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Longer titles found: Glycogen synthase kinase-3 beta (view)

searching for Glycogen synthase 163 found (215 total)

(glycogen-synthase-D) phosphatase (132 words) [view diff] no match in snippet view article

[glycogen-synthase-D] phosphatase ({EC 3.1.3.42) catalyzes the reaction [glycogen-synthase D] + H2O ⇌ {\displaystyle \rightleftharpoons } [glycogen-synthase

Tideglusib (559 words) [view diff] exact match in snippet view article find links to article

Tideglusib (NP-12, NP031112) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor. There are few classes of GSK-inhibitors

List of MeSH codes (D12.776.476) (1,240 words) [view diff] no match in snippet view article

The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)

1D-chiro-Inositol (456 words) [view diff] exact match in snippet view article find links to article

insulin signal transduction. DCI accelerates the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, rate limiting enzymes of non-oxidative

Tau-protein kinase (404 words) [view diff] exact match in snippet view article find links to article

O-hosphotransferase, brain protein kinase PK40erk, cdk5/p20, CDK5/p23, glycogen synthase kinase-3beta, GSK, protein tau kinase, STK31, tau kinase, [tau-protein]

SGK3 (1,022 words) [view diff] exact match in snippet view article find links to article

PMID 11707620. S2CID 25927734. Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8):

ILKAP (448 words) [view diff] exact match in snippet view article find links to article

protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway

PRKD3 (1,073 words) [view diff] exact match in snippet view article find links to article

PRKD3 protein kinase D3". Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8):

Proadifen (253 words) [view diff] exact match in snippet view article find links to article

(HT-29 colon adenocarcinoma), believed to be caused by mediation of glycogen synthase kinase 3 β (GSK-3β). In the same study administration of proadifen

Philip Cohen (British biochemist) (1,422 words) [view diff] exact match in snippet view article

following: Glycogen synthase kinase-3 from rabbit skeletal muscle; separation from cyclic AMP-dependent protein kinase and phosphorylase kinase. Glycogen synthase

Hagit Eldar-Finkelman (1,114 words) [view diff] exact match in snippet view article find links to article

well known for her pioneering work on the protein kinase function, glycogen synthase kinase-3 (GSK-3), revealing its contribution to pathological disorders

EIF2B5 (1,096 words) [view diff] exact match in snippet view article find links to article

stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". The Journal of Biological Chemistry. 271 (19): 11410–3

DYRK2 (585 words) [view diff] exact match in snippet view article find links to article

microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase". Biochem. J. 355 (Pt 3): 609–15. doi:10.1042/bj3550609

Glycosome (1,922 words) [view diff] exact match in snippet view article find links to article

glycosomes in the rough and smooth endoplasmic reticulum make use of its glycogen synthase and phosphorylase phosphatases. Glycosomes function in many processes

MARK1 (957 words) [view diff] exact match in snippet view article find links to article

PMID 7706316. Yang SD, Yu JS, Shiah SG, Huang JJ (1994). "Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites

CTP synthetase (1,977 words) [view diff] exact match in snippet view article find links to article

major example of this is phosphorylation of the Ser-571 residue by glycogen synthase kinase 3 (GSK3) in response to low serum conditions. Additionally

Frzb (665 words) [view diff] exact match in snippet view article find links to article

absence of Wnt, β-Catenin is phosphorylated by complex containing GSK3 (glycogen synthase kinase 3) which targets β-Cat for proteosomal degradation. In the

FRAT1 (653 words) [view diff] exact match in snippet view article find links to article

Culbert AA, et al. (2007). "FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A." J

PRKAR2A (2,093 words) [view diff] exact match in snippet view article find links to article

Kikuchi A (Oct 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent

AKAP11 (1,015 words) [view diff] exact match in snippet view article find links to article

Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent

WDR68 (729 words) [view diff] exact match in snippet view article find links to article

AV, Dietrich AD (Jan 2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10

Geoffrey M. Cooper (644 words) [view diff] exact match in snippet view article find links to article

control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3b pathway. Mol. Cell. Biol. 22:578-586. Hartley, D. and Cooper

