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searching for Carbonyl group 294 found (499 total)

Knoevenagel condensation (691 words) [view diff] exact match in snippet view article find links to article

condensation is a nucleophilic addition of an active hydrogen compound to a carbonyl group followed by a dehydration reaction in which a molecule of water is eliminated

Dakin oxidation (1,519 words) [view diff] exact match in snippet view article find links to article

(H2O2) in base to form a benzenediol and a carboxylate. Overall, the carbonyl group is oxidised, whereas the H2O2 is reduced. The Dakin oxidation, which

Reductive amination (2,134 words) [view diff] exact match in snippet view article find links to article

amination that involves the conversion of a carbonyl group to an amine via an intermediate imine. The carbonyl group is most commonly a ketone or an aldehyde

Double bond (933 words) [view diff] exact match in snippet view article find links to article

double bonds exist between two different elements: for example, in a carbonyl group between a carbon atom and an oxygen atom. Other common double bonds

Barbier reaction (486 words) [view diff] exact match in snippet view article find links to article

organometallic reaction between an alkyl halide (chloride, bromide, iodide), a carbonyl group and a metal. The reaction can be performed using magnesium, aluminium

Luche reduction (334 words) [view diff] exact match in snippet view article find links to article

catalyzed by the cerium salt by increasing the electrophilicity of the carbonyl group. This is selective for ketones because they are more Lewis basic. In

Acid catalysis (883 words) [view diff] exact match in snippet view article find links to article

these reactions, the conjugate acid of the carbonyl group is a better electrophile than the neutral carbonyl group itself. Depending on the chemical species

Wolff–Kishner reduction (4,211 words) [view diff] exact match in snippet view article find links to article

complex molecule synthesis, it is most frequently employed to remove a carbonyl group after it has served its synthetic purpose of activating an intermediate

Regioselectivity (438 words) [view diff] exact match in snippet view article find links to article

this reaction, an oxygen is regioselectively inserted near an adjacent carbonyl group. In ketones, this insertion is directed toward the carbon which is more

Oxo-Diels–Alder reaction (152 words) [view diff] exact match in snippet view article find links to article

known. Many strategies rely on coordinating a chiral Lewis acid to the carbonyl group. Aza Diels–Alder reaction Imine Diels–Alder reaction A Diels–Alder Type

Carboxypeptidase (816 words) [view diff] exact match in snippet view article find links to article

mechanism as it acts as a base to allow for the attack at the amide carbonyl group during nucleophilic addition. It acts as an acid during elimination

Favorskii reaction (605 words) [view diff] exact match in snippet view article find links to article

Favorskii reaction is an organic chemistry reaction between an alkyne and a carbonyl group, under basic conditions. The reaction was discovered in the early 1900s

Pechmann condensation (434 words) [view diff] exact match in snippet view article find links to article

starting from a phenol and a carboxylic acid or ester containing a β-carbonyl group. The condensation is performed under acidic conditions. The mechanism

Acyl halide (1,075 words) [view diff] exact match in snippet view article find links to article

the compound contains a −C(=O)X functional group, which consists of a carbonyl group (C=O) singly bonded to a halogen atom. The general formula for such

Willgerodt rearrangement (449 words) [view diff] exact match in snippet view article find links to article

ending up at the terminal end. The net effect is thus migration of the carbonyl group to the end of the chain and oxidation. An example with modified reagents

Cyclopropenone (185 words) [view diff] exact match in snippet view article find links to article

properties of the compound are dominated by the strong polarization of the carbonyl group, which gives a partial positive charge with aromatic stabilization on

Semipinacol rearrangement (309 words) [view diff] exact match in snippet view article find links to article

2-migration of a C–C or C–H bond to terminate the process, generating a carbonyl group ". The rearrangement reaction can be classified into 4 types. Type 1

Pinacolone (385 words) [view diff] exact match in snippet view article find links to article

The α-methyl group can participate in condensation reactions. The carbonyl group can undergo the usual reactions (hydrogenation, reductive amination

Tetrahedral carbonyl addition compound (2,329 words) [view diff] exact match in snippet view article find links to article

tetrahedral. Tetrahedral intermediates result from nucleophilic addition to a carbonyl group. The stability of tetrahedral intermediate depends on the ability of

Lomefloxacin (209 words) [view diff] exact match in snippet view article find links to article

magnesium chelate with itself. The chelate is formed between the 2-carbonyl group of two separate lomefloxacin molecules." It was patented in 1983 and

Lithium diisopropylamide (776 words) [view diff] exact match in snippet view article find links to article

the deprotonation of esters at the α position without attack of the carbonyl group. LDA is commonly formed by treating a cooled (0 to −78 °C) mixture of

Mannich reaction (1,013 words) [view diff] exact match in snippet view article find links to article

Mannich reaction starts with the nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff base. The Schiff base is an electrophile

Neighbouring group participation (818 words) [view diff] exact match in snippet view article find links to article

gives the endo isomer because of a secondary effect {overlap of the carbonyl group π orbitals with the transition state in the Diels-Alder reaction}) this

Dowd–Beckwith ring-expansion reaction (426 words) [view diff] exact match in snippet view article find links to article

the halogen atom to form an alkyl radical. This radical attacks the carbonyl group to an intermediate bicyclic ketyl. This intermediate then rearranges

Uronic acid (240 words) [view diff] exact match in snippet view article find links to article

groups. They are sugars in which the hydroxyl group furthest from the carbonyl group has been oxidized to a carboxylic acid. Usually the sugar is an aldose

Chlorophyll b (525 words) [view diff] exact match in snippet view article find links to article

is more soluble than chlorophyll a in polar solvents because of its carbonyl group. Its color is green, and it primarily absorbs blue light. In land plants

Vinylogy (906 words) [view diff] exact match in snippet view article find links to article

carbon–carbon double bond. For example, a carboxylic acid is defined as a carbonyl group (C=O) directly attached to a hydroxyl group (OH): O=C–OH. A vinylogous

Triose (150 words) [view diff] exact match in snippet view article find links to article

D-Glyceraldehyde is an aldotriose because the carbonyl group is at the end of the chain

Hexose (1,908 words) [view diff] exact match in snippet view article find links to article

connected by a single bond, and one has an oxo group (=O), forming a carbonyl group (C=O). The remaining bonds of the carbon atoms are satisfied by seven

Α-Ketol rearrangement (1,281 words) [view diff] exact match in snippet view article find links to article

α-ketol rearrangement involves the transformation of an alkoxide into a carbonyl group with concomitant movement of the bonding electrons of the migrating

Nucleophilic acyl substitution (3,012 words) [view diff] exact match in snippet view article find links to article

order for a reaction to be practical. Under acidic conditions, the carbonyl group of the acyl compound 1 is protonated, which activates it towards nucleophilic

Oxazolone (203 words) [view diff] exact match in snippet view article find links to article

structural isomers of oxazolone; 3 according to the location of the carbonyl group and 2 more according to the location of the double bound C=X (with X=

Nucleophilic acyl substitution (3,012 words) [view diff] exact match in snippet view article find links to article

order for a reaction to be practical. Under acidic conditions, the carbonyl group of the acyl compound 1 is protonated, which activates it towards nucleophilic

Carbonate ester (1,314 words) [view diff] exact match in snippet view article find links to article

organocarbonate) is an ester of carbonic acid. This functional group consists of a carbonyl group flanked by two alkoxy groups. The general structure of these carbonates

Methylcrotonyl-CoA carboxylase (1,329 words) [view diff] exact match in snippet view article find links to article

group source to catalyze the carboxylation of a carbon adjacent to a carbonyl group performing the fourth step in processing leucine, an essential amino

Α-Halo ketone (670 words) [view diff] exact match in snippet view article find links to article

a functional group consisting of a ketone group or more generally a carbonyl group with an α-halogen substituent. α-Halo ketones are alkylating agents

Para-Dimethylaminobenzaldehyde (527 words) [view diff] exact match in snippet view article find links to article

used in Ehrlich's reagent and Kovac's reagent to test for indoles. The carbonyl group typically reacts with the electron rich 2-position of the indole but

Acridone (291 words) [view diff] exact match in snippet view article find links to article

Acridone is an organic compound based on the acridine skeleton, with a carbonyl group at the 9 position. The molecule is planar. Optical spectra reveal that

