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searching for CYP3A 52 found (266 total)

alternate case: cYP3A

Xenobiotic-sensing receptor (533 words) [view diff] exact match in snippet view article find links to article

glucocorticoids induction of CYP3A were perceived to utilize glucocorticoid receptor. This was explained by the induction of the CYP3A relationships obtained

EMBiology (227 words) [view diff] exact match in snippet view article find links to article

chemical reaction CYP3A has a "ChemicalReaction" relationship with ticagrelor Molecular Synthesis Changes the concentration of the target CYP3A has a "MolSynthesis"

Toxication (928 words) [view diff] exact match in snippet view article find links to article

more toxic forms. Among Phase I CYP450 enzymes, the subfamilies CYP2D6 and CYP3A are responsible for hepatotoxicity during drug metabolism with a number

OR2AE1 (253 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347

Pregnane X receptor (1,978 words) [view diff] exact match in snippet view article find links to article

"Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction". Proceedings of the National Academy of Sciences of the United

Banpeiyu (453 words) [view diff] exact match in snippet view article find links to article

Friedl's Blog "Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans" "Production of Haploid Plant of 'Banpeiyu' Pummelo

Banpeiyu (453 words) [view diff] exact match in snippet view article find links to article

Friedl's Blog "Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans" "Production of Haploid Plant of 'Banpeiyu' Pummelo

Drug-induced QT prolongation (2,162 words) [view diff] exact match in snippet view article find links to article

prolongation and TdP. Erythromycin works inhibiting the CYP3A protein. Patients who have low CYP3A activity and are also concurrently taking other medications

Simnotrelvir/ritonavir (332 words) [view diff] exact match in snippet view article find links to article

drug of simnotrelvir, an inhibitor of SARS-CoV-2 3CLpro, and ritonavir, a CYP3A inhibitor. It was developed by Simcere Pharmaceutical and conditionally

Slavery hypertension hypothesis (878 words) [view diff] exact match in snippet view article find links to article

received considerable media attention. In December 2004, a paper titled CYP3A Variation and the Evolution of Salt-Sensitivity Variants was published which

Ethylmorphine (445 words) [view diff] exact match in snippet view article find links to article

"Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25

ZNF655 (585 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347

Afimoxifene (473 words) [view diff] exact match in snippet view article find links to article

biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6". The Journal of Pharmacology and Experimental Therapeutics.

Bioavailability (2,749 words) [view diff] exact match in snippet view article find links to article

inhibition (decreased rate of metabolism), e.g., grapefruit juice inhibits CYP3A → higher nifedipine concentrations Individual variation in metabolic differences

Clementine (1,451 words) [view diff] exact match in snippet view article find links to article

interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance". European Journal of Pharmaceutical Sciences

Naringin (830 words) [view diff] exact match in snippet view article find links to article

Bernier SM (January 1996). "Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice". Life Sciences. 59 (13): 1025–1030. doi:10

Zonisamide (2,026 words) [view diff] exact match in snippet view article find links to article

catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells". Biochimica et Biophysica Acta (BBA) -

Grapefruit–drug interactions (5,674 words) [view diff] exact match in snippet view article find links to article

lead to increased imatinib plasma concentrations via inhibition of the CYP3A isoenzymes. Seville orange juice is not usually consumed as a juice because

6β-Hydroxycortisol (716 words) [view diff] exact match in snippet view article find links to article

on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies". Xenobiotica. 51 (10): 1199–1206

Triamcinolone (1,498 words) [view diff] exact match in snippet view article find links to article

(February 2013). "Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes". Drug Metabolism and Disposition. 41 (2): 379–389. doi:10.1124/dmd

Lesinurad (896 words) [view diff] exact match in snippet view article find links to article

by microsomal epoxide hydrolase (mEH). The enzymes CYP1A1, CYP2C19 and CYP3A only play minor roles in its metabolization. Glucuronidation by the enzymes

Tadalafil (3,238 words) [view diff] exact match in snippet view article find links to article

Hall SD (February 2003). "Droperidol is predominantly metabolized by human CYP3A enzymes". Clinical Pharmacology & Therapeutics. 73 (2): P16. doi:10

Levobupivacaine (2,303 words) [view diff] exact match in snippet view article find links to article

biotransformation in the liver by the cytochrome P450 enzyme, specifically CYP1A2 and CYP3A isoforms as part of phase one biotransformation, thereby producing inactive

Constitutive androstane receptor (2,272 words) [view diff] exact match in snippet view article find links to article

Examples for CAR-regulated genes are members of the CYP2B, CYP2C, and CYP3A subfamilies, sulfotransferases, and glutathione-S-transferases. Ligands

Guggulsterone (497 words) [view diff] exact match in snippet view article find links to article

(2004). "Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor". Journal of Pharmacology

Calanolide A (2,249 words) [view diff] exact match in snippet view article find links to article

drug has half-life of 20 hours. The drug is metabolised by cytochrome P450 CYP3A. Calanolide A is unique among non-nucleoside reverse transcriptase inhibitor

Norketamine (1,026 words) [view diff] exact match in snippet view article find links to article

by the superfamily of cytochrome P450 enzymes, particularly CYP2B6 and CYP3A. Though these enzymes are predominantly found in the liver, they are present

Irinotecan (2,315 words) [view diff] exact match in snippet view article find links to article

converted by CES1 and CES2 in the liver to SN-38. Induction or inhibition of CYP3A enzymes by smoking, some herbs and medications may result in interactions

