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Longer titles found: Role of microglia in disease (view)

searching for Microglia 199 found (450 total)

alternate case: microglia

Volkensin (614 words) [view diff] exact match in snippet view article find links to article

Experiments performed in vitro showed increased toxicity of volkensin to microglia and astrocytes. Barbieri, Luigi; Falasca, Anna Ida; Stirpe, Fiorenzo (11

Aticaprant (2,211 words) [view diff] exact match in snippet view article find links to article

compromised by the countervailing activation of pro-inflammatory cytokines in microglia within the CNS. Aticaprant was also under development for the treatment

TREM2 (4,092 words) [view diff] exact match in snippet view article find links to article

macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. In the liver, TREM2

Radiation-induced cognitive decline (3,527 words) [view diff] exact match in snippet view article find links to article

activated microglia per dentate gyrus in comparison to microglia activation in irradiated rats without indomethacin treatment. This decrease in microglia activation

Immuno-psychiatry (1,947 words) [view diff] exact match in snippet view article find links to article

glutamate by astrocytes and microglia, leading to an excitotoxic state. This loss of oligodendrocytes (the astrocytes and microglia mentioned before) are a

KCNA3 (4,363 words) [view diff] exact match in snippet view article find links to article

been found to be highly expressed by activated and plaque-associated microglia in human Alzheimer's disease (AD) post-mortem brains as well as in mouse

PK-11195 (768 words) [view diff] exact match in snippet view article find links to article

binding sites have since been determined to be on glial cells, including microglia, astrocytes, and infiltrating macrophages. The binding of [3H]PK11195

Nuclear receptor 4A2 (2,159 words) [view diff] exact match in snippet view article find links to article

inflammatory gene expression in microglia and astrocytes. When a short hairpin for NR4A2 was expressed in microglia and astrocytes, these cells produced

GJD2 (551 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons". J. Neurosci. Res

N-Arachidonoyl dopamine (1,484 words) [view diff] exact match in snippet view article find links to article

prostaglandin E2 (PGE2) from lipopolysaccharide (LPS)-activated astrocytes, microglia and mouse brain ECs (MEC-Brain). NADA also promotes the inflammatory resolution

GPR84 (2,610 words) [view diff] exact match in snippet view article find links to article

autoimmune encephalomyelitis before the onset of clinical disease. In cultured microglia in response to simulated blast overpressure the expression of GPR84 was

AOAH (802 words) [view diff] exact match in snippet view article find links to article

AOAH gene. AOAH is produced by macrophages (including Kupffer cells and microglia), dendritic cells (especially in the colon), NK cells, ILC1 cells, neutrophils

Ellen R. Sandor (991 words) [view diff] exact match in snippet view article find links to article

historical events, and scientific phenomena such as the AIDS virus, Neutrinos, Microglia, and CRISPR. Sandor holds a B.A. from Brooklyn College (1963) and an MFA

Stichodactyla toxin (8,626 words) [view diff] exact match in snippet view article find links to article

protein 1 (EHD1), a protein involved in microglia trafficking. Increased Kv1.3 expression was reported in microglia in Alzheimer plaques. Kv1.3 inhibitors

Toll-like receptor 4 (9,082 words) [view diff] exact match in snippet view article find links to article

non-neuronal glial cells, which include microglia, astrocytes, and oligodendrocytes. TLR4 is expressed primarily by microglia, and to a lesser extent by astrocytes

MARCO (2,232 words) [view diff] exact match in snippet view article find links to article

the microglia clear the Aβ, which binds to receptors such as MARCO. During development of Alzheimer's disease, however, the ability of microglia to clear

Peptide T (1,377 words) [view diff] exact match in snippet view article find links to article

viral reservoirs, such as the persistently infected monocytes or brain microglia, is an important treatment goal. Peptide T clinical development was stopped

Excitatory amino acid transporter 1 (1,814 words) [view diff] exact match in snippet view article find links to article

transporter-1 in brain macrophages and microglia of HIV-infected patients. A neuroprotective role for activated microglia?". Journal of Neuropathology and Experimental

Kalipada Pahan (517 words) [view diff] exact match in snippet view article find links to article

the application of statins in suppressing the inflammatory events in microglia, astroglia and macrophages. This finding has revolutionized the research

Staci Bilbo (2,152 words) [view diff] exact match in snippet view article find links to article

developments in adult offspring. In 2018, Bilbo and her lab studied the role of microglia in the regulation of social behavior in adolescent rats. Following these

Hereditary diffuse leukoencephalopathy with spheroids (2,136 words) [view diff] exact match in snippet view article find links to article

the colony stimulating factor 1 receptor (CSF1R), a growth factor for microglia and monocyte/macrophages, suggesting that microglial dysfunction may be

Fananas cell (501 words) [view diff] exact match in snippet view article find links to article

changes in Fañanas glia. These variances were also described in cerebellar microglia and Bergmann cells. However, the results of the study did not point at

(+)-Naloxone (1,017 words) [view diff] exact match in snippet view article

dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation". The Journal of Pharmacology and

Paeonol (682 words) [view diff] exact match in snippet view article find links to article

Paeonol also reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. Paeonol shows antimutagenic

PHA-543,613 (471 words) [view diff] exact match in snippet view article find links to article

receptors reduces neuropathic pain by decreasing dynorphin A release from microglia". Brain Research. 1715: 57–65. doi:10.1016/j.brainres.2019.03.016. PMID 30898676

TSPAN2 (385 words) [view diff] exact match in snippet view article find links to article

signaling pathway axon development brain development oligodendrocyte differentiation inflammatory response microglia development Sources:Amigo / QuickGO

Elizabeth F. Neufeld (556 words) [view diff] exact match in snippet view article find links to article

DS, Rajavel KS, Ryazantsev S, Li HH, Neufeld EF., (2003), "Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB." Proceedings

Central nervous system effects from radiation exposure during spaceflight (9,521 words) [view diff] exact match in snippet view article find links to article

the supporting cells and consist of astrocytes, oligodendroglia, and microglia. These cells permeate and support the nervous tissue of the CNS, binding

Valentina Fossati (1,583 words) [view diff] exact match in snippet view article find links to article

Fossati V. Directed Differentiation of Human Pluripotent Stem Cells to Microglia. Stem Cell Reports. 2017 Jun 6;8(6):1516-1524. doi: 10.1016/j.stemcr.2017

Fluoro-jade stain (1,910 words) [view diff] exact match in snippet view article find links to article

is also useful in detecting glia, specifically reactive astroglia and microglia. Thus fluoro-jade may be used to assess glial responses associated with

Sulfonylurea receptor (651 words) [view diff] exact match in snippet view article find links to article

neurons, astrocytes, oligodendrocytes, endothelial cells and by reactive microglia. Blockade of SUR1 receptors with glibenclamide has been involved in improved

René Kahn (1,880 words) [view diff] exact match in snippet view article find links to article

Hol EM, Siegmund B, Glauben R, Spruth EJ, de Witte LD, Priller J. Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell

Malú G. Tansey (2,796 words) [view diff] exact match in snippet view article find links to article

Alzheimer's Disease and Parkinson's Disease. Tansey also explores the roles of microglia and brain macrophages in neurological disease pathogenesis as well as

Internexin (974 words) [view diff] exact match in snippet view article find links to article

alpha-internexin which reveals, in red, neuronal processes and cell bodies. Cells were also labelled in green for Coronin 1a, a marker for microglia.

Ibudilast (1,093 words) [view diff] exact match in snippet view article find links to article

phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia". Neuropharmacology. 46 (3): 404–411. doi:10.1016/j.neuropharm.2003.09

Stefano Pluchino (2,014 words) [view diff] exact match in snippet view article find links to article

research has also elucidated the role of mitochondrial complex I activity in microglia, showcasing its pivotal role in sustaining neuroinflammation. This finding

Trogocytosis (2,135 words) [view diff] exact match in snippet view article find links to article

the term has been attributed to macrophages, such as the CNS resident microglia, which are able to partially remove small portions of neuronal axons during

Prostaglandin D2 receptor (869 words) [view diff] exact match in snippet view article find links to article

They also discovered PGD2 receptors on dopaminergic cells but not on microglia. Eicosanoid receptor Prostaglandin E2 receptor Domingo C, Palomares O

Bumetanide (1,371 words) [view diff] exact match in snippet view article find links to article

Portal: Medicine title = "Repurposed drug boosts the positive effect of microglia to improve cognitive performance following brain trauma". 24 May 2023

Sonia Garel (571 words) [view diff] exact match in snippet view article find links to article

contribute to the proper wiring of brain circuits. It has also shown that microglia are involved in the deleterious effects of prenatal inflammation, a potential

ABCA7 (2,880 words) [view diff] exact match in snippet view article find links to article

rapid endocytosis of amyloid precursor protein was observed in primary microglia from ABCA7 deficient mice. Roles of ABCA7 are also implicated for microglial

ICAM5 (849 words) [view diff] exact match in snippet view article find links to article

"Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia". Brain Res. 849 (1–2): 58–66. doi:10.1016/S0006-8993(99)01984-8. PMID 10592287

TNFRSF19 (698 words) [view diff] exact match in snippet view article find links to article

et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol. 33 (1):

OX40 ligand (961 words) [view diff] exact match in snippet view article find links to article

Xiong J, Yang X, et al. (February 2008). "Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro"

GPR65 (1,713 words) [view diff] exact match in snippet view article find links to article

photoreceptors in a degenerating retina by sensing pH and activating microglia after light-injury. Vagal afferents expressing GPR65 innervate intestinal

SALL1 (1,309 words) [view diff] exact match in snippet view article find links to article

(January 2019). "Expression of Tmem119/Sall1 and Ccr2/CD69 in FACS-Sorted Microglia- and Monocyte/Macrophage-Enriched Cell Populations After Intracerebral

CCL1 (1,363 words) [view diff] exact match in snippet view article find links to article

been shown to be associated with phagocytic macrophages and activated microglia in MS lesions and directly correlate with demyelinating activity. The

Pinoresinol (863 words) [view diff] exact match in snippet view article find links to article

of Forsythia koreana inhibits inflammatory responses in LPS-activated microglia". Neuroscience Letters. 480 (3): 215–220. doi:10.1016/j.neulet.2010.06

