Find link

language:

Find link is a tool written by Edward Betts.

Longer titles found: Pleiotropy (drugs) (view), Antagonistic pleiotropy hypothesis (view)

searching for Pleiotropy 51 found (161 total)

alternate case: pleiotropy

Michael R. Rose (1,005 words) [view diff] exact match in snippet view article find links to article

Biology of Aging exploring a view of the subject based on antagonistic pleiotropy, the hypothesis that aging is caused by genes that have two effects, one

George Christopher Williams (1,905 words) [view diff] exact match in snippet view article find links to article

the gene-centered view of evolution in the 1960s. Williams' 1957 paper Pleiotropy, Natural Selection, and the Evolution of Senescence is one of the most

Anders Dale (3,455 words) [view diff] exact match in snippet view article find links to article

methods for evaluating genetic overlap (pleiotropy) across diseases and phenotypes. These genetic pleiotropy methods have provided valuable insights across

Omnigenic model (1,471 words) [view diff] exact match in snippet view article find links to article

that the authors propose that facilitates this effect is called “network pleiotropy”, in which peripheral genes can affect core genes, not by having a direct

Outline of life extension (586 words) [view diff] exact match in snippet view article find links to article

Lipofuscin Viral infections (acute or chronic) Theories of aging Antagonistic pleiotropy theory of aging Caloric restriction theory Cross-linkage theory of aging

Mendelian randomization (2,830 words) [view diff] exact match in snippet view article find links to article

exposure. This is known as the "exclusion restriction" or "no horizontal pleiotropy" assumption. To ensure that the first core assumption is validated, Mendelian

Marla Sokolowski (1,194 words) [view diff] exact match in snippet view article find links to article

fundamental concepts in behavioural evolution, plasticity, and genetic pleiotropy. Specifically, Sokolowski is best known for her discovery of the foraging

Host–parasite coevolution (3,038 words) [view diff] exact match in snippet view article find links to article

the parasite population from being highly pathogenic. The costs of gene pleiotropy have been investigated in coevolving Escherichia coli and bacteriophages

Genetic ecology (817 words) [view diff] exact match in snippet view article find links to article

Frachon, L et al. (27 July 2017) "Intermediate degrees of synergistic pleiotropy drive adaptive evolution in ecological time" Nature, Ecology, and Evolution

Peter Keightley (701 words) [view diff] exact match in snippet view article find links to article

Edinburgh. hdl:1842/12340. Keightley, P D; Kacser, H (1987). "Dominance, pleiotropy and metabolic structure". Genetics. 117 (2): 319–329. doi:10.1093/genetics/117

Kir2.1 (1,491 words) [view diff] exact match in snippet view article find links to article

LJ (2004). "Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity". Ann. Med. 36 (Suppl 1): 92–7. doi:10.1080/17431380410032490

Norman Sharpless (2,080 words) [view diff] exact match in snippet view article find links to article

immune system, providing the first genetic evidence for lineage-specific pleiotropy in immune aging and genetic basis for heterogeneity of human aging and

FAM13C (229 words) [view diff] exact match in snippet view article find links to article

YH, Zhou Y, Cupples LA, Kiel DP, Demissie S (July 2010). "Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study". Journal of

Age-1 (1,462 words) [view diff] exact match in snippet view article find links to article

phenotype was caused by a single mutation. Johnson proposed a negative pleiotropy theory, in which the age-1 gene is beneficial early in life but harmful

Chris Perrins (1,316 words) [view diff] exact match in snippet view article find links to article

genetics of age at reproduction in wild swans: Support for antagonistic pleiotropy models of senescence". Proceedings of the National Academy of Sciences

Erythranthe cuprea (754 words) [view diff] exact match in snippet view article find links to article

Streisfeld, Matthew A.; Rausher, Mark D. (March 2011). "Population Genetics, Pleiotropy, and the Preferential Fixation of Mutations During Adaptive Evolution"

