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Longer titles found: Chromosome 21 (TV series) (view), Chromosome 21 open reading frame 91 (view)

searching for Chromosome 21 75 found (301 total)

Ayazi syndrome (163 words) [view diff] exact match in snippet view article find links to article

Ayazi syndrome (or Chromosome 21 Xq21 deletion syndrome) is a syndrome characterized by choroideremia, congenital deafness and obesity. The presentation

Genetic architecture (1,485 words) [view diff] exact match in snippet view article find links to article

copies of functional genomic elements on chromosome 21 and genetic variation of chromosome 21 and non-chromosome 21 loci predispose patients to abnormal heart

Radiation hybrid mapping (268 words) [view diff] exact match in snippet view article find links to article

the RH procedure was used to map 14 DNA probes from a region of human chromosome 21 spanning 20 megabase pairs. Radiation hybrid mapping was also used in

Gene dosage (783 words) [view diff] exact match in snippet view article find links to article

Syndrome is caused by trisomy 21, which means having three copies of chromosome 21. Thus gene dosage is increased by 50% for the genes on that chromosome

Human artificial chromosome (1,264 words) [view diff] exact match in snippet view article find links to article

based on a stripped copy of human chromosome 21, producing a chromosome 5 Mb in length. Truncation of chromosome 21 resulted in a human artificial chromosome

Nondisjunction (2,847 words) [view diff] exact match in snippet view article find links to article

the normal number of 2 in diploid cells. Down syndrome, a trisomy of chromosome 21, is the most common anomaly of chromosome number in humans. The majority

Developmental disability (8,237 words) [view diff] exact match in snippet view article find links to article

a genetic condition in which people are born with an extra copy of chromosome 21. This extra copy affects the development of the body and brain, causing

List of diseases (C) (3,648 words) [view diff] exact match in snippet view article

Chromosome 20, trisomy Chromosome 21 monosomy Chromosome 21 ring Chromosome 21, monosomy 21q22 Chromosome 21, tetrasomy 21q Chromosome 21, uniparental disomy

Congenital contractural arachnodactyly in cattle (389 words) [view diff] exact match in snippet view article find links to article

Greys. The mutation which causes this defect is a deletion on bovine chromosome 21. Affected calves are usually born alive with normal body weight, and

TTC3P1 (143 words) [view diff] no match in snippet view article find links to article

Tetratricopeptide repeat domain 3 pseudogene 1 is a protein that in humans is encoded by the TTC3P1 gene. GeneCards Symbol: TTC3P1 2 Tetratricopeptide

Jean-Loup Huret (494 words) [view diff] exact match in snippet view article find links to article

team, that it was due to a microduplication (less than 3 Mb) of DNA on chromosome 21, demonstrating that only a very few genes alteration could be responsible

Lymphocyte function-associated antigen 1 (946 words) [view diff] exact match in snippet view article find links to article

LAD1 is caused by low expression of CD11 and CD18. CD18 is found on chromosome 21 and CD11 is found on chromosome 16. Leukocyte adhesion deficiency Lifitegrast

ERF (gene) (733 words) [view diff] exact match in snippet view article

Busciglio J, Kola I, Hertzog PJ (December 2003). "Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis". Neurobiology

Mitochondrial ribosomal protein L10 (542 words) [view diff] exact match in snippet view article find links to article

neurons differentiated from mouse ES cells containing a single human chromosome 21". Biochem. Biophys. Res. Commun. 314 (2): 335–50. doi:10.1016/j.bbrc

NcRNA therapy (5,353 words) [view diff] exact match in snippet view article find links to article

observe the inactivation of one of chromosome 21 in the form of a condensed heterochromatin and labeled it as a chromosome 21 barr body. Such experiments have

SH3BGRL3 (949 words) [view diff] exact match in snippet view article find links to article

0. SH3 binding glutamic acid-rich (SH3BGR) gene is located to human chromosome 21. Two homologous genes, SH3BGRL and SH3BGRL3 are located to chromosome

Meiosis (7,297 words) [view diff] exact match in snippet view article find links to article

aneuploidies can be tolerated, such as trisomy for the smallest chromosome, chromosome 21. Phenotypes of these aneuploidies range from severe developmental disorders

