Find link

language:

Find link is a tool written by Edward Betts.

searching for Hsp90 147 found (343 total)

alternate case: hsp90

Tetratricopeptide repeat (1,220 words) [view diff] exact match in snippet view article find links to article

(APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67-phox, hsp90-binding immunophilins, transcription factors, the protein kinase R (PKR)

FKBP5 (1,356 words) [view diff] exact match in snippet view article find links to article

along with the 90 kDa heat shock protein and PTGES3 (P23 protein). As an Hsp90-associated co-chaperone that regulates the responsiveness of steroid hormone

PTGES3 (966 words) [view diff] exact match in snippet view article find links to article

the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating

Luminespib (484 words) [view diff] exact match in snippet view article find links to article

resorcinylic isoxazole amide Luminespib is an inhibitor of heat shock protein 90 (Hsp90), which is a chaperone protein that plays a role in the modification of

Chaperone code (1,312 words) [view diff] case mismatch in snippet view article find links to article

instance, the monomethylation of HSP90 lysine 616 by Smyd2, and its reversal by LSD1, regulate enzymatic activity of HSP90. Nitika; Porter, Corey M.; Truman

AHSA1 (690 words) [view diff] exact match in snippet view article find links to article

Pearl LH, Prodromou C (Dec 2002). "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1" (PDF). Mol. Cell. 10 (6): 1307–18

Novobiocin (2,266 words) [view diff] exact match in snippet view article find links to article

C-terminus of the eukaryotic Hsp90 protein (high micromolar IC50). Modification of the novobiocin scaffold has led to more selective Hsp90 inhibitors. Novobiocin

Chaperome (733 words) [view diff] exact match in snippet view article find links to article

Cell by Balch and co-workers on the finding that down-regulation of the Hsp90 co-chaperone Aha1 rescues misfolding of CFTR in cystic fibrosis to describe

Keratin 7 (1,172 words) [view diff] exact match in snippet view article find links to article

novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist

MSR1 (1,260 words) [view diff] case mismatch in snippet view article find links to article

Imanishi Takeshi; Wada Youichiro; Kodama Tatsuhiko; Doi Takefumi (Jan 2002). "HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage

FourU thermometer (1,229 words) [view diff] exact match in snippet view article find links to article

cholerae virulence. Other known RNA thermometers include the ROSE element and Hsp90 cis-reg element. Hairpin II appears to be a dynamic feature of FourU's secondary

Pimitespib (167 words) [view diff] exact match in snippet view article find links to article

mechanism of action of pimitespib involves inhibition of heat shock protein 90 (Hsp90). In June 2022, it received approval in Japan for gastrointestinal stromal

Cardioprotection (1,063 words) [view diff] exact match in snippet view article find links to article

beneficial effects of these regimens. A recent study showed that blocking Hsp90 function with geldanamycin inhibits PostC protection and PKCε translocation

PPP5C (1,302 words) [view diff] exact match in snippet view article find links to article

"Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin". The Journal

Cyclin-dependent kinase 4 (2,367 words) [view diff] exact match in snippet view article find links to article

JW (1996). "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4". Genes Dev. 10 (12): 1491–502. doi:10.1101/gad

HBV RNA encapsidation signal epsilon (323 words) [view diff] exact match in snippet view article find links to article

(2003). "Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein"

AH receptor-interacting protein (1,468 words) [view diff] exact match in snippet view article find links to article

Kazlauskas A, Sundström S, Poellinger L, Pongratz I (April 2001). "The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor"

Euglenid (2,031 words) [view diff] exact match in snippet view article find links to article

Decastava; Scytomonas saepesedens; Entosiphon oblongum), Hsp90 introns, and putative euglenoid Hsp90 pre-mRNA insertional editing". European Journal of Protistology

Transheterozygote (709 words) [view diff] exact match in snippet view article find links to article

definition reported cases of transvection between different alleles of Hsp90. This second definition is also sometimes applied to the situation where

UNC45A (420 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB

TOMM70 (548 words) [view diff] exact match in snippet view article find links to article

PMID 12477932. Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70"

Proteostasis (2,922 words) [view diff] exact match in snippet view article find links to article

HSF (heat shock family). HSF is constitutively bound by Hsp90. Upon a proteotoxic stimulus Hsp90 is recruited away from HSF, which can then bind to heat

YTHDC2 (231 words) [view diff] case mismatch in snippet view article find links to article

proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein". Molecular & Cellular Proteomics