Domestication syndrome (3,403 words) [view diff] exact match in snippet view article find links to article

syndrome because their criteria assumed it must be caused by genetic pleiotropy, and arises in response to 'selection for tameness'--as was claimed by

Andersen–Tawil syndrome (2,389 words) [view diff] exact match in snippet view article find links to article

LJ (2004). "Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity". Annals of Medicine. 36 (Suppl 1): 92–7. doi:10

Flower constancy (970 words) [view diff] exact match in snippet view article find links to article

Dornhaus, A.; Saleh, N.; Chittka, L. (2006). "Adaptation, genetic drift, pleiotropy, and history in the evolution of bee foraging behavior". Advances in the

Grandmother hypothesis (3,129 words) [view diff] exact match in snippet view article find links to article

Man's Adaptations. Aldine. ISBN 0-202-02013-4. Williams, GC (1957). "Pleiotropy, natural selection, and the evolution of senescence". Evolution. 11 (4):

Proud syndrome (495 words) [view diff] exact match in snippet view article find links to article

Karen L. (February 2004). "Mutations of ARX are associated with striking pleiotropy and consistent genotype-phenotype correlation". Human Mutation. 23 (2):

R/K selection theory (3,131 words) [view diff] exact match in snippet view article find links to article

Templeton A.R.; Johnson, J.S. (1982). "Life History Evolution Under Pleiotropy and K-selection in a Natural Population of Drosophila mercatorum". In

Degeneracy (biology) (2,302 words) [view diff] exact match in snippet view article

Pour la Science. 46: 39–43. Wagner (2000). "The role of population size, pleiotropy and fitness effects of mutations in the evolution of overlapping gene

Human iron metabolism (5,563 words) [view diff] exact match in snippet view article find links to article

pathological in old age, which supports the notion that antagonistic pleiotropy or "hyperfunction" drives human aging. Chronic iron toxicity is usually

COX18, cytochrome c oxidase assembly factor (426 words) [view diff] exact match in snippet view article find links to article

Hsu YH, Zhou Y, Cupples LA, Kiel DP, Demissie S (2010). "Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study". J. Bone Miner

Facilitated variation (2,021 words) [view diff] exact match in snippet view article find links to article

variation theory, such as weak regulatory linkage, modularity, and reduced pleiotropy of mutations, evolve spontaneously under realistic conditions. In the

Evolutionary medicine (4,582 words) [view diff] exact match in snippet view article find links to article

1007/s00508-007-0834-z. PMID 17721763. S2CID 22737085. Williams GC (1957). "Pleiotropy, Natural Selection, and the Evolution of Senescence" (PDF). Evolution

Optimal virulence (1,482 words) [view diff] exact match in snippet view article find links to article

selection that operates on other traits, as is the case with antagonistic pleiotropy. A potential for virulence exists whenever a pathogen invades a new environment

Darwin Medal (3,096 words) [view diff] exact match in snippet view article find links to article

evolution of ageing, and testing the theories of mutation accumulation and pleiotropy, developing models for the evolution of genetic systems, including sex

Avena barbata (2,094 words) [view diff] exact match in snippet view article find links to article

selection across multiple years and sites in Avena barbata: epistasis, pleiotropy, and genotype-by-environment interactions". Genetics. 185 (1): 375–85

Andreas Wagner (1,296 words) [view diff] exact match in snippet view article find links to article

Journal of Evolutionary Biology 12:1-16. Wagner A (2000) The role of pleiotropy, population size fluctuations, and fitness effects of mutations in the

Bing Liu (scientist) (783 words) [view diff] exact match in snippet view article

"Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1", Frontiers in Pharmacology

Genotype-first approach (1,534 words) [view diff] exact match in snippet view article find links to article

expressivity. This approach contributes to studying both expressivity, pleiotropy and sporadic mutations. This approach examines highly penetrant mutations

Apolipoprotein E (6,457 words) [view diff] exact match in snippet view article find links to article

to differences in potential fertility in women: a case of antagonistic pleiotropy?". Proceedings. Biological Sciences. 282 (1803): 20142395. doi:10.1098/rspb