CD163 (2,166 words) [view diff] exact match in snippet view article find links to article

Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons". Translational Stroke Research. 8 (6): 612–616

Interleukin 10 (4,858 words) [view diff] exact match in snippet view article find links to article

X, Han X, Durham F, Wan J, Weiland A, Koehler RC, Wang J (May 2021). "Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma

CD22 (1,761 words) [view diff] exact match in snippet view article find links to article

image of microglia

Robyn S. Klein (2,672 words) [view diff] exact match in snippet view article find links to article

Klein’s lab researches ways to prevent this from occurring. She found that microglia, the brain’s innate immune cells, accumulate around neurons at the site

Berta Scharrer (1,164 words) [view diff] exact match in snippet view article find links to article

invertebrate immune cells. Proc. Natl. Acad. Sci. U.S.A., 89:9316–9320. 1994 Microglia in invertebrate ganglia. Proc. Natl. Acad. Sci. U.S.A., 91:9180–9184.

ADCY9 (882 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001

Phagoptosis (1,318 words) [view diff] exact match in snippet view article find links to article

senescence and are then phagocytosed by macrophages. Brain macrophages (microglia) can regulate the number of neural precursor cells in the developing brain

O-1602 (444 words) [view diff] exact match in snippet view article find links to article

Bradshaw HB (July 2012). "siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration". Journal of

RBFOX1 (3,549 words) [view diff] exact match in snippet view article find links to article

ties with microglia. According to genome wide association (GWA) data, moduleQTL (modQTL) RBFOX1 SNP may alter gene expression of microglia. Alternative

CCR3 (gene) (1,447 words) [view diff] exact match in snippet view article

Gabuzda D (1997). "CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia". Nature. 385 (6617): 645–9. Bibcode:1997Natur.385..645H. doi:10.1038/385645a0

Schisandrin (327 words) [view diff] exact match in snippet view article find links to article

effects by upregulating phase II detoxifying/antioxidant enzymes in microglia". International Immunopharmacology. 17 (2): 415–26. doi:10.1016/j.intimp

ADCY4 (686 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001

CX3CL1 (1,441 words) [view diff] exact match in snippet view article find links to article

brain cells: migratory and activation signals for CX3CR-1-expressing microglia". Journal of Immunology. 163 (3): 1628–1635. doi:10.4049/jimmunol.163

Michal Schwartz (2,228 words) [view diff] exact match in snippet view article find links to article

central nervous system (CNS) repair. The brain-resident myeloid cells (the microglia), and infiltrating monocyte-derived macrophages are not redundant populations

CD69 (2,275 words) [view diff] exact match in snippet view article find links to article

(January 2019). "Expression of Tmem119/Sall1 and Ccr2/CD69 in FACS-Sorted Microglia- and Monocyte/Macrophage-Enriched Cell Populations After Intracerebral

ADCY1 (886 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159

Polyinosinic:polycytidylic acid (396 words) [view diff] exact match in snippet view article find links to article

Zhang Z, Lin W, Yan J, Zhu C, Yin D, et al. (October 2020). "Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant

Mathias Jucker (1,302 words) [view diff] exact match in snippet view article find links to article

maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia". Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA

ADCY7 (934 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001

Gerald Muench (551 words) [view diff] exact match in snippet view article find links to article

lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages Interdisciplinary Center for Clinical Research Inflammation

Spiperone (302 words) [view diff] exact match in snippet view article find links to article

antipsychotic spiperone attenuates inflammatory response in cultured microglia via the reduction of proinflammatory cytokine expression and nitric oxide

ADCY3 (987 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159

Swietenia macrophylla (1,503 words) [view diff] exact match in snippet view article find links to article

anti-inflammatory properties using lipopolysaccharide (LPS)-induced BV-2 microglia. SMEAF significantly attenuated the LPS-induced production of nitric oxide

Gamma secretase (2,207 words) [view diff] exact match in snippet view article find links to article

D (November 2010). "g secretase component presenilin is important for microglia b-Amyloid clearance". Annals of Neurology. 69 (1): 170–80. doi:10.1002/ana

CBD-DMH (576 words) [view diff] exact match in snippet view article find links to article

the cannabidiol derivative dimethylheptyl-cannabidiol - studies in BV-2 microglia and encephalitogenic T cells". Journal of Basic and Clinical Physiology

CCAAT-enhancer-binding proteins (1,790 words) [view diff] exact match in snippet view article find links to article

Parkinson's disease victims at autopsy. Cell culture studies in mice and human microglia lines also find increased C/EBPβ activity associated with pathogenic inflammation

ADCY5 (997 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001

Gennadij Raivich (586 words) [view diff] exact match in snippet view article find links to article

18.15 (1998): 5804–5816. Raivich, Gennadij, and Richard Banati. "Brain microglia and blood-derived macrophages: molecular profiles and functional roles

ADCY6 (926 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001

Bradlee Heckmann (1,205 words) [view diff] exact match in snippet view article find links to article

first to show that loss of the LC3-associated endocytosis pathway in microglia greatly exacerbated the disease pathology of Alzheimer's Disease and that

