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searching for Surrogate endpoint 12 found (31 total)

Aberrant crypt foci (330 words) [view diff] exact match in snippet view article find links to article

chemopreventive agents, in people and in animals. The relevance of ACF as a surrogate endpoint biomarker for cancer is controversial. Recently, several alternative

Electrical impedance myography (2,523 words) [view diff] exact match in snippet view article find links to article

potential as an ALS biomarker (also known as a biological correlate or surrogate endpoint) by Prize4Life, a 501(c)(3) nonprofit organization dedicated to accelerating

Resmetirom (455 words) [view diff] exact match in snippet view article find links to article

analysis of a surrogate endpoint at month twelve in a 54-month, randomized, double-blind placebo-controlled trial. The surrogate endpoint measured the

Proof of concept (2,152 words) [view diff] exact match in snippet view article find links to article

measure that a drug is effective in treating the desired disease, and a surrogate endpoint is used to guide whether or not it is appropriate to proceed with

MVC COVID-19 vaccine (1,455 words) [view diff] exact match in snippet view article find links to article

FDA for the application of EUA. Seroconversion rate was used as the surrogate endpoint, though there was lack of evidence at that time. Compared to EUA of

Leronlimab (2,001 words) [view diff] exact match in snippet view article find links to article

intervals compared to baseline observations. CTCs are a potential surrogate endpoint in oncology trials, with reduced levels suggesting long-term clinical

Axitinib (1,126 words) [view diff] case mismatch in snippet view article find links to article

2012. Fauber J, Chu E (October 27, 2014). "The Slippery Slope: Is a Surrogate Endpoint Evidence of Efficacy?". MedPage Today. "Inlyta : EPAR - Product Information"

Obeticholic acid (1,693 words) [view diff] exact match in snippet view article find links to article

reduction in the level of the biomarker alkaline phosphatase as a surrogate endpoint for clinical benefit. It is indicated for the treatment of primary

Triple-negative breast cancer (3,411 words) [view diff] exact match in snippet view article find links to article

intervals compared to baseline observations. CTCs are a potential surrogate endpoint in oncology trials, with reduced levels suggesting long-term clinical

Adaptive design (medicine) (4,365 words) [view diff] exact match in snippet view article

clinical endpoint other than survival or irreversible morbidity, or on a surrogate endpoint, likely to predict clinical benefit." By 2019, the FDA updated their

Rosiglitazone (5,929 words) [view diff] exact match in snippet view article find links to article

2 diabetes, as measured by glycated haemoglobin A1c (HbA1c) as a surrogate endpoint, similar to that of other oral antidiabetic drugs. The controversy

Hydroxyprogesterone caproate (12,047 words) [view diff] exact match in snippet view article find links to article

fill an unmet need for serious conditions can be approved based on a surrogate endpoint. The pharmaceutical company is required to conduct confirmatory studies