KSR1 (553 words) [view diff] exact match in snippet view article find links to article

activity mitogen-activated protein kinase kinase binding chaperone binding Hsp90 protein binding 14-3-3 protein binding Cellular component cytoplasm cytosol

HSPBP1 (1,155 words) [view diff] case mismatch in snippet view article find links to article

1998). "Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1". Cell. 94 (4):

STUB1 (1,473 words) [view diff] exact match in snippet view article find links to article

neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation"

Senotherapy (1,261 words) [view diff] case mismatch in snippet view article find links to article

McGowan SJ, Zhu Y, Brooks RW, et al. (September 2017). "Identification of HSP90 inhibitors as a novel class of senolytics". Nature Communications. 8 (1):

CLCN2 (1,044 words) [view diff] exact match in snippet view article find links to article

M, Dadlez M, Edelman A, Fritsch J (January 2006). "Association between Hsp90 and the ClC-2 chloride channel upregulates channel function". American Journal

EIF2AK1 (1,113 words) [view diff] exact match in snippet view article find links to article

PMID 10931946. Shao J, Grammatikakis N, Scroggins BT, et al. (2001). "Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation

Utthara Nayar (494 words) [view diff] exact match in snippet view article find links to article

Tony; Erdjument-Bromage, Hediye; Chomet, Max (2013-10-17). "Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies"

Sue Wickner (697 words) [view diff] exact match in snippet view article find links to article

Company Pte Ltd, ISBN 9789814749329. Genest O, Wickner S, Doyle SM. (2019) "Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling." J Biol Chem

PRKCE (6,268 words) [view diff] exact match in snippet view article find links to article

stimulus. Specifically, a seven amino acid peptide, termed TAT-εHSP90, homologous to the Hsp90 sequence within the PKCε C2 domain induced translocation of

CLCN3 (1,054 words) [view diff] exact match in snippet view article find links to article

Jensen TJ, Cui L, Hou Y, Chang XB, Riordan JR (1998). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its

Petalomonas (1,026 words) [view diff] exact match in snippet view article find links to article

Decastava; Scytomonas saepesedens; Entosiphon oblongum), Hsp90 introns, and putative euglenoid Hsp90 pre-mRNA insertional editing”. European Journal of Protistology

40S ribosomal protein S3 (1,024 words) [view diff] exact match in snippet view article find links to article

endodeoxyribonuclease activity protein kinase binding supercoiled DNA binding DNA binding Hsp90 protein binding microtubule binding protein kinase A binding RNA binding

TGF beta receptor 2 (960 words) [view diff] exact match in snippet view article find links to article

Lin X, Feng XH (Jul 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proceedings of the National Academy of Sciences of the United States of

Anaplastic lymphoma kinase (5,299 words) [view diff] exact match in snippet view article find links to article

novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist

P2Y receptor (1,868 words) [view diff] exact match in snippet view article find links to article

"Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines". Bone. 39 (4): 739–53. doi:10.1016/j.bone

IKK2 (1,527 words) [view diff] exact match in snippet view article find links to article

"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Molecular Cell. 9 (2): 401–10. doi:10.1016/S1097-2765(02)00450-1. PMID 11864612

GPR31 (1,888 words) [view diff] exact match in snippet view article find links to article

acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit". Archives

EIF2AK3 (1,365 words) [view diff] exact match in snippet view article find links to article

ontology Molecular function transferase activity protein kinase activity Hsp90 protein binding nucleotide binding protein homodimerization activity kinase

Proto-oncogene tyrosine-protein kinase Src (2,795 words) [view diff] case mismatch in snippet view article find links to article

include bosutinib, bafetinib, Saracatinib(AZD-0530), XLl-999, KX01 and XL228. HSP90 inhibitor NVP-BEP800 has been described to affect stability of Src tyrosine

CSM1 (244 words) [view diff] exact match in snippet view article find links to article

"Heterozygous yeast deletion collection screens reveal essential targets of Hsp90". PLOS ONE. 6 (11): e28211. Bibcode:2011PLoSO...628211F. doi:10.1371/journal

RUNX1T1 (1,732 words) [view diff] case mismatch in snippet view article find links to article

leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines". Jpn. J. Cancer Res. 90 (1): 60–8. doi:10

Neoflavan (55 words) [view diff] exact match in snippet view article find links to article

