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searching for DNMT1 41 found (75 total)

alternate case: dNMT1

5-Methylcytosine (2,598 words) [view diff] exact match in snippet view article find links to article

DNMTs in humans: DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L, and in algae and fungi 3 more are present (DNMT4, DNMT5, and DNMT6). DNMT1 contains the replication

GLAD-PCR assay (628 words) [view diff] exact match in snippet view article find links to article

at all. Mammalian DNA-methyltransferases DNMT1, DNMT3a and DNMT3b catalyze a reaction of DNA methylation. DNMT1 maintains DNA methylation pattern in vivo

Hereditary sensory and autonomic neuropathy type I (5,140 words) [view diff] exact match in snippet view article find links to article

with heterozygous missense mutations in the DNMT1 gene which encodes DNA methyltransferase 1 (Dnmt1). Dnmt1 belongs to a family of enzymes that catalyze

Epigenetics of anxiety and stress–related disorders (11,227 words) [view diff] exact match in snippet view article find links to article

DNMT1. DNMT1 aids in regulation of gene expression by methylating promoter regions of genes, causing transcriptional repression of these genes. DNMT1

Epigenetics of schizophrenia (5,482 words) [view diff] exact match in snippet view article find links to article

methamphetamine users had altered DNMT1 levels, similar to how patients with schizophrenia have shown abnormal levels of DNMT1 in GABAergic neurons. Research

DNA methylation (13,264 words) [view diff] exact match in snippet view article find links to article

Mouse models with both copies of DNMT1 deleted are embryonic lethal at approximately day 9, due to the requirement of DNMT1 activity for development in mammalian

Carcinogenic bacteria (2,637 words) [view diff] exact match in snippet view article find links to article

suppressor genes. This is achieved by upregulating the methyltransferase DNMT1 via the AKT–NF-κB pathway. Lastly, CagA also induces the expression of the

RGS6 (609 words) [view diff] exact match in snippet view article find links to article

PMID 10083744. Liu Z, Fisher RA (April 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". The Journal of Biological

DNA methylation in cancer (3,792 words) [view diff] exact match in snippet view article find links to article

hypomethylated state of DNA (Урба К. 1991 ) - Changes in the activity of methylases DNMT1/3A/3B, their relocalization (Hoffmann MJ, Schulz WA. 2005; Nishiyama A.

Epigenetics of autoimmune disorders (7,765 words) [view diff] exact match in snippet view article find links to article

suggested that inhibition of DNMT1 produces the loss of methylation observed in those afflicted by systemic lupus. DNMT1 is a DNA methyltransferase that

Decitabine (713 words) [view diff] exact match in snippet view article find links to article

upon replication, and then when DNA methyltransferases (DNMTs) such as DNMT1, are engaged to bind the DNA and to replicate the methylation to the daughter

DNA repair (15,713 words) [view diff] exact match in snippet view article find links to article

1 (DNMT1) to sites of DNA double-strand breaks. During homologous recombinational repair (HR) of the double-strand break, the involvement of DNMT1 causes

HESX1 (1,024 words) [view diff] exact match in snippet view article find links to article

PMID 20949537. Sajedi E, Gaston-Massuet C, Andoniadou CL, et al. (2008). "DNMT1 interacts with the developmental transcriptional repressor HESX1". Biochim

E2F5 (1,232 words) [view diff] exact match in snippet view article find links to article

"pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha

Transcription (biology) (6,780 words) [view diff] exact match in snippet view article

DNA methyltransferasess (DNMT1, DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a maintenance methyltransferase

DDX20 (1,739 words) [view diff] case mismatch in snippet view article find links to article

controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression". Hepatology. 57 (1): 162–170. doi:10.1002/hep.26011. PMC 3521841

Proliferative index (1,555 words) [view diff] exact match in snippet view article find links to article

Husin, Azlan; Salleh, Md. Salzihan Md.; Banham, Alison H. (December 2017). "DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated

Transcriptional regulation (6,343 words) [view diff] exact match in snippet view article find links to article

DNA methyltransferasess (DNMT1, DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a “maintenance” methyltransferase

Methyltransferase (2,911 words) [view diff] exact match in snippet view article find links to article

epigenetic modification catalyzed by DNA methyltransferase enzymes, including DNMT1, DNMT2 (renamed TRDMT1 to reflect its function methylating tRNA, not DNA)

EHMT2 (1,761 words) [view diff] exact match in snippet view article find links to article

Karpf AR, Carey MF, Pradhan S (November 2006). "Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication". Genes

Methyl-CpG-binding domain protein 2 (1,442 words) [view diff] exact match in snippet view article find links to article

"MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". Genes Cells. 5 (8): 677–88. doi:10

