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searching for MEK inhibitor 17 found (35 total)

U0126 (722 words) [view diff] exact match in snippet view article find links to article

protects cells against oxidative stress independent of its function as a MEK inhibitor". ACS Chemical Neuroscience. 6 (1): 130–137. doi:10.1021/cn500288n.

Neurocutaneous melanosis (1,586 words) [view diff] exact match in snippet view article find links to article

pathogenesis of NCM. Recently, experimental treatment with MEK162, a MEK inhibitor, has been tried in a patient with NCM and progressive symptomatic leptomeningeal

Nifuroxazide (444 words) [view diff] exact match in snippet view article find links to article

models. ALDH1 is enriched in melanoma patient samples following BRAF and MEK inhibitor treatments, and it has been proposed that nifuroxazide may be useful

Mitogen-activated protein kinase kinase (296 words) [view diff] exact match in snippet view article find links to article

Douglas J.; Fecher, Leslie A.; et al. (2012). "Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation

Array BioPharma (184 words) [view diff] exact match in snippet view article find links to article

company for approximately $11 billion. MEKTOVI (Binimetinib) - selective MEK inhibitor - Approved 2018, acquired by Pfizer TUKYSA (Tucatinib) - HER2 inhibitor

Acral lentiginous melanoma (1,382 words) [view diff] exact match in snippet view article find links to article

nivolumab; BRAF inhibitors, such as vemurafenib and dabrafenib; and a MEK inhibitor trametinib. When arising in the nailbed of a digit, the evidence suggests

Costello syndrome (1,406 words) [view diff] exact match in snippet view article find links to article

third medication that might help children with Costello syndrome is a MEK inhibitor that helps inhibit the pathway closer to the cell nucleus.[citation

Lifileucel (590 words) [view diff] exact match in snippet view article find links to article

if BRAF V600 mutation positive, a BRAF inhibitor with or without a MEK inhibitor). The safety and effectiveness of lifileucel was evaluated in a global

Brigitte C. Widemann (379 words) [view diff] exact match in snippet view article find links to article

trials, Widemann’s team led the phase II registration trial of the MEK inhibitor selumetinib, which resulted in the first ever Food and Drug Administration

Erdheim–Chester disease (2,228 words) [view diff] case mismatch in snippet view article find links to article

PMID 35844342. The ASCO Post Staff (2 November 2022). "FDA Approves Oral MEK Inhibitor Cobimetinib for Histiocytic Neoplasms". The ASCO Post. Retrieved 2022-11-19

H. Lee Moffitt Cancer Center & Research Institute (2,894 words) [view diff] exact match in snippet view article find links to article

if BRAF V600 mutation positive, a BRAF inhibitor with or without a MEK inhibitor. Kirstie Alley (1951-2022), American actress, Scientologist Casey DeSantis

Encorafenib (721 words) [view diff] exact match in snippet view article find links to article

clinical trials of LGX818, either alone or in combinations with the MEK inhibitor MEK162, are being run. As a result of a successful Phase Ib/II trials

Dabrafenib (1,122 words) [view diff] exact match in snippet view article find links to article

this resistance, the BRAF inhibitor dabrafenib was combined with the MEK inhibitor trametinib. In January 2014, the FDA approved this combination of dabrafenib

Channing Der (745 words) [view diff] exact match in snippet view article find links to article

Cancer Center, a new clinical trial evaluating the combination of the MEK inhibitor binimetinib with the autophagy inhibitor hydroxychloroquine in pancreatic

Mitogen-activated protein kinase (5,501 words) [view diff] exact match in snippet view article find links to article

are successful antineoplastic agents against various types of cancer. MEK inhibitor cobimetinib has been investigated in pre-clinical lung cancer models

Nicholas J. Vogelzang (2,616 words) [view diff] exact match in snippet view article find links to article

Rene; Kurzrock, Razelle; Fecher, Leslie A (2012). "Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation

Bradley J. Monk (3,280 words) [view diff] exact match in snippet view article find links to article

serous cancers. His pivotal study of binimetinib showed activity of this MEK inhibitor in a setting of high unmet need. Like ovarian cancer, he is developing