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searching for Efflux pump 76 found (88 total)

Ketolide (314 words) [view diff] no match in snippet view article find links to article

having a structural modification that makes them poor substrates for efflux-pump mediated resistance. Ketolides block protein synthesis by binding to

Clorgiline (403 words) [view diff] exact match in snippet view article find links to article

I2 imidazoline receptor (Ki = 40 pM). Clorgiline is also a multidrug efflux pump inhibitor. Holmes et al., 2012 reverse azole fungicide resistance using

Antibiotic resistance in gonorrhea (1,703 words) [view diff] exact match in snippet view article find links to article

codes for the penicillin-binding protein (PBP-2); mtr, which encodes an efflux pump that removes penicillin from the cell; and penB, which encodes the bacterial

Thiomer (3,607 words) [view diff] exact match in snippet view article find links to article

efflux pumps. Because of this property the mucosal uptake of various efflux pump substrates such as anticancer drugs, antimycotic drugs and antiinflammatory

Multidrug resistance pump (550 words) [view diff] exact match in snippet view article find links to article

resistance pumps (MDR pumps) also known Multidrug efflux pumps are a type of efflux pump and P-glycoprotein. MDR pumps in the cell membrane extrudes many foreign

Zosuquidar (256 words) [view diff] exact match in snippet view article find links to article

multi-drug resistant. Zosuquidar inhibits P-glycoproteins, inhibiting the efflux pump and restoring sensitivity to chemotherapeutic agents. Zosuqidar was initially

SmeT (1,855 words) [view diff] exact match in snippet view article find links to article

is responsible for the regulation of the Multidrug Resistance (MDR) efflux pump, SmeDEF, that gives the bacteria resistance to several antibiotics including

Manganese exporter (400 words) [view diff] exact match in snippet view article find links to article

TC# 2.A.107.1.1) has been shown to function as a putative manganese efflux pump. Manganese sensitivity and intracellular manganese levels significantly

P-glycoprotein (3,960 words) [view diff] exact match in snippet view article find links to article

foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi, and bacteria

P-Aminobenzoyl-glutamate transporter (859 words) [view diff] exact match in snippet view article find links to article

the biosynthesis of folic acid. MtrF was annotated as a putative drug efflux pump. AbgT is 510 amino acyl residues long and has 12-13 putative transmembrane

ArsB and ArsAB transporters (1,375 words) [view diff] exact match in snippet view article find links to article

Debatably, a unique member of the ArsB family is the rice silicon (silicate) efflux pump, Lsi2 (TC# 2.A.45.2.4). The silicon uptake systems, Lsi1 (TC# 1.A.8.12

Resistance-nodulation-cell division superfamily (1,644 words) [view diff] exact match in snippet view article find links to article

action of HAE-RND proteins, and other RND family proteins. Mdt(A) is an efflux pump that confers resistance to a variety of drugs. It is expressed in L.

Govindan Rajamohan (334 words) [view diff] case mismatch in snippet view article find links to article

Klebsiella pneumoniae Cell Envelope Stress Response Regulon, Is an SMR-Type Efflux Pump Involved in Broad-Spectrum Antimicrobial Resistance". Antimicrobial Agents

ABCC11 (2,218 words) [view diff] exact match in snippet view article find links to article

2003). "MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and

Multi-antimicrobial extrusion protein (551 words) [view diff] case mismatch in snippet view article find links to article

(December 2000). "NorM of Vibrio parahaemolyticus Is an Na+-Driven Multidrug Efflux Pump". J. Bacteriol. 182 (23): 6694–7. doi:10.1128/JB.182.23.6694-6697.2000

Colin Hughes (microbiologist) (1,000 words) [view diff] exact match in snippet view article

(2004). "Structure of the periplasmic component of a bacterial drug efflux pump". Proceedings of the National Academy of Sciences. 101 (27): 9994–9999

Gisela Storz (792 words) [view diff] exact match in snippet view article find links to article

demonstrated that one such small protein, AcrZ, binds to the multidrug efflux pump protein AcrB to affect its ability to export certain classes of antibiotics

Multidrug and toxin extrusion protein 2 (666 words) [view diff] exact match in snippet view article find links to article

2000). "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". Journal of Bacteriology. 182 (23): 6694–7. doi:10.1128/JB.182.23.6694-6697