Robert (2014). "High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors". Biology. 3 (1): 101–138. doi:10.3390/biology3010101. PMC 4009755

LYN (3,807 words) [view diff] case mismatch in snippet view article find links to article

rheostat that modulates signaling rather than as a binary on-off switch. HSP90 inhibitor NVP-BEP800 has been described to affect stability of LYN kinase

ATP5I (708 words) [view diff] exact match in snippet view article find links to article

Bencsura A, Vu HA (2006). "F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes". Biochem. Biophys. Res. Commun. 345 (1): 419–29

NLRP (2,056 words) [view diff] exact match in snippet view article find links to article

(2012-03-01). "The HSP90 complex of plants". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Heat Shock Protein 90 (Hsp90). 1823 (3): 689–697

Kinase insert domain receptor (794 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function transferase activity Hsp90 protein binding nucleotide binding protein kinase activity growth factor binding vascular

Galaxea astreata (861 words) [view diff] exact match in snippet view article find links to article

S2CID 35809820. Shen, C; Liu, CW; Liu, L. "Heat-induced stress genes Hsp70, Hsp90 and chloroplast psaA and psbA gene expressions of Galaxea astreata endosymbiotic

Erec Stebbins (1,046 words) [view diff] exact match in snippet view article find links to article

Studies of the von Hippel-Lindau Tumor Suppressor and the Oncogene Chaperone Hsp90 Archived 2014-04-07 at the Wayback Machine, completed in the laboratory

TGF beta receptor 1 (1,618 words) [view diff] exact match in snippet view article find links to article

Lin X, Feng XH (July 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proceedings of the National Academy of Sciences of the United States of

Center for Integrated Protein Science Munich (1,711 words) [view diff] exact match in snippet view article find links to article

Liebig-Vereinigung für Chemie, the 4th International Conference on the Hsp90 Chaperone Machine (2008). The project Science Comment has been established

Tyrosin-protein kinase Lck (4,466 words) [view diff] case mismatch in snippet view article find links to article

may have some impact on its therapeutic effects in canine mastocytoma. HSP90 inhibitor NVP-BEP800 has been described to affect stability of the LCK kinase

CYP1A1 (1,835 words) [view diff] exact match in snippet view article find links to article

monooxygenase activity estrogen 16-alpha-hydroxylase activity Hsp70 protein binding Hsp90 protein binding Cellular component cytoplasm organelle membrane endoplasmic

CYP1A1 (1,835 words) [view diff] exact match in snippet view article find links to article

monooxygenase activity estrogen 16-alpha-hydroxylase activity Hsp70 protein binding Hsp90 protein binding Cellular component cytoplasm organelle membrane endoplasmic

Repression of heat shock gene expression (ROSE) element (580 words) [view diff] exact match in snippet view article

at lower temperatures. Cyanobacterial RNA thermometer FourU thermometer Hsp90 cis-regulatory element Chowdhury S, Maris C, Allain FH, Narberhaus F (2006)

White-footed mouse (2,389 words) [view diff] exact match in snippet view article find links to article

metabolism. The genes under positive selection pressure include CYPA1A and Hsp90, which are known to be involved in the metabolism of foreign substances

UBXN6 (473 words) [view diff] exact match in snippet view article find links to article

Gesslbauer B, Rek A, Kungl AJ (July 2007). "A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome". Proteomics. 7 (14): 2375–83. doi:10

MAPK14 (5,259 words) [view diff] exact match in snippet view article find links to article

In addition to these phosphatases, other molecular components such as Hsp90-Cdc37 chaperone complex can also modulate p38 MAPK autophosphorylation activity

LMTK3 (1,436 words) [view diff] case mismatch in snippet view article find links to article

is an effective inhibitor of breast cancer growth in vivo. LMTK3 is an HSP90-CDC37 client protein which requires this interaction for folding and stability

USP19 (95 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function Hsp90 protein binding cysteine-type peptidase activity metal ion binding Lys48-specific deubiquitinase activity peptidase

CHUK (2,736 words) [view diff] exact match in snippet view article find links to article

"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Mol. Cell. 9 (2): 401–10. doi:10.1016/S1097-2765(02)00450-1. PMID 11864612

David Agard (278 words) [view diff] exact match in snippet view article find links to article

1980) MRC Laboratory (Postdoctoral, 1981–82) Known for Protein Folding, Hsp90 Awards Presidential Young Investigator Award (1983–1991) Sidhu Award for

