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AKR7A2
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Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene. Aldo-keto reductases, such as AKR7A2, are involvedAflatoxin total synthesis (567 words) [view diff] exact match in snippet view article find links to article
sources as part of a biological weapons program. The synthesis of racemic aflatoxin B1 has been reported by Buechi et al. in 1967 and that of racemic aflatoxinAspergillus pseudonomius (226 words) [view diff] exact match in snippet view article find links to article
the United States. It is most related to Aspergillus nomius, producing aflatoxin B1, chrysogine, and kojic acid. A. pseudonomius has been cultivated on bothAspergillus rambellii (268 words) [view diff] exact match in snippet view article find links to article
very large amounts of sterigmatocystin, 3-O-methylsterigmatocystin and aflatoxin B1. A. rambellii has been cultivated on both Czapek yeast extract agar (CYA)Aspergillus pseudotamarii (152 words) [view diff] exact match in snippet view article find links to article
The species was first described in 2001. It has been shown to produce aflatoxin B1, aflatoxin B2, cyclopiazonic acid, and kojic acid. A. pseudotamarii hasIntercalation (biochemistry) (751 words) [view diff] exact match in snippet view article
often carcinogenic, such as the exo (but not the endo) 8,9 epoxide of aflatoxin B1 and acridines such as proflavine or quinacrine. Intercalation as a mechanismAspergillus miraensis (199 words) [view diff] exact match in snippet view article find links to article
var. stenophyllum, in Tibet, China. It has been reported to produce aflatoxin B1. A. miraensis has been cultivated on both Czapek yeast extract agar (CYA)Olumbe Bassir (1,222 words) [view diff] exact match in snippet view article find links to article
content of fresh leaves and wilted leaves. 1970 - Oxidative metabolism of aflatoxin B1 by mammalian liver slices and microsomes. 1979 - The uncoupling effectGeorge Tawia Odamtten (1,391 words) [view diff] exact match in snippet view article find links to article
Link NRRL 5906, 1980; (contrib.) IFFIT Report No. 13 – Production of Aflatoxin B1 by Aspergillus Flavus Link in Submerged Static Culture After Combination2013 European aflatoxin contamination (646 words) [view diff] exact match in snippet view article find links to article
Alert System for Food and Feed (RASFF) has reported 10 notifications of aflatoxin B1 in maize of European origin since the last maize harvest in autumn 2012Bioenhancer (2,375 words) [view diff] exact match in snippet view article find links to article
drugs such as phenytoin, theophylline, propanolol and a toxin called aflatoxin B1. Increased Bioavailabiity means increased levels of drug in the bloodCopra (1,457 words) [view diff] exact match in snippet view article find links to article
December 2019. Tosun, Halil; Arslan, Recep (2013). "Determination of Aflatoxin B1 Levels in Organic Spices and Herbs". The Scientific World Journal. 2013:Mycobacterium fluoranthenivorans (95 words) [view diff] exact match in snippet view article find links to article
2004. Mycobacterium fluoranthenivorans sp. nov., a fluoranthene and aflatoxin B1 degrading bacterium from contaminated soil of a former coal gas plantAldo-keto reductase family 1, member A1 (1,630 words) [view diff] exact match in snippet view article find links to article
differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 familyCellulosimicrobium funkei (257 words) [view diff] exact match in snippet view article find links to article
novel strain of Cellulosimicrobium funkei can biologically detoxify aflatoxin B1 in ducklings". Microbial Biotechnology. 8 (3): 490–498. doi:10.1111/1751-7915AKR7A3 (118 words) [view diff] exact match in snippet view article find links to article
overview of all the structure information available in the PDB for Human Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) This article incorporates text fromAKR1C1 (1,146 words) [view diff] exact match in snippet view article find links to article
differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 familyAlbert P. Li (1,512 words) [view diff] exact match in snippet view article find links to article
metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1. Chem Biol Interact. 179(1), 4–8. Li, A. P. and Doshi U. (2011) HigherMycotoxicology (2,586 words) [view diff] exact match in snippet view article find links to article
relative chromatographic mobility during thin-layer chromatography. Aflatoxin B1 is the most potent natural carcinogen known and is usually the majorEbenezer Olatunde Farombi (625 words) [view diff] exact match in snippet view article find links to article