EIF2B3 (921 words) [view diff] exact match in snippet view article find links to article

stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi:10.1074/jbc.271.19

Cyclin D (4,605 words) [view diff] exact match in snippet view article find links to article

binds to cyclin D- dependent CDKs and inactivates the whole complex. Glycogen synthase kinase three beta, GSK3β, causes Cyclin D degradation by inhibitory

EIF2B1 (1,002 words) [view diff] exact match in snippet view article find links to article

stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi:10.1074/jbc.271.19

EIF2B1 (1,002 words) [view diff] exact match in snippet view article find links to article

stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi:10.1074/jbc.271.19

Restriction point (2,729 words) [view diff] exact match in snippet view article find links to article

addition to other pro-growth and pro-survival functions, Akt inhibits glycogen synthase kinase-3β (GSK3β), thereby preventing GSK3β -mediated phosphorylation

Vanadyl acetylacetonate (468 words) [view diff] exact match in snippet view article find links to article

can stimulate the phosphorylation of protein kinase B (PKB/Akt) and glycogen synthase kinase 3 (GSK-3). It has also been shown inhibit tyrosine phosphatase

DYRK1B (894 words) [view diff] exact match in snippet view article find links to article

Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10

EIF2B2 (1,121 words) [view diff] exact match in snippet view article find links to article

stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–11413. doi:10.1074/jbc.271

Ribosomal s6 kinase (510 words) [view diff] exact match in snippet view article find links to article

proteins. Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion molecule; Son of Sevenless

List of causes of hypoglycemia (1,265 words) [view diff] exact match in snippet view article find links to article

Leucine-induced hypoglycaemia Levomepromazine Liver cancer Liver glycogen synthase deficiency Long-chain hydroxyacyl-CoA dehydrogenase deficiency Malabsorption

NHLRC1 (461 words) [view diff] exact match in snippet view article find links to article

PMID 15930137. Lohi H, Ianzano L, Zhao XC, et al. (2006). "Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy"

Mucin short variant S1 (2,926 words) [view diff] exact match in snippet view article find links to article

Bharti A, Chen D, Gong J, Kufe D (December 1998). "Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin"

Ninein (911 words) [view diff] exact match in snippet view article find links to article

characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta. 1492 (2–3): 513–6. doi:10

CRACD-like protein (1,339 words) [view diff] case mismatch in snippet view article find links to article

miRNA-132, which is depicted in the conceptual translation figure. Glycogen Synthase Kinase 3 Beta (GSK3B) GSK3B is a protein kinase that regulates transcription

PRKCG (526 words) [view diff] exact match in snippet view article find links to article

ISSN 0021-9258. PMID 12471040. Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8):

Cinobufagin (905 words) [view diff] exact match in snippet view article find links to article

Huang G, Wang J, Zou CY, Tan PX, Yong BC, Jia Q, Shen JN (2013). "The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced

PHKG1 (1,036 words) [view diff] exact match in snippet view article find links to article

mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta". J. Neurochem. 74 (4): 1587–95. doi:10.1046/j.1471-4159

Kelch-like protein 1 (398 words) [view diff] exact match in snippet view article find links to article

Jiang S, et al. (2007). "KLHL1/MRP2 mediates neurite outgrowth in a glycogen synthase kinase 3beta-dependent manner". Mol. Cell. Biol. 26 (22): 8371–84

ZCCHC8 (576 words) [view diff] exact match in snippet view article find links to article

Gustafson MP, Welcker M, Hwang HC, Clurman BE (2006). "Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA-binding proteins". Biochem

Casein kinase 1 (4,068 words) [view diff] exact match in snippet view article find links to article

muscle glycogen synthase by cyclic AMP-dependent protein kinase and casein kinase I. Implications for hormonal regulation of glycogen synthase". The Journal

FRAT2 (481 words) [view diff] exact match in snippet view article find links to article

McDonald RP, Johnson GV (2005). "FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results

LRP6 (1,411 words) [view diff] exact match in snippet view article find links to article

low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity". J. Biol. Chem. 281 (8): 4787–94

RPS6KA3 (1,380 words) [view diff] exact match in snippet view article find links to article

Mandelkow E (March 1998). "Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the

EN1 (gene) (1,168 words) [view diff] exact match in snippet view article

beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway". Molecular Biology of the Cell.