Receptor for activated C kinase 1 (2,598 words) [view diff] case mismatch in snippet view article find links to article

PMC 108906. PMID 9584165. Liu YV, Semenza GL (March 2007). "RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization". Cell Cycle

MIB1 (696 words) [view diff] case mismatch in snippet view article find links to article

(2007). "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes". J. Biol. Chem. 282 (16): 11795–804. doi:10.1074/jbc.M610430200

TELO2 (669 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function molecular adaptor activity Hsp90 protein binding protein binding protein kinase binding protein-containing complex binding

Targeted therapy (2,197 words) [view diff] exact match in snippet view article find links to article

treat melanoma CDK inhibitors, e.g. PD-0332991, LEE011 in clinical trials Hsp90 inhibitors, some in clinical trials Hedgehog pathway inhibitors (e.g. FDA

JMJD1C (267 words) [view diff] case mismatch in snippet view article find links to article

interaction between JMJD1C with JMJD1c's partner proteins, for example, MDC1 and HSP90.[citation needed] GRCh38: Ensembl release 89: ENSG00000171988 – Ensembl

REPS1 (541 words) [view diff] case mismatch in snippet view article find links to article

Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200

NOD2 (1,547 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function Hsp90 protein binding nucleotide binding Hsp70 protein binding protein binding peptidoglycan binding enzyme binding actin

Evolution of molecular chaperones (1,217 words) [view diff] exact match in snippet view article find links to article

families, based on sequence homology and molecular weight (hsp110, hsp100, hsp90, hsp70, hsp60, hsp40, hsp10, and small hsp families). Proteins are highly

TOMM34 (686 words) [view diff] exact match in snippet view article find links to article

of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90". J. Biol. Chem. 273 (29): 18007–10. doi:10.1074/jbc.273.29.18007. PMID 9660753

Resorcinol (2,040 words) [view diff] case mismatch in snippet view article find links to article

doi:10.1002/cber.187600902133. Sidera, K.; Patsavoudi, E. (January 2014). "HSP90 inhibitors: current development and potential in cancer therapy". Recent

Affinity chromatography (3,420 words) [view diff] case mismatch in snippet view article find links to article

Chromatography: Comparison with Established Techniques for Screening against HSP90". Analytical Chemistry. 85 (14): 6756–6766. doi:10.1021/ac400715t. PMID 23806099

CKAP5 (921 words) [view diff] exact match in snippet view article find links to article

Browser. Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW (2007). "Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle

Hsp17 thermometer (168 words) [view diff] exact match in snippet view article find links to article

translation takes place. RNA thermometer ROSE element FourU thermometer Hsp90 cis-regulatory element Cyanobacterial RNA thermometers Kortmann J, Sczodrok

SELENBP1 (723 words) [view diff] exact match in snippet view article find links to article

of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex". The Journal of Biological Chemistry. 269 (15):

Protein phosphatase with ef-hand domain 2 (182 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function iron ion binding Hsp90 protein binding calcium ion binding phosphoprotein phosphatase activity manganese ion binding

Nuclear pore glycoprotein p62 (2,260 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function Hsp90 protein binding SH2 domain binding chromatin binding thyroid hormone receptor binding PTB domain binding Hsp70

Baculoviral IAP repeat-containing protein 2 (1,879 words) [view diff] case mismatch in snippet view article find links to article

Garrido C (2008). "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell

RNF216 (933 words) [view diff] exact match in snippet view article find links to article

ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding". J. Biol. Chem. 281 (45): 34592–600. doi:10.1074/jbc.M604019200

IKBKG (3,277 words) [view diff] exact match in snippet view article find links to article

"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Molecular Cell. 9 (2): 401–10. doi:10.1016/s1097-2765(02)00450-1. PMID 11864612

HDAC8 (1,538 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function Hsp90 protein binding NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity metal

IKBKG (3,277 words) [view diff] exact match in snippet view article find links to article

"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90". Molecular Cell. 9 (2): 401–10. doi:10.1016/s1097-2765(02)00450-1. PMID 11864612

RALBP1 (1,239 words) [view diff] case mismatch in snippet view article find links to article

Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo". J. Biol. Chem. 278 (19): 17299–306. doi:10.1074/jbc.M300788200

Casein kinase 2, alpha 1 (1,175 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function transferase activity nucleotide binding Hsp90 protein binding protein kinase activity protein N-terminus binding protein

