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Longer titles found: Blood–brain barrier disruption (view)

searching for Blood–brain barrier 105 found (1348 total)

Choreoathetosis (163 words) [view diff] no match in snippet view article find links to article

kernicterus (rapidly increasing unconjugated bilirubin that cross the blood-brain-barrier in infants). Choreoathetosis is also a common presentation of dyskinesia

Homatropine methylbromide (136 words) [view diff] exact match in snippet view article find links to article

and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal

Deltorphin (413 words) [view diff] exact match in snippet view article find links to article

agonist of the δ-opioid receptor. Deltorphins have an unusually high blood–brain barrier penetration rate. The nonselective opiate antagonist naloxone inhibits

Osmotic diuretic (604 words) [view diff] exact match in snippet view article find links to article

diuretics increase plasma volume, but because they do not cross the blood-brain barrier, this does not affect the nervous system. In effect, this is the

Periventricular nucleus (868 words) [view diff] exact match in snippet view article find links to article

rage center. The periventricular nucleus does not have an effective blood–brain barrier. 11β-HSD2 expression turns cortisol into cortisone. This nucleus

Nasal spray (664 words) [view diff] exact match in snippet view article find links to article

efficient way of transporting drugs with potential use in crossing the blood–brain barrier. Antihistamines work by competing for receptor sites to block the

ABCG4 (689 words) [view diff] exact match in snippet view article find links to article

expressed in the brain, but its localization and function at the blood-brain barrier (BBB) level remain unknown. ATP-binding cassette transporter GRCh38:

4-O-Methylhonokiol (426 words) [view diff] exact match in snippet view article find links to article

also provided data that 4-O-methylhonokiol can readily pass the blood–brain barrier. Clark, Alice M.; El-Feraly, Arouk S.; Li, Wen-Shyong (1981). "Antimicrobial

Arterial spin labelling (2,465 words) [view diff] exact match in snippet view article find links to article

magnetically labels water molecules and measures their movement across the blood-brain barrier complex, which allows for the calculation of the water exchange rate

Amita Sehgal (2,065 words) [view diff] no match in snippet view article find links to article

found that sleep promotes endocytosis through the blood brain barrier in flies. The blood brain barrier (BBB) protects the brain from potentially harmful

Triheptanoin (969 words) [view diff] exact match in snippet view article find links to article

beta-hydroxypentanoate. Each of these ketone bodies easily crosses the blood–brain barrier and enters the brain. Dojolvi is indicated as a source of calories

Cryptococcus neoformans (3,097 words) [view diff] exact match in snippet view article find links to article

the blood–brain barrier by C. neoformans plays a key role in meningitis pathogenesis. However, precise mechanisms by which it passes the blood-brain barrier

Ring-enhancing lesion (139 words) [view diff] exact match in snippet view article find links to article

enhancing contrast dye. This enhancement may represent breakdown of the blood-brain barrier and the development of an inflammatory capsule. This can be a finding

Semustine (1,933 words) [view diff] exact match in snippet view article find links to article

tumours. Due to its lipophilic property, semustine can cross the blood-brain barrier for the chemotherapy of brain tumours, where it interferes with DNA

Sodium pyruvate (342 words) [view diff] exact match in snippet view article find links to article

producing effects, sodium pyruvate has the ability to cross the blood-brain barrier and is used in several studies on brain injury because of these characteristics

Paracellular transport (1,021 words) [view diff] exact match in snippet view article find links to article

faster transit time of food through the gut. Capillaries of the blood–brain barrier have only transcellular transport, in contrast with normal capillaries

Free base (851 words) [view diff] exact match in snippet view article find links to article

(5.81%) of cocaine will remain as free-base and pass through the blood-brain barrier; according to Le Chatelier's principle the acid form of cocaine will

GSK2606414 (284 words) [view diff] exact match in snippet view article find links to article

selective inhibitor of PERK, with good oral bioavailability and blood-brain barrier penetration. PERK mediates the unfolded protein response pathway