ATOH1 (955 words) [view diff] exact match in snippet view article find links to article

(January 2007). "Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer". Gastroenterology. 132 (1): 208–20

PRKCB1 (675 words) [view diff] exact match in snippet view article find links to article

7716516. PMID 7716516. Ali A, Hoeflich KP, Woodgett JR (August 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical Reviews

DPYSL3 (771 words) [view diff] exact match in snippet view article find links to article

differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo". The Journal of Biological Chemistry. 281 (24):

PRKCD (1,096 words) [view diff] exact match in snippet view article find links to article

M301053200. PMID 12807916. Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8):

Beta-secretase 2 (1,586 words) [view diff] exact match in snippet view article find links to article

phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta". Journal of Neurochemistry. 67 (2): 699–707. doi:10

Lipid emulsion (1,502 words) [view diff] exact match in snippet view article find links to article

localized at the mitochondria. The Akt and ERK pathways converge to alter glycogen synthase kinase-3 beta (GSK-3β) activity. Specifically, Akt and ERK phosphorylate

Dario Alessi (737 words) [view diff] exact match in snippet view article find links to article

Cohen, P; Andjelkovich, M; Hemmings, B. A. (1995). "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B". Nature. 378 (6559):

ARHGAP31 (746 words) [view diff] exact match in snippet view article find links to article

PMID 8889548. Danek EI, Tcherkezian J, Triki I, et al. (2007). "Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site"

CDK5R2 (632 words) [view diff] exact match in snippet view article find links to article

"Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry. 133 (2): 165–71

NFATC1 (1,107 words) [view diff] exact match in snippet view article find links to article

P, Crabtree GR (Mar 1997). "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3". Science. 275 (5308): 1930–4. doi:10.1126/science.275.5308

DYRK1A (1,499 words) [view diff] exact match in snippet view article find links to article

Dietrich AD (January 2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10

PPP1R2 (966 words) [view diff] exact match in snippet view article find links to article

"Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry. 133 (2): 165–71

Transmembrane protein 44 (406 words) [view diff] exact match in snippet view article find links to article

are seven predicted transmembrane domains in TMEM44 protein. GSK3B (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with

Christopher E. Rudd (898 words) [view diff] exact match in snippet view article find links to article

pioneered the use of small molecule inhibitors (SMIs) of the kinase glycogen synthase kinase-3 (GSK-3) to down-regulate the inhibitory co-receptor programmed

N2a cell (943 words) [view diff] exact match in snippet view article find links to article

PI3K/Akt pathway. It does so by activating Akt while inactivating glycogen synthase kinase-3β (GSK-3β), an inhibitor of the Akt pathway. Emodin specifically

Major basic protein (1,515 words) [view diff] exact match in snippet view article find links to article

Dedhar S (1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase".

Notch 2 (1,612 words) [view diff] exact match in snippet view article find links to article

Inglés-Esteve J, Aguilera C, Bigas A (August 2003). "Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and

Catenin beta-1 (12,345 words) [view diff] case mismatch in snippet view article find links to article

capable to bind β-TrCP. Phosphorylation of the motif is performed by Glycogen Synthase Kinase 3 alpha and beta (GSK3α and GSK3β). GSK3s are constitutively

Pauline Schaap (504 words) [view diff] exact match in snippet view article find links to article

Morio, Takahiro; Tanaka, Yoshimasa; Schaap, Pauline (9 May 2018). "Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation

CRMP1 (1,024 words) [view diff] case mismatch in snippet view article find links to article

Differential Regulation of Collapsin Response Mediator Proteins by Glycogen Synthase Kinase-3 in Vivo". J. Biol. Chem. 281 (24): 16591–8. doi:10.1074/jbc

BRD7 (1,072 words) [view diff] exact match in snippet view article find links to article

protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta". Cancer Res. 63 (16): 4792–5. PMID 12941796. Ota T

