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IPEX syndrome
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syndrome FOXP3 Autoimmune polyendocrine syndrome type 2 "Orphanet: Immune dysregulation polyendocrinopathy enteropathy X linked syndrome". www.orpha.netAutoimmune polyendocrine syndrome (770 words) [view diff] exact match in snippet view article find links to article
Retrieved 2017-05-11. RESERVED, INSERM US14 -- ALL RIGHTS. "Orphanet: Immune dysregulation polyendocrinopathy enteropathy X linked syndrome". www.orpha.netX-linked lymphoproliferative disease (1,362 words) [view diff] no match in snippet view article find links to article
X-linked lymphoproliferative disease (also known as Duncan disease: 86 or Purtilo syndrome and abbreviated as XLP) is a lymphoproliferative disorder,Griscelli syndrome (967 words) [view diff] no match in snippet view article find links to article
Griscelli syndrome is a rare autosomal recessive disorder characterized by albinism (hypopigmentation) with immunodeficiency, that usually causes deathChédiak–Higashi syndrome (1,317 words) [view diff] no match in snippet view article find links to article
Chédiak–Higashi syndrome (CHS) is a rare autosomal recessive disorder that arises from a mutation of a lysosomal trafficking regulator protein, which leadsInsulin autoimmune syndrome (643 words) [view diff] no match in snippet view article find links to article
Insulin autoimmune syndrome (IAS), a rare cause of reversible autoimmune hypoglycemia also known as Hirata's disease, was first described by Hirata inHemophagocytic lymphohistiocytosis (3,418 words) [view diff] no match in snippet view article find links to article
In hematology, hemophagocytic lymphohistiocytosis (HLH), also known as haemophagocytic lymphohistiocytosis (British spelling), and hemophagocytic or haemophagocyticMultiple sclerosis (17,356 words) [view diff] exact match in snippet view article find links to article
of the myelin-producing cells. Proposed causes for this include immune dysregulation, genetics, and environmental factors, such as viral infections. MSAutoimmune enteropathy (5,487 words) [view diff] exact match in snippet view article find links to article
most prominent being Autoimmune polyendocrine syndrome type 1 and immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome. ClinicalSpondyloenchondrodysplasia (2,808 words) [view diff] exact match in snippet view article find links to article
with immune dysregulation: MedlinePlus Genetics". medlineplus.gov. Retrieved 2022-10-23. "Spondyloenchondrodysplasia with immune dysregulation - About thePaul Ashwood (849 words) [view diff] no match in snippet view article find links to article
peer-reviewed papers, that "these findings point to a pivotal role for immune-dysregulation in the pathogenesis of ASD". Another of his studies, presented atList of primary immunodeficiencies (1,809 words) [view diff] exact match in snippet view article find links to article
TREX1, SAMHD1 or IFIH1 mutations Spondyloenchondro-dysplasia with immune dysregulation (ACP5 mutation) STING-associated vasculopathy with onset in infancyJosé Gilberto Montoya (1,340 words) [view diff] exact match in snippet view article find links to article
research has shed light on the potential involvement of pathogens and immune dysregulation in the pathophysiology of CFS. He was a Professor of Medicine inCytotoxic T-lymphocyte associated protein 4 (3,464 words) [view diff] exact match in snippet view article find links to article
Symptomatic patients with CTLA-4 mutations are characterized by an immune dysregulation syndrome including extensive T cell infiltration in a number of organsGene Shearer (2,072 words) [view diff] exact match in snippet view article find links to article
Shearer was one of the first immunologists to begin studying the immune dysregulation in AIDS patients and discovered that infection with human immunodeficiencyDepression and immune function (6,980 words) [view diff] case mismatch in snippet view article find links to article
emphasizes the role of environmental mismatch is the Immune Dysregulation Hypothesis. The Immune Dysregulation hypothesis is based on the old friends hypothesisTartrate-resistant acid phosphatase (1,746 words) [view diff] exact match in snippet view article find links to article
pathogenesis probably includes a defect in bone reabsorption as well as immune dysregulation because of impaired dephosphorylation of osteopontin, but may beEpigenetics of anxiety and stress–related disorders (11,227 words) [view diff] exact match in snippet view article find links to article
with immune dysregulation. Traumatic experiences can induce epigenetic changes at the gene loci that are immune-related which can lead to immune dysregulationDysgammaglobulinemia (629 words) [view diff] exact match in snippet view article find links to article
Itzhak; Vardy, Daniel (March 1, 2014). "Selective IgE deficiency, immune dysregulation, and autoimmunity". Allergy and Asthma Proceedings. 35 (2). OceansideLRBA deficiency (1,110 words) [view diff] exact match in snippet view article find links to article
haploinsufficiency. Since LRBA loss results in a loss of CTLA4 protein, the immune dysregulation syndrome of LRBA deficient patients can be attributed to the secondaryGranulomatous–lymphocytic interstitial lung disease (904 words) [view diff] exact match in snippet view article find links to article
2015;3:651-660 Schubert D, Bode C, Kenefeck R et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med 2014;20:1410-1416Immune-mediated inflammatory diseases (212 words) [view diff] exact match in snippet view article find links to article
Springer, 2007. idid.us: immune mediated inflammatory diseases, inflammatory diseases of immune dysregulation Archived 2018-03-08 at the Wayback MachineSubacute cutaneous lupus erythematosus (658 words) [view diff] exact match in snippet view article find links to article
exposure is the traditional precipitating factor in patients with immune dysregulation and an aberrant milieu of genetic predisposition. There have alsoIL2RA (2,548 words) [view diff] exact match in snippet view article find links to article
population. These SNPs have been linked mainly to susceptibility to immune dysregulation disorders, with majority found in research on multiple sclerosisList of conditions treated with hematopoietic stem cell transplantation (364 words) [view diff] exact match in snippet view article find links to article
Phagocyte disorders Kostmann syndrome Shwachman–Diamond syndrome Immune dysregulation diseases Griscelli syndrome, type II Innate immune deficiencies NF-Kappa-BStrain (biology) (1,376 words) [view diff] case mismatch in snippet view article
; Bluestone, Jeffrey A. (2004-11-29). "THE NOD MOUSE: A Model of Immune Dysregulation". Annual Review of Immunology. 23 (1): 447–485. doi:10.1146/annurevCHAI disease (277 words) [view diff] exact match in snippet view article find links to article
; Stoddard, Jennifer; Zhang, Yu; Frucht, David M. (2014-09-26). "Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4"Evans syndrome (1,830 words) [view diff] exact match in snippet view article find links to article
immunodeficiency (CVID), systemic autoimmune disease, or another disorder of immune dysregulation. Other antibodies may occur directed against neutrophils and lymphocytesNOD mice (980 words) [view diff] exact match in snippet view article find links to article
"The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD". Immunity. 7 (6): 727–38. doi:10.1016/s1074-7613(00)80392-1Ehrlichiosis (1,939 words) [view diff] exact match in snippet view article find links to article
signs and symptoms of ehrlichiosis can likely be ascribed to the immune dysregulation that it causes.[citation needed] A "toxic shock-like" syndrome isUremic pruritus (1,942 words) [view diff] exact match in snippet view article find links to article
There are several potential causes of uremic pruritus, including immune dysregulation, uremic toxins, neuropathy, and opioid imbalance. Vitamin A, parathyroidTumid lupus erythematosus (1,493 words) [view diff] exact match in snippet view article find links to article
started if an autoimmune disease is suspected. It is suggested that immune dysregulation results in T cell suppression. There has been evidence of a correlationRAG1 (948 words) [view diff] exact match in snippet view article find links to article
system. In humans, RAG deficiency was first recognised as a form of immune dysregulation known as Omenn syndrome. RAG deficiency is considered an autosomalLPS-responsive beige-like anchor protein deficiency (266 words) [view diff] exact match in snippet view article find links to article
making the diagnosis difficult. The most common features include Immune dysregulation (95%) Organomegaly (86%) Recurrent infections (71%) HypogammaglobulinemiaGranulopoiesis (1,916 words) [view diff] exact match in snippet view article find links to article