Puromycin (829 words) [view diff] exact match in snippet view article find links to article

than mammalian cell lines. Deletion of the gene encoding the multidrug efflux pump Pdr5 sensitizes cells to puromycin.[citation needed] Long-term synaptic

CodonCode Aligner (836 words) [view diff] case mismatch in snippet view article find links to article

Amsterdam K, Bart A, van der Ende A (2005). "A Helicobacter pylori TolC Efflux Pump Confers Resistance to Metronidazole". Antimicrob Agents Chemother. 49

Multidrug and toxin extrusion protein 1 (1,003 words) [view diff] exact match in snippet view article find links to article

2000). "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". J. Bacteriol. 182 (23): 6694–7. doi:10.1128/JB.182.23.6694-6697.2000

Mirabilis jalapa (3,065 words) [view diff] exact match in snippet view article find links to article

N-trans-feruloyl 4′-O-methyldopamine. This compound shows moderate activity as an efflux pump inhibitor against multidrug-resistant Staphylococcus aureus. The flowers

YybP-ykoY leader (454 words) [view diff] exact match in snippet view article find links to article

coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis". Journal of Bacteriology. 193 (21):

Moxidectin (1,200 words) [view diff] exact match in snippet view article find links to article

increased expression of p-glycoprotein, which is a transmembrane drug efflux pump. Allele frequency changes corresponding to resistance to moxidectin and/or

Chemogenomics (1,623 words) [view diff] exact match in snippet view article find links to article

progression such as steroid-5-alpha-reductase and synergistic targets like the efflux pump P-gp. These target-phenotype links can help identify novel MOAs. Beyond

Laura Piddock (592 words) [view diff] exact match in snippet view article find links to article

asymptotic analysis of the gene regulatory network of the AcrAB-TolC efflux pump system in gram-negative bacteria. Journal of Mathematical Biology 82

Totarol (4,785 words) [view diff] exact match in snippet view article find links to article

strains through inhibition of MsrA, although it is unclear if MsrA is an efflux pump. Totarol may also gain its antibacterial properties by inhibiting bacterial

Edaravone (1,610 words) [view diff] exact match in snippet view article find links to article

improves the oral bioavailability of edaravone by modulating drug efflux pump of enterocytes". J Pharm Sci. 103 (2): 730–42. doi:10.1002/jps.23807

Cecropin (1,552 words) [view diff] exact match in snippet view article find links to article

permeabilization followed by biofilm disruption triggered by the inhibition of efflux pump activity and interactions with extracellular and intracellular nucleic

Beverly Torok-Storb (876 words) [view diff] exact match in snippet view article find links to article

January 2002). "The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors"

ABCA1 (2,082 words) [view diff] exact match in snippet view article find links to article

cholesterol as its substrate, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. While the complete 3D-structure

Acriflavine resistance protein family (334 words) [view diff] exact match in snippet view article find links to article

structural basis of multiple binding capacity of the acrb multidrug efflux pump Identifiers Symbol ACR_tran Pfam PF00873 Pfam clan CL0322 InterPro IPR001036

Purine riboswitch (1,343 words) [view diff] exact match in snippet view article find links to article

remaining portion to magnesium. The pbuE gene encodes a purine base efflux pump. Binding of adenine to the pbuE adenine riboswitch disrupts the structure

Ars operon (814 words) [view diff] exact match in snippet view article find links to article

trivalent metalloids to ArsA, the catalytic subunit of an As(III)/Sb(III) efflux pump. Interaction with ArsD increases the affinity of ArsA for arsenite, thus

Antimicrobial peptides (6,545 words) [view diff] exact match in snippet view article find links to article

permeabilization followed by biofilm disruption triggered by the inhibition of efflux pump activity and interactions with extracellular and intracellular nucleic

Rhodoferax (1,442 words) [view diff] exact match in snippet view article find links to article

metalloids and heavy metals. These genes include a putative arsenite efflux pump and an arsenate reductase, as well as genes similar to those found in

Persister cells (1,817 words) [view diff] exact match in snippet view article find links to article

transport intracellular accumulations antibiotic using an energy requiring efflux pump called TolC. A persister subpopulation has also been demonstrated in

Mitotic inhibitor (6,908 words) [view diff] exact match in snippet view article find links to article

resistance. It was discovered that another transporter MRP1 also work as the efflux pump, but in this case substrates are negatively charged natural compounds

