Find link

language:

Find link is a tool written by Edward Betts.

searching for ED50 85 found (156 total)

alternate case: eD50

Therapeutic index (3,203 words) [view diff] exact match in snippet view article find links to article

desired pharmacological effect (e.g. efficacious dose in 50% of subjects, ED50). In contrast, in a drug development setting TI is calculated based on plasma

Median toxic dose (260 words) [view diff] exact match in snippet view article find links to article

category of toxicity that is greater than half maximum effective concentration (ED50) but less than the median lethal dose (LD50). However, for some highly potent

RTI-112 (602 words) [view diff] exact match in snippet view article find links to article

inhibitors that were used in this study. In vivo at the ED50, RTI-112 had no DAT occupancy at all. At the ED50, almost all of the RTI-112 occupied the SERT at

Phenylpiracetam hydrazide (242 words) [view diff] exact match in snippet view article find links to article

investigated as anticonvulsants. In an electroshock test it was found to have an ED50 of 310 mg/kg. All piracetam derivatives are not permitted to be sold as dietary

Morphiceptin (151 words) [view diff] exact match in snippet view article find links to article

(into the ventricular system of the brain), morphiceptin had an analgesic ED50 of 1.7 nmol per animal. The analgesic effects of morphiceptin were reversed

SCH-48461 (251 words) [view diff] exact match in snippet view article find links to article

discovery of the prototypical 2-azetidinone CAI, SCH-48461 (ACAT IC50 ~26 mM, ED50 of CE reduction in hamsters ~2.2 mpk) and the details of the first-generation

4-Fluoromethylphenidate (513 words) [view diff] exact match in snippet view article find links to article

potential as anti-cocaine medications. 4F-MPH was reported as having an ED50 mg/kg of 0.26 (0.18–0.36), regarding its efficacy as a substitute for cocaine

Furanylfentanyl (908 words) [view diff] exact match in snippet view article find links to article

is an analog of fentanyl and has been sold as a designer drug. It has an ED50 value of 0.02 mg/kg in mice. This makes it approximately one fifth as potent

Kelatorphan (353 words) [view diff] exact match in snippet view article find links to article

crossing the blood-brain-barrier) hence alongside exogenous [Met]enkephalin (ED50 approximately 10 ng), it potentiated the analgesic effects of the latter

Zaprinast (430 words) [view diff] exact match in snippet view article find links to article

of asexual blood-stage malaria parasites (P. falciparum) in vitro with an ED50 value of 35 μM, and inhibits PfPDE1, a P. falciparum cGMP-specific phosphodiesterase

CAR-302,282 (197 words) [view diff] exact match in snippet view article find links to article

Edgewood Arsenal in the 1960s. It is a potent incapacitating agent with an ED50 of 1.2μg/kg and a high central to peripheral effects ratio, and a relatively

DMPX (104 words) [view diff] exact match in snippet view article find links to article

peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED50 10 μmol/kg) was similarly higher than caffeine. DPCPX 8-PT CPX (8-CPT) 8-Chlorotheophylline

WAY-161503 (261 words) [view diff] exact match in snippet view article find links to article

Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively. WAY-161503 has been used

CAR-302,668 (111 words) [view diff] exact match in snippet view article find links to article

Arsenal in the 1960s. It is a reasonably potent incapacitating agent with an ED50 of 4μg/kg and a long duration of action of around 16-24 hours. CAR-302,282

3-Allylfentanyl (230 words) [view diff] exact match in snippet view article find links to article

of the allyl group makes it somewhat less dangerous than fentanyl itself (ED50(rat) of 80μg/kg vs 11μg/kg for fentanyl), although this is relative. For

Phenylethanolamine (1,633 words) [view diff] exact match in snippet view article find links to article

had an ED50 of ~1800 nM, with an Emax of ~ 110%, whereas S-(+)-phenylethanolamine (referred to as "S-(+)-β-hydroxy-β-phenylethylamine") had an ED50 of ~1720

Linifanib (206 words) [view diff] exact match in snippet view article find links to article

effective orally in mechanism-based murine models of VEGF-induced uterine edema (ED50 = 0.5 mg/kg) and corneal angiogenesis (>50%inhibition, 15 mg/kg). Albert

Lysergic acid 2-butyl amide (415 words) [view diff] exact match in snippet view article find links to article

LSD in animal drug discrimination assays, with the (R) isomer having an ED50 of 33nmol/kg for producing drug-appropriate responding, vs 48nmol/kg for

Lacosamide (3,809 words) [view diff] exact match in snippet view article find links to article

preventing the spread of seizures induced by MES in mice (ED50 = 4.5 mg/kg, i.p.) and rats (ED50 = 3.9 mg/kg, p.o.). In preclinical trials, administration

Protective index (501 words) [view diff] exact match in snippet view article find links to article

(TD50) divided by the minimum effective dose for 50% of the population (ED50). A high protective index is preferable to a low one: this corresponds to

Ocfentanil (661 words) [view diff] exact match in snippet view article find links to article

analgesic activity of ocfentanil using the mouse hot plate test (55 °C) gave an ED50 of 0.007 mg/kg compared to 0.018 mg/kg for fentanyl; ocfentanil being approximately

Median lethal dose (3,860 words) [view diff] exact match in snippet view article find links to article

effective dose (ED50). Therefore, it is more useful to compare such substances by therapeutic index, which is simply the ratio of LD50 to ED50.[citation needed]

Bromazolam (2,075 words) [view diff] exact match in snippet view article find links to article

resulted in full dose-dependent substitution with an ED50 of 0.54 mg/kg. In comparison the ED50 of midazolam and diazepam were 0.09 and 0.66 respectively

U-77891 (303 words) [view diff] exact match in snippet view article find links to article

receptors with Ki values of 2, 105 and 2300 nM, respectively. The compound has ED50 values of 0.02 mg/kg and 0.21 mg/kg in mouse phenylquinone writhing and tail-flick

Seletracetam (2,338 words) [view diff] exact match in snippet view article find links to article

seizures, doses as low as 0.07 mg/kg intraperitoneal injection (i.p.), and ED50 of 0.31 mg/kg i.p. were effective. Occurrence of audiogenic seizures—those

N-2′-Indolylnaltrexamine (514 words) [view diff] exact match in snippet view article find links to article

intrathecal ED50 of 21.07 pmol/mouse, a subcutaneous ED50 0.97 mg/kg, which is nine times more effective than morphine and an oral ED50 9.08 mg/kg which

Pravadoline (492 words) [view diff] exact match in snippet view article find links to article

adjuvant-arthritic rat (ED50 41 mg/kg, p.o.) Prevented the nociceptive response of bradykinin-induced head and forepaw flexion (ED50 78 mg/kg, p.o.) The antinociceptive

Agonist (1,618 words) [view diff] exact match in snippet view article find links to article

relationship, termed the therapeutic index, is defined as the ratio TD50:ED50. In general, the narrower this margin, the more likely it is that the drug

Reverse pharmacology (294 words) [view diff] exact match in snippet view article find links to article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Emylcamate (259 words) [view diff] exact match in snippet view article find links to article

Meprobamate Emylcamate Effect 175 123 ED50 (mg/kg) 600 550 LD50 (mg/kg) 3.4 4.4 Therapeutic index

Classical pharmacology (512 words) [view diff] exact match in snippet view article find links to article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Dose–response relationship (1,788 words) [view diff] exact match in snippet view article find links to article

the dose response curve reflect measures of potency (such as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response)

RTI-32 (129 words) [view diff] exact match in snippet view article find links to article

Comparison of Data Compound DAT DA NET NA SERT 5HT ED50 Troparil 23 49.8 550 37.2 178 173 0.34 RTI-32 1.7 7.02 36 8.42 23 19.4 0.31 RTI-31 1.1 3.68 22

Isoetales (481 words) [view diff] case mismatch in snippet view article find links to article

Paleobiology Database: 55160 PPE: isoetales Tropicos: 100000977 VASCAN: 34 VicFlora: 6b634e5c-ed50-4c4c-be79-25991a33214f WFO: wfo-9000000275 WoRMS: 886372

Phosphodiesterase (1,660 words) [view diff] exact match in snippet view article find links to article

asexual blood-stage malaria parasites (Plasmodium falciparum) in vitro with an ED50 value of 35 μM, and inhibits PfPDE1, a P. falciparum cGMP-specific phosphodiesterase

IC50 (1,072 words) [view diff] exact match in snippet view article find links to article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

N,N-Dimethyldopamine (1,653 words) [view diff] exact match in snippet view article find links to article

[3H]-ACh release from mouse striatal slices evoked by K+. In this assay, the ED50 for DMDA was ~ 0.06 μM, and for dopamine it was ~ 1.9 μM. The LD50 for N

Arachidonate 5-lipoxygenase inhibitor (1,291 words) [view diff] exact match in snippet view article find links to article

and of PGE2 production in vitro [53] and in vivo with superior efficiency (ED50 = 1 mg/kg) compared to indomethacin (5 mg/kg) [54]. Hyperforin turned out

Gabaculine (725 words) [view diff] exact match in snippet view article find links to article

potent and toxic when compared to other GABA transaminase inhibitors, with an ED50 of 35 mg/kg and LD50 of 86 mg/kg. Because of this potential lethal effect

Antileukotriene (1,070 words) [view diff] exact match in snippet view article find links to article

and of PGE2 production in vitro [53] and in vivo with superior efficiency (ED50 = 1 mg/kg) compared to indomethacin (5 mg/kg) [54]. Hyperforin turned out

Convulxin (1,472 words) [view diff] exact match in snippet view article find links to article

intravenously (I.V) elicited tachypnea, followed by apnea, within 20 seconds. The ED50 for brief duration apnea was determined to be 180 μg/kg. Higher doses (10

Volume of distribution (1,132 words) [view diff] exact match in snippet view article find links to article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Up-and-down procedure (425 words) [view diff] exact match in snippet view article find links to article

substantially reduces the number of animals required to determine antinociceptive ED50 values". Journal of Pharmacological and Toxicological Methods. 40 (2): 81–85

Cycloheptyl CP 55,940 (106 words) [view diff] exact match in snippet view article find links to article

Cycloheptyl CP 55,940 has similar potency to CP 55,940 itself, with an ED50 of 0.06 mg/kg in animal studies. Abeo-HHC acetate CP 47,497 O-1656 US 4371720

4-Methylaminorex (1,802 words) [view diff] exact match in snippet view article find links to article

4-methylaminorex can be smoked, insufflated or taken orally. As an anorectic, the ED50 is 8.8 mg/kg in rats for the (±)-cis isomers. The (±)-trans isomers are slightly

Haloperidol (4,889 words) [view diff] exact match in snippet view article find links to article

D2 and α1 receptors at low dose (ED50 = 0.13 and 0.42 mg/kg, respectively), and 5-HT2 receptors at a higher dose (ED50 = 2.6 mg/kg). Given that antagonism

Huwentoxin (2,090 words) [view diff] exact match in snippet view article find links to article

reversibly paralyze cockroaches for several hours, with a median knockdown dose ED50 of 127 ± 54 µg/g. HWTX-II blocks neuromuscular transmission in the isolated

SHTX (1,083 words) [view diff] exact match in snippet view article find links to article

paralytic activity (ED50) and lethal activity (LD50). SHTX I, II and III are not lethal to crabs, but they induce paralysis. The values of ED50 are 430 µg/kg

Poison (4,179 words) [view diff] exact match in snippet view article find links to article

medications—such as fentanyl—have an LD50 only one order of magnitude greater than the ED50. An alternative classification distinguishes between lethal substances that

Area under the curve (pharmacokinetics) (1,271 words) [view diff] exact match in snippet view article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Enobosarm (12,879 words) [view diff] exact match in snippet view article find links to article

castrated male rats relative to gonadally intact control male rats, with an ED50 dose for muscle of 0.03 mg/day. For comparison, testosterone propionate was

Caudal anaesthesia (922 words) [view diff] exact match in snippet view article find links to article

"Effect of epidural clonidine on minimum local anesthetic concentration (ED50) of levobupivacaine for caudal block in children". Pediatric Anesthesia.

