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searching for Chiral inversion 5 found (14 total)

Dexibuprofen (422 words) [view diff] exact match in snippet view article find links to article

inactive (R)-enantiomer, the distomer, undergoes a unidirectional chiral inversion to give the active (S)-enantiomer, the former acting as a prodrug for

Alpha-methylacyl-CoA racemase (2,219 words) [view diff] exact match in snippet view article find links to article

overexpressed in this type of tumour. The enzyme is also involved in a chiral inversion pathway which converts ibuprofen, a member of the 2-arylpropionic acid

Flunoxaprofen (843 words) [view diff] exact match in snippet view article find links to article

through biotransformation to the S-enantiomer. This stereospecific chiral inversion is mediated by the FLX-S-Acyl-CoA thioester. Pharmacokinetic studies

Eudysmic ratio (1,250 words) [view diff] exact match in snippet view article find links to article

Roth B, Fyge A, Höglund P (1995). "Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide"

Enantiopure drug (2,502 words) [view diff] exact match in snippet view article find links to article

enters the body, a little over half of the R-enantiomers experience chiral inversion and transform into the favored S-enantiomer. This observation has led