Insulin-degrading enzyme (2,074 words) [view diff] exact match in snippet view article find links to article

"Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion"

Neuroimmunology (2,716 words) [view diff] exact match in snippet view article find links to article

(2015-01-01). "Lipopolysaccharide from Rhodobacter sphaeroides Attenuates Microglia-Mediated Inflammation and Phagocytosis and Directs Regulatory T Cell Response"

Catechol (2,025 words) [view diff] exact match in snippet view article find links to article

"Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: Inhibition of microglial neurotoxicity". European Journal of Pharmacology

ADCY8 (929 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159

N(6)-Carboxymethyllysine (291 words) [view diff] exact match in snippet view article

microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine". Nat. Neurosci. 25 (3): 295–305

Ben Barres (3,351 words) [view diff] exact match in snippet view article find links to article

Richard M.; Greenberg, Michael E.; Barres, Ben A.; Stevens, Beth (2012). "Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent

CXCR5 (1,956 words) [view diff] exact match in snippet view article find links to article

D (March 2003). "Regulation of chemokine receptor expression in human microglia and astrocytes". Journal of Neuroimmunology. 136 (1–2): 84–93. doi:10

SR9011 (379 words) [view diff] exact match in snippet view article find links to article

Rev-erbα Agonist SR9011 on the Immune Response and Cell Metabolism of Microglia". Frontiers in Immunology. 11: 550145. doi:10.3389/fimmu.2020.550145.

ADCY2 (1,512 words) [view diff] exact match in snippet view article find links to article

immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. doi:10.1046/j.1471-4159

PQBP1 (3,160 words) [view diff] exact match in snippet view article find links to article

recent investigations revealed pathological roles of PQBP1 in neurons and microglia under neurodegeneration of Alzheimer's disease and tauopathy. SRRM2 phosphorylation

CCL2 (2,415 words) [view diff] exact match in snippet view article find links to article

differentiation. The CCL2 chemokine is also expressed by neurons, astrocytes and microglia. The expression of CCL2 in neurons is mainly found in the cerebral cortex

Curcuma comosa (562 words) [view diff] exact match in snippet view article find links to article

Curcuma comosa on NO production and cytokine expression in LPS-activated microglia. Life Sci 78(6): 571–577. Rattanachamnong P., et al. (2008). Effects of

MYD88 (2,250 words) [view diff] exact match in snippet view article find links to article

primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia". Brain, Behavior, and Immunity. 61: 326–339. doi:10.1016/j.bbi.2016.12

Cathepsin Z (1,787 words) [view diff] exact match in snippet view article find links to article

Schliebs R, Kos J (August 2013). "Neuroprotective role of γ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X".

ABCC1 (1,849 words) [view diff] exact match in snippet view article find links to article

Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice". Current Alzheimer Research. 10 (10): 1057–69. doi:10

Ted M. Dawson (2,746 words) [view diff] exact match in snippet view article find links to article

induced by pathologic α-synuclein in Parkinson's disease via inhibition of microglia and prevention of the conversion of resting astrocytes to activated A1

Microcystis aeruginosa (1,867 words) [view diff] exact match in snippet view article find links to article

Thromboxane B2, Cytokines, Chemokines, and Matrix Metalloproteinase-9 by Rat Microglia". Toxicological Sciences. 121 (1): 63–72. doi:10.1093/toxsci/kfr045. PMID 21362633

Neuroprotection (3,639 words) [view diff] exact match in snippet view article find links to article

neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia". Journal of Immunology. 166 (12): 7527–7533. doi:10.4049/jimmunol.166

Glial fibrillary acidic protein (3,268 words) [view diff] exact match in snippet view article find links to article

LW (February 1993). "Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies

Mannose receptor (3,686 words) [view diff] exact match in snippet view article find links to article

Renfroe SC, Heller NM, Wang J (July 2017). "Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral

Complement system (5,014 words) [view diff] exact match in snippet view article find links to article

Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, et al. (May 2012). "Microglia sculpt postnatal neural circuits in an activity and complement-dependent

Immune system contribution to regeneration (1,366 words) [view diff] exact match in snippet view article find links to article

nerve tissue is followed by brain injury and inflammation that activate microglia and leukocytes. The secretion of Leukotriene C4 consequently activates

Georgette D. Kanmogne (2,345 words) [view diff] exact match in snippet view article find links to article

explored using non-human primate (NHP) microglia to study HIV pathogenesis in the brain. She found that NHP microglia express HIV-1 receptors and can be used

DAA-1106 (611 words) [view diff] exact match in snippet view article find links to article

emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders". Journal of Neuropathology and Experimental

Nicergoline (1,078 words) [view diff] exact match in snippet view article find links to article

effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes". Brain Research. 1066 (1–2): 78–85. doi:10.1016/j.brainres

Tryptophan 2,3-dioxygenase (2,094 words) [view diff] exact match in snippet view article find links to article

indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons". Glia. 49 (1): 15–23. doi:10.1002/glia.20090

Brain metastasis (2,967 words) [view diff] exact match in snippet view article find links to article

methylome and transcriptome profiling of MBM revealed immune cell and microglia-enriched tumor subsets showing favorable outcome. The prognosis for brain