6TMS neutral amino acid transporter family (586 words) [view diff] exact match in snippet view article find links to article

other genes such as acrAB (encoding the principal E. coli multidrug efflux pump of the RND superfamily (TC #2.A.6.2)) and the mar regulon itself, and

Piper (plant) (2,549 words) [view diff] exact match in snippet view article

(2008). "Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus". Journal of Antimicrobial Chemotherapy. 61

ATP7A (2,865 words) [view diff] exact match in snippet view article find links to article

(1997). "Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: a novel mechanism of

Drug resistance (2,490 words) [view diff] exact match in snippet view article find links to article

Strouse JJ, Khan MM, Bologa CG, Oprea TI, Sklar LA (2011). "Microbial efflux pump inhibition: tactics and strategies". Current Pharmaceutical Design. 17

Sabizabulin (709 words) [view diff] exact match in snippet view article find links to article

inflammatory cells. Sabizabulin is not a substrate of P-glycoprotein (Pgp), an efflux pump that, when overexpressed, can confer resistance to taxanes, a group of

Adverse drug reaction (3,424 words) [view diff] exact match in snippet view article find links to article

Additionally, Clarithromycin is a permeability glycoprotein (P-gp) efflux pump inhibitor, which when given with apixaban (a substrate for P-gp) will

Verapamil (2,510 words) [view diff] exact match in snippet view article find links to article

carcinomas. Verapamil is also used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein and other ABC transporter proteins. This

North Sichuan Medical University (1,350 words) [view diff] exact match in snippet view article find links to article

PMID 19153022. Lin L, Ling BD, Li XZ (2009). "Distribution of the multidrug efflux pump genes, adeABC, adeDE and adeIJK, and class 1 integron genes in

Bacterial small RNA (3,499 words) [view diff] exact match in snippet view article find links to article

confer antibiotic resistance. For example, the sRNA DsrA regulates a drug efflux pump in E. coli, which is a system that mechanically pumps antibiotic out

Tigecycline (3,287 words) [view diff] exact match in snippet view article find links to article

to an up-regulation of bacterial efflux pumps, such as the RND type efflux pump AcrAB. Some bacterial species such as Pseudomonas spp. can be naturally

Paclitaxel trevatide (1,252 words) [view diff] exact match in snippet view article find links to article

prevented from reaching its target in the cell due to the presence of the efflux pump P-glycoprotein (P-gp) at the barrier. This is known as a multidrug resistant-associated

Protide (1,372 words) [view diff] exact match in snippet view article find links to article

AZT-insensitive due to poor phosphorylation. It later emerged that an AZT-efflux pump was the source of this poor AZT sensitivity. However, the conclusion

Transient receptor potential channel (5,514 words) [view diff] exact match in snippet view article find links to article

factor in chemoresistance in cancer cells, as it functions as an active efflux pump that can remove various foreign substances, including chemotherapeutic

Platelet (8,489 words) [view diff] exact match in snippet view article find links to article

accumulation of calcium inside the platelet by inactivating the cAMP calcium efflux pump. The other ADP-receptor P2Y1 couples to Gq that activates phospholipase

Adult stem cell (5,960 words) [view diff] exact match in snippet view article find links to article

(July 1991). "Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells". Cell. 66 (1): 85–94. doi:10

Bcr-Abl tyrosine-kinase inhibitor (6,383 words) [view diff] exact match in snippet view article find links to article

be partly due to an increase in the expression of the P-glycoprotein efflux pump. By utilizing agents that inhibit P-glycoprotein activity imatinib susceptibility

Pseudomonas aeruginosa (10,002 words) [view diff] exact match in snippet view article find links to article

Bondì R, Baldelli V, Messina M, et al. (September 2017). "Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence". Scientific

Acetobacter aceti (2,197 words) [view diff] exact match in snippet view article find links to article

mediated by phosphotransacetylase and acetate kinase. Alternativley, an efflux pump can also drive acetate out of the microbe. A. aceti strains can tolerate

Burkholderia cenocepacia (4,039 words) [view diff] exact match in snippet view article find links to article

resistance of B. cenocepacia include: an impermeable outer membrane, an efflux pump mechanism, and the production of a beta-lactamase. This microbe challenges

Candida albicans (9,956 words) [view diff] exact match in snippet view article find links to article

"Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2". Molecular Microbiology. 62 (1): 170–186. doi:10

Topoisomerase inhibitor (9,591 words) [view diff] exact match in snippet view article find links to article

smaller quinolones have shown to bind with high affinity in the multi-drug efflux pump in Escherichia coli and Staphylococcus aureus. Despite quinolones ability

Andreas Bernkop-Schnürch (2,149 words) [view diff] exact match in snippet view article find links to article

time on mucosal membranes, exhibiting permeation enhancing as well as efflux pump inhibiting properties, and improving cellular uptake. Furthermore, Andreas

Cluster of Excellence Frankfurt Macromolecular Complexes (15,449 words) [view diff] exact match in snippet view article find links to article

double resonance (PELDOR/DEER) spectroscopy. The secondary multidrug efflux pump EmrE from E. coli was extensively studied with 31P- and DNP-enhanced

Linezolid (10,601 words) [view diff] exact match in snippet view article find links to article

coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation". Journal of Antimicrobial Chemotherapy. 59

ESKAPE (2,470 words) [view diff] exact match in snippet view article find links to article

Gram-negative aspects of the membrane surface of A. baumannii, including the efflux pump and outer membrane, affords it a wider range of antibiotic resistance

Biofilm (14,130 words) [view diff] exact match in snippet view article find links to article

permeabilization followed by biofilm disruption triggered by the inhibition of efflux pump activity and interactions with extracellular and intracellular nucleic

Evolution (24,701 words) [view diff] case mismatch in snippet view article find links to article

Resistance in Pseudomonas aeruginosa Due to Interplay of the MexAB-OprM Efflux Pump and the DNA Gyrase Mutation". Microbiology and Immunology. 46 (6): 391–395

DNA nanotechnology (9,648 words) [view diff] exact match in snippet view article find links to article

into MCF-7 breast cancer cells that contained the P-glycoprotein drug efflux pump. The results of the experiment showed the DOX was not being pumped out

Overlapping gene (5,334 words) [view diff] case mismatch in snippet view article find links to article

"Translational Coupling Controls Expression and Function of the DrrAB Drug Efflux Pump". Journal of Molecular Biology. 385 (3): 831–842. doi:10.1016/j.jmb.2008

Pyoverdine (3,953 words) [view diff] exact match in snippet view article find links to article

completely matured, pyoverdine is exported from the periplasm by PvdRT-OpmQ efflux pump. A complete organic synthesis pathway for the pyoverdine produced by

Cancer stem cell (10,288 words) [view diff] exact match in snippet view article find links to article

(January 2002). "The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors"

Phage therapy (10,995 words) [view diff] exact match in snippet view article find links to article

that the evolution of bacterial resistance to phage attack changes the efflux pump mechanism, causing increased sensitivity to drugs from several antibiotic

ABC transporter (14,391 words) [view diff] exact match in snippet view article find links to article

caused by active efflux of a drug. P-glycoprotein is the best-studied efflux pump and as such has offered important insights into the mechanism of bacterial

Wilfred Stein (2,880 words) [view diff] exact match in snippet view article find links to article

out a simple equation for the “leak-pump” mode of action of the drug efflux pump, P-glycoprotein. In collaboration with Michael M. Gottesman, Stein demonstrated

Hyperbilirubinemia in adults (3,363 words) [view diff] exact match in snippet view article find links to article

Nies, Anne T.; Keppler, Dietrich (2007-01-29). "The apical conjugate efflux pump ABCC2 (MRP2)". Pflügers Archiv: European Journal of Physiology. 453 (5):

MOP flippase (2,689 words) [view diff] exact match in snippet view article find links to article

Saccharomyces cerevisiae (ERC1 (YHR032w); TC# 2.A.66.1.5), a cationic drug efflux pump in A. thaliana (i.e., AtDTX1 aka AT2G04040; TC# 2.A.66.1.8) and the functionally

H19 (gene) (6,242 words) [view diff] exact match in snippet view article

Drug-resistant MCF-AdrVp cells do not overexpress P-glycoprotein, a cell membrane efflux pump commonly found in multidrug resistant cells; instead, they overexpress

Carbapenem-resistant enterobacteriaceae (8,478 words) [view diff] exact match in snippet view article find links to article

proteins OmpF and OmpC, and showed increased expression of a multidrug efflux pump, but did not produce carbapenemase. CR Pseudomonas aeruginosa is commonly