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searching for Bcl-2 family 65 found (105 total)

Phorbol-12-myristate-13-acetate-induced protein 1 (1,311 words) [view diff] exact match in snippet view article find links to article

(Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic

VDAC1 (4,079 words) [view diff] exact match in snippet view article find links to article

been observed to interact with pro- or antiapoptotic proteins, such as Bcl-2 family proteins and kinases, and so may contribute to apoptosis independently

P53 upregulated modulator of apoptosis (3,387 words) [view diff] exact match in snippet view article find links to article

post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis

BCL2-related protein A1 (1,410 words) [view diff] exact match in snippet view article find links to article

Wang K, Boise LH, Thompson CB, Korsmeyer SJ (Aug 15, 1995). "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax". Proc. Natl. Acad

BNIP3 (2,672 words) [view diff] exact match in snippet view article find links to article

cell death while also assisting with cell survival. Like many of the Bcl-2 family proteins, BNIP3 modulates the permeability state of the outer mitochondrial

BCL2L12 (696 words) [view diff] exact match in snippet view article find links to article

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic

HRK (gene) (971 words) [view diff] exact match in snippet view article

Staddon JM (Nov 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Anal. Biochem. 322 (2): 170–8. doi:10.1016/j.ab.2003.07.014

Germinal center B-cell like diffuse large B-cell lymphoma (2,442 words) [view diff] no match in snippet view article find links to article

cancer cells to radiation and cytotoxic agents. B-cell lymphoma-2 (Bcl-2) family members create a balance between pro and anti-apoptotic proteins. Pro-apoptotic

BCL2L14 (676 words) [view diff] exact match in snippet view article find links to article

Godzik A, Reed JC (May 2001). "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family". J Biol Chem. 276 (4): 2780–5. doi:10.1074/jbc.M005889200. PMID 11054413

Bcl-2-interacting killer (1,379 words) [view diff] exact match in snippet view article find links to article

a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins"

Forskolin (907 words) [view diff] exact match in snippet view article find links to article

cancer BGC823 cells through caspase activation involving regulation of Bcl-2 family gene expression, dissipation of mitochondrial membrane potential and

Mir-29 microRNA precursor (949 words) [view diff] exact match in snippet view article find links to article

cell differentiation protein (MCL1), an anti-apoptotic member of the Bcl-2 family of proteins. The TCL1A (T cell leukemia/lymphoma 1) oncogene, found to

Protein kinase B (3,754 words) [view diff] exact match in snippet view article find links to article

binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins, master lysosomal regulator TFEB and murine double minute 2

Sanford Burnham Prebys Medical Discovery Institute (2,507 words) [view diff] exact match in snippet view article find links to article

unknown pro- and anti-apoptotic proteins, namely caspases, IAPs, and Bcl-2 family members. The demonstration by Institute scientists that cells deprived

Calpain-2 catalytic subunit (1,088 words) [view diff] exact match in snippet view article find links to article

"Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members". J. Biol. Chem. 277 (30): 27217–26. doi:10.1074/jbc.M202945200

DYNLL1 (1,545 words) [view diff] exact match in snippet view article find links to article

LA, King SM, Strasser A (Mar 1999). "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex"

MELK (977 words) [view diff] exact match in snippet view article find links to article

carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family". Breast Cancer Research. 9 (1): R17. doi:10.1186/bcr1650. PMC 1851384

Apoptosome (3,908 words) [view diff] exact match in snippet view article find links to article

Apoptosome was first introduced in Yoshihide Tsujimoto's 1998 paper "Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?". However, the Apoptosome

Richard Youle (614 words) [view diff] exact match in snippet view article find links to article

onto the mitochondria. But his group also found that members of the Bcl-2 family play a role in regulating the morphogenesis of mitochondria, which form

Voltage-dependent anion channel (1,701 words) [view diff] exact match in snippet view article find links to article

PMC 1134768. PMID 15456403. Shimizu S; Narita M; Tsujimoto Y. (1999). "Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial

Patriarch hypothesis (1,237 words) [view diff] exact match in snippet view article find links to article

atresia. Future analysis of the differential expression of genes of the bcl-2 family may hold the key. Longevity is a central determinant of the grandmother

Adenovirus E1B protein (952 words) [view diff] exact match in snippet view article find links to article

PMID 12368257. Cory, Suzanne; Huang, David; Adams, Jerry (2003). "The Bcl-2 family: roles in cell survival and oncogenesis". Oncogene. 22 (53): 8590–8607

Howel–Evans syndrome (1,558 words) [view diff] no match in snippet view article find links to article

Bcl-2-interacting killer (BIK) – a proapoptotic member of the B cell lymphoma 2 (Bcl-2) family. These proteins may also have a role in diabetes. The differential diagnosis

Peter Colman (1,299 words) [view diff] case mismatch in snippet view article find links to article

Colman on YouTube Lessene, G.; Czabotar, P. E.; Colman, P. M. (2008). "BCL-2 family antagonists for cancer therapy". Nature Reviews Drug Discovery. 7 (12):