Early-onset Alzheimer's disease (3,621 words) [view diff] exact match in snippet view article find links to article

involved in these pathways include glial cells (specifically astrocytes and microglia), beta-amyloid, and proinflammatory compounds. As neurons are injured

Lipid droplet (1,582 words) [view diff] exact match in snippet view article find links to article

label-free, using label-free live-cell imaging. Lipid droplets in murine microglia Oil bodies in Nardia scalaris, a leafy liverwort Oil body Adipocyte Lipolysis

Thomas Reh (632 words) [view diff] exact match in snippet view article find links to article

Connor; Wong, Claire K.; Hooper, Marcus J.; Reh, Thomas A. (2020). "Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice". Cell Reports. 33

Multiple sclerosis drug pipeline (9,409 words) [view diff] exact match in snippet view article find links to article

immune responses, It targets the innate immune system (mast cells and microglia) and has shown efficacy in the progressive courses. The appropriate pathway

Sickness behavior (2,364 words) [view diff] exact match in snippet view article find links to article

(1992). "Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: A pathway for the induction of

Fractal (8,021 words) [view diff] exact match in snippet view article find links to article

Jelinek, Herbert F.; Buchan, Alastair M. (2008). "Box-Counting Analysis of Microglia Form in Schizophrenia, Alzheimer's Disease and Affective Disorder". Fractals

Rudolph E. Tanzi (4,371 words) [view diff] exact match in snippet view article find links to article

AD gene, CD33, which encodes a cell-surface receptor on monocytes and microglia. When first identified as an AD gene, nothing was known about CD33 in

PiggyBac Transposable Element Derived 5 (688 words) [view diff] exact match in snippet view article find links to article

ogliodendrocytes, mature astrocytes, fetal astrocytes, endothelial cells and then microglia/macrophages. GRCh38: Ensembl release 89: ENSG00000177614 – Ensembl, May

JMJD6 (1,276 words) [view diff] exact match in snippet view article find links to article

R (September 2003). "Phagocytosis of apoptotic inflammatory cells by microglia and its therapeutic implications: termination of CNS autoimmune inflammation

Locus coeruleus (4,387 words) [view diff] exact match in snippet view article find links to article

and hippocampus. It has been shown that norepinephrine stimulates mouse microglia to suppress Aβ-induced production of cytokines and promotes phagocytosis

Plasmalogen (2,396 words) [view diff] exact match in snippet view article find links to article

(2022). "Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice". Front. Mol. Biosci. 9: 815320. doi:10

Plasminogen activator inhibitor-2 (2,905 words) [view diff] exact match in snippet view article find links to article

PMID 7867722. Akiyama H, Ikeda K, Kondo H, Kato M, McGeer PL (December 1993). "Microglia express the type 2 plasminogen activator inhibitor in the brain of control

Yves De Koninck (1,980 words) [view diff] exact match in snippet view article find links to article

Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Periventricular leukomalacia (3,271 words) [view diff] exact match in snippet view article find links to article

2007.00587.x. PMID 17635203. S2CID 43764163. Aldskogius H (July 2000). "[Microglia--new target cells for neurological therapy]" (Free full text). Läkartidningen

Tumor necrosis factor (6,302 words) [view diff] exact match in snippet view article find links to article

TNF in neurons promotes their survival, whereas TNF in macrophages and microglia results in neurotoxins that induce apoptosis. TNF-α and IL-6 concentrations

Andrew Lumsden (scientist) (1,695 words) [view diff] exact match in snippet view article

"Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia". F1000Research. 2: 148. doi:10.12688/f1000research.2-148.v1. PMC 3782347

Plasminogen activator inhibitor-2 (2,905 words) [view diff] exact match in snippet view article find links to article

PMID 7867722. Akiyama H, Ikeda K, Kondo H, Kato M, McGeer PL (December 1993). "Microglia express the type 2 plasminogen activator inhibitor in the brain of control

Toll-like receptor 11 (1,460 words) [view diff] exact match in snippet view article find links to article

Karakuş E, Terzi OS, Canpolat S, Anteplioğlu T (June 2014). "Astrocytes, microglia/macrophages, and neurons expressing Toll-like receptor 11 contribute to

Yves De Koninck (1,980 words) [view diff] exact match in snippet view article find links to article

Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Neuroregeneration (3,575 words) [view diff] exact match in snippet view article find links to article

inhibitors, astrocytes, oligodendrocytes, oligodendrocyte precursors, and microglia. The environment within the CNS, especially following trauma, counteracts

Glutamate decarboxylase (4,772 words) [view diff] exact match in snippet view article find links to article

inhibition of subtypes of GABA receptors. Higher glutamate levels activate microglia and activation of xc(−) increases the extracellular glutamate release

Ladislas J. Meduna (1,765 words) [view diff] exact match in snippet view article find links to article

neuropathology of the structure and development of the pineal gland and of microglia, lead poisoning, and avitaminosis. In 1927 he moved to the Psychiatric

Imatinib (6,513 words) [view diff] exact match in snippet view article find links to article

2024. Green KN, Crapser JD, Hohsfield LA (September 2020). "To Kill a Microglia: A Case for CSF1R Inhibitors". Trends in Immunology. 41 (9): 771–784.