deficiencies. Balancing rapid neutrophil mobilization against the risk of immune dysregulation is critical, as imbalances can lead to severe conditions like acuteCD25 deficiency (354 words) [view diff] exact match in snippet view article find links to article
Chatila T, Atkinson JP, Verbsky JB (2007). "CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like syndrome, and defectiveSparassis (1,368 words) [view diff] case mismatch in snippet view article find links to article
1155/2013/982317. PMC 3613060. PMID 23586068. Rao (2020). "Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 PatientsInflammatory cytokine (2,244 words) [view diff] exact match in snippet view article find links to article
PMID 24429094. Slocum C, Kramer C, Genco CA (Jan 2016). "Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammationNecrotizing meningoencephalitis (1,050 words) [view diff] exact match in snippet view article find links to article
histopathological examination through a necropsy. First signs of this immune dysregulation can show through lethargy and the reluctance to walk. BehavioralEosinopenia (1,693 words) [view diff] exact match in snippet view article find links to article
potential explanation is that eosinopenia may be an indication of immune dysregulation. In the body's response to a pathogen, the immune system activatesSTAT4 (1,895 words) [view diff] exact match in snippet view article find links to article
mostly in third intron of the STAT4 has shown to be associated with immune dysregulation and autoimmunity including systemic lupus erythematosus (SLE) andInterleukin 4 (2,293 words) [view diff] exact match in snippet view article find links to article
Auxiliary T cells are a key element of HIV-1 infection. Several signs of immune dysregulation such as polyclonal B cell initialization, previous cell-mediatedNon-Hodgkin lymphoma (3,234 words) [view diff] case mismatch in snippet view article find links to article
Polychlorinated Biphenyls and Non-Hodgkin Lymphoma, and the Role of Immune Dysregulation". Environmental Health Perspectives. 120 (8): 1067–75. doi:10.1289/ehpTyrosine kinase 2 (2,850 words) [view diff] exact match in snippet view article find links to article
Wills-Karp M (July 2000). "Murine models of asthma in understanding immune dysregulation in human asthma". Immunopharmacology. 48 (3): 263–268. doi:10Lichen sclerosus (4,219 words) [view diff] exact match in snippet view article find links to article
1258/0956462054308440. PMID 16004624. S2CID 21471620. Regauer, S (2005). "Immune dysregulation in lichen sclerosus". European Journal of Cell Biology. 84 (2–3):Functional gastrointestinal disorder (3,825 words) [view diff] exact match in snippet view article find links to article
Visceral hypersensitivity may be amplified in patients with FGIDs. Immune dysregulation, inflammation, and barrier dysfunction Studies on postinfectiousCold urticaria (2,547 words) [view diff] exact match in snippet view article find links to article
have named the condition PLCG2-associated antibody deficiency and immune dysregulation, or PLAID." Diagnosis is typically obtained by an allergist or otherType 3 innate lymphoid cells (2,835 words) [view diff] exact match in snippet view article find links to article
tract, that have been linked to a plethora of factors including immune dysregulation and environmental cues, as well as genetic predisposition. Most well-knownCommon variable immunodeficiency (3,368 words) [view diff] exact match in snippet view article find links to article
pathology and inflammation in CVID that is a part of the general immune dysregulation affecting patients with CVID. The most common upper gastrointestinalDeramciclane (1,724 words) [view diff] exact match in snippet view article find links to article
Scheinberg LC (March 1992). "A prospective study of depression and immune dysregulation in multiple sclerosis". Archives of Neurology. 49 (3): 238–44. doi:10PGM3 deficiency (999 words) [view diff] exact match in snippet view article find links to article
to explain the link between glycosylation abnormalities and the immune dysregulation has not yet been established. This disorder demonstrates a previouslyWiskott–Aldrich syndrome protein (2,588 words) [view diff] exact match in snippet view article find links to article
a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WASpKonstance Knox (1,693 words) [view diff] exact match in snippet view article find links to article
immunocompromised individuals causing or contributing to immune suppression and immune dysregulation. Born and raised in Wisconsin, Knox received her bachelor's degreeMemory T cell (3,781 words) [view diff] exact match in snippet view article find links to article