Avibirnavirus (1,372 words) [view diff] case mismatch in snippet view article find links to article

antibody. Another receptor that can be bound is heat shock protein 90 (HSP90) on the surface of the DF-1 cell membrane. Although, this receptor will

Aggresome (1,654 words) [view diff] exact match in snippet view article find links to article

1 forms multiple small highly mobile aggregates. However, proteasome or Hsp90 inhibition rapidly triggered their translocation into the aggresome, and

AKT1 (2,850 words) [view diff] exact match in snippet view article find links to article

Tsuruo T (Sep 2000). "Modulation of Akt kinase activity by binding to Hsp90". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10832–7. Bibcode:2000PNAS...9710832S

GBP1 (912 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function nucleotide binding Hsp90 protein binding spectrin binding protein binding identical protein binding enzyme binding actin

P53 (13,103 words) [view diff] exact match in snippet view article find links to article

M100200200. PMID 11297531. Wang C, Chen J (January 2003). "Phosphorylation and hsp90 binding mediate heat shock stabilization of p53". The Journal of Biological

Sporothrix schenckii (2,926 words) [view diff] case mismatch in snippet view article find links to article

(2011). "Calcium/calmodulin kinase1 and its relation to thermotolerance and HSP90 in Sporothrix schenckii: an RNAi and yeast two-hybrid study". BMC Microbiol

GOPC (1,213 words) [view diff] exact match in snippet view article find links to article

PMID 12885772. Loo MA, Jensen TJ, Cui L, et al. (1999). "Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its

KPNB1 (1,942 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function Hsp90 protein binding protein domain specific binding zinc ion binding protein binding nuclear localization sequence

HEAT repeat (3,022 words) [view diff] exact match in snippet view article find links to article

Y, de Lange T, Pavletich NP (2010). "Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes". Genes Dev. 24 (18): 2019–2030

Leah E. Cowen (511 words) [view diff] exact match in snippet view article find links to article

Candida albicans fungus was tied to the function of heat-shock protein 90 (Hsp90). In 2012, Cowen was appointed a Canada Research Chair (CRC) in Microbial

BRMS1 (837 words) [view diff] exact match in snippet view article find links to article

(2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j

Calpain-2 (1,084 words) [view diff] case mismatch in snippet view article find links to article

Hall C, Hu J, Greer PA (August 2016). "Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis". Molecular and Cellular

HER2 (4,735 words) [view diff] exact match in snippet view article find links to article

conferred by its kinase domain and is mediated by the chaperone protein Hsp90". The Journal of Biological Chemistry. 276 (5): 3702–3708. doi:10.1074/jbc

PACRG (1,027 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function Hsp70 protein binding Hsp90 protein binding actin binding alpha-tubulin binding chaperone binding G protein-coupled receptor

Dario Altieri (600 words) [view diff] exact match in snippet view article find links to article

cancer. Altieri has also been involved in the development of gamitrinib, a Hsp90 inhibitor that was shown to disable the activity of mitochondria in cancerous

Organozinc chemistry (3,394 words) [view diff] exact match in snippet view article find links to article

Cycloproparadicicol as Synthetically Feasible Preclinical Anticancer Agent Based on Hsp90 as the Target". Journal of the American Chemical Society. 126 (25): 7881–9

ERN1 (1,889 words) [view diff] exact match in snippet view article find links to article

magnesium ion binding hydrolase activity Hsp70 protein binding kinase activity Hsp90 protein binding catalytic activity endonuclease activity ATP binding enzyme

Selective progesterone receptor modulator (5,148 words) [view diff] exact match in snippet view article find links to article

receptor, forms a complex consisting of itself, heat shock proteins (hsp70, hsp90) and immunophilins. Upon activation, due to hormone binding to ligand binding

C19orf44 (865 words) [view diff] exact match in snippet view article find links to article

various proteins from the two-hybrid screening method. Interactions with Hsp90 co-chaperone (CDC37), and spermatid associated protein (SPERT) have been

NASP (gene) (978 words) [view diff] case mismatch in snippet view article

EE, Richardson RT, O'Rand MG (January 2005). "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport

Cyclin-dependent kinase 5 (5,356 words) [view diff] exact match in snippet view article find links to article

serine/threonine kinase activity microtubule binding tau protein binding Hsp90 protein binding voltage-gated calcium channel activity involved in positive

Basic helix-loop-helix ARNT-like protein 1 (5,635 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function DNA binding Hsp90 protein binding protein dimerization activity DNA-binding transcription factor activity aryl hydrocarbon

Mitochondrial membrane transport protein (3,410 words) [view diff] exact match in snippet view article find links to article

Young JC, Hoogenraad NJ, Hartl FU (January 2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70"

Tau protein (6,277 words) [view diff] exact match in snippet view article find links to article

dynactin binding receptor ligand activity protein phosphatase 2A binding Hsp90 protein binding minor groove of adenine-thymine-rich DNA binding double-stranded

Quinone methide (1,865 words) [view diff] exact match in snippet view article find links to article

sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90". Int J Mol Med. 27 (3): 441–446. doi:10.3892/ijmm.2011.601. PMID 21249311

Resimmune (862 words) [view diff] exact match in snippet view article find links to article

translocates the catalytic domain to the cytosol by interaction with cytosolic Hsp90 and thioredoxin reductase. This single chain recombinant immunotoxin selectively

Estradiol (7,059 words) [view diff] case mismatch in snippet view article find links to article

multimolecular chaperone complexes organized around the heat shock protein 90 (HSP90), containing p23 protein, and immunophilin, and located in majority in cytoplasm

HIF1A (6,534 words) [view diff] exact match in snippet view article find links to article

protein binding histone acetyltransferase binding protein kinase binding Hsp90 protein binding sequence-specific DNA binding DNA binding transcription

Lutetium (177Lu) chloride (678 words) [view diff] case mismatch in snippet view article

Lundsten S, Spiegelberg D, Stenerlöw B, Nestor M (December 2019). "The HSP90 inhibitor onalespib potentiates 177Lu‑DOTATATE therapy in neuroendocrine

Candida albicans (9,894 words) [view diff] exact match in snippet view article find links to article

"Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway". PLOS Biology. 17 (3): e2006966. doi:10.1371/journal.pbio.2006966

Tumor-infiltrating lymphocytes (2,756 words) [view diff] case mismatch in snippet view article find links to article

Lizee G, Hanash SM, Proia D, Amaria R, Davis RE, Hwu P (September 2017). "HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response

Purinosome (1,426 words) [view diff] exact match in snippet view article find links to article

PMC 2856985. PMID 20157113. French, J. B.; et al. (2013-01-28). "Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome". Proceedings

Diverted total synthesis (619 words) [view diff] exact match in snippet view article find links to article

Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition. Adv. Synth. Catal., 350: 1677–1681. doi:10.1002/adsc.200800187

Retinoblastoma protein (9,499 words) [view diff] exact match in snippet view article find links to article

Dai K, Chen PL, Riley DJ, Lee WH (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein

Tetratricopeptide repeat domain 16 isoform 1 (721 words) [view diff] exact match in snippet view article find links to article

domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine". Cell. 101 (2): 199–210. doi:10.1016/S0092-8674(00)80830-2

Topoisomerase inhibitor (9,591 words) [view diff] exact match in snippet view article find links to article

activity. It acts as a competitive inhibitor and specifically inhibits Hsp90 and TopII. Novobiocin has been investigated and used in metastatic breast

SLX4IP (1,360 words) [view diff] case mismatch in snippet view article find links to article

Lillard-Wetherell K, Tahmaseb K, et al. (May 2009). "Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized

12-Hydroxyeicosatetraenoic acid (6,987 words) [view diff] exact match in snippet view article find links to article

acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit". Archives

Damage-associated molecular pattern (3,556 words) [view diff] case mismatch in snippet view article find links to article

have also been reported. For nonsmall-cell lung cancer, HSP27, HSP70, and HSP90 inhibitors are under investigation in clinical trials. In addition, treatment

Lorenz Studer (1,422 words) [view diff] case mismatch in snippet view article find links to article

Nature Biotechnology 37.4 (2019): 436-444. Kishinevsky, Sarah, et al. "HSP90-incorporating chaperome networks as biosensor for disease-related pathways

BAG3 (3,610 words) [view diff] exact match in snippet view article find links to article

complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins". The Journal of Biological Chemistry. 278 (31): 28490–500

Haifan Lin (2,283 words) [view diff] exact match in snippet view article find links to article

Wang, J., Huang, A. X., and Lin, H. (2010) Drosophila Piwi Functions in Hsp90-Mediated Suppression of Phenotypic Variation. Nature Genetics 43, 153–158