Carbohydrate (5,639 words) [view diff] exact match in snippet view article find links to article

characteristics: the placement of its carbonyl group, the number of carbon atoms it contains, and its chiral handedness. If the carbonyl group is an aldehyde, the monosaccharide

Dibenzyl ketone (182 words) [view diff] exact match in snippet view article find links to article

organic compound composed of two benzyl groups attached to a central carbonyl group. This results in the central carbonyl carbon atom being electrophilic

Carbonyl α-substitution reactions (982 words) [view diff] exact match in snippet view article find links to article

Alpha-substitution reactions occur at the position next to the carbonyl group, the α-position, and involve the substitution of an α hydrogen atom by an

Beta oxidation (3,362 words) [view diff] exact match in snippet view article find links to article

carbon of the fatty acid chain undergoes oxidation and is converted to a carbonyl group to start the cycle all over again. Beta-oxidation is primarily facilitated

Benzilic acid rearrangement (950 words) [view diff] exact match in snippet view article find links to article

position for attack on the second carbonyl group. In a concerted step, the migrating R group attacks the α-carbonyl group forming another alkoxide with concomitant

Diazo (1,342 words) [view diff] exact match in snippet view article find links to article

electron density is further delocalized into an electron-withdrawing carbonyl group. In contrast, most diazoalkanes without electron-withdrawing substituents

Beta bend ribbon (722 words) [view diff] exact match in snippet view article find links to article

bonded beta turns in which the carbonyl group of residue i is hydrogen-bonded to the NH of residue i+3 while the carbonyl group of residue i+2 is hydrogen-bonded

2,4-Dinitrophenylhydrazine (565 words) [view diff] exact match in snippet view article find links to article

addition-elimination reaction: nucleophilic addition of the -NH2 group to the C=O carbonyl group, followed by the elimination of a H2O molecule: DNP-derived hydrazones

Prins reaction (1,068 words) [view diff] exact match in snippet view article find links to article

and addition can be concerted with transfer of an allyl proton to the carbonyl group which in effect is an ene reaction in scheme 6. in green: capture of

Transposed Paternò−Büchi reaction (96 words) [view diff] exact match in snippet view article find links to article

reversal of the traditional Paternò−Büchi reaction where an excited carbonyl group reacts with a ground state alkene. This strategy was first reported

Self-condensation (488 words) [view diff] exact match in snippet view article find links to article

self-condensation is an organic reaction in which a chemical compound containing a carbonyl group (C=O) acts both as the electrophile and the nucleophile in an aldol

Ketone halogenation (812 words) [view diff] exact match in snippet view article find links to article

selectively in the alpha position of a ketone. The position alpha to the carbonyl group (C=O) in a ketone is easily halogenated. This is due to its ability

Topicity (1,129 words) [view diff] exact match in snippet view article find links to article

the carbonyl group in cis-2,6-dimethylcyclohexanone are enantiotopic; they are related by an internal plane of symmetry passing through the carbonyl group

N-Acetylglutamate synthase (1,223 words) [view diff] exact match in snippet view article find links to article

one-step mechanism through direct attack of the amino nitrogen on the carbonyl group. Studies conducted using NAGS derived from Neisseria gonorrhoeae suggest

Reductone (118 words) [view diff] exact match in snippet view article find links to article

reductone is a special class of organic compounds. They are enediols with a carbonyl group adjacent to the enediol group, i.e. RC(OH)=C(OH)-C(O)R. The enediol

Umpolung (1,784 words) [view diff] exact match in snippet view article find links to article

Ordinarily the oxygen atom in the carbonyl group is more electronegative than the carbon atom and therefore the carbonyl group reacts as an electrophile at

Piranha solution (2,165 words) [view diff] exact match in snippet view article find links to article

oxidation, for example, can convert the initial carbonyl group into carbon dioxide and create a new carbonyl group on the neighbouring carbon whose bonds were

ST staple (252 words) [view diff] exact match in snippet view article find links to article

serine or threonine (at residue i + 3 or i + 4) and the main chain carbonyl group of residue i. Motifs are of two types, depending whether the motif has

Hydrolysis (2,269 words) [view diff] exact match in snippet view article find links to article

nucleus-seeking agent, e.g., water or hydroxyl ion) attacks the carbon of the carbonyl group of the ester or amide. In an aqueous base, hydroxyl ions are better

Prokaryotic large ribosomal subunit (1,476 words) [view diff] exact match in snippet view article find links to article

group of an aminoacyl-tRNA (binds to A site) attacks the carbon of a carbonyl group of a peptidyl-tRNA (binds to P site) and finally yields a peptide extended

Pellizzari reaction (417 words) [view diff] exact match in snippet view article find links to article

compound 5. The nitrogen then performs an intramolecular attack on the carbonyl group to form the five-membered ring of compound 6. After another proton migration

Β-Lactamase inhibitor (1,696 words) [view diff] exact match in snippet view article find links to article

active site forms a transient covalent bond to the beta-lactam ring carbonyl group, cleaving the beta-lactam ring in the process. In a second step, nucleophilic

IC-26 (218 words) [view diff] exact match in snippet view article find links to article

Methiodone) is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group. Human and animal

1,1-Dihydroxyethene (275 words) [view diff] exact match in snippet view article find links to article

formally involves an addition reaction of one water molecule onto the carbonyl group, is likely catalyzed by a second water molecule. The compound has now

Benzoin condensation (781 words) [view diff] exact match in snippet view article find links to article

intermediate results in polarity reversal of the carbonyl group, which then adds to the second carbonyl group in a second nucleophilic addition. Proton transfer

Danishefsky's diene (963 words) [view diff] exact match in snippet view article find links to article

reaction: In the cycloaddition product, the silyl ether is a synthon for a carbonyl group through the enol. The methoxy group is susceptible to an elimination

Danishefsky Taxol total synthesis (1,409 words) [view diff] exact match in snippet view article find links to article

peroxide gave alcohol 5. The hydroxyl group was then oxidized to a carbonyl group giving ketone 6 by action of pyridinium dichromate. With all the sensitive

Prostaglandin F synthase (1,352 words) [view diff] exact match in snippet view article find links to article

substrate binds to the active site through hydrogen bonding between the carbonyl group of PGD2 and the hydroxyl group of tyrosine (Y55) as well as one of the

1,1-Diphenylacetone (106 words) [view diff] exact match in snippet view article find links to article

composed of a benzhydryl group and a methyl group attached to a central carbonyl group. One method is where phenylacetone is dissolved in benzene, reacted

Quinuclidone (594 words) [view diff] exact match in snippet view article find links to article

very unstable because its amide group has the amine lone pair and the carbonyl group not properly aligned, as may be expected for an amide, as a result of

Stuart Warren (615 words) [view diff] case mismatch in snippet view article find links to article

Warren is well known for his university-level textbooks Chemistry of the Carbonyl Group (1974), Designing Organic Syntheses: The Synthon Approach (1978), Organic

Norrish reaction (1,067 words) [view diff] exact match in snippet view article find links to article

aldehydes and ketones into two free radical intermediates (α-scission). The carbonyl group accepts a photon and is excited to a photochemical singlet state. Through

Kulinkovich reaction (1,696 words) [view diff] exact match in snippet view article find links to article

an alkane molecule and a titanacyclopropane 1. The insertion of the carbonyl group of the ester in the weakest carbon-titanium bond, leads to an oxatitanacyclopentane

Demjanov rearrangement (755 words) [view diff] exact match in snippet view article find links to article

5α-3-oxosteroids. Evidence for predominant equatorial approach of the C-3 carbonyl group by diazomethane". Tetrahedron. 29 (14): 1941–1947. doi:10.1016/0040-4020(73)80128-0

Einhorn–Brunner reaction (655 words) [view diff] exact match in snippet view article find links to article

allows for an attack on the electrophilic carbon of the protonated carbonyl group by the primary amino group of the hydrazine, producing 3. The loss of

Tropolone (1,188 words) [view diff] exact match in snippet view article find links to article

acidity compared to phenol is due to resonance stabilization with the carbonyl group, as a vinylogous carboxylic acid. The compound readily undergoes O-alkylation

Allylic rearrangement (643 words) [view diff] exact match in snippet view article find links to article

shifts can also take place with electrophiles. In the example below the carbonyl group in benzaldehyde is activated by diboronic acid prior to reaction with

Paternò–Büchi reaction (331 words) [view diff] exact match in snippet view article find links to article

Here an electronically excited carbonyl group is added to a ground state olefin yielding an oxetane.

5-HT3 antagonist (4,628 words) [view diff] exact match in snippet view article find links to article

The carbonyl group is responsible for a strong interaction with the receptor and contributes significantly to the binding process. This carbonyl group is

Enone–alkene cycloadditions (1,024 words) [view diff] exact match in snippet view article find links to article

depending on the orientation of substituents on the alkene and the enone carbonyl group. When the enone carbonyl and substituent of highest priority are proximal

2-Oxazolidone (770 words) [view diff] exact match in snippet view article find links to article

clinical trials for use in humans. Oxazolidine – the ring without the carbonyl group Oxazolone – the unsaturated analogues Shinabarger, D. (1999). "Mechanism

Schmidt reaction (909 words) [view diff] exact match in snippet view article find links to article

In the reaction mechanism for the Schmidt reaction of ketones, the carbonyl group is activated by protonation for nucleophilic addition by the azide,

Gabriel–Colman rearrangement (831 words) [view diff] exact match in snippet view article find links to article

either CO or SO2. The reaction mechanism starts with an attack on the carbonyl group by a strong base, such as methoxide ion. The ring is then opened, forming

Saponification (1,246 words) [view diff] exact match in snippet view article find links to article

oil batch and laboratory averages. The hydroxide anion adds to the carbonyl group of the ester. The immediate product is called an orthoester. Expulsion

Kiliani–Fischer synthesis (772 words) [view diff] exact match in snippet view article find links to article

(typically NaCN); the cyanide undergoes nucleophilic addition to the carbonyl group of the sugar (while sugars tend to exist mainly as cyclic hemiacetal

TMTFA (313 words) [view diff] exact match in snippet view article find links to article

This is due to the electron-withdrawing trifluoromethyl group on the carbonyl group. Acetylcholinesterase inhibitor Methylfluorophosphonylcholine Transition

Methicillin (698 words) [view diff] exact match in snippet view article find links to article

the ortho-dimethoxyphenyl group directly attached to the side-chain carbonyl group of the penicillin nucleus facilitates the β-lactamase resistance, since

Molindone (434 words) [view diff] exact match in snippet view article find links to article

tautomeric equilibrium with imine 4. Aldol condensation of the side chain carbonyl group with the doubly activated ring methylene group would then result in

Cyclol (6,361 words) [view diff] exact match in snippet view article find links to article

is added to a peptidyl carbonyl group. Likewise, a thiacyclol is formed by adding an SH thiol moiety to a peptidyl carbonyl group. The oxacyclol alkaloid

Pinacol coupling reaction (891 words) [view diff] exact match in snippet view article find links to article

first step in the reaction mechanism is a one-electron reduction of the carbonyl group by a reducing agent —such as magnesium— to a ketyl radical anion species

Prelog strain (1,185 words) [view diff] exact match in snippet view article find links to article

hand, some nucleophilic addition reactions involving addition to a carbonyl group in general show the opposite trend. Smaller and normal rings, with five

Procaterol (370 words) [view diff] exact match in snippet view article find links to article

This undergoes action of isopropylamine, forming an aminoketone, the carbonyl group of which is reduced by sodium borohydride, giving procaterol 4. It is

Moxazocine (304 words) [view diff] exact match in snippet view article find links to article

10x as potent by weight as morphine as an analgesic. Reduction of the carbonyl group in oxygenated benzomorphan 1 affords the corresponding alcohol (2).

Shiina macrolactonization (1,172 words) [view diff] exact match in snippet view article find links to article

with the activated TFBA to produce mixed anhydride (MA) once. Then, a carbonyl group derived from the seco acid in MA is selectively activated and is attacked

Nozaki–Hiyama–Kishi reaction (664 words) [view diff] exact match in snippet view article find links to article

intermediate and regenerating Ni(II). This species reacts with the carbonyl group in a nucleophilic addition. The amount of nickel used should be low

Organolithium reagent (5,971 words) [view diff] exact match in snippet view article find links to article

sterically hindered, using Grignard reagents often leads to reduction of the carbonyl group instead of addition. However, alkyllithium reagents are less likely

Osazone (308 words) [view diff] exact match in snippet view article find links to article

oxidation and condensation reactions. Since the reaction requires a free carbonyl group, only "reducing sugars" participate. Sucrose, which is nonreducing,

Geminal halide hydrolysis (285 words) [view diff] exact match in snippet view article find links to article

and this enables the newly created hydroxy group to convert into a carbonyl group by expelling the halide: RCH(OH)Cl ⟶ {\textstyle \longrightarrow } Rearrangement

Oxathiazolones (763 words) [view diff] exact match in snippet view article find links to article

isothiazole, analogues without the carbonyl group or oxygen atom. Oxazole and isoxazole, analogues without the carbonyl group or sulfur atom. Jukič M, Grabrijan

E1cB-elimination reaction (2,146 words) [view diff] exact match in snippet view article find links to article

conditions. This involves the deprotonation of a compound containing a carbonyl group that results in the formation of an enolate. The enolate is the very

Oxazole (616 words) [view diff] exact match in snippet view article find links to article

Oxazolidine, which has both double bonds reduced. Oxazolone, an analog with a carbonyl group Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

Shiina esterification (1,478 words) [view diff] exact match in snippet view article find links to article

with the activated TFBA to produce mixed anhydride (MA) once. Then, a carbonyl group derived from the carboxylic acid in MA is selectively activated and

Ketene (1,260 words) [view diff] exact match in snippet view article find links to article

base, usually triethylamine, removes the acidic proton alpha to the carbonyl group, inducing the formation of the carbon-carbon double bond and the loss

Demethylation (1,462 words) [view diff] exact match in snippet view article find links to article

EtSNa. Aromatic methyl ethers, particularly those with an adjacent carbonyl group, can be regioselectively demethylated using magnesium iodide etherate

Biginelli reaction (1,074 words) [view diff] exact match in snippet view article find links to article

the ring is closed by the nucleophilic attack by the amine onto the carbonyl group. This final step ensues a second condensation and results in the Biginelli

Linopirdine (487 words) [view diff] exact match in snippet view article find links to article

position is now activated by the adjacent benzene ring on one side and the carbonyl group on the other. Alkylation with 4-picolylchloride [10445-91-7] (8) proceeds

Nucleophilic substitution (1,436 words) [view diff] exact match in snippet view article find links to article

aromatic substitution article. When the substitution occurs at the carbonyl group, the acyl group may undergo nucleophilic acyl substitution. This is

Aldehyde deformylating oxygenase (984 words) [view diff] exact match in snippet view article find links to article

of medium and long chain aldehydes to alkanes via the removal of a carbonyl group as formate. n-aldehyde + O2 + 2 NADPH + H+ → (n-1)-alkane + formate

Oxonium ion (1,095 words) [view diff] exact match in snippet view article find links to article

is the oxocarbenium ions, obtained by protonation or alkylation of a carbonyl group e.g. R−C=+O−R′ which forms a resonance structure with the fully-fledged

1,3-Dipolar cycloaddition (6,426 words) [view diff] exact match in snippet view article find links to article

conversion to the metallocarbene, an intermolecular reaction with a carbonyl group can generate the carbonyl ylide. Subsequent cycloaddition reaction with

Glyceraldehyde 3-phosphate dehydrogenase (3,750 words) [view diff] exact match in snippet view article find links to article

First, a cysteine residue in the active site of GAPDH attacks the carbonyl group of G3P, creating a hemithioacetal intermediate (covalent catalysis)

Wittig reaction (1,600 words) [view diff] exact match in snippet view article find links to article

leukotriene A methyl ester. The first step uses a stabilised ylide, where the carbonyl group is conjugated with the ylide preventing self condensation, although

1,3-Dipolar cycloaddition (6,426 words) [view diff] exact match in snippet view article find links to article

conversion to the metallocarbene, an intermolecular reaction with a carbonyl group can generate the carbonyl ylide. Subsequent cycloaddition reaction with

Fucoxanthin (826 words) [view diff] exact match in snippet view article find links to article

allenic bond (two adjacent carbon-carbon double bonds) and a conjugated carbonyl group (carbon-oxygen double bond) in the polyene chain. All of these features

Wittig reaction (1,600 words) [view diff] exact match in snippet view article find links to article

leukotriene A methyl ester. The first step uses a stabilised ylide, where the carbonyl group is conjugated with the ylide preventing self condensation, although

