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searching for CCR5 115 found (418 total)

alternate case: cCR5

Richard Pestell (2,739 words) [view diff] exact match in snippet view article find links to article

pathway, the cell fate determination pathway protein DACH1, and CCR5. Pestell discovered CCR5 governs cancer metastasis in both breast and prostate cancer

Allele age (1,583 words) [view diff] exact match in snippet view article find links to article

for the CCR5 mutation. Because the CCR5 mutation also offers resistance to smallpox, these results are consistent with the idea that the CCR5 mutation

List of Canadian airports by location indicator: CC (78 words) [view diff] exact match in snippet view article find links to article

Water Aerodrome St. John's NL CCR3 Florenceville Airport Florenceville NB CCR5 Cline River Heliport Cline River AB CCR6 Campbell River (E & B Helicopters)

Pathophysiology of HIV/AIDS (1,841 words) [view diff] exact match in snippet view article find links to article

cells express the CCR5 coreceptor, whereas a small fraction of CD4+ T cells in the bloodstream do so. HIV seeks out and destroys CCR5 expressing CD4+ cells

GPR15 (1,503 words) [view diff] exact match in snippet view article find links to article

astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation". Glia. 41 (4): 354–370. doi:10.1002/glia.10181. PMID 12555203

Azamulin (174 words) [view diff] exact match in snippet view article find links to article

liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist". Drug Metabolism and Disposition. 35 (12): 2186–95.

G protein-coupled receptor kinase 3 (2,012 words) [view diff] exact match in snippet view article find links to article

chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus". The Journal of Biological

Nc/Nga mice model (500 words) [view diff] exact match in snippet view article find links to article

and IL-5. Considering receptors, CCR3 and CCR5 are expressed in both lesional and nonlesional skin but CCR5 is higher in lesional skin. CCR4 is receptor

CLCA3 (472 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proceedings of the National Academy of Sciences of

Leukocidin (292 words) [view diff] exact match in snippet view article find links to article

; Landau, Nathaniel R.; Unutmaz, Derya; Torres, Victor J. (2012-12-12). "CCR5 is a receptor for Staphylococcus aureus leukotoxin ED". Nature. 493 (7430):

CLCA4 (507 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

2003 Bradford Bulls season (1,191 words) [view diff] exact match in snippet view article find links to article

try and reached 200 points for the Bulls. CCR5: Lesley Vainikolo scored his 1st hat-trick for the Bulls. CCR5: Karl Pratt and Rob Parker scored their 1st

2000 Bradford Bulls season (1,201 words) [view diff] exact match in snippet view article find links to article

40–12 against Wigan Warriors. CCR5: Michael Withers scored his 3rd hat-trick and reached 100 points for the Bulls. CCR5: Brad Mackay and Hudson Smith

NR58-3.14.3 (1,333 words) [view diff] exact match in snippet view article find links to article

of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction". Retrovirology Med. Chem. 2 (1):

2010 Bradford Bulls season (404 words) [view diff] exact match in snippet view article find links to article

try and kicked his 1st goal for the Bulls. CCR5: Chris Nero scored his 2nd hat-trick for the Bulls. CCR5: Glenn Hall kicked his 1st goal for the Bulls

Restriction modification system (2,623 words) [view diff] exact match in snippet view article find links to article

A recent Phase I clinical trial of ZFN for the targeted abolition of the CCR5 co-receptor for HIV-1 has been undertaken. R-M systems are major players

Subtypes of HIV (3,870 words) [view diff] exact match in snippet view article find links to article

non-nucleoside reverse transcriptase inhibitors (NNRTIs) with the addition of CCR5 co-receptor antagonists and fusion inhibitors. Choice of initial and/or second-line

Human betaherpesvirus 7 (3,726 words) [view diff] exact match in snippet view article find links to article

inquiry into the relationship between HHV-7 and HIV-1 co-receptors CXCR4 and CCR5. During infection, HHV-7 causes a loss of CXCR4 in CD4+ T-cells in addition