SIM1 (1,379 words) [view diff] exact match in snippet view article find links to article

proposed that the human SIM2 gene, which resides in a critical region of chromosome 21, is a candidate for involvement in certain dysmorphic features (particularly

Bacterial artificial chromosome (925 words) [view diff] exact match in snippet view article find links to article

750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene". Genome Research

CFAP298 (1,247 words) [view diff] exact match in snippet view article find links to article

intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728

MEMO1 (358 words) [view diff] exact match in snippet view article find links to article

PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001

Rudolph E. Tanzi (4,371 words) [view diff] exact match in snippet view article find links to article

gene, SOD1, by providing the key genetic and physical mapping data for chromosome 21 used to find the gene defect. As the leader of the Cure Alzheimer's

Chestnut (horse color) (2,060 words) [view diff] exact match in snippet view article

responsible for the palomino and buckskin coat colors, mapes to horse chromosome 21". Animal Genetics. 32 (6): 340–343. doi:10.1046/j.1365-2052.2001.00806

Germline mutation (3,080 words) [view diff] exact match in snippet view article find links to article

having 3 copies of chromosome 21. This chromosome duplication occurs during germ cell formation, when both copies of chromosome 21 end up in the same

Cytogenetics (2,921 words) [view diff] exact match in snippet view article find links to article

Lejeune discovered patients with Down syndrome had an extra copy of chromosome 21. Down syndrome is also referred to as trisomy 21. Other numerical abnormalities

Palomino (2,199 words) [view diff] exact match in snippet view article find links to article

responsible for the palomino and buckskin coat colors, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–343. doi:10.1046/j.1365-2052.2001.00806

Genetic disorder (3,582 words) [view diff] exact match in snippet view article find links to article

most common form of Down syndrome), in which there is an extra copy of chromosome 21 in all cells. Due to the wide range of genetic disorders that are known

X-inactivation (5,683 words) [view diff] exact match in snippet view article find links to article

example, Jiang et al. inserted a copy of the Xist gene into one copy of chromosome 21 in stem cells derived from an individual with trisomy 21 (Down syndrome)

G protein-gated ion channel (3,706 words) [view diff] exact match in snippet view article find links to article

chromosome 21 and encodes for the GIRK2 protein subunit of G protein-gated K+ channels. People with Down Syndrome have three copies of chromosome 21,

Gregg L. Semenza (1,556 words) [view diff] exact match in snippet view article find links to article

Harvard University, he studied medical genetics and mapped genes on chromosome 21. For his PhD at the University of Pennsylvania, he sequenced genes linked

Mania (5,447 words) [view diff] exact match in snippet view article find links to article

William (1995). "Search for a gene predisposing to manic-depression on chromosome 21". American Journal of Medical Genetics. 60 (3): 231–233. doi:10.1002/ajmg

MYL7 (2,346 words) [view diff] exact match in snippet view article find links to article

Shirayoshi Y, Kurimasa A, Oshimura M (July 2002). "An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome" (PDF)

Endostatin (2,612 words) [view diff] exact match in snippet view article find links to article

be protected from diabetic retinopathy due to an additional copy of chromosome 21, and elevated expression of endostatin. Folkman, J. (2006). "Antiangiogenesis

Atrioventricular septal defect (1,694 words) [view diff] exact match in snippet view article find links to article

create multiple disease manifestations, leading to broad syndromes. Chromosome 21 harbors important regulators for cilia, and trisomy 21 (Down syndrome)

Ploidy (5,951 words) [view diff] exact match in snippet view article find links to article

(as in Down syndrome, where affected individuals have three copies of chromosome 21) or missing a chromosome (as in Turner syndrome, where affected individuals

Smoky black (1,426 words) [view diff] exact match in snippet view article find links to article

responsible for the palomino and buckskin coat colors, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–343. doi:10.1046/j.1365-2052.2001.00806

Roan (color) (2,032 words) [view diff] exact match in snippet view article

roan has not yet been identified exactly, but been assigned to equine chromosome 21 (ECA21) in the KIT sequence. The overall effect is that of a silver

Silver dapple gene (1,488 words) [view diff] exact match in snippet view article find links to article

responsible for the palomino and buckskin coat colours, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–3. doi:10.1046/j.1365-2052.2001.00806