Aldol condensation (1,679 words) [view diff] exact match in snippet view article find links to article

displacement A Robinson annulation involves an α,β-unsaturated ketone and a carbonyl group, which first engage in a Michael reaction prior to the aldol condensation

Acid (5,955 words) [view diff] exact match in snippet view article find links to article

where R is an organic radical. The carboxyl group -C(O)OH contains a carbonyl group, C=O, and a hydroxyl group, O-H. Acetic acid (CH3COOH) Citric acid (C6H8O7)

Stereoselectivity (1,006 words) [view diff] exact match in snippet view article find links to article

diastereomer resulting from the diastereoselective nucleophilic addition to a carbonyl group next to a chiral center. The chiral center need not be optically pure

Beta-peptide (879 words) [view diff] exact match in snippet view article find links to article

next to the amine are called β3 and those with position next to the carbonyl group are called β2. A β-peptide can consist of only one kind of these amino

Ring-closing metathesis (4,700 words) [view diff] exact match in snippet view article find links to article

transition state) passing through the front of the carbonyl group in and not the back. The carbonyl group then locks the ring permanently in place. The E/Z

Dimethyldioxirane (445 words) [view diff] case mismatch in snippet view article find links to article

"A Mild and Efficient Nef Reaction for the Conversion of Nitro to Carbonyl Group by Dimethyldioxirane (DMD) Oxidation of Nitronate Anions". Synlett.

Fructose-bisphosphate aldolase (1,622 words) [view diff] exact match in snippet view article find links to article

acceptors. Class II proteins use a different mechanism which polarizes the carbonyl group with a divalent cation like Zn2+. The Escherichia coli galactitol operon

Aminolevulinic acid synthase (1,308 words) [view diff] exact match in snippet view article find links to article

condensation with succinyl-CoA and loss of CoA. Protonation of the carbonyl group of the intermediate by an active site histidine leads to loss of the

NT5C (1,438 words) [view diff] exact match in snippet view article find links to article

chain amides form hydrogen bonds with the 4-carbonyl group of dUMP and dTMP and with the 6-carbonyl group of dGMP and dIMP, while repelling the 4-amino

Monosaccharide (2,059 words) [view diff] exact match in snippet view article find links to article

a cyclic form, through a nucleophilic addition reaction between the carbonyl group and one of the hydroxyl groups of the same molecule. The reaction creates

Guanine (1,523 words) [view diff] exact match in snippet view article find links to article

and the N-3 amine as the hydrogen-bond acceptors. Guanine has the C-6 carbonyl group that acts as the hydrogen bond acceptor, while a group at N-1 and the

Trimethylsilyl chloride (921 words) [view diff] exact match in snippet view article find links to article

by epoxidation or dihydroxylation can be used to return the original carbonyl group with an alcohol group at the alpha carbon. The trimethylsilyl enol ethers

Chymotrypsin (1,100 words) [view diff] exact match in snippet view article find links to article

assays. Chymotrypsin cleaves peptide bonds by attacking the unreactive carbonyl group with a powerful nucleophile, the serine 195 residue located in the active

Nucleobase (1,374 words) [view diff] no match in snippet view article find links to article

of them through deamination (replacement of the amine-group with a carbonyl-group). Hypoxanthine is produced from adenine, xanthine from guanine, and

Dieter Seebach (297 words) [view diff] exact match in snippet view article find links to article

beta-peptides. The development of the umpolung, a polarity inversion of the carbonyl group, with 1,3-propanedithiol together with Corey had a big influence on

Nucleophilic abstraction (807 words) [view diff] exact match in snippet view article find links to article

carbonyl. There is an nucleophilic attack of Me3NO on the carbon of the carbonyl group which pushes electrons on the metal. The reaction then proceeds to kick

Protease (2,799 words) [view diff] exact match in snippet view article find links to article

and metalloproteases) nucleophilic so that it can attack the peptide carbonyl group. One way to make a nucleophile is by a catalytic triad, where a histidine

Dieter Seebach (297 words) [view diff] exact match in snippet view article find links to article

beta-peptides. The development of the umpolung, a polarity inversion of the carbonyl group, with 1,3-propanedithiol together with Corey had a big influence on

Protease (2,799 words) [view diff] exact match in snippet view article find links to article

and metalloproteases) nucleophilic so that it can attack the peptide carbonyl group. One way to make a nucleophile is by a catalytic triad, where a histidine

Polyketide (2,213 words) [view diff] exact match in snippet view article find links to article

because they contain different combinations of domains that reduce the carbonyl group to a hydroxyl (via a ketoreductase), an olefin (via a dehydratase),

Pyridoxamine (1,517 words) [view diff] exact match in snippet view article find links to article

research study found that pyridoxamine specifically reacts with the carbonyl group in Amadori products, but inhibition of post-Amadori reactions (that

Diethyl malonate (765 words) [view diff] exact match in snippet view article find links to article

groups (−C(=O)−). The hydrogen atoms on the carbon adjacent to the carbonyl group in a molecule is significantly more acidic than hydrogen atoms on a

Urea nitrate (452 words) [view diff] exact match in snippet view article find links to article

nitrate explosions may be initiated using a blasting cap. Urea contains a carbonyl group. The more electronegative oxygen atom pulls electrons away from the

Ugi reaction (1,607 words) [view diff] exact match in snippet view article find links to article

reaction (lacking the amine) the isocyanide reacts directly with the carbonyl group but other aspects of the reaction are the same. This reaction can take

Ethane-1,2-dithiol (277 words) [view diff] exact match in snippet view article find links to article

Protecting a carbonyl group by converting it to a 1,3-dithiolane, using ethane-1,2-dithiol

Spin label (389 words) [view diff] exact match in snippet view article find links to article

carbons (5, 7, 9, 12, 13, 14 and 16) with respect to first carbon of carbonyl group have been used to study the flexibility gradient of membrane lipids

Marker degradation (1,828 words) [view diff] exact match in snippet view article find links to article

from ring B to ring A so that it is in conjugation with the ketone carbonyl group at position 3. Alternatively, a three-step procedure involving Br2,

Stille reaction (5,491 words) [view diff] exact match in snippet view article find links to article

Stille-carbonylative cross-coupling reaction, which introduces the carbonyl group via carbon monoxide insertion. Allylic, benzylic, and propargylic halides

Kinetic inhibitor (329 words) [view diff] exact match in snippet view article find links to article

resides. Instead, the alkyl group penetrates the cavity followed by the carbonyl group of the amide group hydrogen bonding to the surface of the hydrate, thus

Lawesson's reagent (686 words) [view diff] exact match in snippet view article find links to article

intermediate. In general, the more electron rich a carbonyl is, the faster the carbonyl group will be converted into the corresponding thiocarbonyl by Lawesson's

Cyclohexenone (683 words) [view diff] exact match in snippet view article find links to article

With strong bases, the positions 4 and 6 (the two CH2-groups of the carbonyl group and the C-C double bond adjacent) are deprotonated. Cyclohexenone is

C2-Symmetric ligands (1,164 words) [view diff] exact match in snippet view article find links to article

like expected). The ligand and metal presence changes all that. The carbonyl group will coordinate with the metal and due to the steric bulk of the phenyl

Sigmatropic reaction (2,106 words) [view diff] exact match in snippet view article find links to article

upon heating yields a γ,δ-unsaturated carbonyl. The formation of a carbonyl group makes this reaction, unlike other sigmatropic rearrangements, inherently

D-Amino acid (1,588 words) [view diff] exact match in snippet view article find links to article

between these enantiomers. ᴅ-glyceraldehyde on the other hand, contains a carbonyl group and hydroxy (alcohol) groups with the chiral carbon in the center. The

Nucleic acid sequence (2,409 words) [view diff] no match in snippet view article find links to article

of them through deamination (replacement of the amine-group with a carbonyl-group). Hypoxanthine is produced from adenine, and xanthine is produced from

Acridine (1,349 words) [view diff] exact match in snippet view article find links to article

with aniline and zinc chloride or by distilling acridone (9-position a carbonyl group) over zinc dust. Another classic method for the synthesis of acridones

SDHA (1,965 words) [view diff] exact match in snippet view article find links to article

This facilitates a second hydrogen bond interaction between the O4 carbonyl group of ubiquinone and Ser27 of SDHC. Following the first single electron

