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Longer titles found: Bioavailability (soil) (view)

searching for Bioavailability 103 found (2326 total)

Analgesic (5,952 words) [view diff] exact match in snippet view article find links to article

Bondesson U, Boréus LO, Hartvig P (1982). "Single-dose kinetics and bioavailability of ketobemidone". Acta Anaesthesiologica Scandinavica. Supplementum

Coenzyme Q10 (4,852 words) [view diff] exact match in snippet view article find links to article

absorbed, there is a concern about CoQ10 bioavailability when it is taken as a dietary supplement. Bioavailability of CoQ10 supplements may be reduced due

AC-90179 (196 words) [view diff] exact match in snippet view article find links to article

antipsychotic but was not pursued for medical applications due to poor oral bioavailability; however, it continues to be used as a tool compound in pharmacological

Naringenin (1,229 words) [view diff] exact match in snippet view article find links to article

dietary naringenin is generally regarded as safe, mainly due to its low bioavailability. Taking dietary supplements or consuming grapefruit excessively may

Epigallocatechin gallate (1,197 words) [view diff] exact match in snippet view article find links to article

A; Rémésy, C (January 2005). "Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies". The American Journal

Prajmaline (827 words) [view diff] exact match in snippet view article find links to article

Prajmaline is a semi-synthetic propyl derivative of ajmaline, with a higher bioavailability than its predecessor. It acts to stop arrhythmias of the heart through

Midaflur (140 words) [view diff] exact match in snippet view article find links to article

humans and other species of mammals, exhibiting consistently high oral bioavailability and a long duration of action. While its pharmacodynamics remain poorly

PD-0298029 (160 words) [view diff] exact match in snippet view article find links to article

It was developed for the treatment of Parkinson's disease, but poor bioavailability and rapid metabolism in animal studies have meant its use is largely

ABT-724 (358 words) [view diff] exact match in snippet view article find links to article

drug for the treatment of erectile dysfunction, although poor oral bioavailability means alternative drugs such as ABT-670 may be more likely to be developed

Latent TGF-beta binding protein (171 words) [view diff] exact match in snippet view article find links to article

matrix proteins and may play a role in the regulation of TGF beta bioavailability. Rifkin DB (March 2005). "Latent transforming growth factor-beta (TGF-beta)

A-86929 (555 words) [view diff] exact match in snippet view article find links to article

its diacetate ester prodrug adrogolide (ABT-431), which has better bioavailability. Michaelides MR, Hong Y, DiDomenico S, Asin KE, Britton DR, Lin CW

WAY-317538 (201 words) [view diff] exact match in snippet view article find links to article

ease of synthesis, and good in vivo properties including high oral bioavailability and good brain penetration. It has nootropic and neuroprotective effects

Glucosamine (3,421 words) [view diff] exact match in snippet view article find links to article

guiding treatment of horses. A number of studies have measured the bioavailability of glucosamine after oral administration to horses. When given as a

PHA-543,613 (471 words) [view diff] exact match in snippet view article find links to article

acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits

Ubiquinol (622 words) [view diff] exact match in snippet view article find links to article

molecule and may be a significant factor behind the observed enhanced bioavailability of ubiquinol. Varying amounts of ubiquinol are found in different types

BHFF (98 words) [view diff] exact match in snippet view article find links to article

receptor. It has anxiolytic effects in animal studies, and good oral bioavailability. Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner

LGD-3303 (203 words) [view diff] exact match in snippet view article find links to article

as a selective androgen receptor modulator (SARM), with good oral bioavailability. It is a selective agonist for the androgen receptor, producing functional

LGD-3303 (203 words) [view diff] exact match in snippet view article find links to article

as a selective androgen receptor modulator (SARM), with good oral bioavailability. It is a selective agonist for the androgen receptor, producing functional

CTEP (155 words) [view diff] exact match in snippet view article find links to article

targets tested. In animal studies it was found to have a high oral bioavailability and a long duration of action, lasting 18 hours after a single dose

DR-4485 (133 words) [view diff] exact match in snippet view article find links to article

potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability. It has been used to research the function of this still comparatively

Self-microemulsifying drug delivery system (3,176 words) [view diff] exact match in snippet view article find links to article

marketed as a SMEDDS was cyclosporin, and it had significantly improved bioavailability compared with the conventional solution. In the last decade, several

Metopon (565 words) [view diff] exact match in snippet view article find links to article

longer acting than hydromorphone, metopon is less potent and its oral bioavailability is fairly low. Generally, metopon has few advantages to distinguish