Protectin D1 (2,846 words) [view diff] exact match in snippet view article find links to article

addition, PD1 has an important role in regulating the expression of the Bcl-2 family proteins (Bcl-2, Bcl-xL, Bax and Bad) that precedes the release of the

Mitochondrial apoptosis-induced channel (498 words) [view diff] case mismatch in snippet view article find links to article

"Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins". Biochim Biophys Acta. 1762 (2): 191–201. doi:10.1016/j.bbadis

VDAC3 (2,552 words) [view diff] exact match in snippet view article find links to article

been observed to interact with pro- or antiapoptotic proteins, such as Bcl-2 family proteins and kinases, and so may contribute to apoptosis independently

VDAC2 (2,653 words) [view diff] exact match in snippet view article find links to article

been observed to interact with pro- or antiapoptotic proteins, such as Bcl-2 family proteins and kinases, and so may contribute to apoptosis independently

Paraptosis (2,767 words) [view diff] exact match in snippet view article find links to article

p53, BAF), x-chromosome-linked inhibitor (xiap), and Bcl-xL( from the Bcl-2 family) did not prevent cell death in 293T cells when induced by IGFIR-IC. Therefore

Cell division (4,256 words) [view diff] exact match in snippet view article find links to article

protein that rapidly induces apoptosis by inhibiting the anti-apoptotic Bcl-2 family members. Multicellular organisms replace worn-out cells through cell

Gliotoxin (3,112 words) [view diff] exact match in snippet view article find links to article

residues in the cell membrane. Gliotoxin also activates a member of the Bcl-2 family called Bak in order to mediate cell apoptosis. Activated Bak then causes

Suzanne Cory (1,224 words) [view diff] exact match in snippet view article find links to article

Suzanne; Huang, David C. S.; Adams, Jerry M. (1 January 2003). "The Bcl-2 family: roles in cell survival and oncogenesis". Oncogene. 22 (53): 8590–8607

BECN1 (1,482 words) [view diff] exact match in snippet view article find links to article

Adi-Harel S, et al. (2007). "Differential interactions between Beclin 1 and Bcl-2 family members". Autophagy. 3 (6): 561–8. doi:10.4161/auto.4713. PMID 17643073

Venus flytrap (6,947 words) [view diff] exact match in snippet view article find links to article

is known to induce apoptosis, associated with the regulation of the Bcl-2 family of proteins. When the Dionaea extracts were pre-incubated with diaphorases

BMF (gene) (834 words) [view diff] exact match in snippet view article

et al. (2007). "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas". Tumori

Akt/PKB signaling pathway (4,116 words) [view diff] exact match in snippet view article find links to article

by direct phosphorylation. For example, phosphorylation of BAD, the Bcl-2 family member, on Ser136 causes translocation from the mitochondrial membrane

GroES (4,104 words) [view diff] exact match in snippet view article find links to article

Samsamshariat A, Mestril R, Wang PH (2003). "Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac

COX5A (988 words) [view diff] exact match in snippet view article find links to article

interacts specifically with Bcl-2, but not with other members of the Bcl-2 family, such as Bcl-xL, Bax or Bak. The Trans-activator of transcription protein

University of Konstanz (4,404 words) [view diff] exact match in snippet view article find links to article

and Physical Health (Risk Dynamics – FOR 2374) New Insights into the Bcl-2 family interactions – from biophysics to function (FOR 2036) Nonlinear response

Mitochondrial fusion (2,367 words) [view diff] exact match in snippet view article find links to article

addition, Mfn2 specifically has been shown to associate with Bax and Bak (Bcl-2 family, TC#1.A.21), resulting in altered Mfn2 activity, indicating that the

BCL2L13 (1,345 words) [view diff] exact match in snippet view article find links to article

exact mechanisms remain to be elucidated. Bcl-rambo is a member of the Bcl-2 family of proteins that regulate apoptosis. In cells, Bcl-rambo is localized

Cyclin-dependent kinase 5 (5,356 words) [view diff] case mismatch in snippet view article find links to article

by cyclin I, this regulator causes an increase in the expression of BCl-2 family proteins, which are associated with anti-apoptotic functions. The chemical

Methaneseleninic acid (1,092 words) [view diff] no match in snippet view article find links to article

acid shows promise as a sensitizing agent for apoptosis induced by the Bcl-2-family inhibitor ABT-737 in several cancer lines, and that methaneseleninic

GHITM (1,219 words) [view diff] exact match in snippet view article find links to article

may be involved in tumor metastasis through its interactions with the Bcl-2 family proteins to regulate apoptosis. Its role as an apoptotic regulator may

MiR-125 (2,239 words) [view diff] exact match in snippet view article find links to article

transcripts of genes such as transcription factors, matrix-metalloproteinases, Bcl-2 family gene members, small GTPases, miR-125 dysregulation may lead to abnormal

