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searching for PRC1 48 found (59 total)

alternate case: pRC1

PRC2 (558 words) [view diff] exact match in snippet view article find links to article

polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1 (Polycomb Repressive Complex 1). This complex has histone methyltransferase

Polycomb-group proteins (1,435 words) [view diff] exact match in snippet view article find links to article

least three kinds of multiprotein complex Polycomb Repressive Complex 1 (PRC1), PRC2 and PhoRC. These complexes work together to carry out their repressive

Polycomb repressive complex 1 (207 words) [view diff] exact match in snippet view article find links to article

Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. Polycomb-group proteins play a major

PCGF1 (854 words) [view diff] exact match in snippet view article find links to article

component defining the non-canonical polycomb repressive complex 1.1 (ncPRC1) interacting with RING1A/B, RYBP, BCOR and KDM2B. PCGF1-BCOR assembles via

Rixosome (223 words) [view diff] exact match in snippet view article find links to article

is associated with human PRC1 and PRC2 complexes. The interaction with PRC1 appears to be through the RING1B domain of PRC1 based on mutational analysis

PCGF2 (1,480 words) [view diff] exact match in snippet view article find links to article

canonical PRC1 complex composed of RING1A/B, CBX2/CBX4, polyhomeotic (PHC) proteins and is very similar to the PCGF4/BMI1 containing PRC1. Canonical PRC1 binds

Polycomb recruitment in X chromosome inactivation (1,594 words) [view diff] exact match in snippet view article find links to article

chromatin changes, RNA pol II exclusion, or PRC1 recruitment. For instance, PRC2 recruitment is linked to PRC1-mediated H2A119 ubiquitination in differentiating

Theseus1 (1,158 words) [view diff] case mismatch in snippet view article find links to article

It was first characterised from its interaction with a Procuste1 mutant (prc1-1). This Procuste1 mutant produces less cellulose because of alterations

KIF4A (1,061 words) [view diff] exact match in snippet view article find links to article

Todokoro K (August 2004). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". The EMBO Journal. 23 (16):

KDM2B (1,477 words) [view diff] exact match in snippet view article find links to article

activity of the ncPRC1.1 complex at DNA lesions was necessary for the proper recruitment of the two canonical PRC1 complexes (cPRC1.2 and cPRC1.4), defined

Histone (9,575 words) [view diff] exact match in snippet view article find links to article

complex, PRC1, can bind H3K27me3 and adds the histone modification H2AK119Ub which aids chromatin compaction. Based on this data it appears that PRC1 is recruited

Cytokinesis (3,533 words) [view diff] exact match in snippet view article find links to article

in the phosphoregulation of other central spindle components, including PRC1 (microtubule-bundling protein required for cytokinesis 1) and MKLP1 (a kinesin

H3K27me3 (2,611 words) [view diff] exact match in snippet view article find links to article

lysine 27 through histone methyl transferase activity. This mark can recruit PRC1 which will bind and contribute to the compaction of the chromatin. The inflammatory

Centromere protein E (1,069 words) [view diff] exact match in snippet view article find links to article

Dohmae N, Todokoro K (2005). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". EMBO J. 23 (16): 3237–48

CBX2 (gene) (528 words) [view diff] exact match in snippet view article

binding Cellular component heterochromatin euchromatin PcG protein complex PRC1 complex nucleus nucleoplasm chromosome Biological process cell differentiation

INK4 (1,459 words) [view diff] exact match in snippet view article find links to article

regulation involves epigenetic control and multiple transcription factors. PRC1, PRC2, YY1, and Id1 play a role in the suppression of p16INK4A expression

Chromatin remodeling (5,523 words) [view diff] exact match in snippet view article find links to article

silenced by chromatin confirmation and polycomb repressive complexes as seen in PRC1/PCR2 silencing of p16. Specific remodeler depletion results in activation

PCGF5 (409 words) [view diff] exact match in snippet view article find links to article

centrosome nucleolus nucleus nucleoplasm X chromosome PcG protein complex PRC1 complex Biological process regulation of transcription, DNA-templated transcription

Heterochromatin (2,116 words) [view diff] exact match in snippet view article find links to article

spreading is still a matter of controversy. The polycomb repressive complexes PRC1 and PRC2 regulate chromatin compaction and gene expression and have a fundamental

PHC3 (488 words) [view diff] exact match in snippet view article find links to article

protein binding metal ion binding Cellular component PcG protein complex PRC1 complex nucleus nucleoplasm Biological process multicellular organism development

Cellular differentiation (6,014 words) [view diff] exact match in snippet view article find links to article

lysine 27 (H3K27me2/me3). By binding to the H3K27me2/3-tagged nucleosome, PRC1 (also a complex of PcG family proteins) catalyzes the mono-ubiquitinylation

Bivalent chromatin (964 words) [view diff] exact match in snippet view article find links to article

GR (February 2017). "Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin". Nature Genetics. 49 (2): 282–288. doi:10.1038/ng.3735. PMC 5373480

PHC2 (853 words) [view diff] exact match in snippet view article find links to article

binding metal ion binding zinc ion binding Cellular component heterochromatin PRC1 complex PcG protein complex nucleus nucleoplasm Biological process spermatogenesis