Life expectancy (10,374 words) [view diff] exact match in snippet view article find links to article

Science. 343. 1478–85. 10.1126/science.1248429. Williams G (1957). "Pleiotropy, natural selection, and the evolution of senescence". Evolution. 11 (4)

CCR5 (7,844 words) [view diff] exact match in snippet view article find links to article

create further pathology. The best evidence for this proposed antagonistic pleiotropy is found in flavivirus infections. In general many viral infections are

Intelligence quotient (17,809 words) [view diff] exact match in snippet view article find links to article

"Investigating cognitive transfer within the framework of music practice: genetic pleiotropy rather than causality". Developmental Science. 19 (3): 504–512. doi:10

Codling moth (6,583 words) [view diff] exact match in snippet view article find links to article

Bouvier, Jean C.; Beslay, Dominique; Sauphanor, Benoît (2001-06-01). "Pleiotropy of insecticide resistance in the codling moth, Cydia pomonella". Entomologia

TMEM70 (1,276 words) [view diff] exact match in snippet view article find links to article

YH, Zhou Y, Cupples LA, Kiel DP, Demissie S (July 2010). "Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study". Journal of

Generalized anxiety disorder (14,463 words) [view diff] exact match in snippet view article find links to article

GAD and depressive disorders have been suggested, ranging from genetic pleiotropy (i.e., GAD and nonbipolar depression might represent different phenotypic

Janina Jeff (1,556 words) [view diff] exact match in snippet view article find links to article

Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans". PLOS ONE. 14 (12): e0226771. Bibcode:2019PLoSO

David Gems (1,471 words) [view diff] exact match in snippet view article find links to article

2021.101557. PMC 7612201. PMID 34990845. Williams, George C. (1957). "Pleiotropy, natural selection and the evolution of senescence". Evolution. 11 (4):

Instituto Gulbenkian de Ciência (4,125 words) [view diff] exact match in snippet view article find links to article

architecture is a selectable trait that can be maintained by antagonistic pleiotropy" (PDF). Nature Communications. 4 (1): 2235. Bibcode:2013NatCo...4.2235T

Erythranthe (6,788 words) [view diff] exact match in snippet view article find links to article

Streisfeld, Matthew A.; Rausher, Mark D. (March 2011). "Population Genetics, Pleiotropy, and the Preferential Fixation of Mutations During Adaptive Evolution"

Study of Health in Pomerania (3,432 words) [view diff] exact match in snippet view article find links to article

haematological parameters identifies 22 associated loci and extensive disease pleiotropy on chromosome 12q24. Nat Genetics, in press Spitzer C, Barnow S, Völzke

Limbic-predominant age-related TDP-43 encephalopathy (2,996 words) [view diff] exact match in snippet view article find links to article

"Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy". Laboratory Investigation. 99 (7): 993–1007. doi:10.1038/s41374-019-0196-y

Abdominal pigmentation in Drosophila melanogaster (2,709 words) [view diff] exact match in snippet view article find links to article

insect pigmentation: genetic mechanisms and the potential consequences of pleiotropy". Seminars in Cell & Developmental Biology. 20 (1): 65–71. doi:10.1016/j

Garth Ehrlich (3,486 words) [view diff] exact match in snippet view article find links to article

Garmendia, Junkal (November 7, 2018). Parkhill, Julian (ed.). "Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of

Igor Rudan (6,904 words) [view diff] exact match in snippet view article find links to article

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. PLoS Genet. 2013;9(1):e1003225

Education of Generation Z (5,084 words) [view diff] exact match in snippet view article find links to article

Kaili; Kovas, Yulia; Dale, Philip S.; Plomin, Robert (July 23, 2015). "Pleiotropy across academic subjects at the end of compulsory education". Nature.

Bias in the introduction of variation (14,440 words) [view diff] exact match in snippet view article find links to article

Lenormand (2010). "Fisher's model and the genomics of adaptation: restricted pleiotropy, heterogenous mutation, and parallel evolution". Evolution. 64 (11): 3213–31