2001 Bradford Bulls season (1,234 words) [view diff] exact match in snippet view article find links to article

scored his 4th hat-trick for the Bulls. CCR5: Daniel Gartner and Lee Gilmour scored their 1st tries for the Bulls. CCR5: Robbie Paul scored his 75th try and

C-C motif chemokine ligand 3 like 3 (218 words) [view diff] exact match in snippet view article find links to article

and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of

C-C motif chemokine ligand 3 like 3 (218 words) [view diff] exact match in snippet view article find links to article

and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of

KCNMB4 (622 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

List of airports in Canada (C–D) (162 words) [view diff] exact match in snippet view article

NB Clearwater River Airport CFS8 Clearwater River AB Cline River Heliport CCR5 Cline River AB Clova/Lac Duchamp Water Aerodrome CST6 Clova QC Clyde River

KCNN2 (1,152 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

KCNN1 (668 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

KCNMB3 (825 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

Christian aTunde Adjuah (991 words) [view diff] exact match in snippet view article find links to article

wake of hurricane Katrina ("Danziger"), and HIV/AIDS ("The Berlin Patient: CCR5")... Scott's music is instrumental rather than vocal, so he addresses these

Broad-spectrum chemokine inhibitor (1,706 words) [view diff] exact match in snippet view article find links to article

of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitro without blocking gp120/CCR5 interaction". Retrovirology Med. Chem. 2 (1):

2008 Bradford Bulls season (304 words) [view diff] exact match in snippet view article find links to article

the Bulls. Round 12: Paul Deacon kicked his 1,000th goal for the Bulls. CCR5: Semi Tadulala scored his 3rd hat-trick for the Bulls. Round 20: Iestyn Harris

CLCA1 (1,012 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

2010 Catalans Dragons season (553 words) [view diff] exact match in snippet view article find links to article

try and reached 100 points for the Dragons. CCR5: Thomas Bosc made his 100th appearance for the Dragons. CCR5: Setaimata Sa scored his 1st hat-trick for

KCNN4 (1,297 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

CLCA2 (926 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

Bradykinin receptor B2 (1,311 words) [view diff] exact match in snippet view article find links to article

Efremov R, Truong MJ, Darcissac EC, et al. (1999). "Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop

2007 Bradford Bulls season (373 words) [view diff] exact match in snippet view article find links to article

for the Bulls. Round 12: Paul Deacon reached 2,100 points for the Bulls. CCR5: Matt Cook scored his 1st try for the Bulls. Round 15: Lesley Vainikolo scored

Formyl peptide receptor 2 (4,312 words) [view diff] exact match in snippet view article find links to article

1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled

2007 Bradford Bulls season (373 words) [view diff] exact match in snippet view article find links to article

for the Bulls. Round 12: Paul Deacon reached 2,100 points for the Bulls. CCR5: Matt Cook scored his 1st try for the Bulls. Round 15: Lesley Vainikolo scored

Paula Cannon (389 words) [view diff] exact match in snippet view article find links to article

Harvard Cannon's recent work is aimed at disrupting the CCR viral co-receptor, CCR5, using zinc finger nucleases(ZFNs). She also studies SARS-CoV-2 and highly

Gajendra Pal Singh Raghava (776 words) [view diff] exact match in snippet view article find links to article

of Science. HIVcoPred: A server for prediction of HIV coreceptor usage (CCR5). TumorHPD: Computational approach for designing tumor homing peptides. Scientific

Alcino J. Silva (6,318 words) [view diff] exact match in snippet view article find links to article

the delayed expression of the receptor CCR5 closes the window of time in which two memories can be linked. CCR5 activation results in a decrease in neuronal

MAPK10 (1,348 words) [view diff] exact match in snippet view article find links to article

B, Yi Y, Freedman BD, Collman RG (2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol.