nontarget Nauphoeta cinerea nymphs Cellular and molecular mechanisms of aflatoxin B1-mediated neurotoxicity: The therapeutic role of natural bioactive compoundsSugarcane juice (1,373 words) [view diff] exact match in snippet view article find links to article
Egypt may pose health risks due to contamination with the mycotoxins, aflatoxin B1 and fumonisin B1. Sugarcane juice, known locally as caldo de cana, isMedian lethal dose (3,860 words) [view diff] exact match in snippet view article find links to article
Meister Pub Co. p. 664. ISBN 978-1892829269. "Safety (MSDS) data for aflatoxin B1". ox.ac.uk. Archived from the original on 2010-08-11. Voelz GL, BuicanT. A. Venkitasubramanian (904 words) [view diff] exact match in snippet view article find links to article
A.; Raj H. G. (November 1986). "Changes in liver polyamines due to aflatoxin B1". Toxicol Lett. 34 (1): 1–4. doi:10.1016/0378-4274(86)90138-4. PMID 3097877Finrozole (49 words) [view diff] exact match in snippet view article find links to article
Huuskonen, P; Myllynen, P; Storvik, M; Pasanen, M (2013). "The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells". ToxicologyButylated hydroxytoluene (2,934 words) [view diff] exact match in snippet view article find links to article
Egner, PA; Trush, MA; Bueding, E; Groopman, JD (1985). "Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquinCYP2A6 (1,131 words) [view diff] exact match in snippet view article find links to article
Inhibitors Inducers Many Carcinogens MNAN NNK NDEA MTBE Other toxins aflatoxin B1 (mycotoxin) 1,3-butadiene (in synthetic rubber) coumarin (anticoagulantSterigmatocystin 8-O-methyltransferase (181 words) [view diff] exact match in snippet view article find links to article
LS, Hill RA (1987). "Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus". Appl. Environ. MicrobiolPhytoalexin (1,762 words) [view diff] exact match in snippet view article find links to article
phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1". Cancer Lett. 59 (2): 89–94. doi:10.1016/0304-3835(91)90171-D. PMID 1909211National Institute of Molecular Biology and Biotechnology (866 words) [view diff] exact match in snippet view article find links to article
The laboratory can determine the concentrations of the mycotoxins, aflatoxin B1 and M1, ochratoxin A, zearalenone, fumonisin and red tide toxins to asABCC1 (1,849 words) [view diff] exact match in snippet view article find links to article
transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfateCadmium-free quantum dot (2,947 words) [view diff] exact match in snippet view article find links to article
is the detection of food toxins including the harmful toxin, aflatoxin- B1. Aflatoxin B1 is a very toxic compound that can cause serious and permanentRhizopus oligosporus (1,106 words) [view diff] exact match in snippet view article find links to article
growth of Aspergillus flavus and A. parasiticus and accumulation of aflatoxin B1 in groundnut". Mycological Research. 93 (4): 518–523. doi:10.1016/s0953-7562(89)80046-2AKR1B1 (1,831 words) [view diff] exact match in snippet view article find links to article
differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 familyRibosomal protein SA (2,584 words) [view diff] exact match in snippet view article find links to article
in vitro. RPSA is also a receptor for small molecules. (i) RPSA binds aflatoxin B1 both in vivo and in vitro. (ii) RPSA is a receptor for epigallocatechin-gallateCYP1A2 (2,819 words) [view diff] exact match in snippet view article find links to article
intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and paracetamol (acetaminophen). The transcript from this gene containsSimplified molecular-input line-entry system (3,619 words) [view diff] exact match in snippet view article find links to article
CC1=C(C(=O)C[C@@H]1OC(=O)[C@@H]2[C@H](C2(C)C)/C=C(\C)/C(=O)OC)C/C=C\C=C Aflatoxin B1 (C17H12O6) O1C=C[C@H]([C@H]1O2)c3c2cc(OC)c4c3OC(=O)C5=C4CCC(=O)5 GlucoseAspergillus flavus (2,829 words) [view diff] exact match in snippet view article find links to article
of the major toxins is a result of particular strains of A. flavus. Aflatoxin B1 is the most toxic and potent hepatocarcinogenic natural compound characterizedMycotoxin (4,507 words) [view diff] exact match in snippet view article find links to article
different types of mycotoxins produced, which are B1, B2, G1, and G2. Aflatoxin B1, the most toxic, is a potent carcinogen and has been directly correlatedCarcinogen (4,566 words) [view diff] exact match in snippet view article find links to article