Tet methylcytosine dioxygenase 1 (1,893 words) [view diff] case mismatch in snippet view article find links to article

"Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1". PLOS ONE. 6 (2): e16627. Bibcode:2011PLoSO...616627F. doi:10

MBD3 (1,442 words) [view diff] exact match in snippet view article find links to article

"MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". Genes to Cells. 5 (8): 677–88

TSG101 (2,013 words) [view diff] exact match in snippet view article find links to article

PMC 1171607. PMID 10508170. Rountree MR, Bachman KE, Baylin SB (2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication

Charles Brenner (biochemist) (3,874 words) [view diff] case mismatch in snippet view article

Focus Targeting Sequence (RFTS) Domain is a DNA-Competitive Inhibitor of Dnmt1". J. Biol. Chem. 286 (17): 15344–15351. doi:10.1074/jbc.M110.209882. PMC 3083197

N-alpha-acetyltransferase 10 (5,405 words) [view diff] exact match in snippet view article find links to article

LJ (August 2010). "hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing". The Journal of Clinical Investigation

HDAC1 (5,476 words) [view diff] case mismatch in snippet view article find links to article

A, Hughes-Davies L, Kouzarides T (January 2000). "DNA methyltransferase Dnmt1 associates with histone deacetylase activity". Nature Genetics. 24 (1):

Epigenetic regulation of neurogenesis (5,725 words) [view diff] exact match in snippet view article find links to article

corticogenesis has been shown through knockout experiments in mice. When DNMT3b and DNMT1 were ablated separately in mouse embryos they died due to impairment of

Sara Cherry (1,500 words) [view diff] case mismatch in snippet view article find links to article

S.; Nguyen, Suzanne; Cherry, Sara R. (2001-11-01). "A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival". Immunity

H3K9me2 (2,601 words) [view diff] exact match in snippet view article find links to article

Rodriguez S, et al. (2017). "Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription

Cytoplasmic polyadenylation element (1,178 words) [view diff] case mismatch in snippet view article find links to article

Colum P.; Lees-Murdock, Diane J. (2014-02-20). "Efficient Translation of Dnmt1 Requires Cytoplasmic Polyadenylation and Musashi Binding Elements". PLOS

XIST (4,229 words) [view diff] exact match in snippet view article find links to article

Tian XC, Soukoyan M, Pereira LV (2007). "XIST repression in the absence of DNMT1 and DNMT3B". DNA Research. 12 (5): 373–8. doi:10.1093/dnares/dsi013. PMID 16769694

Paul Khavari (1,802 words) [view diff] exact match in snippet view article find links to article

; Webster, Daniel E.; Zhu, Lilly; Khavari, Paul A. (28 January 2010). "DNMT1 maintains progenitor function in self-renewing somatic tissue". Nature.

HOXA11-AS1 (2,050 words) [view diff] exact match in snippet view article find links to article

Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1". Cancer Research. 76 (21): 6299–6310. doi:10.1158/0008-5472.CAN-16-0356

Epigenetics of neurodegenerative diseases (13,392 words) [view diff] exact match in snippet view article find links to article

gravis largely points to upregulation of the DNA methyltransferase genes DNMT1, DNMT3A, and DNMT3B in patients with myasthenia gravis. In addition to CTLA-4

Epigenetic therapy (5,831 words) [view diff] exact match in snippet view article find links to article

compounds become more relevant as therapies. There are three types of DNMT's. DNMT1 is a maintenance DNMT whereas DNMT3a and DNMT 3b are a de novo factor. There

Telomeric repeat–containing RNA (4,668 words) [view diff] exact match in snippet view article find links to article

at the telomere is through the enzymes DNA methyltransferases 1 and 3b (DNMT1/3b). Experiments where these factors have been depleted result in increased

Epigenetics of physical exercise (8,910 words) [view diff] exact match in snippet view article find links to article

decreases hippocampus expression of the gene-repressive DNA methylating enzymes DNMT1, DNMT3a and DNMT3b. The hippocampus has important functions in memory, spatial

Jacob Hanna (5,562 words) [view diff] exact match in snippet view article find links to article

ablation or RNA and DNA methylation (deposited and maintained by METTL3 and DNMT1 enzymes, respectively). Hanna used the latter property to screen for conditions

RNA-directed DNA methylation (14,860 words) [view diff] exact match in snippet view article find links to article

patterns. The highly conserved methyltransferase MET1 (homolog of mammalian DNMT1) maintains DNA methylation in the CG context, while two conserved plant-specific

List of human transcription factors (81 words) [view diff] exact match in snippet view article find links to article

specific TF according to literature or domain structure – No motif [156] DNMT1 ENSG00000130816 CxxC Known motif – High-throughput in vitro [157] CGG DNTTIP1