Valina L. Dawson (3,374 words) [view diff] exact match in snippet view article find links to article

induced by pathologic α-synuclein in Parkinson's disease via inhibition of microglia and prevention of the conversion of resting astrocytes to activated A1

PPIC (1,387 words) [view diff] exact match in snippet view article find links to article

PPIC complexes with cyclophilin C-associated protein (CyCAP) to activate microglia and macrophage function via the calcineurin/NFAT pathway. As a cyclophilin

John Katzenellenbogen (1,645 words) [view diff] exact match in snippet view article find links to article

(2011-05-13). "An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation". Cell. 145 (4): 584–595. doi:10.1016/j.cell.2011

Howard E. Gendelman (1,750 words) [view diff] exact match in snippet view article find links to article

explores the role of mononuclear phagocytes (monocytes, macrophages, microglia, and dendritic cells) as viral reservoirs, perpetrators of disease, and

Mir-32 microRNA precursor family (971 words) [view diff] exact match in snippet view article find links to article

necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia". Journal of Neuroinflammation. 9 (1): 131. doi:10.1186/1742-2094-9-131

Marion Buckwalter (2,467 words) [view diff] exact match in snippet view article find links to article

activated macrophages and microglia were the predominant sources of TGFb after stroke and that astrocytes, macrophages, and microglia all upregulate their

Methamphetamine (14,837 words) [view diff] exact match in snippet view article find links to article

ISBN 978-0-12-420118-7. PMC 4103010. PMID 24484974. Glia (including astrocytes, microglia, and oligodendrocytes), which constitute the majority of cells in the

Metaphocyte (276 words) [view diff] exact match in snippet view article find links to article

). "Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes". eLife. 9: e53403. doi:10

Oxytocin (11,642 words) [view diff] exact match in snippet view article find links to article

observed inhibitory impact by oxytocin on the inflammatory activity of the microglia was proposed to be an important factor. In the prairie vole, oxytocin

Anti-interleukin-6 (1,289 words) [view diff] exact match in snippet view article find links to article

S, Kelley KW, Johnson RW (2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1". Proceedings

Amyloid-beta precursor protein (5,525 words) [view diff] exact match in snippet view article find links to article

expression positive regulation of peptidyl-threonine phosphorylation microglia development regulation of Wnt signaling pathway positive regulation of

Alzheimer's disease (18,887 words) [view diff] exact match in snippet view article find links to article

2741/e605. PMID 23276979. Perea JR, Bolós M, Avila J (October 2020). "Microglia in Alzheimer's Disease in the Context of Tau Pathology". Biomolecules

NF-κB (9,815 words) [view diff] exact match in snippet view article find links to article

through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia". Blood. 106 (9): 3114–3122. doi:10.1182/blood-2005-02-0759. PMC 1895321

Fractal analysis (3,529 words) [view diff] exact match in snippet view article find links to article

Jelinek, Herbert F.; Buchan, Alastair M. (2008). "Box-Counting Analysis of Microglia Form in Schizophrenia, Alzheimer's Disease and Affective Disorder". Fractals

Visna-maedi virus (3,774 words) [view diff] exact match in snippet view article find links to article

mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells". J Exp Med. 189 (12): 1961–1972

Anti-interleukin-6 (1,289 words) [view diff] exact match in snippet view article find links to article

S, Kelley KW, Johnson RW (2008). "Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1". Proceedings

DNA oxidation (4,790 words) [view diff] exact match in snippet view article find links to article

accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainite-induced excitotoxicity". J. Neurosci. 26 (6): 1688–1689

Alexei Verkhratsky (3,031 words) [view diff] exact match in snippet view article find links to article

Uwe-Karsten; Noda, Mami; Verkhratsky, Alexei (November 2011). "Physiology of Microglia". Physiological Reviews. 91 (2). American Physiological Society: 461–553

Candida albicans (9,956 words) [view diff] exact match in snippet view article find links to article

Du S, Johnson JL, Tung HY, Landers CT, Liu Y, et al. (January 2019). "Microglia and amyloid precursor protein coordinate control of transient Candida

Bing Liu (scientist) (783 words) [view diff] exact match in snippet view article

"Redox Lipid Reprogramming Commands Susceptibility of Macrophages and Microglia to Ferroptotic Death," Nature Chemical Biology, 16:2780-290 (2020). doi:

Alpinia rafflesiana (691 words) [view diff] exact match in snippet view article find links to article

rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway". Immunopharmacology. 12 (4): 657–665. doi:10

Bernhard Landwehrmeyer (3,155 words) [view diff] exact match in snippet view article find links to article

Landwehrmeyer, G Bernhard (2002). "Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal

Hartog Jacob Hamburger (614 words) [view diff] exact match in snippet view article find links to article

Cytometer-Based Assay". In Joseph, Bertrand; Venero, José Luis (eds.). Microglia: Methods and Protocols V. Humana Press Inc. pp. 121–127. ISBN 978-1-62703-519-4

Lacunarity (1,885 words) [view diff] exact match in snippet view article find links to article

Milosevic, Nebojsa (June 2011). "Lacunarity Analysis and Classification of Microglia in Neuroscience". 8th European Conference on Mathematical and Theoretical

Betaarterivirus suid 1 (5,031 words) [view diff] exact match in snippet view article find links to article

"Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: Implications for HP-PRRSV neuropathogenesis". Veterinary Microbiology

TAR DNA-binding protein 43 (4,663 words) [view diff] exact match in snippet view article find links to article

"Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons"

Alison Goate (1,290 words) [view diff] exact match in snippet view article find links to article

"APOE4 confers transcriptomic and functional alterations to primary mouse microglia". Journal of Neuroscience Research. 99 (1): 9–12. doi:10.1002/jnr.24570

Gilles J. Guillemin (1,513 words) [view diff] exact match in snippet view article find links to article

S2CID 4314650. Guillemin, Gilles J.; Brew, Bruce J. (11 November 2003). "Microglia, macrophages, perivascular macrophages, and pericytes: a review of function

Clinical neurochemistry (2,611 words) [view diff] exact match in snippet view article find links to article

Neurosci, 2003, pp. 1–30 Coull, JA; Beggs, S; Boudreau D, et al.BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Brain morphometry (4,132 words) [view diff] exact match in snippet view article find links to article

that changes also occur in non-neural tissue, e.g. the vasculature or microglia. Perhaps the most profound impact to date of brain morphometry on our

GABRB2 (5,576 words) [view diff] exact match in snippet view article find links to article

schizophrenia-like and comorbid phenotypes with interneuron-astrocyte-microglia dysregulation". Translational Psychiatry. 8 (1): 128. doi:10.1038/s41398-018-0176-9

Aviptadil (1,361 words) [view diff] exact match in snippet view article find links to article

arteries. Immunoreactive VIP is also present in neuronal cell bodies forming microglia that provide a source of intrinsic innervation of pulmonary structures

Casper Hoogenraad (2,801 words) [view diff] exact match in snippet view article find links to article

"Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release". Nat Commun. 14 (1): 6322. Bibcode:2023NatCo

Dental pulp stem cell (2,474 words) [view diff] exact match in snippet view article find links to article

contribute to functional recovery after traumatic brain injury by shifting microglia M1/M2 polarization in rats". Stem Cell Research & Therapy. 8 (1): 198

Blood–spinal cord barrier (3,811 words) [view diff] exact match in snippet view article find links to article

absent particles, an inflammatory response is triggered by astrocytes and microglia that extends the initial injury into previously uncompromised segments

2-hydroxy-dATP diphosphatase (2,845 words) [view diff] exact match in snippet view article find links to article

accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity". The Journal of Neuroscience. 26

TMEM106B (2,786 words) [view diff] exact match in snippet view article find links to article

identified as another important protein for lysosomal function in neurons and microglia, particularly during aging and neurodegenerative disease. As TMEM106B

Crystal C. Watkins Johansson (2,174 words) [view diff] exact match in snippet view article find links to article

regardless of antiretroviral therapy due to the harboring of virus in microglia and astrocytes in the brain. Based on the infection of glial cells in

Causes of autism (15,885 words) [view diff] exact match in snippet view article find links to article

proinflammatory cytokines, leading to peripheral inflammation and activation of microglia in the brain, which indicates neuroinflammation. In addition, neuroactive

Tissue cytometry (2,515 words) [view diff] exact match in snippet view article find links to article

cytometry is utilized to image the murine hippocampus and visualize M1/M2 microglia in mice with MSCs transplantation as a model for Alzheimer’s disease.

Clodagh O'Shea (933 words) [view diff] exact match in snippet view article find links to article

"Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia". Neuron. 93 (3): 574–586.e8. doi:10.1016/j.neuron.2016.12.021. PMC 5600182

N-Acylamides (2,196 words) [view diff] exact match in snippet view article find links to article

(2014). "Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation". Frontiers

MiR-155 (10,421 words) [view diff] exact match in snippet view article find links to article

CNS-resident myeloid cells, including circulating blood monocytes and activated microglia. It was also found that mir-155 is implicated in inflammation. Overexpression

Sortilin 1 (3,170 words) [view diff] exact match in snippet view article find links to article

neurotensin receptor-3 in the neurotensin-induced migration of human microglia". The Journal of Neuroscience. 23 (4): 1198–1205. doi:10.1523/JNEUROSCI

Neuroproteomics (2,577 words) [view diff] exact match in snippet view article find links to article

an immunosuppressant, however, but rather it acts as a shield against microglia. NGF promotes neuron viability and differentiation by binding to TrkA

Microvesicle (6,048 words) [view diff] exact match in snippet view article find links to article

space upon microvesicle degradation. Dendritic cells, macrophage and microglia derived microvesicles contain proinflammatory cytokines and neurons and

ASH1L (3,070 words) [view diff] exact match in snippet view article find links to article

excitatory and inhibitory neurons, astrocytes, oligodendrocytes, and microglia. ASH1L also does not appear to show specificity to any brain region. In

Perlecan (11,011 words) [view diff] exact match in snippet view article find links to article

1999). "Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions". Mol. Med. 5 (5):

Max Bennett (scientist) (2,559 words) [view diff] exact match in snippet view article

transmission and propagation of calcium waves in cultured spinal cord microglia networks. Purinergic Sig. 4: 47-59. This work showed for the first time