Terry Elton (1,163 words) [view diff] exact match in snippet view article find links to article

As of 2020, seven of Elton's research papers have been retracted. Chromosome 21-derived MicroRNAs Provide an Etiological Basis for Aberrant Protein

Laminin, beta 1 (1,257 words) [view diff] exact match in snippet view article find links to article

Sabatelli P, et al. (1999). "Decreased expression of laminin beta 1 in chromosome 21-linked Bethlem myopathy". Neuromuscul. Disord. 9 (5): 326–9. doi:10

Early-onset Alzheimer's disease (3,621 words) [view diff] exact match in snippet view article find links to article

amyloid beta A4 precursor protein (APP) located on the long arm of chromosome 21 (21q21.3) cause familial Alzheimer disease. Further research into molecules

Amyloid plaques (3,370 words) [view diff] exact match in snippet view article find links to article

result from the excess production of Aβ because the APP gene is on chromosome 21, which exists as three copies in Down syndrome. Amyloid plaques naturally

Human Protein Atlas (2,989 words) [view diff] exact match in snippet view article find links to article

fragments was carried out for a chromosome-wide protein profiling of chromosome 21. Other projects were also carried out to establish processes for parallel

Ribosomal RNA (7,195 words) [view diff] exact match in snippet view article find links to article

Lee HS, Koren S, Dudekula D, et al. (July 2018). "Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing"

Interferon (7,054 words) [view diff] exact match in snippet view article find links to article

1084/jem.137.2.317. PMC 2139494. PMID 4346649. Tan YH (March 1976). "Chromosome 21 and the cell growth inhibitory effect of human interferon preparations"

Uterine serpin (1,514 words) [view diff] exact match in snippet view article find links to article

(domestic cow) Symbol SERPINA14 Entrez 286871 RefSeq (mRNA) NM_174797 RefSeq (Prot) NP_777222 UniProt P46201 Other data Chromosome 21: 59.39 - 59.4 Mb

Herpes (8,735 words) [view diff] exact match in snippet view article find links to article

play a role in the frequency of cold sore outbreaks. An area of human chromosome 21 that includes six genes has been linked to frequent oral herpes outbreaks

Purinosome (1,426 words) [view diff] exact match in snippet view article find links to article

regulation of genes for two enzymes of purine synthesis assigned to human chromosome 21". Proceedings of the National Academy of Sciences of the United States

Equine vision (2,796 words) [view diff] exact match in snippet view article find links to article

responsible for the palomino and buckskin coat colors, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–343. doi:10.1046/j.1365-2052.2001.00806

POLR2C (1,287 words) [view diff] exact match in snippet view article find links to article

subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. POLR2C has been shown to interact with: ATF4, CCHCR1, Myogenin, POLR2A

Tyler Cymet (795 words) [view diff] exact match in snippet view article find links to article

Retrieved June 20, 2012. Erondu, U. A.; Cymet, T. C. (Winter 2006). "Chromosome 21 abnormalities a review and report of a case of erondu-cymet syndrome"

Eukaryotic translation termination factor 1 (5,512 words) [view diff] exact match in snippet view article find links to article

RH, Heurgué-Hamard V (July 2008). "HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1". FEBS Letters. 582

NDUFA6 (1,056 words) [view diff] exact match in snippet view article find links to article

M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518

Cream gene (4,679 words) [view diff] exact match in snippet view article find links to article

responsible for the palomino and buckskin coat colors, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–343. doi:10.1046/j.1365-2052.2001.00806

Tsuneko Okazaki (1,229 words) [view diff] exact match in snippet view article find links to article

artificial chromosome (HAC) carrying a limited number of genes from human chromosome 21". Transgenic Research. 23 (2): 317–29. doi:10.1007/s11248-013-9772-x

Sequenom (1,978 words) [view diff] exact match in snippet view article find links to article

some DNA from the fetus. The proportions of DNA from sequences from chromosome 21, 18, or 13 can indicate whether the fetus has trisomy in that chromosome

Ann T. Bowling (3,547 words) [view diff] exact match in snippet view article find links to article

responsible for the palomino and buckskin coat colours, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–3. doi:10.1046/j.1365-2052.2001.00806