Hernandulcin (252 words) [view diff] exact match in snippet view article find links to article

of the chemical structure that produced the intense sweet taste—the carbonyl group, the hydroxyl group, and the hydrophobic side chain. Hernandulcin was

Cannabinoid receptor antagonist (4,216 words) [view diff] exact match in snippet view article find links to article

The key binding interaction is a hydrogen bond formed between the carbonyl group of rimonabant and the Lys192 residue of the CB1 receptor. This bond

Diphenylcyclopropenone (517 words) [view diff] exact match in snippet view article find links to article

diphenylcyclopropenone are dominated by the strong polarization of the carbonyl group, which gives a partial positive charge with aromatic stabilization on

Eukaryotic translation termination factor 1 (5,512 words) [view diff] exact match in snippet view article find links to article

the Asn61 and Lys63 residues of NIKS forming hydrogen bonds with the carbonyl group of the uracil. A secondary hydrogen bond is formed between the Asn61

T7 DNA polymerase (2,535 words) [view diff] exact match in snippet view article find links to article

Tyr526, His506, Arg518 side chains and the oxygen from the backbone carbonyl group of Ala476 take part in the hydrogen bond network and assist in aligning

Spirorenone (766 words) [view diff] exact match in snippet view article find links to article

hydroxyl group. Addition of the dianion from propargyl alcohol to the carbonyl group at position 17 adds the required carbon atoms for the future lactone

Robinson annulation (1,743 words) [view diff] exact match in snippet view article find links to article

carbon atoms of the α,β-unsaturated system and the carbon α to its carbonyl group make up the four-carbon bridge of the newly installed ring. In order

Merocyanine (183 words) [view diff] exact match in snippet view article find links to article

streptocyanines and their analogues where both the nitrogen atom and carbonyl group (or any other electron-withdrawing group containing a multiple carbon-heteroatomic

Trypsin (2,776 words) [view diff] exact match in snippet view article find links to article

defined specificity, as it hydrolyzes only the peptide bonds in which the carbonyl group is contributed either by an arginine or lysine residue. Trypsin can

Discovery and development of angiotensin receptor blockers (3,868 words) [view diff] exact match in snippet view article find links to article

than valsartan and losartan and it has an imidazolinone ring where a carbonyl group functions as a hydrogen bond acceptor instead of the hydroxymethyl group

Malonic acid (1,953 words) [view diff] exact match in snippet view article find links to article

Knoevenagel condensation, malonic acid or its diesters are reacted with the carbonyl group of an aldehyde or ketone, followed by a dehydration reaction. When malonic

Lydersen method (497 words) [view diff] exact match in snippet view article find links to article

groups of a molecule. Acetone is fragmented in two different groups, one carbonyl group and two methyl groups. For the critical volume the following calculation

Acetoacetate decarboxylase (2,274 words) [view diff] exact match in snippet view article find links to article

came from a radiolabeling experiment in which researchers labeled the carbonyl group of acetoacetate with 18O and observed that oxygen exchange to water

Cereblon E3 ligase modulator (5,487 words) [view diff] exact match in snippet view article find links to article

added amino group at position 4 of the phthaloyl ring and removal of a carbonyl group from the phthaloyl ring. Development of lenalidomide began in the late

Ketimine Mannich reaction (3,407 words) [view diff] no match in snippet view article find links to article

practical one-pot syntheses are possible. The process of selecting a carbonyl-group gives the reaction a direct versus indirect distinction, wherein the

Bhabatarak Bhattacharyya (856 words) [view diff] exact match in snippet view article find links to article

on colchicine-tubulin interaction and elucidated the effect of the carbonyl group on the side chain of B-ring in the irreversible binding of colchicine

Methcathinone (1,584 words) [view diff] exact match in snippet view article find links to article

Given that the chiral center has an alpha hydrogen and adjacent the carbonyl group, the molecule will racemize in solution via an enol intermediate. This

Phosgene (3,103 words) [view diff] exact match in snippet view article find links to article

N-carboxyanhydrides. More generally, phosgene acts to link two nucleophiles by a carbonyl group. For this purpose, alternatives to phosgene such as carbonyldiimidazole

Succinate dehydrogenase complex subunit C (2,176 words) [view diff] exact match in snippet view article find links to article

This facilitates a second hydrogen bond interaction between the O4 carbonyl group of ubiquinone and Ser27 of SDHC. Following the first single electron

Ascaridole (1,503 words) [view diff] exact match in snippet view article find links to article

Nelson showed that the new substance contained neither a hydroxyl nor a carbonyl group and that upon reduction with iron(II) sulfate it formed a glycol, now

Canthaxanthin (1,586 words) [view diff] exact match in snippet view article find links to article

single protein, known as a beta-carotene ketolase, that is able to add a carbonyl group to carbon 4 and 4' of the beta carotene molecule. Although functionally

Curcumin (2,425 words) [view diff] exact match in snippet view article find links to article

and are readily deprotonated to form enolates; the α,β-unsaturated carbonyl group is a good Michael acceptor and undergoes nucleophilic addition.[citation

Peptide nucleic acid (1,832 words) [view diff] exact match in snippet view article find links to article

bases are linked to the backbone by a methylene bridge (-CH 2-) and a carbonyl group (-(C=O)-). PNAs are depicted like peptides, with the N-terminus at the

2-Dehydro-3-deoxy-phosphogluconate aldolase (1,629 words) [view diff] exact match in snippet view article find links to article

cleavage. Lysine Residue 133 serves as the nucleophile and attacks the carbonyl group of 2-Keto-3-deoxy-6-phosphogluconate to form a protonated carbinolamine

Organic chemistry (4,203 words) [view diff] exact match in snippet view article find links to article

group with a net acidic pKa that gets within range, such as an acyl or carbonyl group is fair game. Since the likelihood of being attacked decreases with

Green–Davies–Mingos rules (792 words) [view diff] exact match in snippet view article find links to article

threshold value The following figure shows a ligated metal attached to a carbonyl group. This group has a partial positive charge and therefore is susceptible

Organoboron chemistry (2,451 words) [view diff] exact match in snippet view article find links to article

pair oxidizes the borane to an alcohol with hydrogen peroxide or to a carbonyl group with chromium oxide. Oxidation of an alkenylborane gives an boron-free

Myeloperoxidase (1,879 words) [view diff] exact match in snippet view article find links to article

exist, differing only by the heavy chain. One of the ligands is the carbonyl group of Asp 96. Calcium-binding is important for structure of the active

Cofactor (biochemistry) (4,628 words) [view diff] exact match in snippet view article

groups Bacteria, archaea and eukaryotes Menaquinone Vitamin K None Carbonyl group and electrons Bacteria, archaea and eukaryotes Ascorbic acid Vitamin

Aza-Cope rearrangement (5,704 words) [view diff] exact match in snippet view article find links to article

thermodynamically beneficial effect. To that end, Fowler and coworkers installed a carbonyl group on the nitrogen, hypothesizing that the lone pair of the nitrogen would

N-Ethylhexedrone (2,348 words) [view diff] exact match in snippet view article find links to article

is likely metabolized through N-dealkylation and/or reduction of the carbonyl group followed by N-dealkylation. Synthetic cathinones are generally less

Polyhedral skeletal electron pair theory (2,188 words) [view diff] exact match in snippet view article find links to article

derivation of this is briefly as follows: Fe has 8 valence electrons. Each carbonyl group is a net 2 electron donor after the internal σ- and π-bonding are taken

Carvone (1,731 words) [view diff] exact match in snippet view article find links to article

using propan-2-ol and aluminium isopropoxide effects reduction of the carbonyl group only to provide carveol (5); a combination of sodium borohydride and

310 helix (1,994 words) [view diff] exact match in snippet view article find links to article

theirs was free of strain; all of the amide groups were planar and every carbonyl group formed a perfect hydrogen bond with an amino group four residues further

SDHD (2,716 words) [view diff] exact match in snippet view article find links to article

This facilitates a second hydrogen bond interaction between the O4 carbonyl group of ubiquinone and Ser27 of subunit C. Following the first single electron

Organosulfur chemistry (3,035 words) [view diff] exact match in snippet view article find links to article

carbonyl groups. Thioacetals and thioketals can also be used to protect a carbonyl group in organic syntheses. The above classes of sulfur compounds also exist

Ondansetron (3,094 words) [view diff] exact match in snippet view article find links to article

metabolized more slowly. The chiral carbon in ondansetron is adjacent to a carbonyl group, so keto-enol tautomerism could theoretically lead to interconversion