causes cancer as a "myth". Several biologic agents are known carcinogens. Aflatoxin B1, a toxin produced by the fungus Aspergillus flavus which is a commonEliezer Huberman (1,567 words) [view diff] exact match in snippet view article find links to article
Huberman, Eliezer (1978). "Cell specificity in metabolic activation of aflatoxin B1 and benzo(a)pyrene to mutagens for mammalian cells". Nature. 276 (5685):Economic botany (3,275 words) [view diff] exact match in snippet view article find links to article
Liver Histopathology and Aflatoxin Residues in Broilers Exposed to Aflatoxin B1". Toxins. 9 (11): 371. doi:10.3390/toxins9110371. PMC 5705986. PMID 29140290Citrinin (4,175 words) [view diff] exact match in snippet view article find links to article
Citrinin often occurs together with other mycotoxins like ochratoxin A or aflatoxin B1, because they are produced by the same fungi species. The combinationCytochrome P450 (individual enzymes) (4,495 words) [view diff] exact match in snippet view article
in terms of their kinetic properties as well as in the metabolism of aflatoxin B1. CYPs have also been extensively studied in insects, often to understandNeosaxitoxin (5,241 words) [view diff] exact match in snippet view article find links to article
Gabliks J, Barter S (April–September 1987). "Comparative cytotoxicity of aflatoxin B1 and saxitoxin in cell cultures". Molecular Toxicology. 1 (2–3): 209–16Liver cancer (6,092 words) [view diff] exact match in snippet view article find links to article
S2CID 20842446. Dai Y, Huang K, Zhang B, Zhu L, Xu W (November 2017). "Aflatoxin B1-induced epigenetic alterations: An overview". Food and Chemical ToxicologyAlmond (6,803 words) [view diff] exact match in snippet view article find links to article
Retrieved 23 August 2012. Rushing, Blake R.; Selim, Mustafa I. (2019). "Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposureC3orf62 (1,233 words) [view diff] exact match in snippet view article find links to article
MFRAP1). Chemicals known to interact with C3orf62 include the following: Aflatoxin B1, Hydralazine, Valproic acid, and Decitabine. Interstitial deletions ofPeanut (7,604 words) [view diff] exact match in snippet view article find links to article
ISBN 978-1-84826-368-0. Hirano, S; Shima, T; Shimada, T (August 2001). "[Proportion of aflatoxin B1 contaminated kernels and its concentration in imported peanut samples]"CYP3A4 (7,730 words) [view diff] exact match in snippet view article find links to article
increases when in the presence of CYP3A4 ligands, such as in the presence of aflatoxin B1, M1, and G1. Indeed, due to the enzyme's large and malleable active siteFoodborne illness (7,508 words) [view diff] exact match in snippet view article find links to article
pronounced forms of aflatoxins are those of B1, B2, G1, and G2, amongst which Aflatoxin B1 predominantly targets the liver, which will result in necrosis, cirrhosisConocephalum (3,491 words) [view diff] exact match in snippet view article find links to article
Chemical structure of aflatoxin B1 found in Aspergillus fungiEPHX1 (2,998 words) [view diff] exact match in snippet view article find links to article
associated with genetic variation in the enzymatic detoxification of aflatoxin B1". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2384–7. Bibcode:1995PNAS...92GNMT (3,150 words) [view diff] exact match in snippet view article find links to article
(March 2009). "Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect". Toxicology and Applied PharmacologyCurtis C. Harris (2,466 words) [view diff] exact match in snippet view article find links to article
the first-known molecular link between an environmental carcinogen, aflatoxin B1, and a specific mutation at codon 249 of the p53-encoding TP53 gene inMold health issues (10,998 words) [view diff] exact match in snippet view article find links to article
Mycotoxins may also contribute to cancer. Dietary exposure to the mycotoxin aflatoxin B1, commonly produced by growth of the fungus Aspergillus flavus on improperlyWilliam A. Haseltine (12,570 words) [view diff] exact match in snippet view article find links to article
PMID 80799. D'Andrea, AD; Haseltine WA (1978). "Modification of DNA by Aflatoxin B1 Creates Alkali-Labile Lesions in DNA at Positions of Guanine and Adenine"Precision cut tissue slices (2,869 words) [view diff] exact match in snippet view article find links to article
paracetamol-induced liver necrosis and the toxicities of various compounds, including aflatoxin B1, endotoxin, cocaine, and paraquat. Additionally, liver slices have been