Ibogaline (377 words) [view diff] exact match in snippet view article find links to article

the study authors found the following order of potency in causing tremors: ED50 (μmol/kg, sc): tabernanthine (4.5) > ibogaline (7.6) > harmaline (12.8) >

Central nervous system effects from radiation exposure during spaceflight (9,521 words) [view diff] exact match in snippet view article find links to article

indicator of the exposure dose. Estimates are ED50 = 1.08 Gy for anorexia, ED50 = 1.58 Gy for nausea, and ED50=2.40 Gy for emesis. The relative effectiveness

Japan Railways locomotive numbering and classification (1,881 words) [view diff] exact match in snippet view article find links to article

1926 Number built 2 2 2 2 17 4 3 3 6 6 2 8 2 12 14 2 Renumbered in 1928 ED10 ED11 ED12 ED13 ED50 ED14 ED15 ED51 ED52 ED53 ED54 EF50 EF51 EC40 ED40 ED41

PRL-8-53 (651 words) [view diff] exact match in snippet view article find links to article

canines. High doses depress motor activity in the rat and mouse, with the ED50 for a 50% reduction in motor activity of mice at 160 mg/kg. PRL-8-53 displays

Cynaropicrin (2,769 words) [view diff] exact match in snippet view article find links to article

effect on some of the human tumor cell lines has been given contradictory ED50 values. SK-OV-3, SK-MEL-2, A549, HCT-15 and XF498 (CNS) cell lines have been

2C-B (4,144 words) [view diff] exact match in snippet view article find links to article

Oral Insufflated ED50 10 mg 4–6 mg Moderate 15–25 mg 5–9 mg Strong 26–35 mg 10–20 mg Extremely Intense >35 mg >20 mg Duration 4–8 hours 2–4 hours

N-Methyltyramine (2,028 words) [view diff] exact match in snippet view article find links to article

found to be a potent stimulant of gastrin release in the rat, with an [[ED50]] of ~ 10 μg/kg. These researchers used a bio-assay-guided isolation procedure

Dimethylheptylpyran (1,725 words) [view diff] exact match in snippet view article find links to article

human and animal studies, with the therapeutic index measured as a ratio of ED50 to LD50 in animals being around 2000 times. There have been no recorded deaths

Dizocilpine (3,400 words) [view diff] exact match in snippet view article find links to article

the hippocampus from ischemia-induced neurodegeneration in the gerbil. The ED50 (effective dose 50) for neuroprotection was 0.3 mg/kg and the majority of

Michael Fox (judge) (983 words) [view diff] case mismatch in snippet view article

CS1 maint: location missing publisher (link) "Lincoln's Inn Great Hall, Ed50 Fox, M". Baz Manning. 13 July 2009. Retrieved 19 December 2020. Obituary

Estrogen insensitivity syndrome (3,802 words) [view diff] exact match in snippet view article find links to article

transcriptional activity in response to stimulation by estradiol, with an ED50 that was approximately 65-fold greater than that of normal/wild-type ERα

Ligand binding assay (4,118 words) [view diff] exact match in snippet view article find links to article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Florence (13,558 words) [view diff] exact match in snippet view article find links to article

subdivided according to the sampling year. Coordinates refer to UTM32T (ED50) system. "World map of Köppen – Geiger Climate Classification". koeppen-geiger

Tramadol (9,009 words) [view diff] exact match in snippet view article find links to article

transporter (SERT) in the thalamus. The estimated median effective dose (ED50) for SERT occupancy hence was 98.1 mg, which was associated with a plasma

Rhesus macaque (9,079 words) [view diff] exact match in snippet view article find links to article

689650 Paleobiology Database: 232541 Species+: 7393 Cercopithecus mulatta Wikidata: Q109647127 GBIF: 9146359 ZooBank: 4D0ED1B4-ED50-4325-8A9B-A8849C8B18A1

Nikon (8,337 words) [view diff] exact match in snippet view article find links to article

60mm Fieldscope ED78/ EDII Fieldscope III/EDIII Fieldscope ED82 Fieldscope ED50 Fieldscopes EDG 65 /85 Fieldscope EDG 85 VR BLACK Monarch 7 Monarch 5 Monarch

Murepavadin (1,186 words) [view diff] exact match in snippet view article find links to article

action. Murepavadin showed outstanding in vivo efficacy in mouse sepsis (ED50 of 0.25 - 0.55 mg/kg) and lung and thigh infection models. It displays linear

Buntanetap (825 words) [view diff] exact match in snippet view article find links to article

the levels of APP protein in the cortex were reduced by buntanetap with an ED50 of ???(median Effective Dose). The β-secretase activity in the mouse brain

Korado Korlević (540 words) [view diff] exact match in snippet view article find links to article