Camptothecin (2,512 words) [view diff] exact match in snippet view article find links to article

covalent complex by forming hydrogen bond. This hydrogen bond is between carbonyl group in position 17 on the D-ring and amino group on the pyrimidine ring

Camptothecin (2,512 words) [view diff] exact match in snippet view article find links to article

covalent complex by forming hydrogen bond. This hydrogen bond is between carbonyl group in position 17 on the D-ring and amino group on the pyrimidine ring

Baker's yeast (3,306 words) [view diff] exact match in snippet view article find links to article

experiments with yeast. Baker's yeast contains enzymes that can reduce a carbonyl group into a hydroxyl group in fairly high yield, thus making it useful for

Long-chain-fatty-acid—CoA ligase (2,740 words) [view diff] exact match in snippet view article find links to article

interactions. An intermolecular hydrogen bond is formed between the main chain carbonyl group of Glu16and the side chain of Arg199. At the interface, Glu175 forms

Cyclic nucleotide (2,416 words) [view diff] exact match in snippet view article find links to article

within a cyclic nucleotide. In the pentose, the carbon closest to the carbonyl group is labeled C-1. When a pentose is connected to a nitrogenous base, carbon

Tropone (1,009 words) [view diff] exact match in snippet view article find links to article

in 1945 proposed that tropones could have aromatic properties. The carbonyl group is more polarized as a result of the triene ring, giving a partial positive

Organogold chemistry (3,036 words) [view diff] exact match in snippet view article find links to article

ligands and the carbon isocyanate group which is then attacked by the carbonyl group. Further studies on the bonding mode of Au(I) indicate that this simple

Menthol (2,865 words) [view diff] exact match in snippet view article find links to article

to form (−)-menthone. (−)-Menthone reductase (MR) then reduces the carbonyl group using NADPH to form (−)-menthol. Natural menthol is obtained by freezing

SDHB (2,955 words) [view diff] exact match in snippet view article find links to article

This facilitates a second hydrogen bond interaction between the O4 carbonyl group of ubiquinone and Ser27 of SDHC. Following the first single electron

Nile red (739 words) [view diff] exact match in snippet view article find links to article

blue with sulfuric acid. This process replaces an iminium group with a carbonyl group. Alternatively, Nile red and its analogs (naphthooxazine dyes) can be

Phenylalanine ammonia-lyase (2,162 words) [view diff] exact match in snippet view article find links to article

intramolecular nucleophilic attack of the nitrogen of Gly204 at the carbonyl group of Ala202. A subsequent water elimination from the side chain of Ser203

Beta-lactam antibiotics (3,696 words) [view diff] exact match in snippet view article find links to article

carries a carboxylate group that is positioned on the same side as the carbonyl group within the β-lactam ring, and, as such, this structural configuration

Ribose-5-phosphate isomerase (2,158 words) [view diff] exact match in snippet view article find links to article

catalysis. In the reaction, the overall consequence is the movement of a carbonyl group from carbon number 1 to carbon number 2; this is achieved by the reaction

Hypothetical types of biochemistry (8,208 words) [view diff] exact match in snippet view article find links to article

because it increases the concentration of the cation ammonium. The carbonyl group (C=O), which is much used in terrestrial biochemistry, would not be

Acetone (5,066 words) [view diff] exact match in snippet view article find links to article

L.; Groeneveld, W.L. (1969). "Complexes with ligands containing the carbonyl group. Part I: Complexes with acetone of some divalent metals containing

Jack D. Dunitz (1,903 words) [view diff] exact match in snippet view article find links to article

"Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group". Journal of the American Chemical Society. 95 (15): 5065. doi:10.1021/ja00796a058

Leaving group (2,532 words) [view diff] exact match in snippet view article find links to article

group in the β position of an enolate as well as the regeneration of a carbonyl group from the tetrahedral intermediate in nucleophilic acyl substitution

Urease (4,155 words) [view diff] exact match in snippet view article find links to article

closed state of the mobile flap generates a rearrangement of Alaα222 carbonyl group in such a way that its oxygen atom points to Ni2. The Alaα170 and Alaα366

Integrasone (1,175 words) [view diff] exact match in snippet view article find links to article

is then relatively straightforward to stereoselectively reduce the carbonyl group on carbon 3 with sodium borohydride to give the diol depicted in structure

Hydrazine (5,245 words) [view diff] exact match in snippet view article find links to article

used in the Wolff–Kishner reduction, a reaction that transforms the carbonyl group of a ketone into a methylene bridge (or an aldehyde into a methyl group)

Monosaccharide nomenclature (1,150 words) [view diff] exact match in snippet view article find links to article

{y}}-H}}} ; that is, a straight chain of carbon atoms, one of which is a carbonyl group, all the others bearing a hydrogen -H and a hydroxyl -OH each, with

Magnesium (8,194 words) [view diff] exact match in snippet view article find links to article

such as the carbon atom that is present within the polar bond of a carbonyl group. A prominent organomagnesium reagent beyond Grignard reagents is magnesium

Adamantane (4,230 words) [view diff] exact match in snippet view article find links to article

adamantane with concentrated sulfuric acid which produces adamantanone. The carbonyl group of adamantanone allows further reactions via the bridging site. For

Membrane fluidity (1,981 words) [view diff] exact match in snippet view article find links to article

doxyl moiety at 5,7,9,12,13,14 and 16th carbons, with reference to carbonyl group), reveals a fluidity gradient. Decreasing linewidth from 5th to 16th

Lomustine (2,795 words) [view diff] exact match in snippet view article find links to article

reacts with the nitrogen-hydrogen bond on the chlorine side of the carbonyl group of 1-(2-chloroethyl)-3-cyclohexylurea (3) to form tert-butanol and a

Nitroxide-mediated radical polymerization (1,636 words) [view diff] exact match in snippet view article find links to article

involves treatment of aldehydes with hydrogen peroxide, which adds to the carbonyl group. The resulting species rearranges in situ in the presence of CuCl forming

Fatty-acyl-CoA synthase (1,667 words) [view diff] exact match in snippet view article find links to article

β-unsaturated acyl group by DH, (9) Reduction of the α,β-unsaturated carbonyl group to a saturated acyl group and finally (10) transfer of the acyl group

Organophosphine (1,699 words) [view diff] exact match in snippet view article find links to article

inverted (see: umpolung) and the resulting phosphine hydride can reduce a carbonyl group as in the example of benzophenone in yet another way. Secondary phosphines

Sugar (10,521 words) [view diff] exact match in snippet view article find links to article

general formula C6H12O6. They have five hydroxyl groups (−OH) and a carbonyl group (C=O) and are cyclic when dissolved in water. They each exist as several

Nosiheptide (885 words) [view diff] exact match in snippet view article find links to article

between two dehydroalanine acids with incorporation of an adjacent carbonyl group. Nosiheptide biosynthesis begins with the translation of a 50 amino

2-pyrone-4,6-dicarboxylate lactonase (311 words) [view diff] exact match in snippet view article find links to article

molecule is activated by the transfer of a proton to Asp-248 whereas the carbonyl group of the 2-pyrone-4,6-dicarboxylate (PDC) lactone substrate is activated

Fluticasone furoate (3,492 words) [view diff] exact match in snippet view article find links to article

by other functional groups under certain conditions. Reduction: The carbonyl group in the molecule might be reduced under appropriate conditions to yield

Sulfur dioxide (7,271 words) [view diff] exact match in snippet view article find links to article

combinations are referred to as total SO2. Binding, for instance to the carbonyl group of acetaldehyde, varies with the wine in question. The free form exists

Anatoxin-a (4,930 words) [view diff] exact match in snippet view article find links to article

enone conformation, has a distance a 6.0 Å between its nitrogen and carbonyl group, which corresponds well to the 5.9 Å distance that separate the nitrogen

Cyclic compound (3,320 words) [view diff] exact match in snippet view article find links to article

large ring synthesis, in which two carboxyl groups combine to form a carbonyl group with loss of CO2 and H2O; the Wenker synthesis converting a beta amino

Branched-chain amino acid aminotransferase (3,560 words) [view diff] exact match in snippet view article find links to article

linkage in a reaction between a lysine residue of the enzyme and the carbonyl group of the cofactor. This conformational change allows the substrates to

