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searching for Glucuronidation 56 found (282 total)

UGT2B10 (581 words) [view diff] exact match in snippet view article find links to article

that in humans is encoded by the UGT2B10 gene. It is responsible for glucuronidation of nicotine and cotinine. UGT2B17 ENSG00000109181 GRCh38: Ensembl release

Biotransformation (553 words) [view diff] no match in snippet view article find links to article

Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds. Biotransformations can be conducted with

UGT1A10 (828 words) [view diff] exact match in snippet view article find links to article

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids

UGT1A6 (1,071 words) [view diff] exact match in snippet view article find links to article

UDP-glucuronosyltransferase 1-6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids

UGT2B17 (644 words) [view diff] exact match in snippet view article find links to article

Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional

UGT1A5 (630 words) [view diff] exact match in snippet view article find links to article

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids

UGT2B15 (845 words) [view diff] exact match in snippet view article find links to article

UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver". J. Pharmacol. Exp. Ther. 310 (2): 656–65. doi:10.1124/jpet

UGT2A2 (277 words) [view diff] exact match in snippet view article find links to article

Biological process sensory perception of smell detection of chemical stimulus cellular glucuronidation response to stimulus metabolism Sources:Amigo / QuickGO

Bromazolam (2,075 words) [view diff] exact match in snippet view article find links to article

bromazolam glucuronide, were detected as phase II metabolites. Bromazolam N-glucuronidation was found to be catalysed by UGT1A4 and UGT2B10. The formation of

ADB-PINACA (505 words) [view diff] exact match in snippet view article find links to article

hydroxylation, hydroxylation followed by oxidation (ketone formation), and glucuronidation. ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs

Kernicterus (1,068 words) [view diff] exact match in snippet view article find links to article

isoform 1A1 (UGT1A1) enzyme, which performs a reaction called "glucuronidation". This reaction adds a large sugar to the bilirubin, which makes the

Katherine Borden (1,174 words) [view diff] exact match in snippet view article find links to article

new form of drug resistance in patients, inducible drug glucuronidation. Drug glucuronidation impacts 50% of drugs usually through liver mediated drug

Difloxacin (1,426 words) [view diff] exact match in snippet view article find links to article

plasma proteins. It is metabolized primarily by the liver through glucuronidation and secreted in the bile. It can also be reabsorbed with the bile.

UGT2A1 (544 words) [view diff] exact match in snippet view article find links to article

Biological process sensory perception of smell detection of chemical stimulus cellular glucuronidation response to stimulus metabolism Sources:Amigo / QuickGO

PF-592,379 (207 words) [view diff] exact match in snippet view article find links to article

2010). "Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human". Xenobiotica;

Allethrins (468 words) [view diff] exact match in snippet view article find links to article

D. J. (2000). "Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity

Desloratadine (981 words) [view diff] exact match in snippet view article find links to article

3-hydroxydesloratadine in a three-step sequence in normal metabolizers. First, n-glucuronidation of desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine

Clonixin (159 words) [view diff] exact match in snippet view article find links to article

Pharmacology Routes of administration per os Pharmacokinetics: Metabolism Glucuronidation via UGT2B7 Legal status US: Not sold in the U.S. Except where otherwise

Mirabegron (927 words) [view diff] exact match in snippet view article find links to article

Bioavailability 29–35% Protein binding 71% Metabolism Liver via (direct) glucuronidation, amide hydrolysis, and minimal oxidative metabolism in vivo by CYP2D6

Fospropofol (396 words) [view diff] exact match in snippet view article find links to article

Schedule IV Pharmacokinetic data Protein binding 98% Metabolism Hepatic glucuronidation Elimination half-life 0.81 hours Excretion Renal Identifiers IUPAC

3-Fluorophenmetrazine (679 words) [view diff] exact match in snippet view article find links to article

the O/N‐bis‐dealkylated metabolite, combinations thereof and further glucuronidation or sulfations. In the United States, 3-fluorophenmetrazine is not explicitly