Insulin glulisine (471 words) [view diff] no match in snippet view article find links to article

Insulin glulisine is a rapid-acting modified form of medical insulin that differs from human insulin in that the amino acid asparagine at position B3 is

Perzinfotel (340 words) [view diff] exact match in snippet view article find links to article

drug has been discontinued. Prodrugs were developed since the oral bioavailability of perzinfotel is only around 3-5%. Kinney WA, Abou-Gharbia M, Garrison

S-40503 (574 words) [view diff] exact match in snippet view article find links to article

similar bone anabolic effects, but longer in vivo half-life and better bioavailability. Selective androgen receptor modulators may also be used by athletes

LY-341495 (1,011 words) [view diff] exact match in snippet view article find links to article

affinity, and making a prodrug from this with the heptyl ester increases bioavailability still further. CECXG Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH

Imipenem/cilastatin (1,352 words) [view diff] no match in snippet view article find links to article

Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. It

Γ-L-Glutamyl-L-cysteine (1,629 words) [view diff] exact match in snippet view article find links to article

can significantly increase lymphocyte GSH levels indicating systemic bioavailability, validating the therapeutic potential of GGC. Animal model studies

Tedalinab (123 words) [view diff] exact match in snippet view article find links to article

selectivity of 4700x for CB2 over the related CB1 receptor, has good oral bioavailability and has shown promising safety results and effective analgesic and

Homosildenafil (434 words) [view diff] exact match in snippet view article find links to article

the equivalent homosildenafil metabolite reaches 40% of sildenafil's bioavailability. The N-desmethyl metabolite is further metabolized, with a half-life

Ro64-6198 (1,005 words) [view diff] exact match in snippet view article find links to article

especially in relation to anxiety and anorexia; however, due to poor oral bioavailability, Ro 64-6198 will most likely not be pursued clinically. Studies in

SB-271046 (733 words) [view diff] exact match in snippet view article find links to article

SB-271046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood–brain barrier, so

Tangeretin (274 words) [view diff] exact match in snippet view article find links to article

low solubility of Tangeretin is one of the main reasons for the low bioavailability of Tangeretin (and other flavonoids in general), and has been reported

CX717 (1,512 words) [view diff] exact match in snippet view article find links to article

shown to be less than the FDA had concluded. The relatively poor oral bioavailability and blood–brain barrier penetration of CX-717 ultimately led to Cortex

Titanium yellow (164 words) [view diff] exact match in snippet view article find links to article

solubility in water. While it contains antimony and nickel, their bioavailability is very low, so the pigment is relatively safe.[citation needed] The

HZ-2 (207 words) [view diff] exact match in snippet view article find links to article

potency as morphine, with a long duration of action and high oral bioavailability. Side effects include sedation, nausea and dysphoria as well as diuretic

Galeterone (803 words) [view diff] exact match in snippet view article find links to article

biologically inactive metabolites. It is known that galeterone has poor oral bioavailability in rodents. Poor pharmacokinetic properties (oral absorption and metabolic

Wax ester (1,313 words) [view diff] no match in snippet view article find links to article

A wax ester (WE) is an ester of a fatty acid and a fatty alcohol. Wax esters are the main components of three commercially important waxes: carnauba wax

Cefditoren (1,999 words) [view diff] exact match in snippet view article find links to article

against β-lactamases, and a pivoxil ester group that enhances oral bioavailability. The spectrum of cefditoren includes both Gram-positive and Gram-negative

11-Hydroxyhexahydrocannabinol (562 words) [view diff] exact match in snippet view article find links to article

producing a shortened half-life within the body and lowering its bioavailability considerably through first-pass metabolism. The 11-OH-9β-HHC isomer

Endothelial dysfunction (1,860 words) [view diff] exact match in snippet view article find links to article

endothelium. The main cause of endothelial dysfunction is impaired bioavailability of nitric oxide, In addition to acting as a semipermeable membrane

Pomaglumetad (3,035 words) [view diff] exact match in snippet view article find links to article

pomaglumetad methionil) since pomaglumetad exhibits low oral absorption and bioavailability in humans. Early human trials using this prodrug form of pomaglumetad

SB-408124 (158 words) [view diff] exact match in snippet view article find links to article

around 70x selectivity for OX1 over OX2 receptors, and improved oral bioavailability compared to the older OX1 antagonist SB-334867. It is used in scientific

Caftaric acid (416 words) [view diff] exact match in snippet view article find links to article