Lithium (medication) (9,543 words) [view diff] exact match in snippet view article

depolarization. Lithium both directly and indirectly inhibits GSK3β (glycogen synthase kinase 3β) which results in the activation of mTOR. This leads to

Protein kinase N1 (1,759 words) [view diff] exact match in snippet view article find links to article

Godemann R, Mandelkow E (1998). "Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the

Dedicator of cytokinesis protein 4 (1,495 words) [view diff] exact match in snippet view article find links to article

In this system Dock4 was reported to undergo phosphorylation by Glycogen synthase kinase 3 (GSK-3) which stimulated an increase in Dock4 GEF activity

PDK2 (1,929 words) [view diff] exact match in snippet view article find links to article

"The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase". Journal

PPP1CA (1,801 words) [view diff] exact match in snippet view article find links to article

Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent

Phyllis Gardner (clinical pharmacologist) (1,078 words) [view diff] case mismatch in snippet view article

Gardner, Phyllis (1997-03-28). "Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3". Science. 275 (5308): 1930–1933. doi:10.1126/science.275

Teratocarcinoma-derived growth factor 1 (902 words) [view diff] exact match in snippet view article find links to article

phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells". Cancer Res. 59 (18):

AKT2 (1,549 words) [view diff] exact match in snippet view article find links to article

Dedhar S (1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase".

Friedrich Miescher Institute for Biomedical Research (1,547 words) [view diff] exact match in snippet view article find links to article

Cohen P, Andjelkovich M, Hemmings BA (December 1995). "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.". Nature. 378 (6559):

TPPP (962 words) [view diff] exact match in snippet view article find links to article

PMID 8889548. Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochim. Biophys. Acta. 1586 (1): 113–22

AXIN2 (1,422 words) [view diff] exact match in snippet view article find links to article

complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin

Prostaglandin receptor (879 words) [view diff] exact match in snippet view article find links to article

alpha subunit stimulates AC, raises cAMP, stimulates beta catenin and Glycogen synthase kinase 3 Prostaglandin EP3 receptor EP3 PGE2>PGF2α,PGI2>PGD2=TXA2

Mir-26 microRNA precursor family (3,054 words) [view diff] exact match in snippet view article find links to article

and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β". J Biol Chem. 285 (38): 29336–47. doi:10.1074/jbc.M110

HNRPD (1,472 words) [view diff] exact match in snippet view article find links to article

Juang YT, Tsokos GC (2002). "Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator

Chaperone code (1,312 words) [view diff] exact match in snippet view article find links to article

such as protein kinase A, casein kinase 1 and 2 (CK1 and CK2), and glycogen synthase kinase B serve as kinases for chaperone proteins. HSP70, a major chaperone

HSF1 (2,447 words) [view diff] exact match in snippet view article find links to article

"Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1"

Notch 1 (1,497 words) [view diff] exact match in snippet view article find links to article

PMID 19571148. Foltz DR, Santiago MC, Berechid BE, Nye JS (June 2002). "Glycogen synthase kinase-3beta modulates notch signaling and stability". Curr. Biol

List of MeSH codes (D12.644) (5,787 words) [view diff] exact match in snippet view article

protein-tyrosine kinases MeSH D12.644.360.300 – glycogen synthase kinases MeSH D12.644.360.300.500 – glycogen synthase kinase 3 MeSH D12.644.360.325 – gtp-binding

Robert G. Shulman (1,516 words) [view diff] case mismatch in snippet view article find links to article

which stored glucose as muscle glycogen, was controlled, not by Glycogen Synthase, as had been assumed, but by glucose transporters that were inadequately

Yossef Av-Gay (552 words) [view diff] exact match in snippet view article find links to article

Steiner, T.; Jean, F.; Pelech, S.; Av-Gay, Y. (2022). "Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2

Serine/threonine-specific protein kinase (1,202 words) [view diff] exact match in snippet view article find links to article

important for insulin actions in cells. A major target of Akt kinases is glycogen synthase kinase-3. EC 2.7.11.1 Pelle is a serine/threonine kinase that can

