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Longer titles found: Malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing) (view), Malonyl-CoA O-methyltransferase (view), Malonyl-CoA decarboxylase (view), Methylmalonyl-CoA (view)

searching for Malonyl-CoA 59 found (212 total)

alternate case: malonyl-CoA

Biotin carboxyl carrier protein (1,387 words) [view diff] exact match in snippet view article find links to article

subunit that allows for Acetyl CoA to be catalyzed and converted to malonyl-CoA. More specifically, BCCP catalyzes the carboxylation of the carrier protein

Malonyl CoA reductase (malonate semialdehyde-forming) (262 words) [view diff] no match in snippet view article

Malonyl CoA reductase (malonate semialdehyde-forming) (EC 1.2.1.75, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with

Biotin carboxylase (1,048 words) [view diff] exact match in snippet view article find links to article

group from BCCP to Acetyl-CoA, forming a malonate analog known as malonyl-CoA. Malonyl-CoA serves as the primary carbon donor in fatty acid biosynthesis,

Mupirocin (2,604 words) [view diff] exact match in snippet view article find links to article

another two carbons by the malonyl-CoA extender unit, followed by ketoreduction (KR) and dehydration. Module three adds a malonyl-CoA extender unit, followed

Ketoacyl synthase (2,238 words) [view diff] exact match in snippet view article find links to article

catalyze the condensation reaction of acyl-CoA or acyl-acyl ACP with malonyl-CoA to form 3-ketoacyl-CoA or with malonyl-ACP to form 3-ketoacyl-ACP. This

Tricin (350 words) [view diff] no match in snippet view article find links to article

studied. In biosynthesizing tricin, there is first stepwise addition of malonyl CoA via the polyketide pathway and p-coumaroyl Coa via the phenylpropanoid

Spectinabilin (411 words) [view diff] case mismatch in snippet view article find links to article

reduction. Briefly, pNBA is loaded onto the PKA and elongated by methyl malonyl-coa (mmCoA), which is then reduced twice to afford the enone. This elongation

Rhizobium leguminosarum (519 words) [view diff] exact match in snippet view article find links to article

Kim, YS (15 October 1998). "A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier

Flavan-3-ol (1,905 words) [view diff] exact match in snippet view article find links to article

cinnamoyl-CoA starter unit, with chain extension using three molecules of malonyl-CoA. Reactions are catalyzed by a type III PKS enzyme. These enzyme do not

Tacrolimus (4,357 words) [view diff] exact match in snippet view article find links to article

of malonyl-CoA, five molecules of methylmalonyl-CoA, one molecule of allylmalonyl-CoA as elongation units. However, two molecules of malonyl-CoA are

List of causes of hypoglycemia (1,265 words) [view diff] exact match in snippet view article find links to article

dehydrogenase deficiency Malabsorption Malaria (malignant tertian) Maldigestion Malonyl-CoA decarboxylase deficiency Maple syrup urine disease Mcquarrie type infantile

ACSF3 (599 words) [view diff] exact match in snippet view article find links to article

has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene have been shown to cause

CROT (gene) (493 words) [view diff] exact match in snippet view article

model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity

Fidaxomicin (1,505 words) [view diff] exact match in snippet view article find links to article

The following eight modules extend and tailor the polyketide using malonyl-CoA, methylmalonyl-CoA, and ethylmalonyl-CoA. The final thioesterase domain

Leptospermone (631 words) [view diff] exact match in snippet view article find links to article

grandiflorone). Phloroglucinol is biosynthesized in a single step from malonyl-CoA and could be the intermediate, but other routes of biosynthesis may be

Eicosapentaenoic acid (3,001 words) [view diff] exact match in snippet view article find links to article

uses acetyl-CoA and malonyl-CoA as building blocks. The mechanism of α-linolenic acid to EPA involves the condensation of malonyl-CoA to the pre-existing

Monascus (539 words) [view diff] exact match in snippet view article find links to article

transferase, acyl carrier protein and the base units of acetyl-CoA and malonyl-CoA to produce a ketone chain that undergoes Knoevenagel aldol condensations

Cyclopiazonic acid (1,258 words) [view diff] exact match in snippet view article find links to article

nonribosomal peptide synthetase (PKS-NRPS). It uses the precursors acetyl-CoA, malonyl-CoA, and tryptophan to produce cyclo-acetoaceytl-L-tryptophan (cAATrp). The

Hyperforin (1,728 words) [view diff] exact match in snippet view article find links to article

condensation of one molecule of isobutyryl-CoA and three molecules of malonyl-CoA, both catalyzed by Isobutyrophenone synthase. Type III PKS enzymes will

Lyngbyastatins (506 words) [view diff] no match in snippet view article find links to article

subsequent loading onto the ketosynthase (KS) of LbnA. An acyl unit from malonyl CoA is then coupled onto the initial substrate via an acyltransferase (AT)