A-971432 (365 words) [view diff] exact match in snippet view article find links to article

disease. Stimulation of S1PR5 with A-971432 has been shown to preserve blood-brain barrier integrity and exert a therapeutic effect in an animal model of Huntington's

ABCB4 (1,213 words) [view diff] exact match in snippet view article find links to article

vitamin A carbohydrate export response to vitamin D maintenance of blood-brain barrier cellular response to mycotoxin daunorubicin transport response to

Memory disorder (5,491 words) [view diff] exact match in snippet view article find links to article

hypertension can be contributory to the breakdown of the BBB. The blood-brain barrier (BBB) serves as a “gatekeeper” for the brain by keeping out water

Pennington Biomedical Research Center (784 words) [view diff] no match in snippet view article find links to article

Signaling, Neurodegeneration: Aging and Neurodegeneration, Blood Brain Barrier I, Blood Brain Barrier II, Inflammation and Neurodegeneration, Nutritional Neuroscience

Zotiraciclib (619 words) [view diff] no match in snippet view article find links to article

under the category of small molecule macrocycles. It crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent

Repinotan (2,572 words) [view diff] exact match in snippet view article find links to article

Additionally, it is an extremely potent drug and is able to cross the blood-brain barrier. After infusion, the distribution equilibrium between plasma and

Corticotropin-releasing hormone antagonist (1,117 words) [view diff] exact match in snippet view article find links to article

clinical interest in CRH receptor antagonists that can cross the blood-brain barrier for the treatment of depression and anxiety, along with other conditions

Itopride (1,599 words) [view diff] no match in snippet view article find links to article

effects do not tend to occur due to poor penetration across the blood brain barrier, although a slight raising of prolactin levels may occur. Raising

Ponce Health Sciences University (1,057 words) [view diff] no match in snippet view article find links to article

awarded to the Oregon Health & Science University Neuro-Oncology Blood Brain Barrier Program has given many PHSU students the opportunity to participate

Benzilone (82 words) [view diff] exact match in snippet view article find links to article

Benzilonium bromide (Parke, Davis & Co., Detroit Mich.) is a quarternary antimuscarinic agent with minimal passage of the blood-brain barrier. v t e

Amyloid-related imaging abnormalities (780 words) [view diff] exact match in snippet view article find links to article

involving the breakdown of the tight endothelial junctions of the blood-brain barrier and subsequent accumulation of fluid. In a double-blind trial of

CLDN5 (840 words) [view diff] exact match in snippet view article find links to article

Genome Browser. Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836

Athetosis (2,645 words) [view diff] exact match in snippet view article find links to article

enter the brain through the blood–brain barrier. Normally bilirubin would not be able to diffuse across the blood–brain barrier, but in infants, the barrier

Vinblastine (1,655 words) [view diff] exact match in snippet view article find links to article

Schinkel AH (April 1999). "P-Glycoprotein, a gatekeeper in the blood-brain barrier". Adv Drug Deliv Rev. 36 (2–3): 179–194. doi:10.1016/s0169-409x(98)00085-4

ABCC1 (1,849 words) [view diff] exact match in snippet view article find links to article

adrenal glands. It is also found in the endothelium cells of the blood-brain barrier. Certain polymorphisms in the ABCC1 gene have been shown to be connected

Sex differences in memory (1,896 words) [view diff] no match in snippet view article find links to article

has been known to damage the blood brain barrier (BBB) by causing micro vascular lesions. Damage to the blood brain barrier seems to be connected to cognitive

Oropouche fever (2,111 words) [view diff] exact match in snippet view article find links to article

inflammation. As the infection progresses, the virus crosses the blood-brain barrier and spreads to the brain parenchyma leading to severe manifestations

Methiodal (143 words) [view diff] exact match in snippet view article find links to article

"Effect of radiologic contrast media and local anaesthetics on the blood-brain barrier and on the leptomeninges". Acta Neurologica Scandinavica. 68 (3):

