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searching for IL-2 receptor 27 found (66 total)

Thomas A. Waldmann (1,411 words) [view diff] exact match in snippet view article find links to article

immunologist who has worked on therapeutic monoclonal antibodies to the IL-2 receptor, Interleukin 15 (IL-15), and Adult T-cell Leukemia (ATL). Until the

Efavaleukin alfa (250 words) [view diff] exact match in snippet view article find links to article

"mutein Fc fusion protein that preferentially binds the high-affinity IL-2 receptor alpha chain (CD25) to selectively promote Treg expansion". It is developed

Otilimab (722 words) [view diff] exact match in snippet view article find links to article

daclizumab and alemtuzumab (both binding to CD25, the α-subunit of IL-2 receptor on the surface of mature lymphocytes), ocrelizumab (against CD20 marker

EIF3B (932 words) [view diff] exact match in snippet view article find links to article

(IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit". J. Biol. Chem. 268 (30): 22765–70. doi:10.1016/S0021-9258(18)41592-X

Hemophagocytic lymphohistiocytosis (3,418 words) [view diff] exact match in snippet view article find links to article

nodes Low or absent natural killer cell activity Soluble CD25 (soluble IL-2 receptor) >2400 U/ml (or per local reference laboratory) In addition, in the

NSG mouse (1,435 words) [view diff] no match in snippet view article find links to article

Diabetic-Recombination Activating Gene-1 (NOD- Rag 1 null ) Interleukin (IL)-2 Receptor Common Gamma Chain ( IL 2 Rγ null ) Null Mice: A Radioresistant Model

Thioredoxin (2,845 words) [view diff] exact match in snippet view article find links to article

factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction". The EMBO

Macrophage activation syndrome (534 words) [view diff] exact match in snippet view article find links to article

activation (e.g. soluble CD163), and lymphocyte activation (e.g. soluble IL-2 receptor) can be helpful. NK cell function analysis may show depressed NK function

List of human clusters of differentiation (467 words) [view diff] exact match in snippet view article find links to article

1, one of the B7 molecules. Causes up-regulation of a high affinity IL-2 receptor allowing T cells to proliferate. CD81 A tetraspanin expressed in a wide

Janus kinase 3 (5,166 words) [view diff] exact match in snippet view article find links to article

"Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045–7. Bibcode:1994Sci...266.1045M

Birdshot chorioretinopathy (1,301 words) [view diff] exact match in snippet view article find links to article

vasculitis have been evident via electroretinography, during daclizumab (IL-2 receptor blocker) therapy. This is also supported by the observation of elevated

JAK-STAT signaling pathway (6,833 words) [view diff] exact match in snippet view article find links to article

JAK-STAT signalling integrating with other pathways is Interleukin-2 (IL-2) receptor signaling in T cells. IL-2 receptors have γ (gamma) chains, which are

Tasuku Honjo (1,467 words) [view diff] exact match in snippet view article find links to article

clonings of IL-4 and IL-5 cytokines involved in class switching and IL-2 receptor alpha chain in 1986, and went on further to discover AID in 2000, demonstrating

Cytokine (3,857 words) [view diff] exact match in snippet view article find links to article

certain conserved motifs in their extracellular amino-acid domain. The IL-2 receptor belongs to this chain, whose γ-chain (common to several other cytokines)

SHB (gene) (1,026 words) [view diff] exact match in snippet view article

1091/mbc.E02-02-0103. PMC 117949. PMID 12181353. Lindholm CK (Aug 2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochemical

C3a (complement) (2,036 words) [view diff] exact match in snippet view article

cell production. The absence of C3 has also been shown to decrease IL-2 receptor expression on T cells. Levels of complement are regulated by moderating

Heinz Wiendl (1,863 words) [view diff] exact match in snippet view article find links to article

regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A 113(21):E2973-2982. Kappos L, Wiendl

LL-100 panel (4,749 words) [view diff] no match in snippet view article find links to article

Minato, N; Tsudo, M (March 1985). "TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells)"

Alveolar macrophage (3,833 words) [view diff] no match in snippet view article find links to article

phosphorylation of the kinases involved in production of the interleukin-2 (IL-2) receptor, the expression of which is fundamental for T cell proliferation. In

Interleukin-1 family (6,005 words) [view diff] exact match in snippet view article find links to article

inhibits the release of both IL-1α and IL-1β, IL-2 secretion, cell surface IL-2 receptor expression. It blocks the stimulation of prostaglandin E2 synthesis

Intestine transplantation (5,336 words) [view diff] no match in snippet view article find links to article

T-lymphocyte activation. Next, various assortments of interleukin-2 (IL-2) receptor antagonists (daclizumab, basiliximab), anti-proliferation agents (azathioprine

Macrophage (10,188 words) [view diff] exact match in snippet view article find links to article

protein Bcl-2, but T cell production of IL-2 and the high-affinity IL-2 receptor IL-2RA both require continued signal from TCR recognition of MHC-bound

Hairy cell leukemia (7,246 words) [view diff] no match in snippet view article find links to article

biopsies Low or no cell-surface expression of CD25 (interleukin-2 [IL-2] receptor alpha chain, or p55). Low levels of CD25, a part of the receptor for

Sunil Shroff (3,816 words) [view diff] exact match in snippet view article find links to article

Kuruvilla, S (2000). "An early experience with Simulect (basiliximab): An IL-2 receptor antibody". Transplantation Proceedings. 32 (7): 1739–40. doi:10

GRB2 (9,365 words) [view diff] no match in snippet view article find links to article

(January 1994). "The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation". The Journal of Biological Chemistry. 269 (3):

K. Christopher Garcia (2,278 words) [view diff] exact match in snippet view article find links to article

immune system. Garcia's lab published the creation of an "orthogonal" IL-2 receptor complex to enable the selective delivery of IL-2 signals to engineered

Epstein–Barr virus–associated lymphoproliferative diseases (16,931 words) [view diff] exact match in snippet view article find links to article

blood levels of ferritin; and elevated blood levels or the soluble IL-2 receptor. The finding of EBV in T cells of blood or involved tissues is required