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searching for SN2 reaction 32 found (98 total)

Concerted reaction (211 words) [view diff] exact match in snippet view article find links to article

reactions, the SN2 reaction, and some rearrangements - such as the Claisen rearrangement - are concerted reactions. The rate of the SN2 reaction is second

Transition state (986 words) [view diff] exact match in snippet view article find links to article

symbol. As an example, the transition state shown below occurs during the SN2 reaction of bromoethane with a hydroxide anion: The activated complex of a reaction

Curtin–Hammett principle (3,757 words) [view diff] no match in snippet view article find links to article

The Curtin–Hammett principle is a principle in chemical kinetics proposed by David Yarrow Curtin and Louis Plack Hammett. It states that, for a reaction

John Isaiah Brauman (679 words) [view diff] case mismatch in snippet view article find links to article

"Perturbed Equilibria and Statistical Energy Redistribution in a Gas Phase SN2 Reaction". Science. 276 (5318): 1536–1538. doi:10.1126/science.276.5318.1536.

Combretastatin (613 words) [view diff] exact match in snippet view article find links to article

synthesis is as follows: 1-Bromomethyl-3,4,5-trimethoxybenzene undergoes an SN2 reaction with triphenylphosphine, which yields a phosphonium salt. This compound

Corey–Link reaction (389 words) [view diff] exact match in snippet view article find links to article

trichloromethyl position to form an epoxide. The azide then opens this ring by an SN2 reaction to give a 2-azido structure whose stereochemistry is inverted compared

Riboflavin synthase (1,086 words) [view diff] exact match in snippet view article find links to article

not been determined if nucleophilic displacement occurs via an SN1 or SN2 reaction. During the dismutation reaction, a four carbon unit is exchanged between

Alkoxide (1,009 words) [view diff] exact match in snippet view article find links to article

The alkoxide ion and its salts react with primary alkyl halides in an SN2 reaction to form an ether via the Williamson Ether Synthesis.[citation needed]

Busulfan (1,249 words) [view diff] exact match in snippet view article find links to article

and adenine and between guanine and guanine. This occurs through an SN2 reaction in which the relatively nucleophilic guanine N7 attacks the carbon adjacent

Halohydrin dehalogenase (969 words) [view diff] case mismatch in snippet view article find links to article

substrate. The deprotonated oxygen then acts as a nucleophile and performs a Sn2 reaction on the vicinal carbon that is bonded to the halogen; this releases a

1,1-Diiodoethane (382 words) [view diff] exact match in snippet view article find links to article

reactant in reaction such as SN2. The following are some examples of SN2 reaction using 1,1-diiodoethane as a reactant. Moreover, is can also be used as

Dimethyl sulfate (1,452 words) [view diff] exact match in snippet view article find links to article

quickly than the second. Methyl transfer is assumed to occur via an SN2 reaction. Compared to other methylating agents, dimethyl sulfate is preferred

Metal–halogen exchange (1,200 words) [view diff] exact match in snippet view article find links to article

an anion stabilized by the adjacent sulfone group. An intramolecular SN2 reaction by the anion forms the cyclic backbone of morphine. Lithium–halogen exchange

Carbonyl α-substitution reactions (982 words) [view diff] exact match in snippet view article find links to article

nucleophilic enolate ion reacts with the electrophilic alkyl halide in an SN2 reaction and displaces the leaving group by backside attack. Alkylation reactions

Chloro(pyridine)cobaloxime (616 words) [view diff] exact match in snippet view article

into the reaction mixture, and the desired Co-C bond is formed via a SN2 reaction. This method can be used to produce cobaloximes containing a primary

2-Chlorobutane (755 words) [view diff] case mismatch in snippet view article find links to article

also a candidate for coupling reactions via a Grignard reagent. In an Sn2 reaction, a nucleophile (iodine) attacks the partially positive carbon, which

Simmons–Smith reaction (2,502 words) [view diff] exact match in snippet view article find links to article

alcohols to produce iodophenylmethane, which can further undergo an SN2 reaction to produce ROCHPh, as in Pathway C. Although not commonly used, Simmons-Smith

Α-Chlorocodide (58 words) [view diff] no match in snippet view article find links to article

chlorine. Chloromorphide Stork, Gilbert; Clarke, Frank H. (1956). "The SN2' Reaction. III. Structure and SN2' Reactions of the Halocodides". Journal of the

Tert-Butyl alcohol (712 words) [view diff] exact match in snippet view article find links to article

nucleophilic substitution, such as in a Williamson ether synthesis or an SN2 reaction. tert-Butyl alcohol reacts with hydrogen chloride to form tert-butyl

VS ribozyme (1,637 words) [view diff] exact match in snippet view article find links to article

an important role in its activity. The cleavage reaction works by an SN2 reaction mechanism. The nucleophilic attack of the 2’-oxygen on the 3’-phosphate

Lewis acids and bases (2,761 words) [view diff] exact match in snippet view article find links to article

nucleophile to the carbon and cleavage of the bond between carbon and iodine (SN2 reaction). Textbooks disagree on this point: some asserting that alkyl halides

Leaving group (2,532 words) [view diff] exact match in snippet view article find links to article

nucleofugal leaving group. The leaving group (LG) is shown in red. Top: SN2 reaction; middle/left: first step of SN1 and E1 reactions; middle/right: second

Tutin (toxin) (2,738 words) [view diff] exact match in snippet view article

removed by using tetra-n-butylammonium fluoride in THF. The intramolecular SN2 reaction at the allylic bromide moiety led to the formation of the epoxy olefin

Hammond's postulate (2,552 words) [view diff] case mismatch in snippet view article find links to article

which resembles the concerted rate limiting step. In the "Depiction of SN2 Reaction" figure, the nucleophile forms a new bond to the carbon, while the halide

NanoPutian (1,442 words) [view diff] exact match in snippet view article find links to article

One of the bromine substituents is converted to an aldehyde through an SN2 reaction with the strong base, n-BuLi, and THF in the aprotic polar solvent, DMF

George S. Hammond (3,775 words) [view diff] case mismatch in snippet view article find links to article

which resembles the concerted rate limiting step. In the "Depiction of SN2 Reaction" figure, the nucleophile forms a new bond to the carbon, while the halide

Fluorodeoxyglucose (18F) (2,441 words) [view diff] exact match in snippet view article

triflate (1); the fluoride anion displaces the triflate leaving group in an SN2 reaction, giving the protected fluorinated deoxyglucose (3). Base hydrolysis removes

Ribozyme (5,181 words) [view diff] exact match in snippet view article find links to article

counterparts. For example, in self cleaving ribozyme RNAs, an in-line SN2 reaction is carried out using the 2’ hydroxyl group as a nucleophile attacking

Hofmann–Löffler reaction (5,291 words) [view diff] exact match in snippet view article find links to article

with base, 25 undergoes deprotonation followed by an intramolecular SN2 reaction to yield pyrrolidine 28 via intermediate 27. The preferential abstraction

Aza-Cope rearrangement (5,704 words) [view diff] exact match in snippet view article find links to article

common method to get to imine precursors. Amine alkylation by direct SN2 reaction is only occasionally useful in producing starting materials due to the

Arsenic biochemistry (5,315 words) [view diff] exact match in snippet view article find links to article

The catalysis involves thiolates of Cys72, Cys174, and Cys224. In an SN2 reaction, the positive charge on the SAM sulfur atom pulls the bonding electron

Superelectrophilic anion (4,212 words) [view diff] exact match in snippet view article find links to article

bound to the boron atom, its substitution by a nucleophile in a typical SN2 reaction is prevented by the cage structure of the borate, since the noble gas-boron