CBX7 (gene) (390 words) [view diff] exact match in snippet view article

binding Cellular component PcG protein complex nucleus nucleoplasm cytosol PRC1 complex Biological process regulation of transcription, DNA-templated negative

Two Bombs, One Satellite (1,639 words) [view diff] exact match in snippet view article find links to article

January 2014. {{cite journal}}: Cite journal requires |journal= (help) "PRC1: NSSDCA - Spacecraft - Details". NASA. Archived from the original on 2022-12-19

PHC1 (1,006 words) [view diff] exact match in snippet view article find links to article

metal ion binding protein binding Cellular component PcG protein complex PRC1 complex nucleus nucleoplasm Biological process multicellular organism development

H2AFY (1,259 words) [view diff] exact match in snippet view article find links to article

van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin

PCGF6 (618 words) [view diff] exact match in snippet view article find links to article

metal ion binding Cellular component nucleus PcG protein complex nucleoplasm PRC1 complex Biological process regulation of transcription, DNA-templated negative

CBX8 (639 words) [view diff] exact match in snippet view article find links to article

Cellular component ubiquitin ligase complex nucleoplasm heterochromatin PRC1 complex PcG protein complex nucleus Biological process positive regulation

COMMD3-BMI1 (134 words) [view diff] exact match in snippet view article find links to article

binding Cellular component cytoplasm ubiquitin ligase complex nucleoplasm PRC1 complex PcG protein complex nucleus cytosol nuclear body Biological process

Mitzi Kuroda (901 words) [view diff] exact match in snippet view article find links to article

Jessica L.; Park, Peter J.; Kuroda, Mitzi I. (2017). "Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila"

SPOP (1,188 words) [view diff] exact match in snippet view article find links to article

van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin

Rob Klose (693 words) [view diff] exact match in snippet view article find links to article

1042/BST20130028. PMC 3685328. PMID 23697932. Klose, Rob (2014). "Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb

RNF2 (1,107 words) [view diff] exact match in snippet view article find links to article

ubiquitin ligase complex nucleoplasm chromosome heterochromatin MLL1 complex PRC1 complex PcG protein complex nucleus nuclear body Biological process germ

BMI1 (2,637 words) [view diff] exact match in snippet view article find links to article

binding Cellular component cytoplasm ubiquitin ligase complex nucleoplasm PRC1 complex PcG protein complex nucleus cytosol nuclear body Biological process

Envelope (3,598 words) [view diff] exact match in snippet view article find links to article

sizes Format Dimensions (mm) Dimensions (in) AR Suitable content format PRC1 Chinese #1 Envelope 102 × 165 4 × 6+1⁄2 ϕ∶1 PRC2 Chinese #2 Envelope 102

SMARCA4 (2,714 words) [view diff] exact match in snippet view article find links to article

GR (February 2017). "Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin". Nature Genetics. 49 (2): 282–288. doi:10.1038/ng.3735. PMC 5373480

P16 (4,236 words) [view diff] exact match in snippet view article find links to article

modification through methylation and repression of the promoter region. PRC1 and PRC2 are two protein complexes that modify the expression of p16 through

DNA microarray (5,427 words) [view diff] exact match in snippet view article find links to article

(H3K27me3, H3K4me2, H3K9me3, etc.), Polycomb-group protein (PRC2:Suz12, PRC1:YY1) and trithorax-group protein (Ash1) to study the epigenetic landscape

Jun dimerization protein (4,169 words) [view diff] exact match in snippet view article find links to article

resistant to replicative senescence by recruiting polycomb-repressive complexes (PRC1 and PRC2) to the promoters at the p16Ink4a locus. The increased accumulation

CUL3 (2,387 words) [view diff] exact match in snippet view article find links to article

van Lohuizen M (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin

RING1 (1,320 words) [view diff] exact match in snippet view article find links to article

ubiquitin ligase complex nucleoplasm PcG protein complex nucleus cytosol PRC1 complex Biological process regulation of transcription, DNA-templated histone

ANLN (2,939 words) [view diff] exact match in snippet view article find links to article

Saoudi Y, Jablonski SA, Perard J, Yen TJ, et al. (March 2005). "Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires

AI-10-49 (2,849 words) [view diff] exact match in snippet view article find links to article

component BRG1 and RUNX1 mediated recruitment of polycomb-repressive complex 1 (PRC1) component RING1B at the three MYC enhancers. Taken together, these results

Robert E. Kingston (2,303 words) [view diff] exact match in snippet view article find links to article

eukaryotic promoters will be regulated. Because Polycomb repressive complex 1 (PRC1) contains a number of proteins that work together to repress SWI/SNF complex

Cancer epigenetics (12,530 words) [view diff] exact match in snippet view article find links to article

Expression of epigenetic modifiers such as that of the BMI1 component of the PRC1 complex is deregulated in chondrosarcoma, Ewing's sarcoma, and osteosarcoma

Nuclear mitochondrial DNA segment (6,819 words) [view diff] exact match in snippet view article find links to article

of mtDNA escape in yme1 strains decreases. Similarly, the disruption of PRC1, which encodes carboxypeptidase Y, lowers the rate of mtDNA escape in yme1

X-chromosome reactivation (5,094 words) [view diff] exact match in snippet view article find links to article

Verhoeven E, et al. (May 2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin