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searching for PARP1 25 found (84 total)

alternate case: pARP1

Small nucleolar RNA SNORA73 (456 words) [view diff] exact match in snippet view article find links to article

Notably, SNORA73 can bind to PARP1, leading to the activation of its ADPRylation (PAR) function. SNORA73 Interacts with the PARP1 DNA-Binding Domain. In addition

Tricetin (269 words) [view diff] exact match in snippet view article find links to article

effect on the DNA damage sensor enzyme poly (ADP-ribose) polymerase-1 (PARP1) and PARP1-mediated cell death and suppression of inflammatory gene expression

Synthetic lethality (2,802 words) [view diff] exact match in snippet view article find links to article

et al., five different PARP1 inhibitors are now undergoing Phase I, II and III clinical trials, to determine if particular PARP1 inhibitors are synthetically

PARP2 (1,307 words) [view diff] exact match in snippet view article find links to article

binding motifs of plant and animal PARP1 proteins. Some PARP inhibitor anti-cancer drugs (primarily aimed at PARP1) also inhibit PARP2, e.g. niraparib

NMNAT1 (1,469 words) [view diff] exact match in snippet view article find links to article

enzyme poly (ADP-ribose) polymerase-1 (PARP1). The dependence of osteosarcoma cells on NMNAT1-derived NAD for the PARP1-dependent DNA repair and survival is

KDM2B (1,477 words) [view diff] exact match in snippet view article find links to article

found to be rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELESS-dependent manner to promote mono-ubiquitylation of histone

Paul Schimmel (1,105 words) [view diff] exact match in snippet view article find links to article

Mathew; Schimmel, Paul (March 19, 2015). "A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol". Nature. 519 (7543): 370–373

Nicotinamide-nucleotide adenylyltransferase (534 words) [view diff] exact match in snippet view article find links to article

Hurtado-Bagès S, Knobloch G, Ladurner AG, Buschbeck M (2020). "The taming of PARP1 and its impact on NAD + metabolisme". Molecular Metabolism. 38: 100950.

Cytokine storm (2,787 words) [view diff] exact match in snippet view article find links to article

"Nicotinamide Augments the Anti-Inflammatory Properties of Resveratrol through PARP1 Activation". Sci Rep. 9 (1): 10219. Bibcode:2019NatSR...910219Y. doi:10

Hydroxylamine (2,574 words) [view diff] exact match in snippet view article find links to article

Black, Ben E.; Pascal, John M. (2021-11-18). "HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications". Nature

Sirtuin 7 (1,531 words) [view diff] exact match in snippet view article find links to article

Gorbunova V (2011). "SIRT6 promotes DNA repair under stress by activating PARP1". Science. 332 (6036): 1443–1446. Bibcode:2011Sci...332.1443M. doi:10.1126/science

Macro domain (1,158 words) [view diff] exact match in snippet view article find links to article

PMC 2991557. PMID 20729089. Ji Y, Tulin AV (October 2010). "The roles of PARP1 in gene control and cell differentiation". Current Opinion in Genetics &

YARS (1,096 words) [view diff] exact match in snippet view article find links to article

Sajish, Mathew; Schimmel, Paul (2015). "A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol". Nature. 519 (7543): 370–373

Aditi Sahu (684 words) [view diff] exact match in snippet view article find links to article

Thomas; Rajadhyaksha, Milind; Jain, Manu (October 1, 2021). "Combined PARP1-targeted nuclear contrast and reflectance contrast enhances confocal microscopic

PNKP (1,881 words) [view diff] exact match in snippet view article find links to article

(2019). "Novel PNKP mutations causing defective DNA strand break repair and PARP1 hyperactivity in MCSZ". Neurol Genet. 5 (2): e320. doi:10.1212/NXG.0000000000000320

P2RX7 (3,358 words) [view diff] exact match in snippet view article find links to article

ADP-ribosyl transferase super family in immune defences: looking beyond PARP1". Biochemical Pharmacology. 84 (1): 11–20. doi:10.1016/j.bcp.2012.02.016

DJ-1 (1,884 words) [view diff] exact match in snippet view article find links to article

Pu JL. Nuclear DJ-1 Regulates DNA Damage Repair via the Regulation of PARP1 Activity. Int J Mol Sci. 2023 May 12;24(10):8651. doi: 10.3390/ijms24108651

Partition coefficient (6,379 words) [view diff] exact match in snippet view article find links to article

processes in living cells at a single-molecule level: a case of olaparib–PARP1 (DNA repair protein) interactions" (PDF). Analyst. 146 (23): 7131–7143.

Jung-Min Lee (865 words) [view diff] exact match in snippet view article find links to article

mediated therapeutic editing of genes involved in disease causing such as PARP1, Rpe65 and Mct8. Additionally, Lee has published clinical guidelines for

Karen E. Knudsen (1,450 words) [view diff] exact match in snippet view article find links to article

Karen E. (2015-06-18). "Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function". Molecular Cell. 58 (6): 925–934. doi:10.1016/j.molcel

Dmitri Nusinow (1,199 words) [view diff] exact match in snippet view article find links to article

mammalian histone variant macroH2A. He discovered that the inhibition of PARP1 by macro-H2A1 contributed to X chromosome inactivation. While in graduate

Epigenetics (18,430 words) [view diff] case mismatch in snippet view article find links to article

modifications (chromatin remodeling - see next section). In addition, the enzyme Parp1 (poly(ADP)-ribose polymerase) and its product poly(ADP)-ribose (PAR) accumulate

DNA repair-deficiency disorder (3,756 words) [view diff] exact match in snippet view article find links to article

PMC 2827637. PMID 20075015. Veith S, Mangerich A (2015). "RecQ helicases and PARP1 team up in maintaining genome integrity". Ageing Res. Rev. 23 (Pt A): 12–28

Cancer epigenetics (12,530 words) [view diff] exact match in snippet view article find links to article

cancers of the breast, prostate, stomach, neuroblastomas, pancreas, and lung. PARP1 is also over-expressed when its promoter region ETS site is epigenetically

Stress granule (12,548 words) [view diff] exact match in snippet view article find links to article

Schembri L, Spano D, Turacchio G, Lo Monte M, et al. (October 2017). "PARP1-produced poly-ADP-ribose causes the PARP12 translocation to stress granules