Skimmianine (280 words) [view diff] exact match in snippet view article find links to article

is formed as a starting unit and able to extend side chain by adding malonyl-CoA by Claisen condensation. Next, lactam is formed through the cyclization

De novo synthesis (1,282 words) [view diff] exact match in snippet view article find links to article

responsible for introducing a carboxyl group to acetyl CoA, rendering malonyl-CoA. Then, the enzyme fatty-acid synthase is responsible for turning malonlyl-CoA

Peucemycin (440 words) [view diff] exact match in snippet view article find links to article

peuC, and an additional gene, peuI, is proposed to introduce the butyl malonyl-CoA in this module. Modules 6 and 7 are encoded by peuD and peuE respectively

Biological carbon fixation (3,915 words) [view diff] exact match in snippet view article find links to article

Acetyl-CoA carboxylase catalyzes the carboxylation of the Acetyl-CoA to Malonyl-CoA and Propionyl-CoA carboxylase catalyses the carboxylation of propionyl-CoA

Cyanidin (817 words) [view diff] no match in snippet view article find links to article

group. The compound reacts with naringenin-chalcone synthase and three malonyl CoA molecules to add six carbon atoms and three more keto groups ring through

Castanospermine (448 words) [view diff] exact match in snippet view article find links to article

forms the enamine, which reduces to L-pipecolic acid. HSCoA and then malonyl-CoA react in a Claisen reaction with L-pipecolic acid to form SCoA ester

Oleandomycin (990 words) [view diff] exact match in snippet view article find links to article

acetyl-CoA starter unit and all remaining moduless carrying a methyl malonyl-CoA elongation unit attached to its keto synthase unit. OLES2 codes for modules

3-Hydroxypropionic acid (549 words) [view diff] exact match in snippet view article find links to article

Xian, Mo; Liu, Min; Liu, Huizhou; Ma, Qingjun; Zhao, Guang (2017). "Malonyl-CoA pathway: A promising route for 3-hydroxypropionate biosynthesis". Critical

Biochanin A (236 words) [view diff] exact match in snippet view article find links to article

The enzyme isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase uses malonyl-CoA and biochanin A 7-O-β-D-glucoside to produce CoA and biochanin A

Communesin B (411 words) [view diff] exact match in snippet view article find links to article

group using acetyl-CoA as a starting material and extending it with two malonyl-CoA units. Then, CnsK performs N-acylation with the CnsI-synthesized hexadienoyl

Acyl-CoA dehydrogenase (NADP+) (279 words) [view diff] exact match in snippet view article

Seubert W, Lamberts I, Kramer R, Ohly B (1968). "On the mechanism of malonyl-CoA-independent fatty acid synthesis. I The mechanism of elongation of long-chain

Aureothin (715 words) [view diff] exact match in snippet view article find links to article

consecutive cycles containing four times of methylmalonyl-CoA and one time of malonyl-CoA occur during the type I Polyketide Synthase (PKS). After O-methylation

(acyl-carrier-protein) S-acetyltransferase (375 words) [view diff] exact match in snippet view article

VS, Smith S (1997). "Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional

Curacin A (794 words) [view diff] exact match in snippet view article find links to article

catlyzes the formation of hydroxymethylglutaryl acid by the addition of an malonyl-CoA unit to the terminal ketide of the aceto-acetyl-ACP moiety of ACP1,ACP2

Pyoluteorin (621 words) [view diff] exact match in snippet view article find links to article

PltC, however, the mechanism of transfer is unknown. The addition of 3 malonyl-CoA monomers, cyclization, and release by the thioesterase PltG gives pyoluteorin

Pisatin (1,370 words) [view diff] exact match in snippet view article find links to article

4-coumarate. Acetyl-CoA is then added to form 4-coumaryl-CoA. Three malonyl-CoA moities are then added and cyclized to introduce a phenol ring. An isomerization

Griseofulvin (961 words) [view diff] exact match in snippet view article find links to article

type I iterative polyketide synthase (PKS) via iterative addition of 6 malonyl-CoA to an acyl-CoA starter unit. The 14-carbon poly-β-keto chain undergoes

Chromosome 22 (2,206 words) [view diff] no match in snippet view article find links to article

intergenic non-protein coding RNA 899 MAPK1 MAPK12 MCAT: encoding enzyme malonyl CoA-acyl carrier protein transacylase, mitochondrial MCM5 MIF MIRLET7BHG:

BI 99179 (608 words) [view diff] exact match in snippet view article find links to article

BI 99179 showed acute efficacy in rat models. Increased hypothalamic Malonyl-CoA concentrations (10 or 100 mg/kg); 2 hours/24 hours post dose (p.d.) Decreased

Anthochlor pigments (861 words) [view diff] exact match in snippet view article find links to article

catalyzes the formation of a hydroxyl chalcone from three molecules of malonyl-CoA and one molecule cinnamoyl-CoA. Functioning as intermediates of the subsequent

