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searching for Chemical space 64 found (74 total)

Dihydrofolate reductase inhibitor (406 words) [view diff] exact match in snippet view article find links to article

found application as antibacterial agents. An extensive review of the chemical space of small-molecules that inhibit DHFR is summarized in Classes of small-molecules

Controlled Substances Act (9,247 words) [view diff] exact match in snippet view article find links to article

fentanyl chemical space, the CSA started to use Markush descriptions to clearly define what analogues or chemical space is controlled. These chemical space, chemical

Advanced Space Propulsion Investigation Committee (256 words) [view diff] exact match in snippet view article find links to article

Aeronautical and Space Sciences in 1994. Its purpose was to study various non-chemical space propulsion systems instead of the conventional rocket for the use of

In vivo (750 words) [view diff] exact match in snippet view article find links to article

Retrieved 2023-12-11. Lipinski C, Hopkins A (December 2004). "Navigating chemical space for biology and medicine". Nature. 432 (7019): 855–61. Bibcode:2004Natur

Druglikeness (890 words) [view diff] exact match in snippet view article find links to article

Simple rules are not always accurate and may unnecessarily limit the chemical space to search: many best-selling drugs have features that cause them to

5-Chloro-DMT (221 words) [view diff] case mismatch in snippet view article find links to article

Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space". Marine Drugs. 15 (8): 248. doi:10.3390/md15080248. PMC 5577603. PMID 28792478

Controlled substance (1,420 words) [view diff] exact match in snippet view article find links to article

However, the reality is that most countries enact “generic statement" or “chemical space” laws, which aim to control all chemicals similar to the “named” substance

Mass driver (3,266 words) [view diff] exact match in snippet view article find links to article

passengers and/or cargo to very high velocities. In contrast to cargo-only chemical space-gun concepts, a mass driver could be any length, affordable, and with

Misuse of Drugs Act 1971 (2,669 words) [view diff] exact match in snippet view article find links to article

list all of these. The act contains several "generic statements" or "chemical space" laws, which aim to control all chemicals similar to the "named" substance

Skyhook (structure) (1,398 words) [view diff] case mismatch in snippet view article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Air launch (1,373 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Open Notebook Science Challenge (325 words) [view diff] case mismatch in snippet view article find links to article

PCA Chemical Space for Ethanol

Portentol (400 words) [view diff] exact match in snippet view article find links to article

cancer cell lines. Of greater interest is the structural skeleton and chemical space the molecule possesses, which were ultimately determined by detailed

PIM2 (gene) (1,990 words) [view diff] exact match in snippet view article

PMID 17406720. Meggers E (Jun 2007). "Exploring biologically relevant chemical space with metal complexes". Current Opinion in Chemical Biology. 11 (3):

Ram accelerator (842 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Stuart Schreiber (3,398 words) [view diff] exact match in snippet view article find links to article

that DOS can produce small molecules distributed in defined ways in chemical space by virtue of their different skeletons and stereochemistry, and that

Coilgun (3,972 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Quorum sensing (9,801 words) [view diff] exact match in snippet view article find links to article

Stalmans S, Bracke N, et al. (January 2013). "Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides". Nucleic

Quicklaunch (569 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Space gun (1,741 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Lipinski's rule of five (1,196 words) [view diff] exact match in snippet view article find links to article

peptides using machine learning algorithms and navigating in their chemical space". Scientific Reports. 11 (1): 7628. Bibcode:2021NatSR..11.7628D. doi:10

Laser propulsion (3,188 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Cyclic compound (3,320 words) [view diff] case mismatch in snippet view article find links to article

doi:10.1007/BF01141802. S2CID 93804259. Reymond, Jean-Louis (2015). "The Chemical Space Project". Accounts of Chemical Research. 48 (3): 722–30. doi:10.1021/ar500432k

Spaceplane (6,081 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Launch loop (2,538 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Assembly theory (2,072 words) [view diff] exact match in snippet view article find links to article

instrument to search for biosignatures. The theory was extended to map chemical space with molecular assembly trees, demonstrating the application of this

Henry Rzepa (1,074 words) [view diff] exact match in snippet view article find links to article

doi:10.1039/b810147g. PMID 19050778. Rzepa, H. S. (2009). "Wormholes in chemical space connecting torus knot and torus link π-electron density topologies"

Markov chain (13,271 words) [view diff] case mismatch in snippet view article find links to article

Algorithm for the de Novo Generation of Molecules Occupying Druglike Chemical Space". Journal of Chemical Information and Modeling. 49 (7): 1630–1642. doi:10

List of spaceplanes (29 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Orbital ring (2,531 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

John Hunter (scientist) (140 words) [view diff] case mismatch in snippet view article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Free-energy perturbation (823 words) [view diff] exact match in snippet view article find links to article

free-energy perturbation for computing potentials of mean force in chemical space is thermodynamic integration. Another alternative, which is probably

Rocket sled launch (1,654 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Non-rocket spacelaunch (5,505 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Space elevator (10,333 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Railgun (12,262 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Defensin (3,451 words) [view diff] exact match in snippet view article find links to article

of cnidarian trans-defensins: Sequence, structure and exploration of chemical space". Proteins. 87 (7): 551–560. doi:10.1002/prot.25679. hdl:11343/285595

Natural product (9,571 words) [view diff] exact match in snippet view article find links to article

and ethnopharmacology, and to find pharmacologically useful areas of chemical space. To achieve this, many technological advances have been made, such as

Chemputation (641 words) [view diff] exact match in snippet view article find links to article

system for the design and execution of chemical code for exploring chemical space, finding reactivity, new reactions, new molecules, and ensuring reproducible

David Beratan (1,409 words) [view diff] exact match in snippet view article find links to article