Echinacea purpurea (Eastern purple coneflower). Caftaric acid has a good bioavailability when fed in rats. Intact trans-caftaric acid was detected in rat plasma

THIQ (379 words) [view diff] exact match in snippet view article find links to article

of sexual dysfunction in humans, although THIQ itself has poor oral bioavailability and a short duration of action so improved analogues will need to be

Diallyl trisulfide (866 words) [view diff] exact match in snippet view article find links to article

activation of the PI3K/Akt pathway, which increases the formation and bioavailability of nitric oxide (NO). This negatively impacts mitochondria functionality

Cyanocobalamin (2,633 words) [view diff] exact match in snippet view article find links to article

for treating vitamin B 12 deficiency because it has slightly lower bioavailability. Some study have shown that it has an antihypotensive effect. Vitamin

L-371,257 (442 words) [view diff] exact match in snippet view article find links to article

first non-peptide oxytocin antagonists developed, and has good oral bioavailability, but poor penetration of the blood–brain barrier, which gives it good

Epelsiban (1,682 words) [view diff] exact match in snippet view article find links to article

human), a good PK profile in the rat with a bioavailability of 55%, oral exposure and bioavailability in the cynomolgus monkey comparable to retosiban

Mitoquinone mesylate (469 words) [view diff] exact match in snippet view article find links to article

developed in New Zealand in the late 1990s. It has significantly improved bioavailability and improved mitochondrial penetration compared to coenzyme Q10, and

Benfotiamine (809 words) [view diff] exact match in snippet view article find links to article

2021). "Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine". International Journal

Mitoquinone mesylate (469 words) [view diff] exact match in snippet view article find links to article

developed in New Zealand in the late 1990s. It has significantly improved bioavailability and improved mitochondrial penetration compared to coenzyme Q10, and

Hydrocortisone acetate (188 words) [view diff] exact match in snippet view article find links to article

and allows it to be absorbed more easily. Hydrocortisone has a lower bioavailability than hydrocortisone acetate when taken orally, because hydrocortisone

Echinocandin (1,900 words) [view diff] exact match in snippet view article find links to article

membrane to facilitate antifungal activity. Due to their limited oral bioavailability, echinocandins are administered through intravenous infusion. Echinocandins

Calcium supplement (4,173 words) [view diff] exact match in snippet view article find links to article

postmenopausal women and when taken with a meal. Calcium citrate showed better bioavailability in some postmenopausal women, possibly due to low gastric acid output

International Union of Pure and Applied Chemistry (2,500 words) [view diff] exact match in snippet view article find links to article

at the Wayback Machine Retrieved 15 April 2010 Metal Speciation and Bioavailability in Aquatic Systems. Series on Analytical and Physical Chemistry of

Calcium citrate malate (170 words) [view diff] exact match in snippet view article find links to article

and malic acid with variable composition. Calcium citrate malate's bioavailability stems from its water-solubility and its method of dissolution. When

Laniquidar (375 words) [view diff] exact match in snippet view article find links to article

myelodysplastic syndrome (MDS). It has been discontinued because of its low bioavailability and a high variability with how the patients responded to the drug

Sodium ascorbate (390 words) [view diff] exact match in snippet view article find links to article

at Sigma-Aldrich Linus Pauling Institute, Oregon State University: "Bioavailability of Different Forms of Vitamin C". Retrieved 2013-09-27. UK Food Standards

Enterolactone (607 words) [view diff] exact match in snippet view article find links to article

1021/jf0629134. PMID 17261017. Clavel, T; Doré, J; Blaut, M (2006). "Bioavailability of lignans in human subjects". Nutrition Research Reviews. 19 (2):

Ergocalciferol (1,969 words) [view diff] exact match in snippet view article find links to article

MF (January 2013). "Photobiology of vitamin D in mushrooms and its bioavailability in humans". Dermato-Endocrinology. 5 (1): 165–176. doi:10.4161/derm

Active metabolite (470 words) [view diff] exact match in snippet view article find links to article

Müller CE (November 2009). "Prodrug approaches for enhancing the bioavailability of drugs with low solubility". Chemistry & Biodiversity. 6 (11): 2071–83

Maltol (453 words) [view diff] exact match in snippet view article find links to article

increase the oral bioavailability of gallium and iron. Maltol's strong metal binding affinity (good iron chelator), high bioavailability, and low toxicity

Zinc chloride hydroxide monohydrate (1,876 words) [view diff] exact match in snippet view article find links to article

the problems with caking. It has been shown that the relative zinc bioavailability for chicks in TBZC is two to three times higher than that in Waselz-processed