List of pharmaceutical compound number prefixes (1,656 words) [view diff] case mismatch in snippet view article find links to article

Archived from the original on 2012-04-16. Retrieved 2012-04-17. "Exelixis HSP90 inhibitor XL888". Archived from the original on 2016-09-18. Retrieved 2016-09-16

C-Raf (8,674 words) [view diff] exact match in snippet view article find links to article

R, Pratt WB (October 1993). "Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system". J. Biol. Chem

Cyclin-dependent kinase complex (2,258 words) [view diff] case mismatch in snippet view article find links to article

S phase KAP, Cks1, p27KIP1, and Spy-1 Cdk4 Cyclins D1, D2, D3 G1 phase HSP90-Cdc37 Cdk6 Cyclins D1, D2, D3 G1 phase p16INK4A, p19INK4D, and P18INK4C-cyclin

Dioxins and dioxin-like compounds (10,766 words) [view diff] case mismatch in snippet view article find links to article

represent the AHR, red bars ARNT, yellow bars ARA9 (AIP, Xap2), blue bars HSP90 and the blue ovals p23. Dioxin binding to the AHR (1.) leads to its translocation

Monocercomonoides (2,545 words) [view diff] case mismatch in snippet view article find links to article

𝛽-tubulin, 𝛾-tubulin, EF-1𝛼, EF-2, cytHSP70, ubiquitin, 18S rRNA, and HSP90 allow the placement of oxymonads near diplomonads and trichomonads, with

RIPK1 (4,148 words) [view diff] exact match in snippet view article find links to article

Miller A, Lin Y, Rodriguez Y, Neckers L, et al. (April 2000). "Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting

Ubiquitin C (4,261 words) [view diff] case mismatch in snippet view article find links to article

Garrido C (May 2008). "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell

Stress granule (12,548 words) [view diff] exact match in snippet view article find links to article

Tahbaz N, López-Orozco J, LaPointe P, Lasko P, Hobman TC (July 2009). "Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules

Chaperone-mediated autophagy (3,623 words) [view diff] exact match in snippet view article find links to article

complex. Assembly and disassembly of CMA translocation complex is mediated by hsp90 and hsc70 chaperones, respectively. Degradation of LAMP-2A monomers at the

Laura Niedernhofer (1,677 words) [view diff] case mismatch in snippet view article find links to article

L.; Niedernhofer, Laura J.; Robbins, Paul D. (2017). "Identification of HSP90 inhibitors as a novel class of senolytics". Nature Communications. 8 (1):

Gedunin (782 words) [view diff] exact match in snippet view article find links to article

Manuj; Thomas, Bobby; Chinta, Shankar J.; Andersen, Julie K. (March 2018). "Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization

Pramod Kumar Srivastava (987 words) [view diff] exact match in snippet view article find links to article

Srivastava PK. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin, Immunity (2001) 14, 303-313, PMID: 11290339 Doi :

Richard I. Morimoto (4,168 words) [view diff] case mismatch in snippet view article find links to article

Freeman, B.C.; Morimoto, R.I. (1996). "The Human Molecular Chaperones HSP90, HSP70 (HSC70) and HDJ-1 have Distinct Roles in Recognition of a Non-native

Taxonomy of Protista (15,311 words) [view diff] exact match in snippet view article find links to article

Decastava; Scytomonas saepesedens; Entosiphon oblongum), Hsp90 introns, and putative euglenoid Hsp90 pre-mRNA insertional editing". European Journal of Protistology

Ocean surface ecosystem (8,431 words) [view diff] exact match in snippet view article find links to article

H. W.; Šenolt, Ladislav; Bečvář, Radim; Tomčík, Michal (2021). "Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin

Folliculin (5,618 words) [view diff] exact match in snippet view article find links to article

Prodromou C, et al. (June 2016). "The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding". Nature Communications. 7: 12037

NOXRED1 (1,544 words) [view diff] case mismatch in snippet view article find links to article

Domain 15 (SAMD15), VPS33B Interacting Protein (VIPAS39), and Activator of HSP90 ATPase Activity 1 (AHSA1). NOXRED1 has three known mRNA isoforms (table

Kari Nadeau (2,992 words) [view diff] exact match in snippet view article find links to article

Stanford University Thesis Biochemical studies on protein folding chaperones : Hsp90 and cyclophilin ; and, On trypanosomal enzymes : trypanothione and glutationylspermidine