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searching for CYP2C8 15 found (83 total)

alternate case: cYP2C8

Cerivastatin (1,690 words) [view diff] exact match in snippet view article find links to article

enzymes CYP2C8 and CYP3A4, which generates a metabolite that is known as M-1 in the cerivastatin metabolite pathway. Hydroxylation is catalysed by CYP2C8, which

Aconitine (3,598 words) [view diff] exact match in snippet view article find links to article

indicate that aconitine was mainly metabolized by CYP3A4, 3A5 and 2D6. CYP2C8 and 2C9 had a minor role to the aconitine metabolism, whereas CYP1A2, 2E1

Cabazitaxel (947 words) [view diff] exact match in snippet view article find links to article

Cabazitaxel is metabolized in the liver by [cytochrome P450 (CYP)3A4/5 > CYP2C8], which result in seven plasma metabolites and excreted 20 metabolites.

Rifapentine (961 words) [view diff] exact match in snippet view article find links to article

includes rifampicin and rifabutin. Rifapentine induces metabolism by CYP3A4, CYP2C8 and CYP2C9 enzymes. It may be necessary to adjust the dosage of drugs metabolized

Repaglinide (990 words) [view diff] exact match in snippet view article find links to article

lead to hypoglycemia. Co-administration of repaglinide and clopidogrel (a CYP2C8 inhibitor) may lead to a significant decrease in blood glucose levels due

Dasabuvir (1,119 words) [view diff] exact match in snippet view article find links to article

(Hypercium perforatum). They are also taking medications that are strong CYP2C8 inhibitors (gemfibrozil). They meet contraindication criteria for ombitasivir

UGT2B7 (3,244 words) [view diff] exact match in snippet view article find links to article

Dekker SJ, Vermeulen NP, Commandeur JN (March 2018). "Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism". Toxicology Letters. 284: 70–78

Pioglitazone (2,518 words) [view diff] exact match in snippet view article find links to article

℞ (Prescription only) Pharmacokinetic data Protein binding >99% Metabolism Liver (CYP2C8) Elimination half-life 3–7 hours Excretion Bile duct Identifiers IUPAC name

WHO Drug Dictionary (516 words) [view diff] exact match in snippet view article find links to article

also defined based on interaction, for example, drugs interacting with CYP2C8 or drugs interacting with UGT. R,Lee Lindquist M. Vigibase, the WHO Global

Chloroquine (5,892 words) [view diff] exact match in snippet view article find links to article

et al. (June 2003). "In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine

5-HT3 antagonist (4,628 words) [view diff] exact match in snippet view article find links to article

μg/kg Vortioxetine (Trintellix) Indole 5-HT3 receptor antagonist Antidepressant 66h CYP 2D6/ 2A6/CYP2B6/CYP2C8/9, CYP2C19 5 mg, 10 mg, 20 mg doses

Eicosanoid (9,517 words) [view diff] exact match in snippet view article find links to article

reaction. The human cytochrome P450 (CYP) epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize arachidonic

Hugo Barrera Saldaña (1,107 words) [view diff] exact match in snippet view article find links to article

506(7488). Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast cancer. Pharmacogenomics

Collen Masimirembwa (806 words) [view diff] exact match in snippet view article find links to article

"Amodiaquine Clearance and Its Metabolism toN-Desethylamodiaquine Is Mediated by CYP2C8: A New High Affinity and Turnover Enzyme-Specific Probe Substrate". Journal

Hugo Zeberg (1,612 words) [view diff] exact match in snippet view article find links to article

Magnus; Pääbo, Svante; Zeberg, Hugo (July 30, 2022). "The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals". The Pharmacogenomics