2017 Toronto Wolfpack season (1,962 words) [view diff] exact match in snippet view article find links to article

Craig Hall reached 100 points for the Wolfpack. CCR5: Ryan Brierley made his debut for the Wolfpack. CCR5: Ryan Brierley scored his 1st try for the Wolfpack

Zinc finger (4,825 words) [view diff] exact match in snippet view article find links to article

ongoing clinical trial is evaluating Zinc finger nucleases that disrupt the CCR5 gene in CD4+ human T-cells as a potential treatment for HIV/AIDS. The majority

Restriction enzyme (5,855 words) [view diff] exact match in snippet view article find links to article

A recent Phase I clinical trial of ZFN for the targeted abolition of the CCR5 co-receptor for HIV-1 has been undertaken. Others have proposed using the

Uterine natural killer cells (1,098 words) [view diff] exact match in snippet view article find links to article

(2001-04-01). "Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice". The Journal of Immunology. 166 (7): 4697–4704. doi:10.4049/jimmunol

KCNMB2 (1,062 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS

CD4 immunoadhesin (2,878 words) [view diff] exact match in snippet view article find links to article

attach to the surface of target cells. HIV then uses a co-receptor, either CCR5 or CXCR4, to facilitate entry into the cell. The ability of CD4 immunoadhesin

Gene silencing (5,608 words) [view diff] exact match in snippet view article find links to article

siRNA was used to silence the primary HIV receptor chemokine receptor 5 (CCR5). This prevented the virus from entering the human peripheral blood lymphocytes

Calcium-activated potassium channel subunit alpha-1 (2,299 words) [view diff] exact match in snippet view article find links to article

gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proceedings of the National Academy of Sciences of

Prevotella (1,866 words) [view diff] exact match in snippet view article find links to article

to the inflamed area, important for women's health since the presence of CCR5+ Th cells in the vaginal mucosa could increase HIV transmission risk during

PTK2B (1,887 words) [view diff] exact match in snippet view article find links to article

Chernock RD, Avraham S, Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". J. Biol. Chem. 275 (23): 17263–8. doi:10

Georgette D. Kanmogne (2,345 words) [view diff] exact match in snippet view article find links to article

discovered that neither cell type expressed the known HIV receptors, CXCR4 and CCR5, and thus other cell types or mechanisms just mediate CNS-HIV infection.

Protein A/G (359 words) [view diff] exact match in snippet view article find links to article

Lowy, Douglas R.; Schiller, John T. (2004). "Induction of Autoantibodies to CCR5 in Macaques and Subsequent Effects upon Challenge with an R5-Tropic Simian/Human

Ligand (biochemistry) (3,144 words) [view diff] exact match in snippet view article

Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)". Journal of Medicinal Chemistry. 58 (21): 8647–8657. doi:10.1021/acs.jmedchem

Jane Osbourn (2,277 words) [view diff] exact match in snippet view article find links to article

membranes, J Vasc Res, 1999 Directed selection of MIP-1 alpha neutralizing CCR5 antibodies from a phage display human antibody library, Nat Biotechnology

Monogram Biosciences (195 words) [view diff] exact match in snippet view article find links to article

Monogram Biosciences Launches New "Trofile" HIV Co-receptor Tropism Test to Select Patients Eligible to User CCR5 Antagonist Maraviroc (Selzentry) [6] v t e

CNIH4 (537 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function protein binding CCR5 chemokine receptor binding Cellular component integral component of membrane endoplasmic reticulum

Joep Lange (1,434 words) [view diff] exact match in snippet view article find links to article

He also expressed frustration that activist groups have prevented newer CCR5 receptor antagonists from being tested in Europe. However, Lange was criticised

Janus kinase 1 (2,423 words) [view diff] exact match in snippet view article find links to article

function transferase activity nucleotide binding protein kinase activity CCR5 chemokine receptor binding growth hormone receptor binding metal ion binding

Tyrosine-protein kinase SYK (2,083 words) [view diff] exact match in snippet view article find links to article

Chernock RD, Avraham S, Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". The Journal of Biological Chemistry

Discredited HIV/AIDS origins theories (1,937 words) [view diff] exact match in snippet view article find links to article

K; Bukrinsky, MI; Brichacek, Beda (18 May 2010). "Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized

Subclinical infection (2,480 words) [view diff] exact match in snippet view article find links to article

Robert A.; Dolan, Matthew J.; Ahuja, Sunil K. (July 1998). "Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of

ARL6IP5 (1,099 words) [view diff] exact match in snippet view article find links to article

Moelling K (2005). "JM4 is a four-transmembrane protein binding to the CCR5 receptor". FEBS Lett. 579 (7): 1751–8. doi:10.1016/j.febslet.2005.02.037

PTPN6 (2,292 words) [view diff] exact match in snippet view article find links to article

Chernock RD, Avraham S, Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". J. Biol. Chem. 275 (23): 17263–8. doi:10

PIK3C3 (901 words) [view diff] exact match in snippet view article find links to article

Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol.

