) and B-cell lymphoma-extra large (Bcl-xl) through activating the STAT3(Signal transducer and activator of transcription)

CUSP9 (883 words) [view diff] exact match in snippet view article find links to article

Westhoff MA, Debatin KM, Wirtz CR, Siegelin MD, Karpel-Massler G. Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic activity

Mathias Bähr (752 words) [view diff] case mismatch in snippet view article find links to article

Germany Kilic E, Dietz GPH, Herrmann DM and Bähr M (2002): Intravenous TAT-Bcl-XL is protective when delivered before and after middle cerebral artery occlusion

Diablo homolog (2,433 words) [view diff] exact match in snippet view article find links to article

XM, Bratton SB, Butterworth M, MacFarlane M, Cohen GM (2002). "Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO

Erythropoietin receptor (3,408 words) [view diff] exact match in snippet view article find links to article

transcriptional factor GATA-1, induces the transcription of pro-survival protein Bcl-xL. Additionally, EpoR has been implicated in suppressing expression of death

Lillian Dyck (2,041 words) [view diff] case mismatch in snippet view article find links to article

Antipsychotics Attenuate Neurotoxicity of β-Amyloid(25-35) by Modulating Bax and Bcl-XL/S Expression and Localization". Journal of Neuroscience Research. 74 (6):

N-alpha-acetyltransferase 10 (5,405 words) [view diff] exact match in snippet view article find links to article

(19 August 2011). "Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival". Cell. 146 (4): 607–20. doi:10.1016/j.cell.2011

YWHAH (3,265 words) [view diff] exact match in snippet view article find links to article

Hsu SY, Kaipia A, Zhu L, Hsueh AJ (November 1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by

Human serum albumin (4,051 words) [view diff] exact match in snippet view article find links to article

human serum albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2 2bx8: HUMAN SERUM ALBUMIN COMPLEXED WITH AZAPROPAZONE 2bxa: HUMAN

Platelet (8,489 words) [view diff] exact match in snippet view article find links to article

is controlled by the internal apoptotic regulating pathway, which has a Bcl-xL timer. Old platelets are destroyed by phagocytosis in the spleen and liver

YWHAZ (3,619 words) [view diff] case mismatch in snippet view article find links to article

cytoplasm, effectively preventing activation of proapoptotic Bcl-2 and Bcl-XL, as well as by preventing NOXA from inhibiting antiapoptotic MCL1. As a

Laura Niedernhofer (1,677 words) [view diff] case mismatch in snippet view article find links to article

"New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463". Aging. 9 (3): 955–963. doi:10.18632/aging

C6orf222 (1,399 words) [view diff] exact match in snippet view article find links to article

domain in the C6orf222 protein was found to interact with both Bcl-2 and Bcl-xL, implicating C6orf222 as being involved in apoptosis. Table of Potential

Peripheral membrane protein (4,391 words) [view diff] exact match in snippet view article find links to article

(June 2006). "Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism". Journal of Molecular Biology

Reactive oxygen species (8,480 words) [view diff] exact match in snippet view article find links to article

cytochrome c release by activating pore-stabilizing proteins (Bcl-2 and Bcl-xL) as well as inhibiting pore-destabilizing proteins (Bcl-2-associated X protein

BNIP3 (2,672 words) [view diff] case mismatch in snippet view article find links to article

until activated. Upon activation, BNIP3 can form heterodimers with BCL2 and BCL-XL and bind to itself. Various conditions have been shown to induce activation

Cladosporium oxysporum (2,291 words) [view diff] case mismatch in snippet view article find links to article

suppressing growth, and down-regulating the expression of NF-B, Bcl-2 and Bcl-XL and up-regulation of pro-apoptotic proteins like Bax, cyt-C and caspase-3

Let-7 microRNA precursor (8,297 words) [view diff] exact match in snippet view article find links to article

T, Hosui A, et al. (May 2010). "The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular

Cell cycle withdrawal (2,194 words) [view diff] case mismatch in snippet view article find links to article

Nettesheim, D.; Chang, B.S.; Thompson, C.B. (1997-04-21). "NMR Structure of BCL-Xl, an Inhibitor of Programmed Cell Death, Minimized Average Structure". doi:10

Major facilitator superfamily (5,029 words) [view diff] exact match in snippet view article find links to article

D (July 2003). "HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death". Cell Death and Differentiation

Andrea Hayes-Jordan (2,464 words) [view diff] exact match in snippet view article find links to article

Lev; Kebin Liu (17 January 2011). "TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated

Mucin-1 (1,787 words) [view diff] case mismatch in snippet view article find links to article

decreases the apoptotic response to DNA damage, and increases anti-apoptotic Bcl-XL and PI3K/Akt pathways. MUC-1 in tumor cells suppresses mitochondria from

Protein acetylation (4,895 words) [view diff] exact match in snippet view article find links to article

Yuan J (2011). "Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival". Cell. 146 (4): 607–620. doi:10.1016/j.cell.2011

Jonathan C. Kagan (3,468 words) [view diff] case mismatch in snippet view article find links to article

(GSDME)-dependent pyroptosis and release of IL-1α. The BCL-2 family members MCL-1 and BCL-xL were identified as the pyroptosis-inducing guards of the translation machinery