Avarol (596 words) [view diff] exact match in snippet view article find links to article

glioblastoma tumour. It was reported that avarol can penetrate the blood–brain barrier while showing a low neurotoxicity on rat brain synaptosomes. Colon

Radiation-induced cognitive decline (3,527 words) [view diff] exact match in snippet view article find links to article

treatment because chemotherapy is often less effective due to the blood–brain barrier.[citation needed] Unfortunately for some patients, as time passes

CSF glucose (439 words) [view diff] exact match in snippet view article find links to article

and the pathogen, and impaired CSF glucose transport through the blood-brain barrier. There is no pathologic process that directly leads to hyperglycorrhachia

Forensic toxicology (2,423 words) [view diff] no match in snippet view article find links to article

the stomach and small intestine. Subsequently, it transverses the blood brain barrier via the circulatory system. The absorbed alcohol can diminish reflexes

Microchimerism (5,130 words) [view diff] no match in snippet view article find links to article

fetal cells can cross the blood brain barrier in mice. The properties of these cells allow them to cross the blood brain barrier and target injured brain

FG-8205 (268 words) [view diff] exact match in snippet view article find links to article

PMC 1917729. PMID 1963808. Lin JH, Chen IW, Lin TH (December 1994). "Blood–brain barrier permeability and in vivo activity of partial agonists of benzodiazepine

Postprandial somnolence (1,778 words) [view diff] exact match in snippet view article find links to article

preferentially available to the large neutral amino acid transporter at the blood–brain barrier. Uptake of tryptophan by the brain thus increases. In the brain,

Postprandial somnolence (1,778 words) [view diff] exact match in snippet view article find links to article

preferentially available to the large neutral amino acid transporter at the blood–brain barrier. Uptake of tryptophan by the brain thus increases. In the brain,

Lixisenatide (1,918 words) [view diff] no match in snippet view article find links to article

agonists liraglutide and lixisenatide. The kinetics of crossing the blood brain barrier (BBB), activation of the GLP-1R by measuring cAMP levels, and physiological

N-Ethylhexedrone (2,348 words) [view diff] exact match in snippet view article find links to article

cathinones are generally less able than amphetamines to cross the blood–brain barrier because the beta-keto group causes an increase in polarity. Unlike

Quinapyramine (96 words) [view diff] exact match in snippet view article find links to article

trypanosomiasis in quinapyramine sulfate-treated horses--a breach of the blood-brain barrier?". Tropical Animal Health and Production. 46 (2): 371–7. doi:10

3-Hydroxyphenazepam (422 words) [view diff] case mismatch in snippet view article find links to article

"Pharmacodynamical and Neuroreceptor Analysis of the Permeability of the Blood-Brain Barrier for Derivatives of 1,4-Benzodiazepine". Neurophysiology. 46 (3):

Adenosine (3,346 words) [view diff] exact match in snippet view article find links to article

have recently shown adenosine receptors to be key in opening the blood-brain barrier (BBB). Mice dosed with adenosine have shown increased transport across

Sickness behavior (2,364 words) [view diff] exact match in snippet view article find links to article

proteins that generally do not easily passively diffuse across the blood-brain barrier. They may also induce the expression of other cytokines in the brain

Neuroprotection (3,639 words) [view diff] no match in snippet view article find links to article

semi-synthetic tetracycline compound that is capable of crossing the blood brain barrier. It is known to be a strong antioxidant and has broad anti-inflammatory

ImKTx88 (1,043 words) [view diff] exact match in snippet view article find links to article

extravasation into central nervous system (CNS) and by stabilizing the blood-brain barrier (BBB). Moreover, this toxin improves the severity of loss or redistribution

1969 Huckleby Mercury Poisoning (1,034 words) [view diff] exact match in snippet view article find links to article

the blood-brain barrier poorly, biotransformation of methyl to inorganic mercury may have occurred after methylmercury crossed the blood-brain barrier, accounting