Santonin (2,592 words) [view diff] exact match in snippet view article find links to article

obtained from santonin is lumisantonin. In this rearrangement, the C-3 carbonyl group moves to C-2, the C-4 methyl moves to C-1, and the C-10 carbon inverts

Biosynthesis (6,671 words) [view diff] exact match in snippet view article find links to article

ribonucleotide (AICAR). AICAR transformylase transfers a carbonyl group to AICAR, forming N-formylaminoimidazole- 4-carboxamide ribonucleotide

P-site (1,528 words) [view diff] exact match in snippet view article find links to article

presented in the A-site. After peptide formation between the C-terminal carbonyl group of the growing polypeptide chain (attached to a P-site bound tRNA) and

Danheiser benzannulation (2,079 words) [view diff] exact match in snippet view article find links to article

specifically in the Dӧtz reaction a carbene coordinated to a metal carbonyl group) to produce substituted aromatic phenols. The reaction proceeds via

Copper protein (2,020 words) [view diff] exact match in snippet view article find links to article

methionine in one axial position, they contain a second axial ligand (a carbonyl group of a glycine residue). T1Cu-containing proteins are usually called "cupredoxins"

Glucose (12,979 words) [view diff] exact match in snippet view article find links to article

the absolute configuration of the asymmetric center farthest from the carbonyl group, and in concordance with the configuration of d- or l-glyceraldehyde

Levofloxacin (5,404 words) [view diff] exact match in snippet view article find links to article

Distinct functional groups on this molecules include a hydroxyl group, carbonyl group, and an aromatic ring.[failed verification] The substance is used as

Electrophilic aromatic directing groups (2,728 words) [view diff] exact match in snippet view article find links to article

-M effect since the electron-withdrawing resonance capacity of the carbonyl group is effectively removed by the delocalisation of the negative charge

Elias James Corey (5,646 words) [view diff] exact match in snippet view article find links to article

lability (scheme 6). 1,3-Dithianes are a temporary modification of a carbonyl group that reverses their reactivity in displacement and addition reactions

Organozinc chemistry (3,394 words) [view diff] case mismatch in snippet view article find links to article

Barry; Fleming, Ian; Schreiber, Stuart (1991). "Transformation of the Carbonyl Group into Nonhydroxylic Groups". Comprehensive Organic Synthesis Volume 1:

Caspase 3 (3,392 words) [view diff] exact match in snippet view article find links to article

of Cys-163 and the imidazole ring of His-121. His-121 stabilizes the carbonyl group of the key aspartate residue, while Cys-163 attacks to ultimately cleave

Selective progesterone receptor modulator (5,148 words) [view diff] exact match in snippet view article find links to article

Even though the polar residue Thr894 is in close proximity to the C20 carbonyl group of progesterone there is not formed any hydrogen bond between these

Imazaquin (1,358 words) [view diff] exact match in snippet view article find links to article

reaction starts with the NH2 group of the benzenamine adding to the second carbonyl group on diethyl 2-oxobutanedioate (diethyl oxaloacetate). Imazaquin is a

Methadone (7,673 words) [view diff] exact match in snippet view article find links to article

it does represent the initial trajectory of attack of an amine on a carbonyl group and was an important piece of experimental evidence for the proposal

Hammett equation (4,056 words) [view diff] exact match in snippet view article find links to article

substituent constant will increase equilibrium constants. Because the carbonyl group is unable to serve a source of electrons for -M groups (in contrast

Oxocarbenium (2,170 words) [view diff] exact match in snippet view article find links to article

selectively from iminium reduction, instead of direct reduction of the carbonyl group (or its protonated form) to form an alcohol. Formation of oxocarbenium

Adenosine-phosphate deaminase (915 words) [view diff] exact match in snippet view article find links to article

to 5'-AMP using water to break the C-N bond and replacing it with a carbonyl group. Ultimately, this produces 5'-IMP (Inosine monophosphate) and NH3 (ammonia)

Biosynthesis of doxorubicin (3,451 words) [view diff] exact match in snippet view article find links to article

the decaketide is still associated with the KS/CLF heterodimer the 9-carbonyl group is reduced by Dps E, the 9-ketoreductase, using NADPH as the reducing

Bromopyrogallol red (1,096 words) [view diff] exact match in snippet view article find links to article

neutral form, bromopyrogallol red is bipolar ion, containing a protonized carbonyl group as well as a dissociated sulfonate group. Through testing at isobestic

Aldehyde tag (2,916 words) [view diff] exact match in snippet view article find links to article

live cells. A typical reaction constant is 10−4 to 10−3 M−1 s−1. A carbonyl group is introduced into proteins as a chemical reporter using various techniques

Benzylic activation and stereocontrol in tricarbonyl(arene)chromium complexes (1,352 words) [view diff] no match in snippet view article

not be diastereoselective, despite the presence of the chromium tri(carbonyl) group. The ortho substituent is necessary for high stereoselectivity; meta-substituted

Metal-catalysed hydroboration (1,771 words) [view diff] exact match in snippet view article find links to article

Whereas uncatalyzed hydroboration using HBcat leads to reduction of the carbonyl group, the catalyzed version is selective for the alkene. As indicated by

Cahn–Ingold–Prelog priority rules (2,838 words) [view diff] exact match in snippet view article find links to article

ketones. A nucleophile in a nucleophilic addition can approach the carbonyl group from two opposite sides or faces. When an achiral nucleophile attacks

Argpyrimidine (1,000 words) [view diff] exact match in snippet view article find links to article

breads and fermented alcohols. The Maillard Reaction occurs between the carbonyl group of a sugar and the amino group on a protein. These react to form a N-substituted

Tetrapeptide (1,938 words) [view diff] exact match in snippet view article find links to article

aldehyde (or ketone) by alpha C-H addition of one reactant molecule to the carbonyl group of a second reactant molecule. This reaction requires at least one of

Ketotifen (6,697 words) [view diff] exact match in snippet view article find links to article

has an oxygen atom that pizotifen molecule lacks—ketotifen contains a carbonyl group (C=O) in the central (7-membered) ring while pizotifen contains methylene

AKR1C2 (1,051 words) [view diff] exact match in snippet view article find links to article

bile acid (a type of steroid molecule) and catalyze the reduction of a carbonyl group (C=O) present in the bile acid to a hydroxy group (-OH), using NADPH

Oxalyl-CoA decarboxylase (1,145 words) [view diff] exact match in snippet view article find links to article

This carbon center ionizes to form a carbanion, which adds to the carbonyl group of oxalyl-CoA. This addition is followed by the decarboxylation of oxalyl-CoA

Protecting group (6,755 words) [view diff] exact match in snippet view article find links to article

compounds in wet acetonitrile. For aldehydes, a temporary protection of the carbonyl group the presence of ketones as hemiaminal ions is shown below. Here it is

Flippin–Lodge angle (3,935 words) [view diff] exact match in snippet view article find links to article

:Nu. The substituents, R and R', attached to the carbon atom of the carbonyl group may be an atom such as hydrogen (H), alkyl groups such as methyl, ethyl

Hydroxylamine-O-sulfonic acid (1,556 words) [view diff] exact match in snippet view article find links to article

produced by nucleophilic attack of hydroxylamine-O-sulfonic acid to the carbonyl group of 2-hydroxybenzaldehyde followed by cyclization. 1,2-Benzisoxazole

Chlorophyllase (1,512 words) [view diff] exact match in snippet view article find links to article

chlorophyll a. Hydrolysis of chlorophyll starts with the attack of a carbonyl group of chlorophyll by the oxygen of the hydroxyl group of the crucial serine

Mitotic inhibitor (6,908 words) [view diff] exact match in snippet view article find links to article

The stability of the tropone ring and the position of the methoxy and carbonyl group are crucial for the binding ability of the compound. The 10-methoxy

Oseltamivir total synthesis (2,309 words) [view diff] exact match in snippet view article find links to article

in 7 (hydrogenolysis in the presence of di-tert-butyl dicarbonate) a carbonyl group is introduced in intermediate 8 by catalytic ruthenium(IV) oxide and

Hydroxylamine-O-sulfonic acid (1,556 words) [view diff] exact match in snippet view article find links to article

produced by nucleophilic attack of hydroxylamine-O-sulfonic acid to the carbonyl group of 2-hydroxybenzaldehyde followed by cyclization. 1,2-Benzisoxazole