Nuclear receptor 4A2 (2,159 words) [view diff] exact match in snippet view article find links to article

interactions. NR4A2 needs to be sumoylated and its co-regulating factor, glycogen synthase kinase 3, needs to be phosphorylated for these interactions to occur

PKC alpha (2,643 words) [view diff] exact match in snippet view article find links to article

2.305. PMID 9468546. Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical Reviews

WWC2 (948 words) [view diff] exact match in snippet view article find links to article

is also predicted that p38 mitogen-activated protein kinases and glycogen synthase kinase 3 bind at position T3, and casein kinase 2 binds at positions

AXIN1 (2,157 words) [view diff] exact match in snippet view article find links to article

adenomatosis polyposis coli, catenin (cadherin-associated protein) beta 1, glycogen synthase kinase 3 beta, protein phosphatase 2, and itself. This protein functions

HK2 (2,505 words) [view diff] exact match in snippet view article find links to article

"Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3". The Journal of Biological Chemistry. 284 (5): 3001–11.

HEK 293 cells (3,065 words) [view diff] exact match in snippet view article find links to article

1194/jlr.M500329-JLR200. PMID 16520488. Li T, Paudel HK (March 2006). "Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of

Neurogenins (2,991 words) [view diff] exact match in snippet view article find links to article

Ngn2 has two serines, S231 and S234, which can be phosphorylated by glycogen synthase kinase 3 (Gsk3). Phosphorylation of Ngn2 enables interaction with

TLN1 (2,835 words) [view diff] exact match in snippet view article find links to article

hypertrophy, which correlated with blunted ERK1/2, p38, Akt, and glycogen synthase kinase 3 responses. These data suggest that upregulation of talin-1

TMEM44 (800 words) [view diff] exact match in snippet view article find links to article

are seven predicted transmembrane domains in TMEM44 protein. GSK3B (Glycogen synthase kinase 3 beta), KAT6B (Histone acetyltransferase KAT6B/Histone acetyltransferase

Mir-19 microRNA precursor family (3,172 words) [view diff] exact match in snippet view article find links to article

and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3β". Cell. 132 (5): 875–886. doi:10.1016/j.cell.2008.02.019

Myricetin (3,000 words) [view diff] exact match in snippet view article find links to article

diabetes, myricetin has been observed to increase the activity of glycogen synthase 1. In trials done on Xenopus laevis oocytes, myricetin is thought

Gastruloid (1,662 words) [view diff] exact match in snippet view article find links to article

Sylvia T.; Reeder, John W.; Samuels, Isa (2003-03-01). "Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport

Tautomycetin (897 words) [view diff] exact match in snippet view article find links to article

suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta". Molecular Cancer Therapeutics. 8 (4): 914–920. doi:10

Neuroprotection (3,639 words) [view diff] exact match in snippet view article find links to article

stimulates neurogenesis via multiple signaling pathways; it inhibits glycogen synthase kinase-3 (GSK-3), upregulates neurotrophins and growth factors (e

CUSP9 (883 words) [view diff] exact match in snippet view article find links to article

Hayashi Y, Minamoto T, Nakada M. Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma

CD97 (3,476 words) [view diff] exact match in snippet view article find links to article

and regulates the localization and degradation of β-catenin through glycogen synthase kinase-3β (GSK-3β) and Akt signaling. Ectopic CD97 expression upregulates

Protein phosphorylation (7,955 words) [view diff] exact match in snippet view article find links to article

the active glycogen phosphorylase a. It was soon discovered that glycogen synthase, another metabolic enzyme, is inactivated by phosphorylation. Phosphorylation

AKT1 (2,850 words) [view diff] exact match in snippet view article find links to article

(Sep 1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase".

