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searching for MTOR inhibitors 22 found (49 total)

Diffuse neonatal hemangiomatosis (4,379 words) [view diff] exact match in snippet view article find links to article

being considered as treatment for diffuse neonatal hemangiomatosis. mTOR inhibitors, an inhibitor that is normally used for post-organ transplantation

XL-388 (326 words) [view diff] exact match in snippet view article find links to article

and has also been used to demonstrate a potential application for mTOR inhibitors in the treatment of neuropathic pain. Takeuchi CS, Kim BG, Blazey CM

Torin-1 (642 words) [view diff] case mismatch in snippet view article find links to article

Wang J, Chang JW, et al. (2012). "Development of ATP-Competitive mTOR Inhibitors". MTOR. Methods in Molecular Biology. Vol. 821. pp. 447–60. doi:10

MTORC1 (7,803 words) [view diff] exact match in snippet view article find links to article

of mTORC1 There have been over 1,300 clinical trials conducted with mTOR inhibitors since 1970. Hay N, Sonenberg N (August 2004). "Upstream and downstream

Transplant rejection (3,272 words) [view diff] exact match in snippet view article find links to article

agent. Where calcineurin inhibitors or steroids are contraindicated, mTOR inhibitors are used. Immunosuppressive drugs: Corticosteroids Prednisolone Hydrocortisone

Gedatolisib (855 words) [view diff] case mismatch in snippet view article find links to article

Tian T, Li X, Zhang J (February 2019). "mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy". International Journal of Molecular

Combination therapy (1,062 words) [view diff] exact match in snippet view article find links to article

(2014-01-30). "Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors". Cell Reports. 6 (2): 377–387. doi:10.1016/j.celrep.2013.12.035. ISSN 2211-1247

Farnesyltransferase inhibitor (1,079 words) [view diff] exact match in snippet view article find links to article

molecules are called FTIs (or farnesyl-transferase inhibitors). As with mTOR inhibitors, many companies developed them to treat cancers, where they were unsuccessful

Carcinoid syndrome (1,812 words) [view diff] exact match in snippet view article find links to article

pasireotide may be effective. In patients who continue to be refractory, mTOR inhibitors such as everolimus. The TPH inhibitor telotristat ethyl may be useful

Voxtalisib (280 words) [view diff] case mismatch in snippet view article find links to article

Stathis A, Bertoni F (February 2020). "Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?". International Journal of Molecular

Phosphoinositide 3-kinase inhibitor (5,305 words) [view diff] exact match in snippet view article find links to article

that converts to LY294002, one of the most widely studied dual PI3K/mTOR inhibitors. A phase II trial with SF1126 has been terminated due to slow enrolment

Autoimmune lymphoproliferative syndrome (2,435 words) [view diff] exact match in snippet view article find links to article

syndrome as immune suppression can decreased tumor immunosurvellence. Its mTOR inhibitors active against lymphomas, especially EBV+ lymphomas. The Goal serum

Endometrial cancer (10,670 words) [view diff] exact match in snippet view article find links to article

compared to having more chemotherapy or hormonal therapy. Though, mTOR inhibitors may increase the chance of experiencing digestive tract ulcers. Adjuvant

Lymphangioleiomyomatosis (11,094 words) [view diff] exact match in snippet view article find links to article

require intervention. Biopsy or resection can lead to prolonged leakage. mTOR inhibitors are effective at shrinking the size of lymphangioleiomyomatosis, and

Papillary renal cell carcinoma (3,726 words) [view diff] no match in snippet view article find links to article

tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors are effective in inhibiting angiogenesis, blocking growth and suppressing

PELP-1 (3,909 words) [view diff] exact match in snippet view article find links to article

to tamoxifen and PELP1 deregulated tumors respond to Src kinase and mTOR inhibitors. Treatment of breast and ovarian cancer xenografts with liposomal PELP1–siRNA–DOPC

Cyclin D1 (5,694 words) [view diff] exact match in snippet view article find links to article

Inhibition of cyclin D1 Inhibiting translation of cyclin D1 mRNA via mTOR inhibitors and RXR activators. Inducing Cyclin D1 degradation Retinoid mediated

Cutaneous squamous-cell carcinoma (5,304 words) [view diff] exact match in snippet view article find links to article

calcineurin inhibitors like cyclosporine and tacrolimus, and least with mTOR inhibitors, such as sirolimus and everolimus. The antimetabolites azathioprine

Nina Babel (1,653 words) [view diff] exact match in snippet view article find links to article

In vitro and in vivo evidence that the switch from calcineurin to mTOR inhibitors may be a strategy for immunosuppression in Epstein-Barr virus-associated

Progeroid syndromes (8,724 words) [view diff] exact match in snippet view article find links to article

Lattanzi, Giovanna (November 2016). "Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders". British Journal

Breast cancer classification (9,503 words) [view diff] exact match in snippet view article find links to article

in BRCA cancers to PARP inhibitors or platinum-based chemotherapy. mTOR inhibitors such as everolimus may show more effect in PIK3CA/Akt e9 mutants than

Encapsulating peritoneal sclerosis (4,970 words) [view diff] no match in snippet view article find links to article

encapsulating peritoneal sclerosis such as mammalian target of rapamycin (mTOR) inhibitors, cyclosporine, mycophenolate mofetil, colchicine, corticosteroids,