Polymethine dyes (1,112 words) [view diff] exact match in snippet view article find links to article

structure of streptocyanine dyes Merocyanine dyes have an amino and a carbonyl group as end groups of the polyene structural element. Both a neutral and

Reductions with metal alkoxyaluminium hydrides (1,747 words) [view diff] exact match in snippet view article find links to article

trimethoxyaluminium hydride results in nearly quantitative direct addition to the carbonyl group (Eq. (9)). On the other hand, use of the bulky reagent LTBA leads to

Cascade reaction (2,825 words) [view diff] exact match in snippet view article find links to article

reactive ylide 65 after an intramolecular cyclization with the neighboring carbonyl group. An intramolecular [3+2] cycloaddition then spontaneously occurred to

APOBEC3G (2,937 words) [view diff] exact match in snippet view article find links to article

2). The deamination (and resulting oxidation) at position 4 yields a carbonyl group and results in a change from cytidine to uridine. The deamination activity

Electronic skin (3,490 words) [view diff] exact match in snippet view article find links to article

hydrogen-bonding network because they are near an electron-withdrawing carbonyl group. This polymer network with embedded nickel particles demonstrates the

Stereoelectronic effect (2,834 words) [view diff] exact match in snippet view article find links to article

effect. Since the σ*C-C orbital adjacent to the electron-withdrawing carbonyl group is lower in energy and is therefore a better acceptor than the σ*C-C

Norethisterone (9,305 words) [view diff] exact match in snippet view article find links to article

chromium trioxide in acetic acid. The conjugated C4-C5 olefin and the carbonyl group at C3 is then transformed to dienol ethyl ether using ethyl orthoformate

Nicotinic agonist (4,258 words) [view diff] exact match in snippet view article find links to article

orthogonal orientation of the nitrogen bridge in relations to the amide carbonyl group is presumed important for the optimal binding. The stability of some

Glossary of chemistry terms (18,187 words) [view diff] exact match in snippet view article find links to article

A functional group and a class of organic compounds consisting of a carbonyl group attached to a hydrogen atom and any other R-group. Aldehydes have the

Reactions of organocopper reagents (1,732 words) [view diff] exact match in snippet view article find links to article

main products are alcohol B (42%) from nucleophilic addition to the carbonyl group and diene C (48%) as its dehydration reaction product. With added salt

Büchner–Curtius–Schlotterbeck reaction (1,953 words) [view diff] exact match in snippet view article find links to article

are well established as proceeding through nucleophilic attack on a carbonyl group. The reaction was originally carried out in diethyl ether and routinely

1,3-Dithiolane (358 words) [view diff] exact match in snippet view article find links to article

Protecting a carbonyl group by converting it to a 1,3-dithiolane, using 1,2-ethanedithiol

Kynurenine 3-monooxygenase (1,970 words) [view diff] exact match in snippet view article find links to article

polar residue is also involved in hydrogen bonding on the L-kynurenine carbonyl group, as well as on the hydrogen on the FAD N3 atom. Arg83 and Tyr97 also

Non steroidal aromatase inhibitors (3,675 words) [view diff] exact match in snippet view article find links to article

electron-withdrawing and that is important for the activity as it acts as carbonyl group of androstenedione. Two aryl groups also play an important role in the

Sequence-controlled polymer (2,243 words) [view diff] exact match in snippet view article find links to article

the monomers are attached to the polymer chain via amidation between carbonyl group and amino group. For purpose of sequence control, the amino groups are

Lewis acid catalysis (5,017 words) [view diff] exact match in snippet view article find links to article

asynchronous than that of the thermal reaction – the bond further from the carbonyl group is formed ahead of the other bond. The carbonyl-ene reaction is almost

N-acetylglucosamine-6-phosphate deacetylase (1,643 words) [view diff] exact match in snippet view article find links to article

base to activate the hydrolytic water molecule in order to attack the carbonyl group of the substrate. Asp-273 then acts as an acid to protonate the amine

Exogenous ketone (1,329 words) [view diff] exact match in snippet view article find links to article

not a ketone due to the structure of the molecule (OH- attached to carbonyl group makes this an acid), β-HB acts like a ketone, providing the body with

Trimethylsilyl isothiocyanate (603 words) [view diff] exact match in snippet view article find links to article

mild conditions. As a nitrogen nucleophile, TMSNCS adds across the carbonyl group of aldehydes and substitutes isothiocyanate for one of the ether groups

Hexa(tert-butoxy)ditungsten(III) (2,120 words) [view diff] exact match in snippet view article

react with W2(O-t-Bu)6 to form W2(O-t-Bu)6(CO). This compound has a carbonyl group that acts as a bridge between two W(III) atoms and has a similar structure

Itaconic anhydride (1,722 words) [view diff] exact match in snippet view article find links to article

This always happens in such a way that the ring opening occurs at the carbonyl group, which is further away from the methylene group (3-position). Nucleophiles

Lactoylglutathione lyase (4,553 words) [view diff] exact match in snippet view article find links to article

(R)-S-lactoylglutathione product, the glutathione moiety is bonded to the C1 carbonyl group. The basic mechanism of glyoxalase I is as follows. The substrate hemithioacetal

Expanding monomer (2,063 words) [view diff] exact match in snippet view article find links to article

in asymmetrical manner (meaning for example that one oxygen forms an carbonyl group and one an ether group). Compound classes which are fulfilling these

Neil Vasdev (1,819 words) [view diff] exact match in snippet view article find links to article

for human use with diverse precursors synthesized by labeling at the carbonyl group (rather than the common methyl group). This methodology can label 11C-carbamates

Yegor Wagner (3,257 words) [view diff] exact match in snippet view article find links to article

carried out with the breaking of the carbon chain on both sides of the carbonyl group, which generally leads to the formation of a mixture of four acids.”

USP27X (2,080 words) [view diff] exact match in snippet view article find links to article

forming a bond between them. The isopeptide bond is broken and the carbonyl group (double bond) remade. The result of the reaction is the release of the

Cynaropicrin (2,769 words) [view diff] exact match in snippet view article find links to article

ring is involved in most of its biological functions. The unsaturated carbonyl group on the lactone ring allows for nucleophilic Michael addition. Cynaropicrin

Hemagglutinin esterase (3,623 words) [view diff] exact match in snippet view article find links to article

help of two other amino acids (histidine and aspartic acid), on the carbonyl group of the substrate. Basic histidine enhances the reactivity of serine

ERAP1 (4,773 words) [view diff] exact match in snippet view article find links to article

exploration and docking studies showed that the N-acetylpiperazine carbonyl group was critical for the activity via its zinc-binding group properties

Enders SAMP/RAMP hydrazone-alkylation reaction (2,515 words) [view diff] exact match in snippet view article find links to article

Regioselective and stereoselective formation of carbon-carbon bonds adjacent to carbonyl group is an important procedure in organic chemistry. Alkylation reaction

Macrocyclic stereocontrol (2,664 words) [view diff] exact match in snippet view article find links to article

and can be modeled by peripheral attack of the sulfur ylide on the carbonyl group in a Johnson-Corey-Chaykovsky reaction to yield the protected form of

Strychnine total synthesis (4,087 words) [view diff] exact match in snippet view article find links to article

in 3 was converted to an epoxide using tert-Butyl hydroperoxide, the carbonyl group was then converted to an alkene in a Wittig reaction using Ph3P=CH2

Carbon-carbon bond activation (1,305 words) [view diff] exact match in snippet view article find links to article

(August 1994). "Selective activation of carbon–carbon bonds next to a carbonyl group". Nature. 370 (6490): 540–541. Bibcode:1994Natur.370..540M. doi:10.1038/370540a0

Inavolisib (2,184 words) [view diff] exact match in snippet view article find links to article

5-bisphosphate 3-kinase, catalytic subunit alpha (p110α), inavolisib’s carbonyl group can accept a hydrogen bond from the Tyr836 (conserved) in p110α. The

Glycerol-1,2-carbonate (2,309 words) [view diff] exact match in snippet view article find links to article

cyclic carbonic acid ester glycerol carbonate is produced by inserting a carbonyl group, reactions with particularly inexpensive urea and with dialkyl carbonates

Linnett double-quartet theory (7,772 words) [view diff] case mismatch in snippet view article find links to article

ISSN 0022-4936. Firestones, Raymond a. (March 1976). "The π-Bond Energy of the Carbonyl Group". Tetrahedron Letters. 17 (10): 735–736. doi:10.1016/S0040-4039(00)77937-8