GLUT3 (768 words) [view diff] exact match in snippet view article find links to article

mediated primarily by a high molecular weight form of GLUT1 in the blood–brain barrier, GLUT3 in neuronal populations and a less glycosylated form of GLUT1

GPR124 (805 words) [view diff] exact match in snippet view article find links to article

endothelial cell migration regulation of chemotaxis angiogenesis signal transduction regulation of establishment of blood-brain barrier Sources:Amigo / QuickGO

Sympatholytic (1,303 words) [view diff] no match in snippet view article find links to article

in the brain. By administering beta blockers which can cross the blood brain barrier immediately following a traumatic event, as well as over the next

Carbidopa/levodopa/entacapone (734 words) [view diff] exact match in snippet view article find links to article

blood–brain barrier. Carbidopa is a peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. Carbidopa, which also does not cross the blood–brain

Angiotensin-converting enzyme (2,536 words) [view diff] exact match in snippet view article find links to article

domain portion on the ACE enzyme. ACE inhibitors that cross the blood–brain barrier and have preferentially selected N-terminal activity may therefore

Martin Lauritzen (1,289 words) [view diff] exact match in snippet view article find links to article

vessels, and the regulation of the cerebral circulation and the blood-brain barrier (BBB) in health and disease. In his early career, he identified the

Ultrafine particle (2,516 words) [view diff] no match in snippet view article find links to article

include targeting the circulatory system, and or passage of the blood brain barrier to name just a few. Certain UFPs like silver based nanostructures

Aprotinin (2,912 words) [view diff] exact match in snippet view article find links to article

reported that treatment with aprotinin prevents disruption of the blood–brain barrier during the C. neoformans infection. Another study in cell cultures

Lisbeth Berg-Hansen (410 words) [view diff] no match in snippet view article find links to article

dangerous effects of the pesticide including its ability to cross the blood brain barrier. Kurt Oddekalv, Norwegian environmental activist called her corrupt

Intracerebral hemorrhage (4,483 words) [view diff] exact match in snippet view article find links to article

the brain and causes brain oedema. Besides, the breaking down of blood-brain barrier also contributes to the odema formation. Apart from CT scans, haematoma

John Treherne (724 words) [view diff] exact match in snippet view article find links to article

Peter Evans, Philip Schofield, and Helen Skaer. He demonstrated the blood-brain barrier in insects, among the few invertebrates to have them. Treherne served

Lord Dowding Fund for Humane Research (978 words) [view diff] no match in snippet view article find links to article

University of Nottingham, and his team have created an artificial human Blood Brain Barrier – a defence mechanism set up by blood vessels to protect the brain

Route of administration (4,524 words) [view diff] no match in snippet view article find links to article

malignancies of the brain. The intracerebral route can also interrupt the blood brain barrier from holding up against subsequent routes. Intracerebroventricular

Pyridostigmine (902 words) [view diff] exact match in snippet view article find links to article

quaternary carbamate inhibitor of cholinesterase that does not cross the blood–brain barrier. It carbamylates about 30% of peripheral cholinesterase enzyme, and

Distribution (pharmacology) (1,433 words) [view diff] exact match in snippet view article

interesting are: Capillary bed permeability, which varies between tissues. Blood-brain barrier: this is located between the blood plasma in the cerebral blood vessels

Pralidoxime (677 words) [view diff] exact match in snippet view article find links to article

reversing paralysis of the respiratory muscles but due to its poor blood–brain barrier penetration, it has little effect on centrally-mediated respiratory

Nicotine salt (1,182 words) [view diff] no match in snippet view article find links to article

September 2019. She also stated that the nicotine salts "cross the blood brain barrier and lead to potentially more effect on the developing brain in adolescents

Flupentixol/melitracen (651 words) [view diff] no match in snippet view article find links to article

plasma proteins; widely distributed in the body and crosses the blood brain barrier. Metabolism: Flupentixol: Extensively hepatic metabolism. Excretion:

GABA transporter type 2 (671 words) [view diff] no match in snippet view article find links to article

GABA and taurine from the brain to circulating blood through the blood brain barrier. GAT1 and GAT3 have higher concentrations in the brain and have higher

Junctional adhesion molecule (1,824 words) [view diff] case mismatch in snippet view article find links to article

Tight Junction in the Blood-Brain Barrier". In HS, Westman J (eds.). 1 - Proteins of the Tight Junction in the Blood-Brain Barrier. San Diego: Academic

Mepacrine (1,451 words) [view diff] exact match in snippet view article find links to article

lack of an in vivo effect include inefficient penetration of the blood–brain barrier, as well as the existence of drug-resistant prion proteins that increase

Desmoteplase (1,346 words) [view diff] exact match in snippet view article find links to article

absence of neurotoxicity, and no apparent negative effect on the blood–brain barrier. Desmoteplase also has a half-life of about four hours; rtPA has

Drug-induced aseptic meningitis (766 words) [view diff] exact match in snippet view article find links to article

MRI and CT imaging of the brain has shown changes consistent with Blood-brain barrier disruption or cerebral edema including T2-weighted changes that were

Cholinergic neuron (2,446 words) [view diff] exact match in snippet view article find links to article

therapy is that choline acetyltransferase is largely blocked by the blood-brain barrier. PTD-ChAT is a fusion protein made up of both protein transduction

Susan M. Lunte (754 words) [view diff] exact match in snippet view article find links to article

transport of peptides across the blood-brain barrier or diagnosis of metabolic disease. In her studies of the blood brain barrier, Lunte seeks to inform the

Dopamine receptor D2 (3,958 words) [view diff] exact match in snippet view article find links to article

and D3 antagonist; does not cross the blood-brain barrier Metoclopramide – Antiemetic, crosses blood-brain barrier. Causes drug-induced Parkinsonism. Eticlopride

Satralizumab (1,447 words) [view diff] exact match in snippet view article find links to article

autoantibodies against aquaporin-4 (AQP4), and the permeability of the blood-brain barrier to mediators of inflammation. The effectiveness and safety of satralizumab

Defensive vomiting (318 words) [view diff] exact match in snippet view article find links to article

zone, the part of the area postrema that relays signals through the blood-brain barrier "Why rats don't vomit". www.ratbehavior.org. Retrieved 13 October

Guangzhao Mao (1,445 words) [view diff] exact match in snippet view article find links to article

transported along specific neural pathways, allowing them to bypass the blood–brain barrier and target the CNS directly. Mao used human embryonic stem cells

Neurotoxic shellfish poisoning (1,074 words) [view diff] exact match in snippet view article find links to article

brevetoxins are able to pass through cell membranes and cross the blood-brain barrier. They are metabolized primarily by the liver and are excreted in

Guangzhao Mao (1,445 words) [view diff] exact match in snippet view article find links to article

transported along specific neural pathways, allowing them to bypass the blood–brain barrier and target the CNS directly. Mao used human embryonic stem cells

CX717 (1,512 words) [view diff] exact match in snippet view article find links to article

FDA had concluded. The relatively poor oral bioavailability and blood–brain barrier penetration of CX-717 ultimately led to Cortex abandoning development

Health effects of pesticides (3,803 words) [view diff] no match in snippet view article find links to article

some pesticides and their metabolites cross the placenta and fetal blood-brain-barrier, which has not fully developed in a fetus. In addition, an accumulation

Blood lead level (2,698 words) [view diff] no match in snippet view article find links to article

child's body, it reaches the brain through the not fully developed blood brain barrier. The body removes lead from blood and stores it in bone, but in children

Antimotility agent (644 words) [view diff] no match in snippet view article find links to article

and frequency. Unlike other opiates, loperamide does not cross the blood brain barrier, so there is minimal risk for abuse. Side effects of use of anti-motility