List of antiviral drugs (513 words) [view diff] exact match in snippet view article find links to article

(Valcyte) Cytomegalovirus (CMV) Vicriviroc HIV-1 Schering-Plough pyrimidine CCR5 entry inhibitor Vidarabine Herpes Simplex, Varicella Zoster Zalcitabine HIV

Marc Parmentier (308 words) [view diff] exact match in snippet view article find links to article

to HIV-1 infection of Caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene, Nature 382 (1996) 722–725. Ledent C, Valverde O

Drug design (5,022 words) [view diff] exact match in snippet view article find links to article

antagonists Bcr-Abl tyrosine-kinase inhibitors Cannabinoid receptor antagonists CCR5 receptor antagonists Cyclooxygenase 2 inhibitors Dipeptidyl peptidase-4 inhibitors

STAT3 (3,565 words) [view diff] exact match in snippet view article find links to article

polymerase II-specific signal transducer activity transcription factor binding CCR5 chemokine receptor binding glucocorticoid receptor binding Cellular component

STAT1 (3,747 words) [view diff] exact match in snippet view article find links to article

RNA polymerase II core promoter proximal region sequence-specific binding CCR5 chemokine receptor binding protein phosphatase 2A binding DNA-binding transcription

1996 Bradford Bulls season (1,317 words) [view diff] exact match in snippet view article find links to article

hat-trick for the Bulls. CCR4: Paul Cook kicked his 1st goal for the Bulls. CCR5: Jon Scales and Simon Knox scored their 1st tries for the Bulls. CCQF: Graeme

T helper 17 cell (3,564 words) [view diff] exact match in snippet view article find links to article

barrier during HIV infection in the gut. Because of their high levels of CCR5 expression, the coreceptor for HIV, they are preferentially infected and

1999 Bradford Bulls season (1,147 words) [view diff] exact match in snippet view article find links to article

CCR4: Nick Zisti and Stuart Fielden scored their 1st tries for the Bulls. CCR5: Henry Paul scored his 1st try for the Bulls. Round 1: Henry Paul kicked

PIK3R2 (1,401 words) [view diff] exact match in snippet view article find links to article

Freedman BD, Collman RG (November 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte

PIK3CB (982 words) [view diff] exact match in snippet view article find links to article

Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol.

Paul Bieniasz (989 words) [view diff] exact match in snippet view article find links to article

determinants of specificity in the viral envelope with the cellular receptor CCR5 and HIV-1 Tat interaction with host factors. Bieniasz started his own independent

CCL4L1 (1,003 words) [view diff] exact match in snippet view article find links to article

similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals

Marybeth Daucher (421 words) [view diff] exact match in snippet view article find links to article

Up‐Regulates Expression of the Human Immunodeficiency Virus Fusion Coreceptor CCR5 by CD4 + Lymphocytes In Vivo". The Journal of Infectious Diseases. 181 (3):

2012 Catalans Dragons season (629 words) [view diff] exact match in snippet view article find links to article

the Dragons. Round 9: Daryl Millard kicked his 1st goal for the Dragons. CCR5: Damien Cardace scored his 2nd hat-trick for the Dragons. CCQF: Ben Fisher

Protein–protein interaction (8,396 words) [view diff] exact match in snippet view article find links to article

used as a cardiovascular drug[citation needed] Maraviroc, inhibitor of the CCR5-gp120 interaction, used as anti-HIV drug. AMG-176, AZD5991, S64315, inhibitors