Biochemical cascade (11,432 words) [view diff] exact match in snippet view article find links to article

trophic factor at cellular development and growth, being involved on microglia activation and migration, and also on axonal myelination by oligodendrocytes

Clinical uses of mesenchymal stem cells (2,731 words) [view diff] exact match in snippet view article find links to article

(December 2010). "Bone marrow-derived mesenchymal stem cells modulate BV2 microglia responses to lipopolysaccharide". International Immunopharmacology. 10

Glutamate hypothesis of schizophrenia (3,902 words) [view diff] exact match in snippet view article find links to article

puts oxidative load on neurons; leading to inflammatory response and microglia activation. Similarly, toxoplasmosis infection in the CNS (positively

Susan Dymecki (2,397 words) [view diff] exact match in snippet view article find links to article

Chang Y, Nattie E, Dymecki SM. Elife 2018-10-23 Sexual dimorphism of microglia and synapses during mouse postnatal development. Weinhard L, Neniskyte

LINGO1 (4,882 words) [view diff] exact match in snippet view article find links to article

(Feb 2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathology and Applied Neurobiology

Laura Manuelidis (3,866 words) [view diff] exact match in snippet view article find links to article

Christopher A.; Martin, Daniel; Manuelidis, Laura (November 2002). "Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show

Parkinson's disease and gut-brain axis (2,819 words) [view diff] exact match in snippet view article find links to article

vivo findings: prevent 6-OHDA neurotoxicity: decrease the activation of microglia and astrocyte via iNOs inhibition neuroprotective on dopaminergic neurons:

Cerebral organoid (6,605 words) [view diff] exact match in snippet view article find links to article

may be used in usual cerebral organoid culturing processes to generate microglia in cerebral organoids. The lack of vasculature limits the size the organoid

Francisco J. Quintana (2,559 words) [view diff] exact match in snippet view article find links to article

, Quintana F.J. Droplet-based forward genetic screening of astrocyte-microglia cross-talk. Science, 379(6636), 1023–1030 (2023). 30. Sanmarco LM, Rone

Cytochrome b-245, alpha polypeptide (4,853 words) [view diff] exact match in snippet view article find links to article

P22phox associated with NOX2 is also found in brain and especially in microglia. Anarchic ROS production by these cells is involved in the pathological

Sandra M. Garraway (2,533 words) [view diff] exact match in snippet view article find links to article

and that downstream TNFa signalling may induce apoptosis in neurons and microglia. In 2019, Garraway and her colleagues found that peripheral inflammation

Artificial enzyme (12,927 words) [view diff] exact match in snippet view article find links to article

Zhang, Hao; Xu, Qi; Yuan, Jiaxin; Li, Zhen (30 December 2020). "Targeting Microglia for Therapy of Parkinson's Disease by Using Biomimetic Ultrasmall Nanoparticles"

Hypertension and the brain (3,460 words) [view diff] exact match in snippet view article find links to article

for molecules to leak into the CNS. This then activates astrocytes and microglia, causing an immune response within the brain. Neuroinflammation can reach

Alzheimer's disease in the Hispanic/Latino population (6,149 words) [view diff] exact match in snippet view article find links to article

are risk factors for AD, such as TREM2. TREM2 are highly expressed in microglia, the immune cell of the brain, tying the progression of AD with dysfunction

Horse ointment (1,444 words) [view diff] exact match in snippet view article find links to article

Eerdun Wurile regulate the transcription of pro-inflammatory cytokines in microglia". Journal of Ethnopharmacology. 246: 112241. doi:10.1016/j.jep.2019.112241

Antonello Bonci (5,386 words) [view diff] exact match in snippet view article find links to article

Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia. Neuron. 2017 Jul 19;95(2):341-356.e6. doi: 10.1016/j.neuron.2017.06.020

Zhenyu Yue (2,354 words) [view diff] exact match in snippet view article find links to article

Peng, Junmin; Zhang, Bin; Yue, Zhenyu (July 2023). "Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence". Nature

Nerve guidance conduit (14,559 words) [view diff] exact match in snippet view article find links to article

suggesting a different developmental origin than other similar nervous system microglia. Another interesting concept is that OECs are found in both the peripheral

Moein Moghimi (2,683 words) [view diff] exact match in snippet view article find links to article

On crossing the blood–brain barrier, the carriers target neurons and microglia and deliver their therapeutic nucleic acid payloads to cells. These peptides

Parasites of phytoplankton (5,076 words) [view diff] exact match in snippet view article find links to article

Table 1. Examples of positive microalgae-bacteria interactions Microglia Bacterium Mediators from microalgae Mediators from bacteria Algal growth improvement

Myelinoid (4,897 words) [view diff] exact match in snippet view article find links to article

cell types found in vivo, however, they fail to capture all cell types. Microglia are absent in some myelinoids as was observed in the 2021 protocol. Myelinoids

List of nominees for the Nobel Prize in Physiology or Medicine (16,409 words) [view diff] exact match in snippet view article find links to article

histopathology of the nervous system, especially studies of glia tissue (microglia and oligodendroglia)" "Work on mitogenetic radiation" "For his work, "The