Hysteroscopy (2,022 words) [view diff] no match in snippet view article find links to article

been reported. Glycine metabolizes into ammonia and can cross the blood brain barrier, causing agitation, vomiting and coma. Mannitol 5% should be used

CCR1 (1,262 words) [view diff] exact match in snippet view article find links to article

(January 1999). "Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection". NeuroReport. 10 (1): 53–6. doi:10

Retinol-binding protein (1,604 words) [view diff] exact match in snippet view article find links to article

retinol-binding protein and retinol-binding protein in cells comprising the blood-brain barrier of rat and human". Proceedings of the National Academy of Sciences

Alpha-tocopherol transfer protein (909 words) [view diff] exact match in snippet view article find links to article

regulation of cell death negative regulation of establishment of blood-brain barrier response to pH vitamin transport response to toxic substance vitamin

Creative biomart (207 words) [view diff] exact match in snippet view article find links to article

Felix (9 January 2013). "Neurovascular protection by targeting early blood–brain barrier disruption with neurotrophic factors after ischemia–reperfusion in

Glycosidic bond (2,047 words) [view diff] exact match in snippet view article find links to article

Yamamura, Henry I. (2005-01-10). "Biousian glycopeptides penetrate the blood–brain barrier". Tetrahedron: Asymmetry. Carbohydrate Science. Part 1. 16 (1): 65–75

PDGFRB (3,403 words) [view diff] exact match in snippet view article find links to article

PDGFRB maintains blood–brain barrier integrity and that loss of the PDGFRB receptor or its ligand, PDGFB, disrupts the blood–brain barrier, subsequently

YAP1 (3,433 words) [view diff] exact match in snippet view article find links to article

signaling pathway may exert neuroprotective effects through mitigating blood-brain barrier disruption after cerebral ischemia/reperfusion injury. Heterozygous

George Cotzias (547 words) [view diff] no match in snippet view article find links to article

early stages of Parkinson's. Unlike dopamine, L-Dopa passes the blood brain barrier. This produced transient benefit after injection of L-dopa. However

Postoperative nausea and vomiting (1,669 words) [view diff] exact match in snippet view article find links to article

floor of the fourth ventricle and is effectively outside of the blood-brain barrier, which makes it incredibly sensitive to toxin and pharmacological

Concentrative nucleoside transporter 2 (907 words) [view diff] exact match in snippet view article find links to article

via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood–brain barrier". J. Pharmacol. Exp. Ther. 299 (2): 735–40. PMID 11602688. Gerstin

Streptomyces avidinii (361 words) [view diff] exact match in snippet view article find links to article

1420. doi:10.1002/cite.201450638. Nag, Sukriti, ed. (2003). The blood-brain barrier biology and research protocols. Totowa, N.J: Humana Press. ISBN 978-1-59259-419-1

Cardiac marker (1,011 words) [view diff] exact match in snippet view article find links to article

enzyme exists in cardiac (heart) and brain tissue. Because of the blood–brain barrier, GP-BB can be seen as being specific to heart muscle. GP-BB is one

Toxic encephalopathy (1,909 words) [view diff] exact match in snippet view article find links to article

rapidly, as they are lipophilic and readily transported across the blood–brain barrier. This is a result of increased membrane solubility and local blood

CLDN22 (402 words) [view diff] exact match in snippet view article find links to article

S2CID 12132159. Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836

Meninges (1,584 words) [view diff] exact match in snippet view article find links to article

Yusof, SR; Begley, DJ (January 2010). "Structure and function of the blood-brain barrier". Neurobiology of Disease. 37 (1): 13–25. doi:10.1016/j.nbd.2009

Hypouricemia (1,438 words) [view diff] exact match in snippet view article find links to article

multiple sclerosis patients correlate with activity of disease and blood–brain barrier dysfunction". Eur. J. Neurol. 9 (3): 221–6. doi:10.1046/j.1468-1331