Diprafenone (52 words) [view diff] exact match in snippet view article find links to article

Mayer, O; Smith, I; Greenwood, M (1996). "Influence of food on the bioavailability and some pharmacokinetic parameters of diprafenone--a novel antiarrhythmic

OMICS Publishing Group (3,459 words) [view diff] no match in snippet view article find links to article

OMICS Publishing Group is a predatory publisher of open access academic journals. It started publishing its first journal in 2008. By 2015, it claimed

Parthasarathi Chakraborty (1,576 words) [view diff] exact match in snippet view article find links to article

kinetics-based approaches to understand metals speciation and their bioavailability in estuarine/coastal and deep sea systems. His research focuses on

ERDRP-0519 (197 words) [view diff] exact match in snippet view article find links to article

essential for viral replication, and in animal studies showed good oral bioavailability and protected ferrets from otherwise lethal doses of a morbillivirus

Vitamin D deficiency (7,906 words) [view diff] exact match in snippet view article find links to article

Matsuoka LY, Chen TC, Lu Z, Holick MF (September 2000). "Decreased bioavailability of vitamin D in obesity". The American Journal of Clinical Nutrition

Grapefruit–drug interactions (5,674 words) [view diff] exact match in snippet view article find links to article

and pink grapefruit juice, with the white juice acting faster. "The bioavailability of paracetamol was significantly reduced following multiple GFJ administration"

Magnesium citrate (764 words) [view diff] exact match in snippet view article find links to article

Hahn, Andreas (2017). "Intestinal Absorption and Factors Influencing Bioavailability of Magnesium- An Update". Current Nutrition & Food Science. 13 (4):

Alpha-1 blocker (4,243 words) [view diff] exact match in snippet view article find links to article

in combination with a nonlipophilic beta-blocker with more reliable bioavailability (e.g., betaxolol, bisoprolol, atenolol and others) have shown a larger

Vegetarian nutrition (2,253 words) [view diff] exact match in snippet view article find links to article

iron intake for vegetarians is 180% that of nonvegetarians due to the bioavailability of non-heme iron. Although a lower percentage of non-heme iron is absorbed

Tetrahydrobiopterin (2,819 words) [view diff] exact match in snippet view article find links to article

of the endothelial nitric oxide synthase (eNOS) enzyme and reduced bioavailability of the vasodilator nitric oxide occur, creating a form of endothelial

Polar surface area (689 words) [view diff] exact match in snippet view article find links to article

drug candidate's TPSA, scientists can predict its potential for oral bioavailability and ability to reach target sites within the body. This prediction

Hydroxybupropion (1,453 words) [view diff] exact match in snippet view article find links to article

extensive first pass metabolism rendering its systemic bioavailability limited. Exact bioavailability has yet to be determined given an intravenous form does

Manganese deficiency (medicine) (346 words) [view diff] exact match in snippet view article

). ILSI Press. pp. 334–343. ISBN 9780944398722. Kies, C. (1994). "Bioavailability of manganese". In Klimis-Tavantzis, D.L. (ed.). Manganese in health

GSK2606414 (284 words) [view diff] exact match in snippet view article find links to article

found to be a potent and selective inhibitor of PERK, with good oral bioavailability and blood-brain barrier penetration. PERK mediates the unfolded protein

Manganese deficiency (medicine) (346 words) [view diff] exact match in snippet view article

). ILSI Press. pp. 334–343. ISBN 9780944398722. Kies, C. (1994). "Bioavailability of manganese". In Klimis-Tavantzis, D.L. (ed.). Manganese in health

EF-24 (307 words) [view diff] exact match in snippet view article find links to article

anti-cancer properties in vitro but has low potency and very poor bioavailability when taken orally, resulting in limited efficacy. EF-24 was developed

Phloretin (647 words) [view diff] exact match in snippet view article find links to article

Morand, C.; Besson, C.; Manach, C.; Demigné, C.; Rémésy, C. (2001). "Bioavailability of phloretin and phloridzin in rats". The Journal of Nutrition. 131

Tiemonium iodide (63 words) [view diff] exact match in snippet view article find links to article

Scoular IT, Monks A, Burgess C, Turner P (1977). "Human studies on the bioavailability of a quaternary ammonium compounds, tiemonium iodide and tiemonium

Clofezone (99 words) [view diff] exact match in snippet view article find links to article

Lasaroff I, Wessel G (December 1984). "[Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)]"