Tiling array (2,036 words) [view diff] exact match in snippet view article find links to article

produce a more precise picture of gene structure. Earlier studies on chromosome 21 and 22 showed the power of tiling arrays for identifying transcription

Colin L. Masters (859 words) [view diff] exact match in snippet view article find links to article

precursor protein (APP), which was subsequently mapped to the region of chromosome 21 that is altered in DS. The notion that Aβ causes AD, called the amyloid

End-sequence profiling (1,534 words) [view diff] exact match in snippet view article find links to article

750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene". Genome Research

ZTTK syndrome (2,954 words) [view diff] exact match in snippet view article find links to article

"The SON gene encodes a conserved DNA binding protein mapping to human chromosome 21". Annals of Human Genetics. 58 (1): 25–34. doi:10.1111/j.1469-1809.1994

Raymond Turpin (499 words) [view diff] exact match in snippet view article find links to article

chromosome instead of the usual two (disomy). This chromosome was designated chromosome 21 in 1960. Turpin discovered, in 1959, the first structural chromosomal

List of French inventions and discoveries (10,613 words) [view diff] exact match in snippet view article find links to article

Laborit (chlorpromazine). Discovery of the cause of Down syndrome (chromosome 21 trisomy) by Jérôme Lejeune in 1958-1959 (syndrome first described by

Mixed-phenotype acute leukemia (1,045 words) [view diff] exact match in snippet view article find links to article

methyltransferases. With updated classification, translocations on chromosome 21 and 22 [t(8;21)(q22;q22)], and on 16 and 22 [t(16;16)(p13.1;q22)], as

YTHDF2 (672 words) [view diff] exact match in snippet view article find links to article

reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene

Haplotype block (622 words) [view diff] exact match in snippet view article find links to article

limited haplotype diversity revealed by high-resolution scanning of human chromosome 21". Science. 294 (5547): 1719–23. Bibcode:2001Sci...294.1719P. doi:10

Cell-free fetal DNA (5,952 words) [view diff] exact match in snippet view article find links to article

procedure's positive predictive value is low. Trisomy 21 Fetal trisomy of chromosome 21 is the cause of Down's syndrome. This trisomy can be detected by analysis

Kairbaan Hodivala-Dilke (1,085 words) [view diff] exact match in snippet view article find links to article

of a mouse model of Down syndrome have found that 3 copies of some chromosome 21 genes can impede the growth of blood vessels in tumours. These mice

Gerald Crabtree (2,721 words) [view diff] exact match in snippet view article find links to article

Crabtree GR. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 441(7093): 595-600, 2006. PMID 16554754. Kuo CJ, Chung J, Fiorentino

PRR29 (1,499 words) [view diff] exact match in snippet view article find links to article

[bare URL] "PAXdb: Protein Abundance Database". pax-db.org. "C21orf58 chromosome 21 open reading frame 58 [Homo sapiens (human)] - Gene - NCBI". www.ncbi

List of New York Institute of Technology faculty (805 words) [view diff] exact match in snippet view article find links to article

Retrieved 2016-02-14. Erondu, U. A.; Cymet, T. C. (Winter 2006). "Chromosome 21 abnormalities a review and report of a case of erondu-cymet syndrome"

Developmental bioelectricity (17,264 words) [view diff] exact match in snippet view article find links to article

Misovicova, Nadezda; Vrbicka, Dita (2013). "Partial trisomy and tetrasomy of chromosome 21 without down syndrome phenotype and short overview of genotype-phenotype

Experimental models of Alzheimer's disease (3,543 words) [view diff] exact match in snippet view article find links to article

accumulation Neurons from down syndrome patients (containing triplication of chromosome 21 containing the APP gene) displayed increased amyloid-β secretion and

List of events in NHGRI history (5,167 words) [view diff] exact match in snippet view article find links to article

May 18 issue of Nature that they have unraveled the genome of human chromosome 21, already known to be involved with Down syndrome, Alzheimer's disease

GATA2 deficiency (5,784 words) [view diff] exact match in snippet view article find links to article

deficiency include chromosome 8 trisomy (8% of cases) and, rarely, chromosome 21 monosomy. GATA2 deficiency is also associated with somatic mutations