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searching for MLH1 31 found (97 total)

alternate case: mLH1

Endometrial intraepithelial neoplasia (1,608 words) [view diff] exact match in snippet view article find links to article

PMID 7585555. Esteller M, Catasus L, Matias-Guiu X, et al. (November 1999). "hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis"

Field cancerization (1,850 words) [view diff] exact match in snippet view article find links to article

Park CS, Juhng SW, Lee JH (October 2011). "Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma

Chromosomal crossover (3,708 words) [view diff] exact match in snippet view article find links to article

crossovers in eukaryotes. The majority of them are repaired by MutL homologs MLH1 and MLH3, which defines the class I crossovers. The remaining are the result

Shapiro–Senapathy algorithm (6,804 words) [view diff] exact match in snippet view article find links to article

ovarian cancer (e.g., SLC9A3R1, COL7A1, HSD17B7), colon cancer (e.g., APC, MLH1, DPYD), colorectal cancer (e.g., COL3A1, APC, HLA-A), skin cancer (e.g.,

PMS1 (958 words) [view diff] exact match in snippet view article find links to article

repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis

Richard Kolodner (632 words) [view diff] exact match in snippet view article find links to article

bacteria and yeast, Kolodner identified two DNA mismatch repair genes, MSH2 and MLH1, that lead to 95 percent of hereditary colon cancer cases. In both cases

Sebaceous carcinoma (3,253 words) [view diff] exact match in snippet view article find links to article

colorectal adenocarcinoma. MTS results from defects in DNA mismatch repair genes, MLH1, MSH2, and MSH6, leading to a buildup of unstable microsatellite sequences

List of genes mutated in cutaneous conditions (108 words) [view diff] exact match in snippet view article find links to article

(Wermer syndrome) Merlin Neurofibromatosis type 2 Merosin Infantile hemangioma MLH1 Muir–Torre syndrome MLPH Griscelli syndrome MITF Waardenburg syndrome type

MAX (gene) (2,347 words) [view diff] exact match in snippet view article

Brown R (February 2003). "Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX". Oncogene. 22 (6): 819–25. doi:10.1038/sj.onc

Carcinoma (3,232 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079

Dana–Farber Cancer Institute (1,783 words) [view diff] exact match in snippet view article find links to article

the risk for a common type of colon cancer. The MSH2 gene and later the MLH1 gene (also by DFCI investigators) are linked to hereditary nonpolyposis colorectal

Cell damage (2,829 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079

Temozolomide (2,958 words) [view diff] exact match in snippet view article find links to article

with temozolomide and then selection or induction of mutant MSH6, MSH2, MLH1, or PMS2 proteins and cells which are MMRd and temozolomide resistant. The

Deleted in lung and esophageal cancer 1 (699 words) [view diff] exact match in snippet view article find links to article

Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish MR (July 2008). "DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell

Bert Vogelstein (3,823 words) [view diff] exact match in snippet view article find links to article

soon led them and other groups to identify repair genes such as MSH2 and MLH1 that are responsible for most cases of this syndrome. In the early 2000s

MUS81 (1,402 words) [view diff] exact match in snippet view article find links to article

J, Edelmann W, McGowan CH, Cohen PE (2008). "MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis". PLOS Genet. 4 (9): e1000186

Glioma (6,374 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079

Combined bisulfite restriction analysis (1,300 words) [view diff] exact match in snippet view article find links to article

PMID 16174854. Suter, Catherine, M.; et al. (2004). "Germline epimutation in MLH1 in individuals with multiple cancers". Nature Genetics. 36 (5): 497–501.

Human genome (10,151 words) [view diff] exact match in snippet view article find links to article

nonpolyposis coli) 1:3500 APC Lynch syndrome 5–10% of all cases of bowel cancer MLH1, MSH2, MSH6, PMS2 Fanconi anemia 1:130000 births FANCC Neurological conditions

Paula Cohen (710 words) [view diff] exact match in snippet view article find links to article

E. Cohen; M. Kane; et al. (28 June 1996). "Meiotic pachytene arrest in MLH1-deficient mice". Cell. 85 (7): 1125–1134. doi:10.1016/S0092-8674(00)81312-4

Male breast cancer (4,641 words) [view diff] exact match in snippet view article find links to article

Lynch syndrome with mutations in any of the four DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2), or the EpCAM gene. The relative risks of men vs. women

Synthetic lethality (2,802 words) [view diff] case mismatch in snippet view article find links to article

genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079

Pachytene (881 words) [view diff] exact match in snippet view article find links to article

non-sister chromatids that were initiated during zygotene. Proteins like MLH1 and MLH3 stabilize the crossover events, ensuring at least one obligatory

MUTYH (2,951 words) [view diff] exact match in snippet view article find links to article

the interaction of Mismatch Repair proteins (MMR) such as MSH 2,3 and 6, MLH1, PMS1 and 2, and MUTYH in which the proposed result of their partnering is

Zygotene (665 words) [view diff] exact match in snippet view article find links to article

occurs between the non-sister chromatids. Key recombination proteins like MLH1/3 and MSH4/5 mark the sites of crossover formation. The number and positioning

Talazoparib (1,214 words) [view diff] exact match in snippet view article find links to article

inhibitor or docetaxel. HRR genes (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) were assessed prospectively using tumor tissue

Bristol LH (1,697 words) [view diff] exact match in snippet view article find links to article

Fleet numbers Registrations Type Built MLH1–19 SMS 671–678H, SWG 669–679H LH C38F 1970 MLH20–33 WMS 920J–925J, WWG 326J–333J LH C41F 1971 MLH34–38 BWG 334–338L

Peter Propping (1,405 words) [view diff] exact match in snippet view article find links to article

Mangold, . . . P. Propping: Spectrum and frequenciens of mutations in MSH2 and MLH1 in 1721 German families suspected of hereditary nonpolyposis colorectal cancer

RAD9A (3,997 words) [view diff] exact match in snippet view article find links to article

have a number of key interactions with mismatch repair protein complexes MLH1, MSH2, MSH3, and MSH6. Also, it has known interaction in the following repair

POLD1 (7,977 words) [view diff] exact match in snippet view article find links to article

example, germline mutations in DNA repair proteins involved in MMR (MSH2, MLH1, MSH6, and PMS2) have been described in Lynch syndrome (LS), which is characterized

Sarah Tabrizi (3,608 words) [view diff] exact match in snippet view article find links to article

Sarah J. (August 2021). "FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease". Cell