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searching for Prenylation 60 found (114 total)

PTP4A1 (1,015 words) [view diff] exact match in snippet view article find links to article

(PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in

Chp (GTPase) (313 words) [view diff] exact match in snippet view article

organisms during evolution. RhoV/Chp depends on palmitoylation rather than prenylation for association with plasma and intracellular membranes. In Xenopus embryos

COQ2 (632 words) [view diff] exact match in snippet view article find links to article

catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et

PTP4A3 (939 words) [view diff] exact match in snippet view article find links to article

This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were

Tipifarnib (673 words) [view diff] exact match in snippet view article find links to article

inhibitors block the activity of the farnesyltransferase enzyme by inhibiting prenylation of the CAAX tail motif, which ultimately prevents Ras from binding to

Rab (G-protein) (1,327 words) [view diff] exact match in snippet view article

both help with the prenylation and transport of Rab proteins. Rab27 has been found to preferentially depend on REP-1 for prenylation, which could be the

Dual-specificity phosphatase (533 words) [view diff] exact match in snippet view article find links to article

PRL-3). They share a high sequence identity and possess an N-terminal prenylation sequence (CAAX box). Despite their up-regulation in colorectal cancer

Humulone (670 words) [view diff] exact match in snippet view article find links to article

give 2,3,4,6-tetrahydroxyisovalerophenone. This step is followed by prenylation with 1-bromo-3-methyl-2-butene to give humulone. As determined by INADEQUATE

Psoromic acid (308 words) [view diff] exact match in snippet view article find links to article

Yao-Wen (2 May 2012). "Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase". Journal of the American

Pt-barrel (323 words) [view diff] exact match in snippet view article find links to article

Richard SB (June 2005). "Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products". Nature. 435 (7044): 983–7. Bibcode:2005Natur

FNTA (1,005 words) [view diff] exact match in snippet view article find links to article

S2CID 83164753. Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate

FNTB (868 words) [view diff] exact match in snippet view article find links to article

S2CID 83164753. Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate

Fusicoccin (478 words) [view diff] exact match in snippet view article find links to article

hydroxylation at the 3-position of fusicocca-2,10(14)-diene-8β,16-diol and prenylation of the hydroxyl group of glucose in fusicoccin P, respectively. Ballio

Patrick J. Casey (980 words) [view diff] exact match in snippet view article find links to article

signaling. Science 268:221-225. Zhang, F.L. & Casey, P.J. (1996) Protein prenylation: Molecular mechanisms and biological consequences. Annu. Rev. Biochem

Spirotryprostatin B (871 words) [view diff] exact match in snippet view article find links to article

at the spirocyclic ring juncture is established by a decarboxylation-prenylation sequence, reminiscent of the Carroll reaction. Here, a prenyl ester serves

Bisphosphonate (3,429 words) [view diff] exact match in snippet view article find links to article

some small proteins to the cell membrane. This phenomenon is known as prenylation, and is important for proper sub-cellular protein trafficking (see "lipid-anchored

Geraniol (913 words) [view diff] exact match in snippet view article find links to article

1002/14356007.a26_205. ISBN 978-3527306732. Fellermeier M, Zenk MH (May 1998). "Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the

Cyclopiazonic acid (1,258 words) [view diff] exact match in snippet view article find links to article

intermediate β-CPA. CpaD has high substrate specificity and will not catalyze prenylation in the presence of DMAPP's isomer isopentyl pyrophosphate (IPP) or the

Olivetolic acid (126 words) [view diff] exact match in snippet view article find links to article

found in lichen. Fellermeier, Monika; Zenk, Meinhart H (May 1998). "Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the

HMG-CoA reductase (4,109 words) [view diff] exact match in snippet view article find links to article

migration in zebrafish is dependent on HMGCoA reductase activity and prenylation". Developmental Cell. 6 (2): 295–302. doi:10.1016/S1534-5807(04)00032-2

Nuclear prelamin A recognition factor (713 words) [view diff] exact match in snippet view article find links to article

carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its

Aszonalenin (165 words) [view diff] exact match in snippet view article find links to article