Dan Foster (physician) (561 words) [view diff] exact match in snippet view article

and lipids. With his colleague, J. Denis McGarry, he discovered the malonyl-CoA regulatory system for fatty acid oxidation and ketogenesis. Awards have

Germicidin (452 words) [view diff] exact match in snippet view article find links to article

(ACP synthase). FabD then converts holo-AcpP into malonyl-AcpP with malonyl-CoA. With either isobutyryl-CoA or 2-methylbutyryl-CoA FabH facilitates decarboxylative

Bleomycin (1,814 words) [view diff] no match in snippet view article find links to article

P-3A from Ser, Asn, His, and Ala PKS-mediated elongation of P-3A by malonyl CoA and AdoMet to yield P-4 NRPS-mediated elongation of P-4 by Thr to P-5

Phoslactomycin B (688 words) [view diff] exact match in snippet view article find links to article

ketone to hydroxyl group with more stable. Module 1 uses the precursor malonyl-CoA and dehydrase domain to create the double bond. Similarly, module 2,

Glibenclamide (1,066 words) [view diff] exact match in snippet view article find links to article

Unger RH, Foster DW, McGarry JD (July 1994). "More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic

Lovastatin (3,305 words) [view diff] no match in snippet view article find links to article

and lovF . The synthesis of dihydromonacolin L requires a total of 9-malonyl Coa . It proceeds in the PKS pathway until it reaches (E) a hexaketide, where

List of diseases (M) (2,469 words) [view diff] exact match in snippet view article

paroxysmal ventricular tachycardia Mallory–Weiss syndrome Malonic aciduria Malonyl-CoA decarboxylase deficiency Malouf syndrome Malpuech facial clefting syndrome

C-1027 (1,181 words) [view diff] exact match in snippet view article find links to article

(TE). Starting with acetyl-CoA, PKSE iteratively combines 7 units of malonyl-CoA creating an intermediate heptaene, which is then catalyzed by accessory

Daptomycin (3,758 words) [view diff] exact match in snippet view article find links to article

an acyltransferase (AT) and a ketosynthase (KS). The AT acts upon a malonyl-CoA substrate and transfers an acyl group to the thiol of the ACP domain

Jagannath Ganguly (3,901 words) [view diff] exact match in snippet view article find links to article

mechanism of fatty acid synthesis: VII: Biosynthesis of fatty acids from malonyl-CoA: J. Ganguly, Biochem. Biophys. Acta., 40, 110–118. 1961 High cholesterol

Coniine (3,358 words) [view diff] exact match in snippet view article find links to article

usual way from acetyl-CoA. Further elongation of butyryl-CoA using 2 malonyl-CoA forms 5-ketooctanal. Ketooctanal then undergoes transamination using

Euglenophycin (2,626 words) [view diff] exact match in snippet view article find links to article

to form acetyl-CoA. This is subsequently converted into butyryl- and malonyl-CoA, the former of which being catalyzed by fatty acid synthetase (FAS).

Beta-ketoacyl-ACP synthase III (2,909 words) [view diff] no match in snippet view article find links to article

Structures have been determined of ecFabH bound with substrates, (CoA, malonyl CoA, degraded CoA). Specific inhibitors developed using rational design have

Plant secondary metabolism (2,992 words) [view diff] exact match in snippet view article find links to article

phenylalanine is used to produce 4-coumaryol-CoA, and this is then combined with malonyl-CoA to produce chalcones which are backbones of Flavonoids Chalcones are

Hydrothermal vent microbial communities (5,270 words) [view diff] exact match in snippet view article find links to article

3-HP and 3-HP/4-HB cycles are acetyl-CoA/propionyl-CoA carboxylase, malonyl-CoA reductase and propionyl-CoA synthase. Most of the organisms that use

Chloroplast (18,774 words) [view diff] exact match in snippet view article find links to article

acetyl-CoA primarily requires two enzymes. Acetyl-CoA carboxylase creates malonyl-CoA, used in both the first step and the extension steps of synthesis. Fatty

Thraustochytrids (10,658 words) [view diff] exact match in snippet view article find links to article

Li, Qingbiao; Lu, Yinghua; He, Ning (2018-05-30). "Overexpression of Malonyl-CoA: ACP Transacylase in Schizochytrium sp. to Improve Polyunsaturated Fatty

List of EC numbers (EC 1) (24,607 words) [view diff] no match in snippet view article

dehydrogenase EC 1.2.1.74: abieta-7,13-dien-18-al dehydrogenase EC 1.2.1.75: malonyl CoA reductase (malonate semialdehyde-forming) EC 1.2.1.76: succinate-semialdehyde

List of OMIM disorder codes (18,877 words) [view diff] exact match in snippet view article find links to article

Male infertility, nonsyndromic, autosomal recessive; 612997; CATSPER1 Malonyl-CoA decarboxylase deficiency; 248360; MLYCD Mandibuloacral dysplasia with