Oxogestone phenpropionate (972 words) [view diff] exact match in snippet view article find links to article

H (1980). "[Bioavailability of cyproterone acetate after oral and intramuscular application in men (author's transl)]" [Bioavailability of Cyproterone

Generic drug (5,162 words) [view diff] exact match in snippet view article find links to article

also recognizes drugs that use the same ingredients with different bioavailability and divides them into therapeutic equivalence groups. For example,

Dark skin (8,452 words) [view diff] exact match in snippet view article find links to article

to lower presence of vitamin D binding agents (and thus its higher bioavailability) in dark-skinned individuals. The global distribution of generally

Bevirimat (1,677 words) [view diff] exact match in snippet view article find links to article

properties of unformulated bevirimat and its salts include: inadequate bioavailability, poor solubility of the pharmaceutical composition in gastric fluid

Nanoparticle drug delivery (5,293 words) [view diff] exact match in snippet view article find links to article

the bioavailability of the drug, meaning the rate at which the drug reaches the circulatory system and thus the target site. Low bioavailability is most

Dactolisib (596 words) [view diff] exact match in snippet view article find links to article

systemic exposure increased in a dose-proportional manner while oral bioavailability was quite low, which may be related to gastrointestinal-specific toxicity

Calcium glucoheptonate (52 words) [view diff] exact match in snippet view article find links to article

Nguyen PH, Valencia O, Dutta S, Pouteau E (April 2020). "Relative bioavailability and pharmacokinetic comparison of calcium glucoheptonate with calcium

Lanosterol (760 words) [view diff] exact match in snippet view article find links to article

ophthalmic products to prevent cataracts. However, the solubility and bioavailability of lanosterol is not conducive to aqueous formulations. Heliostatix

Lamivudine/zidovudine (1,248 words) [view diff] exact match in snippet view article find links to article

the body and distributes widely into the extravascular space. Oral bioavailability is >80% and overall metabolism is insignificant where approximately

O-Dianisidine (223 words) [view diff] exact match in snippet view article find links to article

(2004). "Carcinogenicity of Azo Colorants: Influence of Solubility and Bioavailability". Toxicology Letters. 151 (1): 203–210. doi:10.1016/j.toxlet.2003.11

Constance Kies (2,372 words) [view diff] exact match in snippet view article find links to article

in 1989, 1990, and 1991. Kies, Constance, ed. (1987). Nutritional Bioavailability of Manganese. Washington, D.C.: American Chemical Society. ISBN 0-8412-1433-6

VNI (molecule) (394 words) [view diff] exact match in snippet view article

survival and no observable side effects. Low cost (<$0.10/mg ), oral bioavailability, favorable pharmacokinetics, and low toxicity make this compound an

Eglumetad (1,791 words) [view diff] exact match in snippet view article find links to article

with several clinical trials completed and more planned. Poor oral bioavailability of the original formulation led to limited efficacy in the initial

Hyperforin (1,728 words) [view diff] exact match in snippet view article find links to article

PMID 15708671. Biber A, Fischer H, Römer A, Chatterjee SS (June 1998). "Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers"

Lynestrenol phenylpropionate (1,175 words) [view diff] exact match in snippet view article find links to article

H (1980). "[Bioavailability of cyproterone acetate after oral and intramuscular application in men (author's transl)]" [Bioavailability of Cyproterone

Helene Benveniste (310 words) [view diff] exact match in snippet view article find links to article

Her work at Stony Brook, integrating PET technology, measured the bioavailability and pharmacokinetics of psychoactive compounds and anesthetic drugs

Structure–activity relationship (528 words) [view diff] exact match in snippet view article find links to article

principles of QSAR and often accounting for the role of sorption (bioavailability) in chemical fate. Combinatorial chemistry Congener Conformation activity

Doxifluridine (527 words) [view diff] exact match in snippet view article find links to article

second-generation nucleoside prodrug. Doxifluridine was designed to improve oral bioavailability in order to avoid dihydropyrimidine dehydrogenase degradation in the

Otilonium bromide (352 words) [view diff] exact match in snippet view article find links to article

Kim JJ, Kim J, Hu SK, Kim HJ, Hong SH, et al. (January 2008). "Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats". Archives

Polyphenol (5,659 words) [view diff] exact match in snippet view article find links to article

C, Rémésy C, Jiménez L (May 2004). "Polyphenols: food sources and bioavailability". The American Journal of Clinical Nutrition. 79 (5): 727–747. doi:10