PIK3C2B (1,114 words) [view diff] exact match in snippet view article find links to article

Yi Y, Freedman BD, Collman RG (Nov 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte

2006 Catalans Dragons season (679 words) [view diff] exact match in snippet view article find links to article

Dragons. Round 14: John Wilson scored his 1st hat-trick for the Dragons. CCR5: Michael Dobson reached 100 points for the Dragons. Round 15: Stacey Jones

Zinc finger chimera (4,966 words) [view diff] exact match in snippet view article find links to article

ongoing clinical trial is evaluating Zinc finger nucleases that disrupt the CCR5 gene in CD4+ human T-cells as a potential treatment for HIV/AIDS. These investigations

PIK3C2G (989 words) [view diff] exact match in snippet view article find links to article

Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol.

2015 Bradford Bulls season (1,425 words) [view diff] exact match in snippet view article find links to article

debut for the Bulls. Round 8: Danny Addy reached 100 points for the Bulls. CCR5: Lucas Walshaw scored his 1st try for the Bulls. Round 10: Lee Gaskell scored

PTPN11 (4,300 words) [view diff] exact match in snippet view article find links to article

Chernock RD, Avraham S, Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". J. Biol. Chem. 275 (23): 17263–8. doi:10

2018 Toronto Wolfpack season (2,170 words) [view diff] exact match in snippet view article find links to article

Wolfpack. Round 11: Ryan Brierley kicked his 1st drop goal for the Wolfpack. CCR5: Darcy Lussick made his debut for the Wolfpack. Round 12: Darcy Lussick scored

List of airports in Alberta (202 words) [view diff] exact match in snippet view article find links to article

-115.22833 (Clearwater River Airport) Cline River Cline River Heliport CCR5 52°10′44″N 116°28′45″W / 52.17889°N 116.47917°W / 52.17889; -116.47917

Macrophage (10,188 words) [view diff] exact match in snippet view article find links to article

macrophage through binding of gp120 to CD4 and second membrane receptor, CCR5 (a chemokine receptor). Both circulating monocytes and macrophages serve

Virtual screening (3,895 words) [view diff] exact match in snippet view article find links to article

substituent effect of 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides on CCR5 binding affinity using QSAR and virtual screening techniques". Journal of

PIK3C2A (1,142 words) [view diff] exact match in snippet view article find links to article

Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol.

2012 Leeds Rhinos season (2,815 words) [view diff] exact match in snippet view article find links to article

Round CCR4 CCR5 CCQF CCSF CCF vs Home/Away H H A N N Win/Draw/Loss W W W W L Result 30–20 40–20 38–22 10–8 18–28

Natural killer cell (9,180 words) [view diff] exact match in snippet view article find links to article

CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways". Journal of Autoimmunity. 66: 40–50. doi:10.1016/j.jaut

Julie McElrath (4,171 words) [view diff] exact match in snippet view article find links to article

Repeated Exposure: Evidence for T Cell Immunity in the Absence of Inherited CCR5 Coreceptor Defects". The Journal of Infectious Diseases. 179 (3): 548–57

2014 Bradford Bulls season (1,895 words) [view diff] exact match in snippet view article find links to article

1st try for the Bulls. Round 10: Sam Bates made his debut for the Bulls. CCR5: Jay Pitts made his debut for the Bulls. Round 11: Joe Arundel and Antonio

Eyam (5,201 words) [view diff] exact match in snippet view article find links to article

2000 study led by Dr. Steve O'Brien suggested that a human gene mutation, CCR5-Delta 32, known to give immunity from HIV, may have helped the survivors

Human genetic enhancement (10,464 words) [view diff] exact match in snippet view article find links to article

repeat (CRISPR)-Cas9, a gene editing technique, they disabled a gene called CCR5 in the embryos, aiming to close the protein doorway that allows HIV to enter

Theories of the Black Death (4,340 words) [view diff] exact match in snippet view article find links to article

(March 2005). "Reappraisal of the historical selective pressures for the CCR5-Delta32 mutation". Journal of Medical Genetics. 42 (3): 205–208. doi:10.1136/jmg