Craig B. Thompson (2,348 words) [view diff] exact match in snippet view article find links to article

Thompson, CB (December 2000). "The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple

Peripheral membrane protein (4,391 words) [view diff] exact match in snippet view article find links to article

many types of smooth muscle. Apoptosis regulators Bcl-2 Members of the Bcl-2 family govern mitochondrial outer membrane permeability. Bcl-2 itself suppresses

Lipoarabinomannan (2,663 words) [view diff] exact match in snippet view article find links to article

Activation of a PI3K pathway is sufficient to trigger phosphorylation of the Bcl-2 family member Bad by ManLAM. ManLAM is able to activate the serine/threonine

Said Sebti (927 words) [view diff] exact match in snippet view article find links to article

selective STAT3 signaling pathway inhibitor. Bcl/Mcl. The MCL1 member of the Bcl-2 family interests Sebti due to its role in preventing apoptosis. The Sebti lab

Primary pigmented nodular adrenocortical disease (1,578 words) [view diff] exact match in snippet view article find links to article

Ekert, P; Strasser, A; Puthalakath, H (2014). "Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice". Cell Death and Differentiation

Stapled peptide (1,723 words) [view diff] case mismatch in snippet view article find links to article

these peptides were taken up by cancer cells and bound their physiologic BCL-2 family targets, which correlated with the induction of cell death. It was discovered

C-Raf (8,674 words) [view diff] case mismatch in snippet view article find links to article

Aime-Sempe C, Takayama S, Wang HG (1996). "Structure—Function Analysis of BCL-2 Family Proteins". Mechanisms of Lymphocyte Activation and Immune Regulation

Ivo Meinhold-Heerlein (1,193 words) [view diff] exact match in snippet view article find links to article

Kallioniemi, H. Kim, G. Reifenberger, S. Krajewski, J. C. Reed: Expression of Bcl-2 family member Bid in normal and malignant tissues. In: Neoplasia. 4, Nr. 2,

Druggability (1,988 words) [view diff] case mismatch in snippet view article find links to article

drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members". Clinical Cancer Research. 13 (24): 7264–7270. doi:10.1158/1078-0432

Diffuse large B-cell lymphoma (8,143 words) [view diff] case mismatch in snippet view article find links to article

acquired resistance due to the expression of other major anti-apoptotic BCL-2 family proteins like BCL-XL and MCL-1. Combined therapy using MCL-1 inhibitor

Sexually dimorphic nucleus (3,363 words) [view diff] case mismatch in snippet view article find links to article

Tsukahara S, Kakeyama M, Toyofuku Y (2006). "Sex Differences in the level of Bcl-2 Family Proteins and Caspase-3 Activation in the Sexually Dimorphic Nuclei of

Laura Niedernhofer (1,677 words) [view diff] case mismatch in snippet view article find links to article

"Identification of a novel senolytic agent, navitoclax, targeting the BCL-2 family of anti-apoptotic factors". Aging Cell. 15 (3): 428–435. doi:10.1111/acel

Kevin A. Roth (809 words) [view diff] exact match in snippet view article find links to article

Jan 27. PMID: 20406898; PMCID: PMC2940627 Akhtar RS, Ness JM, Roth KA. Bcl-2 family regulation of neuronal development and neurodegeneration. Biochim Biophys

Senescence-associated secretory phenotype (4,073 words) [view diff] case mismatch in snippet view article find links to article

nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors". Nutrition. 65: 33–38. doi:10.1016/j.nut.2019.01.020. PMID 31029919

AI-10-49 (2,849 words) [view diff] exact match in snippet view article find links to article

Armstrong RC, Augeri DJ, Belli BA, et al. (June 2005). "An inhibitor of Bcl-2 family proteins induces regression of solid tumours". Nature. 435 (7042): 677–681

RAD9A (3,997 words) [view diff] exact match in snippet view article find links to article

Also located in the N-terminal, the BH3 motif is crucial for binding to Bcl-2 family proteins in the mitochondria to induce apoptosis. Finally, 3-5' exonuclease

Tafazzin (6,744 words) [view diff] exact match in snippet view article find links to article

and other machinery involved with its interactions with members of the Bcl-2 family, caspases, Bid, Bax, and Bak. Mutations in the TAFAZZIN gene have been

Jonathan C. Kagan (3,468 words) [view diff] case mismatch in snippet view article find links to article

to gasdermin E (GSDME)-dependent pyroptosis and release of IL-1α. The BCL-2 family members MCL-1 and BCL-xL were identified as the pyroptosis-inducing guards

Kidney ischemia (4,566 words) [view diff] exact match in snippet view article find links to article

dependent on mitochondrial signaling pathways which are regulated by the Bcl-2 family of proteins. Activation of Bcl-2 proteins such as Bax and Bak triggers

Ultrasensitivity (8,818 words) [view diff] exact match in snippet view article find links to article

model also showed similar but different positive feedback controls in Bcl-2 family proteins in apoptotic process. Recently, Jeyeraman et al. have proposed