DL16 29 February 2000 list (47776) 2000 EX 3 March 2000 list (47800) 2000 ED50 7 March 2000 list (48021) 2001 DN6 16 February 2001 list (48641) 1995 UA1

Pharmacomicrobiomics (3,697 words) [view diff] exact match in snippet view article find links to article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Taxodone (3,243 words) [view diff] exact match in snippet view article find links to article

activity against cells derived from human carcinoma of the nasopharynx (KB) (ED50 = 0.6 and 3 ug/ml respectively). Taxodone and taxodione exhibit antifungal

Pharmacoepigenetics (4,224 words) [view diff] exact match in snippet view article find links to article

Metrics Efficacy Intrinsic activity Potency (EC50, IC50, ED50, LD50, TD50) Therapeutic index Affinity

Nimbin (chemical) (3,628 words) [view diff] exact match in snippet view article

lactone ring in nimbolide is crucial for anticancer activity. However, the ED50 value for 6-homodesacetylnimbin illustrates moderate activity. Thus, steric

List of minor planets: 523001–524000 (274 words) [view diff] exact match in snippet view article find links to article

2002 Palomar C. Trujillo, M. E. Brown centaur 77 km MPC · JPL 523598 2003 ED50 — March 11, 2003 Socorro LINEAR APO · PHA · critical 250 m MPC · JPL 523599

List of minor planets: 47001–48000 (274 words) [view diff] exact match in snippet view article find links to article

47799 2000 ES49 — March 9, 2000 Socorro LINEAR EUN 4.2 km MPC · JPL 47800 2000 ED50 — March 7, 2000 Višnjan Observatory K. Korlević EOS 6.3 km MPC · JPL

List of minor planets: 179001–180000 (274 words) [view diff] exact match in snippet view article find links to article

2002 EY28 — March 9, 2002 Socorro LINEAR · 4.8 km MPC · JPL 179563 2002 ED50 — March 12, 2002 Palomar NEAT V 1.1 km MPC · JPL 179564 2002 ES55 — March

List of minor planets: 315001–316000 (274 words) [view diff] exact match in snippet view article find links to article

EK48 — March 9, 2007 Kitt Peak Spacewatch H 1.0 km MPC · JPL 315114 2007 ED50 — March 10, 2007 Mount Lemmon Mount Lemmon Survey HYG 3.0 km MPC · JPL 315115

List of asteroid close approaches to Earth in 2023 (3,990 words) [view diff] exact match in snippet view article find links to article

2023-09-02 JPL 2016 LY48 77-170 5.01 2023-09-16 JPL · CAD (523598) 2003 ED50 231 19.75 2023-09-20 JPL · CAD 103P/Hartley ≈2,000 148.9 2023-09-26 JPL ·

List of minor planets: 254001–255000 (274 words) [view diff] exact match in snippet view article find links to article

254494 2005 EZ44 — March 3, 2005 Catalina CSS NYS 820 m MPC · JPL 254495 2005 ED50 — March 3, 2005 Catalina CSS V 910 m MPC · JPL 254496 2005 EG50 — March 3

Ting-Chao Chou (4,948 words) [view diff] exact match in snippet view article find links to article

or drug, it calculate mass-action law parameters such as Dm values (IC50, ED50, LD50, ICx, EDx and LDx, etc.), m values (shape of dose-effect curves and

List of minor planets: 574001–575000 (274 words) [view diff] exact match in snippet view article find links to article

EF49 — April 13, 2004 Kitt Peak Spacewatch · 750 m MPC · JPL 574979 2011 ED50 — February 25, 2011 Kitt Peak Spacewatch · 1.7 km MPC · JPL 574980 2011

Pharmacology of bicalutamide (20,443 words) [view diff] exact match in snippet view article find links to article

dissociated the anabolic from androgenic effects of AR in terms of potency (ED50) and efficacy (Emax) [29]. Levator ani muscle weight was increased to 131

List of minor planets: 669001–670000 (274 words) [view diff] exact match in snippet view article find links to article

EG48 — February 9, 2002 Kitt Peak Spacewatch · 875 m MPC · JPL 669984 2013 ED50 — March 6, 2013 Haleakala Pan-STARRS · 2.6 km MPC · JPL 669985 2013 EG51