Ruchti, Jonathan; Carreira, Erick M. (2014). "Ir-Catalyzed Reverse Prenylation of 3-Substituted Indoles: Total Synthesis of (+)-Aszonalenin and (–)-Brevicompanine

Geranyl-pyrophosphate—olivetolic acid geranyltransferase (104 words) [view diff] exact match in snippet view article find links to article

pathway of the plant Cannabis sativa. Fellermeier M, Zenk MH (May 1998). "Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the

Debromomarinone (429 words) [view diff] exact match in snippet view article find links to article

Richard SB (June 2005). "Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products". Nature. 435 (7044): 983–987. Bibcode:2005Natur

RRAS (1,142 words) [view diff] exact match in snippet view article find links to article

T, Downward J, Ginsberg M, Hughes PE (2000). "The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function". Oncogene

Marinone (448 words) [view diff] exact match in snippet view article find links to article

Richard SB (June 2005). "Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products". Nature. 435 (7044): 983–987. Bibcode:2005Natur

UBL3 (523 words) [view diff] exact match in snippet view article find links to article

family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation". J. Biol. Chem. 281 (37): 27145–57. doi:10.1074/jbc.M602283200. PMID 16831869

Ascofuranone (558 words) [view diff] exact match in snippet view article find links to article

ascofuranone was reported by Kita et al., as well as by Abe et al. The prenylation of orsellinic acid, followed by terminal cyclization through epoxidation

MTG1 (651 words) [view diff] exact match in snippet view article find links to article

PMID 1629950. Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free

Chemical modification (1,476 words) [view diff] exact match in snippet view article find links to article

lipidation: GPI anchors, N-terminal myristoylation, S-myristoylation, and S-prenylation. Proteolysis is the pathway used to break peptide bonds. Oftentimes,

RAB1B (893 words) [view diff] exact match in snippet view article find links to article

PMID 7592724. Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free

Protein geranylgeranyltransferase type I subunit beta (467 words) [view diff] exact match in snippet view article find links to article

cycle positive regulation of cell population proliferation response to cytokine protein geranylgeranylation protein prenylation Sources:Amigo / QuickGO

Novobiocin (2,266 words) [view diff] exact match in snippet view article find links to article

phenyl ring with dimethylallyl pyrophosphate (DMAPP) otherwise known as prenylation. DMAPP can come from either the mevalonic acid pathway or the deoxyxylulose

Shiina macrolactonization (1,172 words) [view diff] exact match in snippet view article find links to article

Synthesis of (+)-Prunustatin A: Utility of Organotrifluoroborate-Mediated Prenylation and Shiina MNBA Esterification and Macrolactonization To Avoid a Competing

William Schafer (1,271 words) [view diff] exact match in snippet view article find links to article

Berkeley (PhD Biochemistry, 1991) Scientific career Thesis Protein prenylation in saccharomyces cervesiae (1990) Doctoral advisor Jasper Rine Website

RAB8A (1,100 words) [view diff] exact match in snippet view article find links to article

PMID 9226381. Wilson AL, Erdman RA, Castellano F, Maltese WA (Aug 1998). "Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases". The

Otera's catalyst (280 words) [view diff] exact match in snippet view article find links to article

(2007). "Total Synthesis of Spirotryprostatin B via Diastereoselective Prenylation". Org. Lett. 9 (15): 2763–6. doi:10.1021/ol070971k. PMID 17592853.

GGPS1 (746 words) [view diff] exact match in snippet view article find links to article

isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate

Kainic acid (1,117 words) [view diff] exact match in snippet view article find links to article

pathway involves the N-prenyltransferase, KabA, which allows for the prenylation of L-glutamic acid with dimethylallyl pyrophosphate (DMAPP) to form the

GBP1 (912 words) [view diff] exact match in snippet view article find links to article

PMID 1715024. Nantais DE, Schwemmle M, Stickney JT, et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate

Retinitis pigmentosa GTPase regulator (2,273 words) [view diff] exact match in snippet view article find links to article

degeneration. Alternatively, the RPGRconst isoform contains a putative prenylation domain on its C-terminal end which is involved in posttranslational modification

Lorena S. Beese (694 words) [view diff] exact match in snippet view article find links to article

its connection to carcinogenesis. She is also interested in protein prenylation enzymes as targets for structure-based discovery of anticancer therapeutics