Selective estrogen receptor modulator (6,397 words) [view diff] exact match in snippet view article find links to article

potency of lasofoxifene has been attributed to reduced intestinal glucuronidation of the phenol. Unlike raloxifene, lasofoxifene satisfies the requirement

Olodaterol (834 words) [view diff] exact match in snippet view article find links to article

receptors on the heart. Olodaterol is substantially metabolized by glucuronidation (UGT2B7, UGT1A1, UGT1A9) and O-demethylation (CYP2C8, CYP2C9). Once

Fluticasone furoate (3,511 words) [view diff] exact match in snippet view article find links to article

with reduced corticosteroid activity. Conjugation reactions, such as glucuronidation and sulfation, also contribute to the formation of metabolites that

Flavan-3-ol (1,905 words) [view diff] exact match in snippet view article find links to article

metabolized upon uptake in the jejunum, mainly by O-methylation and glucuronidation, and then further metabolized by the liver. The colonic microbiome

Ribavirin (4,708 words) [view diff] exact match in snippet view article find links to article

relapse. Resistance was caused by deactivation of ribavirin through its glucuronidation in AML cells or impaired drug entry/retention in the AML cells. There

Atazanavir (1,025 words) [view diff] exact match in snippet view article find links to article

UDP glucuronosyltransferase (UGT) 1A1, thereby impacting the hepatic glucuronidation and elimination of bilirubin. As such atazanavir may not be prescribed

Morphine-3-glucuronide (296 words) [view diff] exact match in snippet view article find links to article

King CD, Tephly TR (1 January 1997). "Human UGT2B7 catalyzes morphine glucuronidation". Drug Metab. Dispos. 25 (1): 1–4. PMID 9010622. Vindenes V, Ripel

Mycoestrogen (1,243 words) [view diff] exact match in snippet view article find links to article

DNA. In phase-II metabolizing includes glucuronidation and sulfation of the mycoestrogen compound. Glucuronidation is the major phase II metabolic pathway

Cobimetinib (1,016 words) [view diff] exact match in snippet view article find links to article

Intestinal and low Liver clearance (mostly CYP3A4 oxidation and UGT2B7 glucuronidation) Elimination half-life 44 hours (mean) Excretion Feces (76–77%), urine

Hydroxylation of estradiol (1,786 words) [view diff] exact match in snippet view article find links to article

common form of 2- or 4-hydroxyestradiol inactivation, in addition to glucuronidation and sulfation. However, this inactivation can allow for the accumulation

Uracil (2,942 words) [view diff] exact match in snippet view article find links to article

"Characterization of dibenzo[a,l]pyrene-trans-11,12-diol (dibenzo[def,p]chrysene) glucuronidation by UDP-glucuronosyltransferases". Chemical Research in Toxicology.

Naproxen (3,082 words) [view diff] exact match in snippet view article find links to article

Fenselau C, Dulik DM (1987). "Species-dependent enantioselective glucuronidation of three 2-arylpropionic acids. Naproxen, ibuprofen, and benoxaprofen"

Ephenidine (864 words) [view diff] exact match in snippet view article find links to article

conjugated by methylation of one hydroxy group, and hydroxy metabolites by glucuronidation or sulfation. Ephenidine reacts with reagent testing kits to give a

Fenofibrate (2,461 words) [view diff] exact match in snippet view article find links to article

℞ (Prescription only) Pharmacokinetic data Protein binding 99% Metabolism glucuronidation Elimination half-life 20 h Excretion urine (60%), feces (25%) Identifiers

Levothyroxine (3,386 words) [view diff] exact match in snippet view article find links to article

excreted through the kidneys and metabolized through conjugation and glucuronidation and excreted directly into the bile and the gut, where they undergo

Morphine-6-glucuronide (567 words) [view diff] exact match in snippet view article find links to article

King CD, Tephly TR (1 January 1997). "Human UGT2B7 catalyzes morphine glucuronidation". Drug Metab. Dispos. 25 (1): 1–4. PMID 9010622. van Dorp EL, Romberg

Indian yellow (1,613 words) [view diff] exact match in snippet view article find links to article

studies on animals demonstrating euxanthic acid production through glucuronidation pathways in the liver. The replacement for the original pigment (which

Bilirubin (5,322 words) [view diff] exact match in snippet view article find links to article

measurement of indirect bilirubin, as unconjugated bilirubin (without/yet glucuronidation) reacts with diazosulfanilic acid to create azobilirubin which is measured

Mycophenolic acid acyl-glucuronide esterase (740 words) [view diff] exact match in snippet view article find links to article

(December 2014). "An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver". Drug Metabolism and Disposition. 42 (12): 2109–16

Dichlofenthion (3,889 words) [view diff] exact match in snippet view article find links to article

solubility and facilitate excretion. Common conjugation reactions include glucuronidation, sulfation, and amino acid conjugation. Dichlofenthion and its Phase

Mycophenolic acid acyl-glucuronide esterase (740 words) [view diff] exact match in snippet view article find links to article

(December 2014). "An orphan esterase ABHD10 modulates probenecid acyl glucuronidation in human liver". Drug Metabolism and Disposition. 42 (12): 2109–16

Benzyl butyl phthalate (3,110 words) [view diff] exact match in snippet view article find links to article

metabolite is conjugated. This indicates that the conjugation pathway (glucuronidation) is saturated at high amounts of administered BBP. The metabolites

Proline-rich protein haeiii subfamily 2 (463 words) [view diff] exact match in snippet view article find links to article

I, Strömberg N, Jörnvall H, Bergman T (June 2000). "A novel Ser O-glucuronidation in acidic proline-rich proteins identified by tandem mass spectrometry"

Neosaxitoxin (5,241 words) [view diff] exact match in snippet view article find links to article

the presence of metabolic pathways for the sequential oxidation and glucuronidation of PST in vitro, both being the initial detoxication reactions for

Codeine (8,032 words) [view diff] exact match in snippet view article find links to article

rate. CYP2D6 converts codeine into morphine, which then undergoes glucuronidation. Life-threatening intoxication, including respiratory depression requiring

Olanzapine (8,663 words) [view diff] exact match in snippet view article find links to article

Bioavailability 60–65% Protein binding 93% Metabolism Liver (direct glucuronidation and CYP1A2 mediated oxidation) Elimination half-life 33 hours, 51.8

PRKCE (6,268 words) [view diff] exact match in snippet view article find links to article

cellular response to glucose stimulus positive regulation of cellular glucuronidation intracellular signal transduction positive regulation of actin filament

Polybrominated diphenyl ethers (3,037 words) [view diff] exact match in snippet view article find links to article

(EPA) demonstrates that deiodination, active transport, sulfation, and glucuronidation may be involved in disruption of thyroid homeostasis after perinatal

Sean Ekins (2,558 words) [view diff] exact match in snippet view article find links to article

et al. (2002). "Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9". Drug Metab

Chlornaphazine (2,839 words) [view diff] exact match in snippet view article find links to article

Poupko, Jay M.; Hearn, William Lee; Radomski, Jack L. (1979). "N-Glucuronidation of N-hydroxy aromatic amines: A mechanism for their transport and bladder-specific

EIF4E (8,380 words) [view diff] exact match in snippet view article find links to article

sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation". Nature. 511 (7507): 90–93. Bibcode:2014Natur.511...90Z. doi:10.1038/nature13283

Discovery and development of cyclooxygenase 2 inhibitors (4,463 words) [view diff] exact match in snippet view article find links to article

CYP2C9 isoenzyme to carboxylic acid and also by non-CYP-dependent glucuronidation to glucuronide metabolites. The metabolites are excreted in urine and

Bioenhancer (2,375 words) [view diff] exact match in snippet view article find links to article

Dubey RK, Atal CK (February 1986). "Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine:

Medical uses of bicalutamide (13,441 words) [view diff] exact match in snippet view article find links to article

direct glucuronidation is the main metabolic pathway for the rapidly cleared (S)-bicalutamide, whereas hydroxylation followed by glucuronidation is a major

Sonlicromanol (2,476 words) [view diff] exact match in snippet view article find links to article

humans and animals, most of which result from oxidation, hydration and glucuronidation. The extent of metabolism in vitro was rather low: only 2-15% of the