P110δ (2,559 words) [view diff] exact match in snippet view article find links to article

Freedman BD, Collman RG (November 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte

List of heliports in Canada (139 words) [view diff] exact match in snippet view article find links to article

-113.58306 (Claresholm (General Hospital) Heliport) Cline River Heliport CCR5 Public Icefield Heli Tours Cline River AB 52°10′44″N 116°28′45″W / 52.17889°N

AmfAR (6,891 words) [view diff] exact match in snippet view article find links to article

Officer at amfAR, "demonstrating that Leronlimab can functionally phenocopy CCR5 deficiency and replicate the London and Berlin patients would be a major

Race and health (10,828 words) [view diff] exact match in snippet view article find links to article

(October 1999). "Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes". Proceedings of the National Academy of Sciences of the United

Resistance mutation (virology) (1,466 words) [view diff] exact match in snippet view article

enter its target cells. HIV must bind to a CD4 receptor on a T cell or the CCR5/CXCR4 co-receptors to enter the cell. They can also block the fusion of the

2023 Bradford Bulls season (2,631 words) [view diff] exact match in snippet view article find links to article

the Bulls. Round 9: Jordan Lilley made his 100th appearance for the Bulls. CCR5: Jason Qareqare made his debut for the Bulls. Round 10: Luis Roberts and

Soft selective sweep (1,578 words) [view diff] exact match in snippet view article find links to article

increase from a single copy to the frequency observed today (for example CCR5 adaptation to HIV in humans). On the whole, soft sweeps with multiple origins

Gerardo Turcatti (1,995 words) [view diff] exact match in snippet view article find links to article

Photoactivatable MIP-1α Ligands and Interactions with Chemokine Receptors CCR1 and CCR5§". Journal of Medicinal Chemistry. 44 (2): 215–222. doi:10.1021/jm000982i

DNA-directed RNA interference (2,402 words) [view diff] exact match in snippet view article find links to article

different ways: shRNA, that silences the tat and rev genes of the HIV genome CCR5 ribozyme, inhibiting viral cell entry TAR decoy RNA, inhibiting initiation

RNA silencing (5,475 words) [view diff] exact match in snippet view article find links to article

miR-122 Antiviral pHIV7-shI-TAR-CCR5RZ HIV HIV Tat protein, HIV TAR RNA, human CCR5 Antiviral ALN-RSV01 RSV RSV nucleocapsid Antiviral ALN-RSV01 RSV in lung

Charles Flexner (1,573 words) [view diff] exact match in snippet view article find links to article

Pharmacokinetic/pharmacodynamic modeling of the antiretroviral activity of the CCR5 antagonist vicriviroc in treatment experienced HIV-infected subjects (ACTG

GRB2 (9,365 words) [view diff] exact match in snippet view article find links to article

Chernock RD, Avraham S, Groopman JE (June 2000). "Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk". The Journal of Biological Chemistry

HIV associated cardiomyopathy (1,953 words) [view diff] exact match in snippet view article find links to article

This induces cardiomyocyte apoptosis either by signalling through CCR3, CCR5 or CXCR4, by entry into cardiomyocytes (after binding to ganglioside GM1)

2019 in science (24,771 words) [view diff] exact match in snippet view article find links to article

News. Retrieved 3 June 2019. Wei, Xinzhu; Nielsen, Rasmus (3 June 2019). "CCR5-∆32 is deleterious in the homozygous state in humans". Nature Medicine. 25

Robyn S. Klein (2,672 words) [view diff] exact match in snippet view article find links to article

MS, Schmidt RE, Stevens B, Klein RS. Nature. 2016 Jun;534(7608):538-43. CCR5 limits cortical viral loads during West Nile virus infection of the central

Gwendalyn J. Randolph (2,638 words) [view diff] exact match in snippet view article find links to article

Habenicht AJ, and Randolph GJ. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J. Clin. Invest

Graeme Stewart (immunology) (2,906 words) [view diff] exact match in snippet view article

the best possible care. Early indications that an inherited defect in the CCR5 gene would give immunity, and that this might be used to develop a vaccine