Myelin (4,083 words) [view diff] exact match in snippet view article find links to article

promote myelination during development and myelin repair in older age. Glycogen synthase kinase 3β inhibitors such as lithium chloride have been found to promote

Adenomatous polyposis coli (3,225 words) [view diff] exact match in snippet view article find links to article

Polyposis Coli) APC protein normally builds a "destruction complex" with glycogen synthase kinase 3-alpha and or beta (GSK-3α/β) and Axin via interactions with

Protein kinase B (3,754 words) [view diff] exact match in snippet view article find links to article

translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Glycogen synthase kinase 3 (GSK-3) could be inhibited upon phosphorylation by Akt, which

Mania (5,447 words) [view diff] exact match in snippet view article find links to article

3.2.125. Li X, Liu M, Cai Z, Wang G, Li X (2010). "Regulation of glycogen synthase kinase-3 during bipolar mania treatment". Bipolar Disord. 12 (7):

Cholinergic neuron (2,446 words) [view diff] exact match in snippet view article find links to article

also be noted that memantine is able to inhibit the truncation of glycogen synthase kinase-3 (triggered by activated calpain), which is believed to play

Emerin (2,331 words) [view diff] exact match in snippet view article find links to article

architecture and myocyte shape. This interaction appears to be regulated by glycogen synthase kinase 3 beta. Mutations in emerin cause X-linked recessive Emery–Dreifuss

Fluoride (5,001 words) [view diff] exact match in snippet view article find links to article

of a phosphoprotein phosphatase from bovine heart with activity on glycogen synthase, phosphorylase, and histone". J. Biol. Chem. 249 (20): 6459–67. doi:10

Akt/PKB signaling pathway (4,116 words) [view diff] exact match in snippet view article find links to article

phase cell cycle progression by phosphorylating and inactivating glycogen synthase kinase 3 (GSK-3) at Ser9. This prevents the phosphorylation and degradation

Low-density lipoprotein receptor-related protein 8 (3,439 words) [view diff] exact match in snippet view article find links to article

activation leads to inhibitory phosphorylation of the tau kinase glycogen synthase kinase 3 beta (GSK3B), which alters the activity of tau protein, a

NFE2L1 (3,657 words) [view diff] exact match in snippet view article find links to article

PMID 21953459. Biswas M, Kwong EK, Park E, Nagra P, Chan JY (Aug 2013). "Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related

VDAC1 (4,079 words) [view diff] exact match in snippet view article find links to article

Esposti DD, Fanelli E, Boursier C, Henry C, et al. (January 2013). "Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation

Plakoglobin (4,695 words) [view diff] exact match in snippet view article find links to article

Phosphorylation of N-terminal Serines by a “destruction complex” composed of glycogen synthase kinase 3β (GSK3β) and scaffold proteins adenomatous polyposis coli

Rev-ErbA alpha (4,285 words) [view diff] exact match in snippet view article find links to article

regulates the protein at a post-translational level. Lithium inhibits glycogen synthase kinase (GSK 3β), an enzyme that phosphorylates and stabilizes Rev-erbα

TCF7L2 (4,358 words) [view diff] exact match in snippet view article find links to article

"Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion". The Journal of Biological Chemistry

PSMB1 (3,183 words) [view diff] exact match in snippet view article find links to article

apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network". Cell Death & Disease. 4 (7): e715

DNM1L (2,586 words) [view diff] exact match in snippet view article find links to article

CC (August 1998). "Human dynamin-like protein interacts with the glycogen synthase kinase 3beta". Biochemical and Biophysical Research Communications

Development, Growth & Differentiation (298 words) [view diff] case mismatch in snippet view article find links to article

early development. Tong Sun, Bohye Kim and Lou W. Kim 55 207-216 2013 Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K

Paracrine signaling (4,940 words) [view diff] exact match in snippet view article find links to article

active state the Dishevelled protein inhibits the activity of the glycogen synthase kinase 3 (GSK3) enzyme. Normally active GSK3 prevents the dissociation

Prostaglandin EP4 receptor (4,808 words) [view diff] exact match in snippet view article find links to article

Fujino H, West KA, Regan JW (January 2002). "Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation

GAB2 (3,189 words) [view diff] exact match in snippet view article find links to article

antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase". Immunological Reviews

MTOR (12,710 words) [view diff] exact match in snippet view article find links to article

that rapamycin can inhibit mTORC1 so that the phosphorylation of GS (glycogen synthase) can be increased in skeletal muscle. This discovery represents a