ZKSCAN5 (478 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347

Lonafarnib (1,042 words) [view diff] exact match in snippet view article find links to article

Lonafarnib is contraindicated for co-administration with strong or moderate CYP3A inhibitors and inducers, as well as midazolam and certain cholesterol-lowering

Lovastatin (3,305 words) [view diff] exact match in snippet view article find links to article

Pharmacokinetic data Bioavailability <5% Protein binding >98% Metabolism Liver (CYP3A and CYP2C8 substrate) Elimination half-life 2–5 hours Excretion Faeces (83%)

Quinine 3-monooxygenase (305 words) [view diff] exact match in snippet view article find links to article

Birkett, DJ; Wanwimolruk, S (1997). "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine". Br. J. Clin. Pharmacol. 43 (3): 245–52

Hydrocodone (4,924 words) [view diff] exact match in snippet view article find links to article

8.0 hours. Ritonavir is a strong CYP3A4 inhibitor as well as inducer of CYP3A and other enzymes, and the other antivirals are known to inhibit drug transporters

Cystic fibrosis (17,978 words) [view diff] exact match in snippet view article find links to article

the disease as well. The combination drug is also known to interact with CYP3A inducers, such as carbamazepine used in the treatment of bipolar disorder

Dextrorphan (649 words) [view diff] exact match in snippet view article find links to article

vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?". Drug Metabolism and Disposition. 29 (11): 1514–20. PMID 11602530

Docetaxel (4,623 words) [view diff] exact match in snippet view article find links to article

Anticonvulsants induce some metabolic pathways relevant to docetaxel. CYP450 and CYP3A show increased expression in response to the use of anticonvulsants and

Dextromethorphan (4,585 words) [view diff] exact match in snippet view article find links to article

vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?". Drug Metabolism and Disposition. 29 (11): 1514–1520. PMID 11602530

Cortisol (8,516 words) [view diff] exact match in snippet view article find links to article

on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies". Xenobiotica. 51 (10): 1199–1206

Amitriptyline (8,657 words) [view diff] exact match in snippet view article find links to article

von Moltke LL, Graf JA, et al. (October 2001). "Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies". Journal

Epoxydocosapentaenoic acid (2,011 words) [view diff] exact match in snippet view article find links to article

to epoxides include: CYP1A, CYP2B, CYP2C, CYP2E, CYP2J, and within the CYP3A subfamily, CYP3A4. In humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly

Mycoestrogen (1,243 words) [view diff] exact match in snippet view article find links to article

Lichti K, Staudinger JL (June 2006). "The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor". Toxicological Sciences.

List of MeSH codes (D08) (15,232 words) [view diff] case mismatch in snippet view article

972 – cytochrome p-450 cyp2e1 MeSH D08.244.453.040.986 – cytochrome p-450 cyp3a MeSH D08.244.453.085 – camphor 5-monooxygenase MeSH D08.244.453.915 – steroid

Epoxyeicosatrienoic acid (5,934 words) [view diff] exact match in snippet view article find links to article

subfamilies including CYP1A, CYP2B, CYP2C, CYP2E, CYP2J, and within the CYP3A sub family, CYP3A4; in humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly

Sean Ekins (2,558 words) [view diff] exact match in snippet view article find links to article

Ekins, S. et al. (2002) Pharmacophore insights into the active sites of the CYP3A enzymes. The Pharmacologist 44 Supplement, 114. Ethell, B.T.; et al. (2002)

Spironolactone (18,252 words) [view diff] exact match in snippet view article find links to article

the 6α-hydroxylation reaction, whereas other P450 enzymes (such as the CYP3A enzymes in all mammalian species) preferentially catalyze the 6β-hydroxylation

COVID-19 drug development (13,107 words) [view diff] exact match in snippet view article find links to article

Nirmatrelvir inhibits SARS-CoV-2 main protease, while ritonavir is a strong CYP3A inhibitor, slowing down nirmatrelvir metabolism and therefore boosting its

Cyproterone acetate (13,370 words) [view diff] exact match in snippet view article find links to article

M (December 2005). "Functional interactions between P-glycoprotein and CYP3A in drug metabolism". Expert Opinion on Drug Metabolism & Toxicology. 1 (4):

Physiologically based pharmacokinetic modelling (3,144 words) [view diff] exact match in snippet view article find links to article

bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution". Journal of Pharmacy

Epoxyeicosatetraenoic acid (2,559 words) [view diff] exact match in snippet view article find links to article

(i.e.CYP1A), CYP2B, CYP2C, CYP2E, and CYP2J subfamilies, and within the CYP3A subfamily, CYP3A4. In humans, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19

Leon Aarons (1,599 words) [view diff] exact match in snippet view article find links to article

formulations can have [when there are] clinically-relevant DDI involving CYP3A substrates...[and that]... this aspect is generally overlooked when evaluating

List of MeSH codes (D12.776) (7,397 words) [view diff] case mismatch in snippet view article

cytochrome p-450 cyp2e1 MeSH D12.776.422.220.453.040.972 – cytochrome p-450 cyp3a MeSH D12.776.422.220.453.085 – camphor 5-monooxygenase MeSH D12.776.422

Pharmacology of cyproterone acetate (14,433 words) [view diff] exact match in snippet view article find links to article

M (December 2005). "Functional interactions between P-glycoprotein and CYP3A in drug metabolism". Expert Opinion on Drug Metabolism & Toxicology. 1 (4):