Wipf, W. Yang, and D.N. Beratan, “Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds

European Lead Factory (564 words) [view diff] exact match in snippet view article find links to article

Morgentin, Remy; Nelson, Adam; Müller, Gerhard (2015-11-01). "Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead

StarTram (3,455 words) [view diff] case mismatch in snippet view article find links to article

Electrical Coilgun Mass driver Railgun StarTram Chemical Space gun Blast wave accelerator Ram accelerator Mechanical Slingatron

Cholestasis (12,671 words) [view diff] exact match in snippet view article find links to article

2016). "Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists". Scientific Reports

Apple Bank Building (7,310 words) [view diff] case mismatch in snippet view article find links to article

2022. "Banking Changes on the West Side: Chase National Gets Former Chemical Space at Broadway and 73d Street". The New York Times. April 4, 1943. p. RE1

Ramesh Jasti (364 words) [view diff] case mismatch in snippet view article find links to article

Bruce P.; Pluth, Michael D.; Jasti, Ramesh (2018). "Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells". ACS Central Science

Computer Atlas of Surface Topography of Proteins (1,472 words) [view diff] exact match in snippet view article find links to article

specific targets are measured, so how well the compound sets bind to the chemical space will decide the binding efficiency. Success rates of virtually docking

Artificial cell (8,250 words) [view diff] exact match in snippet view article find links to article

self-assemble from two half-cells "lablets" to enclose an internal chemical space, and function with the aid of active electronics powered by the medium

Martin D. Burke (1,254 words) [view diff] exact match in snippet view article find links to article

ISSN 0968-0896. PMID 11425569. Kirkpatrick, Peter (2003). "New directions in chemical space". Nature Reviews Drug Discovery. 2 (12): 948. doi:10.1038/nrd1266. ISSN 1474-1784

Alternatives to animal testing (8,293 words) [view diff] exact match in snippet view article find links to article

Lipinski, Christopher; Hopkins, A (16 December 2004). "Navigating chemical space for biology and medicine". Nature. 432 (7019): 855–61. Bibcode:2004Natur

Biochemical cascade (11,432 words) [view diff] exact match in snippet view article find links to article

categorized as building blocks in the genomic space (KEGG GENES), the chemical space (KEGG LIGAND), wiring diagrams of interaction networks and reaction

2-hydroxy-dATP diphosphatase (2,845 words) [view diff] case mismatch in snippet view article find links to article

Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space". Journal of Medicinal Chemistry. 60 (19): 8160–8169. doi:10.1021/acs

Sean Ekins (2,558 words) [view diff] case mismatch in snippet view article find links to article

28(8):609-613, 2010 Ekins S, Gupta R, Gifford E, Bunin BA, Waller CL, Chemical Space: missing pieces in cheminformatics, Pharm Res, 27: 2035-2039, 2010 Gupta

Interface force field (2,760 words) [view diff] exact match in snippet view article find links to article

parameters for minerals, metals, and polymers. The force fields covered new chemical space and were one to two orders of magnitude more accurate than prior models

Machine learning in bioinformatics (8,072 words) [view diff] exact match in snippet view article find links to article

their encoded pathways, BGCs/GCFs can serve as a proxy to explore the chemical space of microbial secondary metabolism. Cataloging GCFs in sequenced microbial

Druggability (1,987 words) [view diff] exact match in snippet view article find links to article

interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations". IUBMB Life. 62 (10):

Trioxoglutaric acid (283 words) [view diff] exact match in snippet view article find links to article

Aspuru-Guzik, Alán (2018-01-10). "A thermodynamic atlas of carbon redox chemical space". bioRxiv 10.1101/245811. Mikhail Li Rabinovich (2010): "Wood hydrolysis

Function-spacer-lipid Kode construct (3,722 words) [view diff] exact match in snippet view article find links to article

Fig. 1 A structural analogy of a Lego Minifigure to a chemical space filling models of an FSL construct. The FSL construct is a peptide-based partially

Cell-penetrating peptide (7,214 words) [view diff] exact match in snippet view article find links to article

peptides using machine learning algorithms and navigating in their chemical space". Scientific Reports. 11 (1): 7628. Bibcode:2021NatSR..11.7628D. doi:10

Chemoproteomics (6,157 words) [view diff] exact match in snippet view article find links to article

PJ, Ortholand JY, Roche D (2020-10-21). "Exploring new targets and chemical space with affinity selection-mass spectrometry". Nature Reviews Chemistry

Chemical graph generator (5,061 words) [view diff] exact match in snippet view article find links to article

2017). "Molecular structures enumeration and virtual screening in the chemical space with RetroPath2.0". Journal of Cheminformatics. 9 (1): 64. doi:10

Empowering Women in Organic Chemistry (1,472 words) [view diff] case mismatch in snippet view article find links to article

Practical Advice on Telling your Science Stories Emma Parmee Merck & Co. New Directions in Chemistry at Merck: Expanding Exploration of Chemical Space

Mohamed H. Alkordi (866 words) [view diff] exact match in snippet view article find links to article

for their utilization in a myriad of demanding applications where the chemical space within the pores of such solids can readily be tuned and, further, designed

Proto-metabolism (3,734 words) [view diff] case mismatch in snippet view article find links to article

Martin; Merkle, Daniel; Stadler, Peter (2013-09-25). "Navigating the Chemical Space of HCN Polymerization and Hydrolysis: Guiding Graph Grammars by Mass

SIRIUS (software) (5,845 words) [view diff] case mismatch in snippet view article

; Samanipour, Saer (26 September 2023). "Critical Assessment of the Chemical Space Covered by LC–HRMS Non-Targeted Analysis". Environmental Science & Technology