Collapsin response mediator protein family (2,518 words) [view diff] exact match in snippet view article find links to article

degenerating neuritis in Alzheimer's disease. Studies suggest that glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent protein kinase 5 (Cdk5) are

Ceramide-activated protein phosphatase (2,665 words) [view diff] exact match in snippet view article find links to article

(Ghosh et al., 2007). The effects of ceramide on insulin-stimulated glycogen synthase kinase 3β phosphorylation were abolished with PP1 inhibitors, further

Granulin (3,334 words) [view diff] exact match in snippet view article find links to article

progranulin has been shown to increase neurite outgrowth by regulating the glycogen synthase kinase-3 beta. Progranulin may function as an autocrine growth factor

Estrogen receptor (3,818 words) [view diff] exact match in snippet view article find links to article

(MAPK/ERK) pathway and phosphoinositide 3-kinase (Pl3K/AKT) pathway. Glycogen synthase kinase-3 (GSK)-3β inhibits transcription by nuclear ER by inhibiting

Wayne Newton (5,568 words) [view diff] exact match in snippet view article find links to article

rabbit skeletal muscle protein kinase (PC0.7) able to phosphorylate glycogen synthase and phosvitin". The Journal of Biological Chemistry. 256 (17): 8955–62

Integrin-linked kinase (2,654 words) [view diff] exact match in snippet view article find links to article

(September 1998). "Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase".

Telomerase reverse transcriptase (5,301 words) [view diff] exact match in snippet view article find links to article

subsequently been shown to be the most common noncoding mutations in cancer. Glycogen synthase kinase 3 (GSK3) seems to be over-expressed in most cancer cells. GSK3

Insulin signal transduction pathway (3,157 words) [view diff] exact match in snippet view article find links to article

Brady MJ, Nairn AC, Saltiel AR (November 1997). "The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential

Protein Wnt-5a (3,402 words) [view diff] exact match in snippet view article find links to article

translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway". Journal of Immunology. 169 (7): 3717–25. doi:10

Histone deacetylase 2 (4,587 words) [view diff] exact match in snippet view article find links to article

hypertrophic stimuli. However, in HDAC2 transgenic mice with inactivated glycogen synthase kinase 3beta (Gsk3beta), hypertrophy was observed at a higher frequency

Ketamine-assisted psychotherapy (2,365 words) [view diff] exact match in snippet view article find links to article

neuroplasticity. Key among these are mammalian target of rapamycin (mTOR), glycogen synthase kinase-3 (GSK3), and elongation factor 2 (eEF2) kinase. Ketamine has

Wnt signaling pathway (7,427 words) [view diff] exact match in snippet view article find links to article

adenomatosis polyposis coli (APC), protein phosphatase 2A (PP2A), glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α). It degrades β-catenin

MTORC2 (3,678 words) [view diff] exact match in snippet view article find links to article

rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity". Molecular and Cellular Biology. 28 (1): 61–70. doi:10.1128/MCB

Neil Vasdev (1,819 words) [view diff] case mismatch in snippet view article find links to article

; Vasdev, Neil (8 August 2016). "Discovery of a Highly Selective Glycogen Synthase Kinase‐3 Inhibitor (PF‐04802367) That Modulates Tau Phosphorylation

RELA (6,578 words) [view diff] no match in snippet view article find links to article

also able to phosphorylate RELA at different conditions, including glycogen-synthase kinase-3β (GSK3β), AKT/phosphatidylinositol 3-kinase (PI3K) and NF-κB

AMP-activated protein kinase (7,058 words) [view diff] exact match in snippet view article find links to article

inhibits glycogen synthesis through inhibitory phosphorylation of glycogen synthase. In the liver, AMPK inhibits gluconeogenesis by inhibiting transcription

Drosophila circadian rhythm (3,369 words) [view diff] exact match in snippet view article find links to article

circadian pacemakers. In 2001, Young and his team demonstrated that glycogen synthase kinase-3 (GSK-3) ortholog shaggy (SGG) is an enzyme that regulates

CTP synthase 1 (3,095 words) [view diff] exact match in snippet view article find links to article

2007). "Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3". The Journal of Biological Chemistry. 282 (40): 29493–29503

Ketamine (11,363 words) [view diff] exact match in snippet view article find links to article

the mammalian target of rapamycin (mTOR) pathway, deactivation of glycogen synthase kinase 3 (GSK-3), and inhibition of the phosphorylation of the eukaryotic

Androgen receptor (9,362 words) [view diff] exact match in snippet view article find links to article

androgen receptor-mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells". The Journal of Biological Chemistry

Regenerative endodontics (5,670 words) [view diff] exact match in snippet view article find links to article

2017 on the regeneration of dentine with collagen sponge filled with glycogen synthase kinase (GSK-3) . Medicine portal Dental pulp stem cells Toothache

P53 (13,103 words) [view diff] exact match in snippet view article find links to article

Zmijewski JW, et al. (June 2002). "Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage". Proceedings of the National

MTORC1 (7,803 words) [view diff] exact match in snippet view article find links to article

pathway also activates mTORC1. Activation of the Wnt pathway inhibits glycogen synthase kinase 3 beta (GSK3B). When the Wnt pathway is not active, GSK3B is

List of EC numbers (EC 3) (15,553 words) [view diff] no match in snippet view article

EC 3.1.3.41: 4-nitrophenylphosphatase EC 3.1.3.42: glycogen-synthase-D] phosphatase EC 3.1.3.43: [pyruvate dehydrogenase

Xanthatin (1,885 words) [view diff] exact match in snippet view article find links to article

(September 2016). "Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin". Biochemical Pharmacology. 115: 18–27. doi:10

Casein kinase 1 isoform epsilon (5,389 words) [view diff] exact match in snippet view article find links to article

identical, functions. Another functional homolog, the Drosophila gene for glycogen synthase kinase 3 (GSK3), called shaggy and abbreviated sgg, codes for a protein

Biochemical cascade (11,432 words) [view diff] case mismatch in snippet view article find links to article

WNT ligand and G protein-coupled receptor Frizzled inhibits GSK-3 (Glycogen Synthase Kinase-3) and thus formation of β-catenin destruction complex. Although

Induced stem cells (25,002 words) [view diff] exact match in snippet view article find links to article

reversine (the aurora B kinase inhibitor), and some other chemicals (BIO (glycogen synthase-3 kinase inhibitor), lysophosphatidic acid (pleiotropic activator

Reelin (15,715 words) [view diff] exact match in snippet view article find links to article

"Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta". The Journal of Biological Chemistry. 277 (51): 49958–64

Secreted frizzled-related protein 1 (6,317 words) [view diff] exact match in snippet view article find links to article

in the cytoplasm are composed of adenomatous polyposis coli (APC), glycogen synthase kinase 3β (GSK3β) and Axin. APC promotes the degradation of β-catenin

ISLR (4,000 words) [view diff] exact match in snippet view article find links to article

eight distinct phosphorylation sites were identified for the protein: Glycogen synthase kinase-3 (GSK3) phosphorylation site at position 234-241 aa. Phosphatidylinositol

Heavy horse (general) (3,442 words) [view diff] exact match in snippet view article

Anderson, S. M.; McCue, M. E.; Mickelson, J. R. (2010). "Presence of the glycogen synthase 1 (GYS1) mutation causing type 1 polysaccharide storage myopathy in

Ultrasensitivity (8,818 words) [view diff] exact match in snippet view article find links to article

the glycogen cascade system: The ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs"

Biology of bipolar disorder (11,128 words) [view diff] exact match in snippet view article find links to article

cortex as well, potentially leading to progression of manic symptoms. Glycogen synthase kinase 3 has been implicated in bipolar disorder, as bipolar medications

Epigenetics of neurodegenerative diseases (13,392 words) [view diff] exact match in snippet view article find links to article

memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3". Journal of Neurochemistry. 106 (6): 2364–74. doi:10.1111/j

CSNK1D (14,738 words) [view diff] case mismatch in snippet view article find links to article

signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1". Cell. 108 (6): 823–35. doi:10