Ergocryptine (987 words) [view diff] exact match in snippet view article find links to article

two isomers. The biosynthetic pathways to ergocryptine starts with the prenylation of L-tryptophan in an SN1 fashion with dimethylallyl pyrophosphate (DMAPP)

Rubicordifolin (384 words) [view diff] exact match in snippet view article find links to article

reaction. After 2-succinylbenzoic acid has been produced, a cyclization, a prenylation, a methylation, and an oxidation occur which yields a naphthoquinone

GDI1 (1,241 words) [view diff] exact match in snippet view article find links to article

PMID 8826463. Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free

Shiina esterification (1,478 words) [view diff] exact match in snippet view article find links to article

Synthesis of (+)-Prunustatin A: Utility of Organotrifluoroborate-Mediated Prenylation and Shiina MNBA Esterification and Macrolactonization To Avoid a Competing

Brevianamide F (560 words) [view diff] exact match in snippet view article find links to article

M.; Sherman, David H. (2010). "Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents

Hydrogen auto-transfer (1,574 words) [view diff] exact match in snippet view article find links to article

(December 2007). "Catalytic C-C coupling via transfer hydrogenation: reverse prenylation, crotylation, and allylation from the alcohol or aldehyde oxidation level"

Ferulic acid decarboxylase (977 words) [view diff] exact match in snippet view article find links to article

(December 2018). "Flavin metamorphosis: cofactor transformation through prenylation". Current Opinion in Chemical Biology. 47: 117–125. doi:10.1016/j.cbpa

Flavin prenyltransferase (UbiX) (765 words) [view diff] exact match in snippet view article

(December 2018). "Flavin metamorphosis: cofactor transformation through prenylation". Current Opinion in Chemical Biology. 47: 117–125. doi:10.1016/j.cbpa

Geranyltranstransferase (1,253 words) [view diff] exact match in snippet view article find links to article

geranyl pyrophosphate also serve as precursors for prenylated proteins. Prenylation is a common type of covalent post-translational modification at C-terminal

Tetrahydrocannabinol (5,382 words) [view diff] exact match in snippet view article find links to article

2020-06-27. Retrieved 2019-07-04. Fellermeier M, Zenk MH (May 1998). "Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the

Rhodoquinone (972 words) [view diff] exact match in snippet view article find links to article

both COQ-2 protein isoforms (COQ-2a and COQ-2e), and COQ-2e catalyzes prenylation of 3-hydroxyanthranilic acid (instead of p-hydroxybenzoic acid) which

BY1 (557 words) [view diff] exact match in snippet view article find links to article

al. (2016) Biochemical and genetic basis of orsellinic acid biosynthesis and prenylation in a stereaceous basidiomycete. Fungal Genetics and Biology.

Major facilitator superfamily (5,029 words) [view diff] exact match in snippet view article find links to article

S, Pohl S, Quitsch A, Falley K, Braulke T (April 2007). "C-terminal prenylation of the CLN3 membrane glycoprotein is required for efficient endosomal

C17orf98 (1,942 words) [view diff] exact match in snippet view article find links to article

type actin binding motifs. There are no N-myristoylation pattern or prenylation patterns. Kinase finder at Cuckoo determined kinase binding sites for

Eric Oldfield (academic) (3,731 words) [view diff] exact match in snippet view article

in tumor cells and in mice, by targeting protein prenylation with inhibition of protein prenylation also leading to activity as vaccine adjuvants. Mechanistically

DEPDC1B (2,261 words) [view diff] exact match in snippet view article find links to article

transmembrane domains are predicted within human or any ortholog protein. No prenylation sites are predicted in any DEPDC1B orthologs. Expression of DEPDC1B is

List of biochemists (10,612 words) [view diff] exact match in snippet view article find links to article

University, known for structural biochemistry of DNA replication and protein prenylation enzymes. Member Natl. Acad. Sci. USA. Helmut Beinert (1913–2007). German

CSNK1D (14,738 words) [view diff] exact match in snippet view article find links to article

PMID 12270714. Vancura A, Sessler A, Leichus B, Kuret J (July 1994). "A prenylation motif is required for plasma membrane localization and biochemical function