65–70 years of age, immunosenescence stage comes, in which stage immune dysregulation, decline in T cell function and increased susceptibility to pathogensAleixo Muise (1,059 words) [view diff] exact match in snippet view article find links to article
Aleixo M. (2021-03-29). "Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice". Nature Genetics. 53Social determinants of health (11,514 words) [view diff] case mismatch in snippet view article find links to article
4, 2023. Gouin, Jean-Philippe (November 2011). "Chronic Stress, Immune Dysregulation, and Health". American Journal of Lifestyle Medicine. 5 (6): 476–485Menarche (4,662 words) [view diff] exact match in snippet view article find links to article
Levy J, Bernstein L, Silber N (December 2014). "Celiac disease: an immune dysregulation syndrome". Current Problems in Pediatric and Adolescent Health CareHelminthic therapy (3,486 words) [view diff] exact match in snippet view article find links to article
living. As keystone organisms, helminths are central to correcting immune dysregulation, and their replenishment may prevent disease. The biome depletion2008 California wildfires (3,526 words) [view diff] case mismatch in snippet view article find links to article
(2017-02-13). "Early Life Wildfire Smoke Exposure Is Associated with Immune Dysregulation and Lung Function Decrements in Adolescence". American Journal ofNehal N. Mehta (1,717 words) [view diff] exact match in snippet view article find links to article
is dysfunctional which in the face of systemic inflammation and immune dysregulation drives early cholesterol crystal formation. His work has focusedSTAT3 GOF (1,528 words) [view diff] exact match in snippet view article find links to article
Olive; Olbrich, Peter (November 2018). "Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activatorDelayed puberty (4,972 words) [view diff] exact match in snippet view article find links to article
Levy J, Bernstein L, Silber N (December 2014). "Celiac disease: an immune dysregulation syndrome". Current Problems in Pediatric and Adolescent Health CareHashimoto's thyroiditis (7,884 words) [view diff] exact match in snippet view article find links to article
Environmental factors that may predispose patients to this type of immune dysregulation include toxins, medications, dietary factors, and infectious agentsImmune tolerance (6,030 words) [view diff] exact match in snippet view article find links to article
PMC 3485510. PMID 23125865. Verbsky JW, Chatila TA (December 2013). "Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-relatedGut–brain axis (3,442 words) [view diff] case mismatch in snippet view article find links to article
Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation". Clinical Therapeutics. 37 (5): 984–995. doi:10.1016/j.clintheraMechanism of autism (3,652 words) [view diff] exact match in snippet view article find links to article
serotonin signaling and inflammation. A 2015 review proposed that immune dysregulation, gastrointestinal inflammation, autonomic nervous system malfunctionPsychoneuroimmunology (5,448 words) [view diff] exact match in snippet view article find links to article
research resulted in two large meta-analyses, which showed consistent immune dysregulation in healthy people who are experiencing stress. In the first meta-analysisLactose intolerance (7,146 words) [view diff] exact match in snippet view article find links to article
Levy J, Bernstein L, Silber N (December 2014). "Celiac disease: an immune dysregulation syndrome". Current Problems in Pediatric and Adolescent Health CareJulio Montaner (5,062 words) [view diff] exact match in snippet view article find links to article
Montaner pursued this strategy as he "believed [HIV] was a matter of immune dysregulation as much as suppression.". Montaner and his colleagues published theirMicrobiota (7,825 words) [view diff] exact match in snippet view article find links to article
repair damage. Pathogens can influence this coexistence leading to immune dysregulation including and susceptibility to diseases, mechanisms of inflammationPsychosis (14,871 words) [view diff] exact match in snippet view article find links to article
2018). "A clinical approach to new-onset psychosis associated with immune dysregulation: the concept of autoimmune psychosis". Journal of NeuroinflammationEthiopian Jews in Israel (6,478 words) [view diff] exact match in snippet view article find links to article
Weisman, Z.; Moroz, C.; Bar-Yehuda, S.; Kalinkovich, A. (1996). "Immune dysregulation in Ethiopian immigrants in Israel: relevance to helminth infectionsRespiratory syncytial virus (10,275 words) [view diff] exact match in snippet view article find links to article
potentially leading to life-threatening lung disease characterized by immune dysregulation. RSV has evolved numerous strategies to evade the host's antiviralCoeliac disease (15,550 words) [view diff] exact match in snippet view article find links to article
Levy J, Bernstein L, Silber N (December 2014). "Celiac disease: an immune dysregulation syndrome". Current Problems in Pediatric and Adolescent Health CareCD4 immunoadhesin (2,878 words) [view diff] exact match in snippet view article find links to article
investigated as a potential treatment for other diseases that involve immune dysregulation, such as multiple sclerosis and rheumatoid arthritis. In these diseasesAutism (25,655 words) [view diff] exact match in snippet view article find links to article
517–528. doi:10.1038/nrgastro.2016.107. PMC 5005185. PMID 27435372. immune dysregulation, GI inflammation, malfunction of the ANS, genetic and metabolic activityRegulatory T cell (9,560 words) [view diff] exact match in snippet view article find links to article
develop a severe and rapidly fatal autoimmune disorder known as Immune dysregulation, Polyendocrinopathy, Enteropathy X-linked (IPEX) syndrome. The IPEXMajor depressive disorder (20,256 words) [view diff] exact match in snippet view article find links to article
(such as degeneration of the basal ganglia in Parkinson's disease or immune dysregulation in asthma). Depression may also be iatrogenic (the result of healthcare)Irritable bowel syndrome (14,389 words) [view diff] exact match in snippet view article find links to article
Levy J, Bernstein L, Silber N (December 2014). "Celiac disease: an immune dysregulation syndrome". Current Problems in Pediatric and Adolescent Health CareUlcerative colitis (16,072 words) [view diff] exact match in snippet view article find links to article
colitis may improve and enter remission. UC is characterized by immune dysregulation and systemic inflammation, which may result in symptoms and complicationsPolychlorinated biphenyl (14,411 words) [view diff] exact match in snippet view article find links to article
polychlorinated biphenyls and non-hodgkin lymphoma, and the role of immune dysregulation". Environmental Health Perspectives. 120 (8): 1067–1075. doi:10.1289/ehpLoneliness (12,122 words) [view diff] exact match in snippet view article find links to article
predicts pain, depression, and fatigue: Understanding the role of immune dysregulation". Psychoneuroendocrinology. 38 (8): 1310–1317. doi:10.1016/j.psyneuenSusan Zolla-Pazner (3,379 words) [view diff] exact match in snippet view article find links to article
Edelman, A. S.; Zolla-Pazner, S. (1989-01-01). "AIDS: a syndrome of immune dysregulation, dysfunction, and deficiency". FASEB Journal. 3 (1): 22–30. doi:10Peptidoglycan recognition protein 1 (6,550 words) [view diff] exact match in snippet view article find links to article
lacking PGLYRP1 infected with B. burgdorferi also show signs of immune dysregulation, including lower serum IgG levels and higher levels of proinflammatoryList of autoimmune diseases (6,052 words) [view diff] exact match in snippet view article find links to article
PMID 16513876. Jones AL, Mowry BJ, Pender MP, Greer JM (2005). "Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophreniaRisk factors of schizophrenia (14,999 words) [view diff] exact match in snippet view article find links to article
PMID 16513876. Jones AL, Mowry BJ, Pender MP, Greer JM (February 2005). "Immune dysregulation and self-reactivity in schizophrenia: Do some cases of schizophreniaPeptidoglycan recognition protein (11,846 words) [view diff] exact match in snippet view article find links to article
Mice lacking PGLYRP1 infected with B. burgdorferi show signs of immune dysregulation, which results in Th1 cytokine response and impairment of antibodyPathophysiology of autism (2,898 words) [view diff] exact match in snippet view article find links to article
517–528. doi:10.1038/nrgastro.2016.107. PMC 5005185. PMID 27435372. immune dysregulation, GI inflammation, malfunction of the ANS, genetic and metabolic activityHypothyroidism in dogs (4,319 words) [view diff] exact match in snippet view article find links to article
hypertrichosis and some develop either a wool-like or a coarse appearance. Immune dysregulation, caused by hypothyroidism, can lead to superficial bacterial infection